| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EREG | epiregulin | 0.114415 |
| FAM13A | family with sequence similarity 13, member A | 0.098238 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0885723 |
| PRELID2 | PRELI domain containing 2 | 0.0786154 |
| OGA | O-GlcNAcase | 0.0733967 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0723366 |
| GOLGA4 | golgin A4 | 0.0667298 |
| FLNB | filamin B, beta | 0.061787 |
| FAT1 | FAT atypical cadherin 1 | 0.0612634 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0608867 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0606876 |
| ENO1 | enolase 1, (alpha) | 0.0578748 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0564172 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0542371 |
| DSPP | dentin sialophosphoprotein | 0.0533554 |
| AHNAK | AHNAK nucleoprotein | 0.0530336 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0517034 |
| KIF5B | kinesin family member 5B | 0.0497544 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0484365 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0480396 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0479971 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0468963 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0468664 |
| RPS12 | ribosomal protein S12 | 0.0466371 |
| TMSB4X | thymosin beta 4, X-linked | 0.0463234 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0458205 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.045785 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0452879 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0447308 |
| ASPH | aspartate beta-hydroxylase | 0.0447237 |
| ONECUT3 | one cut homeobox 3 | 0.0438662 |
| KRT18 | keratin 18, type I | 0.0434009 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0433516 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0423557 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.041732 |
| CCNY | cyclin Y | 0.0400283 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0392591 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0392384 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0388645 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0380277 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0377851 |
| AFDN | afadin, adherens junction formation factor | 0.0377821 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0377461 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0374432 |
| LMO7 | LIM domain 7 | 0.0374389 |
| PTMA | prothymosin, alpha | 0.0374194 |
| RBM39 | RNA binding motif protein 39 | 0.0373137 |
| RPL3 | ribosomal protein L3 | 0.0371417 |
| EHF | ets homologous factor | 0.0370104 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0367441 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0366709 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0365606 |
| TPM3 | tropomyosin 3 | 0.0365606 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0352459 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0348998 |
| RPS6 | ribosomal protein S6 | 0.0344186 |
| ANXA2 | annexin A2 | 0.0341349 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0340621 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0339415 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0335263 |
| NPSR1 | neuropeptide S receptor 1 | 0.0326838 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.032574 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0324605 |
| MED13L | mediator complex subunit 13-like | 0.0324391 |
| MATR3 | matrin 3 | 0.0323196 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.032082 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0320342 |
| TMF1 | TATA element modulatory factor 1 | 0.031784 |
| NEK7 | NIMA-related kinase 7 | 0.0313216 |
| RPS2 | ribosomal protein S2 | 0.0308763 |
| KRT8 | keratin 8, type II | 0.0305474 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0303075 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.029679 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0294633 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0288625 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0285161 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0282708 |
| WDR45B | WD repeat domain 45B | 0.0282221 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0281909 |
| DIAPH1 | diaphanous-related formin 1 | 0.0279139 |
| NCKAP1 | NCK-associated protein 1 | 0.0275234 |
| BBX | bobby sox homolog (Drosophila) | 0.0273908 |
| EPCAM | epithelial cell adhesion molecule | 0.0269377 |
| ANLN | anillin, actin binding protein | 0.0269209 |
| TPM4 | tropomyosin 4 | 0.0267408 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0266819 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0266576 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0266029 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0266002 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0265187 |
| MYOF | myoferlin | 0.0264696 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0264695 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0264424 |
| SET | SET nuclear proto-oncogene | 0.026417 |
| PNN | pinin, desmosome associated protein | 0.026174 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0259837 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0258929 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0258692 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0253114 |
| TPD52 | tumor protein D52 | 0.0251987 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.325978 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.110649 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.101224 |
| VCL | vinculin | -0.0834363 |
| NDRG1 | N-myc downstream regulated 1 | -0.0834122 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0800122 |
| FTL | ferritin, light polypeptide | -0.0792008 |
| MYO1E | myosin IE | -0.0718823 |
| TMSB10 | thymosin beta 10 | -0.0695845 |
| RPL35A | ribosomal protein L35a | -0.0691004 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.065521 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0625213 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0576625 |
| HMGA1 | high mobility group AT-hook 1 | -0.0526244 |
| TXNIP | thioredoxin interacting protein | -0.0514807 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0476704 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0476651 |
| EGR1 | early growth response 1 | -0.0476041 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0468384 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0446219 |
| RPLP0 | ribosomal protein, large, P0 | -0.0443423 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0410537 |
| RPS19 | ribosomal protein S19 | -0.0401469 |
| JUN | jun proto-oncogene | -0.0385422 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0385025 |
| GPHN | gephyrin | -0.0383166 |
| RPL8 | ribosomal protein L8 | -0.037666 |
| PDLIM5 | PDZ and LIM domain 5 | -0.036996 |
| RPLP1 | ribosomal protein, large, P1 | -0.036029 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0358142 |
| LAMA4 | laminin, alpha 4 | -0.0331173 |
| CLDN7 | claudin 7 | -0.0323924 |
| MUC13 | mucin 13, cell surface associated | -0.0317309 |
| PFN1 | profilin 1 | -0.0310591 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0299243 |
| CLDN4 | claudin 4 | -0.0292076 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0286086 |
| TRIM2 | tripartite motif containing 2 | -0.0285412 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0281878 |
| RPL36 | ribosomal protein L36 | -0.0276227 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0272418 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0268421 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0263618 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0263399 |
| FHL2 | four and a half LIM domains 2 | -0.0261876 |
| MT1X | metallothionein 1X | -0.0257253 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0253711 |
| RAB7A | RAB7A, member RAS oncogene family | -0.025332 |
| RPL34 | ribosomal protein L34 | -0.0253026 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0251916 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0251797 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0249037 |
| S100A9 | S100 calcium binding protein A9 | -0.0247799 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0242683 |
| MED13 | mediator complex subunit 13 | -0.0241954 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0241464 |
| JMJD1C | jumonji domain containing 1C | -0.0239296 |
| MECOM | MDS1 and EVI1 complex locus | -0.0225091 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0218948 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0218795 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0217828 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0216718 |
| MUC17 | mucin 17, cell surface associated | -0.0216393 |
| RAB10 | RAB10, member RAS oncogene family | -0.0214188 |
| TNS4 | tensin 4 | -0.0210917 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0209386 |
| TAGLN2 | transgelin 2 | -0.0208088 |
| RPL12 | ribosomal protein L12 | -0.0206617 |
| ABR | active BCR-related | -0.0206416 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0202821 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0202808 |
| RPS13 | ribosomal protein S13 | -0.0201966 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0201624 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0201317 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0200245 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.020002 |
| RPL32 | ribosomal protein L32 | -0.019679 |
| RPL31 | ribosomal protein L31 | -0.019626 |
| ADIPOR2 | adiponectin receptor 2 | -0.0193291 |
| PRSS3 | protease, serine, 3 | -0.0192347 |
| TJP1 | tight junction protein 1 | -0.0191114 |
| AREG | amphiregulin | -0.0190846 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0190773 |
| FHIT | fragile histidine triad | -0.0187322 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0184783 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | -0.0183785 |
| EFNB2 | ephrin-B2 | -0.0183186 |
| BSG | basigin (Ok blood group) | -0.0179329 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0177327 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0175184 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0171804 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0171274 |
| RPL27A | ribosomal protein L27a | -0.0171254 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0170932 |
| MAGT1 | magnesium transporter 1 | -0.017088 |
| TPI1 | triosephosphate isomerase 1 | -0.0170673 |
| PIGR | polymeric immunoglobulin receptor | -0.0170248 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0170087 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0169351 |
| FBXO11 | F-box protein 11 | -0.016927 |
