| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Glasdegib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.146471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.113131 |
| FNDC3B | fibronectin type III domain containing 3B | 0.108713 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0794083 |
| TF | transferrin | 0.0772491 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.069717 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0683719 |
| AFDN | afadin, adherens junction formation factor | 0.065675 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0652939 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0641213 |
| INSIG2 | insulin induced gene 2 | 0.0637942 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0635089 |
| ENO1 | enolase 1, (alpha) | 0.0627197 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0573426 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0563169 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0563003 |
| DTNA | dystrobrevin, alpha | 0.0537223 |
| ZNF292 | zinc finger protein 292 | 0.0505434 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0480887 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0470218 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0468773 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0465473 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0465427 |
| FMNL2 | formin-like 2 | 0.0460531 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0448052 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0435955 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0429958 |
| RPS6 | ribosomal protein S6 | 0.0429106 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0419147 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0403651 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0403618 |
| RPS12 | ribosomal protein S12 | 0.0396961 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0391638 |
| OGA | O-GlcNAcase | 0.0386383 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0365542 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0358443 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0356843 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0354712 |
| PDE8A | phosphodiesterase 8A | 0.0352452 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0351952 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0349194 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0348866 |
| PRELID2 | PRELI domain containing 2 | 0.034312 |
| WDR45B | WD repeat domain 45B | 0.0342336 |
| ARFGEF3 | ARFGEF family member 3 | 0.0340523 |
| VEGFA | vascular endothelial growth factor A | 0.0332162 |
| MXI1 | MAX interactor 1, dimerization protein | 0.032352 |
| CPE | carboxypeptidase E | 0.0316309 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0315079 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0313327 |
| NGLY1 | N-glycanase 1 | 0.0310362 |
| MATR3 | matrin 3 | 0.0308007 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0304656 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0302561 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0302196 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0300535 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0300137 |
| PLIN2 | perilipin 2 | 0.0298723 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0298328 |
| RPL3 | ribosomal protein L3 | 0.0295887 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0295281 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.029249 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0291202 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0289673 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0284213 |
| ASPH | aspartate beta-hydroxylase | 0.0284173 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | 0.0282207 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0281466 |
| MYO1B | myosin IB | 0.0280418 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0279935 |
| RNF145 | ring finger protein 145 | 0.0278508 |
| FAM13A | family with sequence similarity 13, member A | 0.0275953 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0274106 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0264824 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0262274 |
| TOP1 | topoisomerase (DNA) I | 0.0261557 |
| HLF | hepatic leukemia factor | 0.0258681 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0251499 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0250871 |
| CFB | complement factor B | 0.0248935 |
| SBF2 | SET binding factor 2 | 0.0248507 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0248459 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0248411 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0247398 |
| USP47 | ubiquitin specific peptidase 47 | 0.0245285 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0243181 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0242887 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0242759 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0241687 |
| CDK19 | cyclin-dependent kinase 19 | 0.0241658 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0241063 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0239627 |
| TNS1 | tensin 1 | 0.0237747 |
| LRRC1 | leucine rich repeat containing 1 | 0.023731 |
| RNF24 | ring finger protein 24 | 0.0236838 |
| GOLGA4 | golgin A4 | 0.023265 |
| FBXO42 | F-box protein 42 | 0.0231637 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0231426 |
| NDRG1 | N-myc downstream regulated 1 | 0.0231154 |
| SMAP1 | small ArfGAP 1 | 0.0230174 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.325744 |
| FN1 | fibronectin 1 | -0.172261 |
| VCL | vinculin | -0.138817 |
| APOB | apolipoprotein B | -0.132886 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.113101 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.106848 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.10532 |
| GPC6 | glypican 6 | -0.101119 |
| ITGAV | integrin, alpha V | -0.0987469 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0914517 |
| BCL2L1 | BCL2-like 1 | -0.0755168 |
| EGR1 | early growth response 1 | -0.0753614 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0747052 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0730193 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0725351 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0698424 |
| EHBP1 | EH domain binding protein 1 | -0.06647 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0663192 |
| PTCHD4 | patched domain containing 4 | -0.0643127 |
| GPC3 | glypican 3 | -0.0634529 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0613471 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0612328 |
| EXT1 | exostosin glycosyltransferase 1 | -0.060411 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0603476 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0602956 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0580986 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0580421 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0576186 |
| FOXP1 | forkhead box P1 | -0.0544219 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0533509 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0521689 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0517649 |
| ZNF644 | zinc finger protein 644 | -0.0507417 |
| C3 | complement component 3 | -0.0505643 |
| FAM107B | family with sequence similarity 107, member B | -0.0488193 |
| LOC112694756 | uncharaterized LOC112694756 | -0.048734 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0479048 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0464992 |
| ACTN4 | actinin, alpha 4 | -0.0455718 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0455126 |
| MYO1E | myosin IE | -0.0454996 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0430113 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0424601 |
| FTL | ferritin, light polypeptide | -0.0413834 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0407591 |
| DST | dystonin | -0.0401791 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0400882 |
| VMP1 | vacuole membrane protein 1 | -0.039869 |
| MRTFA | myocardin related transcription factor A | -0.0390703 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0389311 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.038819 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0387726 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0382762 |
| TPM1 | tropomyosin 1 (alpha) | -0.0369506 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.036943 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0364008 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0363623 |
| RPL35A | ribosomal protein L35a | -0.0351857 |
| RPS24 | ribosomal protein S24 | -0.0346213 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0344699 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0343237 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0336782 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0336581 |
| RIGI | RNA sensor RIG-I | -0.0335904 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0326932 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0326188 |
| A2M | alpha-2-macroglobulin | -0.0323301 |
| CP | ceruloplasmin (ferroxidase) | -0.032072 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0308008 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.030361 |
| RPLP1 | ribosomal protein, large, P1 | -0.029903 |
| RNF213 | ring finger protein 213 | -0.0297991 |
| THBS1 | thrombospondin 1 | -0.029354 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0293418 |
| PLAC8 | placenta-specific 8 | -0.0292982 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0286341 |
| SVIL | supervillin | -0.0280151 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0277213 |
| KLF6 | Kruppel-like factor 6 | -0.0274159 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0271697 |
| CTSB | cathepsin B | -0.0270163 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0269334 |
| PRKCA | protein kinase C, alpha | -0.0269276 |
| CADM1 | cell adhesion molecule 1 | -0.026912 |
| SEPTIN9 | septin 9 | -0.0268678 |
| NINL | ninein-like | -0.026753 |
| FILIP1L | filamin A interacting protein 1-like | -0.0266987 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0265728 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0265628 |
| SKI | SKI proto-oncogene | -0.0259378 |
| PALLD | palladin, cytoskeletal associated protein | -0.0259344 |
| ACTG1 | actin gamma 1 | -0.0259157 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -0.0259077 |
| SYNJ2 | synaptojanin 2 | -0.0258069 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0255334 |
| CMIP | c-Maf inducing protein | -0.0254123 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0253304 |
| FUS | FUS RNA binding protein | -0.0251668 |
| RHOB | ras homolog family member B | -0.0251644 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0248718 |
