| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.208901 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.188761 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.135344 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.128169 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120706 |
| NDRG1 | N-myc downstream regulated 1 | 0.113943 |
| COL6A3 | collagen, type VI, alpha 3 | 0.103915 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.102228 |
| PDE10A | phosphodiesterase 10A | 0.0869105 |
| ATP13A3 | ATPase type 13A3 | 0.086851 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.080421 |
| VEGFA | vascular endothelial growth factor A | 0.0768 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0681111 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0679282 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0658103 |
| STC1 | stanniocalcin 1 | 0.0625022 |
| CADM1 | cell adhesion molecule 1 | 0.0614048 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0589366 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0585972 |
| FMNL2 | formin-like 2 | 0.0554838 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0540896 |
| VCAN | versican | 0.0539113 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0528729 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0509545 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0504131 |
| RUNX1 | runt-related transcription factor 1 | 0.0466603 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0463883 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0463719 |
| NAV2 | neuron navigator 2 | 0.0462823 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0452431 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0452275 |
| SETD5 | SET domain containing 5 | 0.0450777 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0450213 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0448122 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0447257 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0422928 |
| PTK2 | protein tyrosine kinase 2 | 0.0411599 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0407844 |
| GOLGA4 | golgin A4 | 0.0395554 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0390148 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0383312 |
| SPAG9 | sperm associated antigen 9 | 0.0371192 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0370037 |
| ZNF292 | zinc finger protein 292 | 0.0369186 |
| SQLE | squalene epoxidase | 0.0364035 |
| COL5A1 | collagen, type V, alpha 1 | 0.0359402 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0355541 |
| FAM13A | family with sequence similarity 13, member A | 0.035301 |
| YEATS2 | YEATS domain containing 2 | 0.0347653 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0347186 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0345263 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0336715 |
| RNF145 | ring finger protein 145 | 0.0335924 |
| MYO10 | myosin X | 0.0333377 |
| ARRDC3 | arrestin domain containing 3 | 0.0333322 |
| OGA | O-GlcNAcase | 0.0330829 |
| MTSS1 | metastasis suppressor 1 | 0.0328236 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0326466 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0324393 |
| MRTFA | myocardin related transcription factor A | 0.0322098 |
| MSN | moesin | 0.0320114 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0318784 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0318411 |
| TMEM165 | transmembrane protein 165 | 0.031634 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0315975 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0313688 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0312927 |
| SMAD3 | SMAD family member 3 | 0.031158 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0310628 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0309889 |
| COL1A2 | collagen, type I, alpha 2 | 0.0309681 |
| ENO1 | enolase 1, (alpha) | 0.0309285 |
| INSIG2 | insulin induced gene 2 | 0.0307944 |
| COPA | coatomer protein complex, subunit alpha | 0.0306339 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0297247 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0296756 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0296619 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.029398 |
| CCNY | cyclin Y | 0.0293947 |
| QKI | QKI, KH domain containing, RNA binding | 0.0293256 |
| EFNA5 | ephrin-A5 | 0.0291409 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0285273 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0283888 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0282847 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0282481 |
| TPR | translocated promoter region, nuclear basket protein | 0.0282385 |
| RPS6 | ribosomal protein S6 | 0.0281658 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0281065 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0277029 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0275924 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0274011 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0271624 |
| HELZ | helicase with zinc finger | 0.0271064 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0270442 |
| CCNL1 | cyclin L1 | 0.0268826 |
| ANXA1 | annexin A1 | 0.0268779 |
| MED13L | mediator complex subunit 13-like | 0.0267027 |
| TMF1 | TATA element modulatory factor 1 | 0.0266963 |
| FLNB | filamin B, beta | 0.0266857 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0266559 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.284654 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.216359 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.168919 |
| EXT1 | exostosin glycosyltransferase 1 | -0.119146 |
| TMSB10 | thymosin beta 10 | -0.0949491 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0925382 |
| COL1A1 | collagen, type I, alpha 1 | -0.0898214 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0821727 |
| CD44 | CD44 molecule (Indian blood group) | -0.0709974 |
| RPL35A | ribosomal protein L35a | -0.0592485 |
| OSMR | oncostatin M receptor | -0.0589818 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0589064 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0572225 |
| ACTG1 | actin gamma 1 | -0.0545971 |
| VCL | vinculin | -0.0525777 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0506886 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0503846 |
| PALLD | palladin, cytoskeletal associated protein | -0.0483703 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0459893 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0454099 |
| EGR1 | early growth response 1 | -0.0442827 |
| GLIS3 | GLIS family zinc finger 3 | -0.0419967 |
| HLA-B | major histocompatibility complex, class I, B | -0.0417825 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0403002 |
| LDHA | lactate dehydrogenase A | -0.0390471 |
| MAP1B | microtubule-associated protein 1B | -0.0389718 |
| IL6ST | interleukin 6 signal transducer | -0.0381031 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0371895 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.037156 |
| CALR | calreticulin | -0.0370618 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0365525 |
| HMGA2 | high mobility group AT-hook 2 | -0.0360049 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0337106 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0330181 |
| CLIC4 | chloride intracellular channel 4 | -0.032416 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0323533 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.032351 |
| RIGI | RNA sensor RIG-I | -0.0317901 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0304803 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0302713 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0297294 |
| LOX | lysyl oxidase | -0.0293917 |
| RRBP1 | ribosome binding protein 1 | -0.0289063 |
| TUBB | tubulin, beta class I | -0.0285045 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0284513 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0283682 |
| RPL8 | ribosomal protein L8 | -0.028088 |
| TAPBP | TAP binding protein (tapasin) | -0.0279246 |
| FTL | ferritin, light polypeptide | -0.0278962 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0277626 |
| MX2 | MX dynamin-like GTPase 2 | -0.0270838 |
| IER3 | immediate early response 3 | -0.0269839 |
| SP100 | SP100 nuclear antigen | -0.026429 |
| NABP1 | nucleic acid binding protein 1 | -0.0262583 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0262482 |
| CNTN5 | contactin 5 | -0.0260674 |
| HDLBP | high density lipoprotein binding protein | -0.0253722 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.025326 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0252039 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0250966 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0250521 |
| ARF1 | ADP-ribosylation factor 1 | -0.025009 |
| RPL30 | ribosomal protein L30 | -0.0248451 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0242223 |
| PLSCR1 | phospholipid scramblase 1 | -0.0239199 |
| SVIL | supervillin | -0.0235535 |
| ZNF644 | zinc finger protein 644 | -0.02339 |
| CANX | calnexin | -0.0232107 |
| JAK2 | Janus kinase 2 | -0.0230131 |
| CAVIN1 | caveolae associated protein 1 | -0.0229407 |
| RPLP0 | ribosomal protein, large, P0 | -0.0228814 |
| ACTN4 | actinin, alpha 4 | -0.0227308 |
| HMGA1 | high mobility group AT-hook 1 | -0.0222678 |
| NRP1 | neuropilin 1 | -0.0217074 |
| RACK1 | receptor for activated C kinase 1 | -0.0215356 |
| RPS24 | ribosomal protein S24 | -0.0208805 |
| COL3A1 | collagen, type III, alpha 1 | -0.0207712 |
| RPLP1 | ribosomal protein, large, P1 | -0.0204755 |
| RASAL2 | RAS protein activator like 2 | -0.0203502 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202753 |
| H1-0 | H1.0 linker histone | -0.0202574 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0202166 |
| NREP | neuronal regeneration related protein | -0.0201056 |
| CPQ | carboxypeptidase Q | -0.020007 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0200033 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0199607 |
| HLA-C | major histocompatibility complex, class I, C | -0.0198371 |
| BSG | basigin (Ok blood group) | -0.0198044 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0195234 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0194797 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0194768 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0192589 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0192483 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0191732 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0188581 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0188296 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0187022 |
| RPL28 | ribosomal protein L28 | -0.0186124 |
| SRGN | serglycin | -0.0185808 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0182867 |
