| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Glasdegib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.163445 |
| LAMC2 | laminin, gamma 2 | 0.0649822 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0616581 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0565385 |
| FAM13A | family with sequence similarity 13, member A | 0.0555579 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0529577 |
| NGLY1 | N-glycanase 1 | 0.0503232 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0452718 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0446954 |
| SMAD3 | SMAD family member 3 | 0.0445251 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0444882 |
| OGA | O-GlcNAcase | 0.0431534 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0408884 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0392264 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.038762 |
| RUNX1 | runt-related transcription factor 1 | 0.0373138 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.037163 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0365029 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0363178 |
| TOP1 | topoisomerase (DNA) I | 0.0357913 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0354689 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0348894 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0345179 |
| SLTM | SAFB-like, transcription modulator | 0.0342558 |
| PGK1 | phosphoglycerate kinase 1 | 0.0340036 |
| YEATS2 | YEATS domain containing 2 | 0.0335243 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0325258 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0324405 |
| ZNF292 | zinc finger protein 292 | 0.0323645 |
| LAMB3 | laminin, beta 3 | 0.032082 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0316966 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.031202 |
| USP34 | ubiquitin specific peptidase 34 | 0.0310219 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0309318 |
| AHNAK | AHNAK nucleoprotein | 0.0307569 |
| PRELID2 | PRELI domain containing 2 | 0.030752 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0304006 |
| ATP13A3 | ATPase type 13A3 | 0.0297598 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0297143 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0290694 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0286388 |
| CDCP1 | CUB domain containing protein 1 | 0.0284545 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0284224 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0280198 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.027066 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0267897 |
| WDR26 | WD repeat domain 26 | 0.0266396 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0262933 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0260402 |
| MKI67 | marker of proliferation Ki-67 | 0.0259613 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0256741 |
| FNIP1 | folliculin interacting protein 1 | 0.025419 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0252758 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0250027 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0248348 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0243907 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0239838 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0238704 |
| GPATCH2L | G patch domain containing 2-like | 0.0233586 |
| MATR3 | matrin 3 | 0.0233059 |
| CTTN | cortactin | 0.0228005 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0227474 |
| RNF169 | ring finger protein 169 | 0.0224452 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0222831 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0222502 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0221638 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0220715 |
| RASA2 | RAS p21 protein activator 2 | 0.0220332 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0219926 |
| PLEC | plectin | 0.0219754 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0219259 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0218152 |
| KLC1 | kinesin light chain 1 | 0.0217715 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0216509 |
| ZNF638 | zinc finger protein 638 | 0.0211723 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0209498 |
| GRAMD1B | GRAM domain containing 1B | 0.0208343 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0207693 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0205652 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.020513 |
| NCKAP1 | NCK-associated protein 1 | 0.0203674 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | 0.0201681 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0200396 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0199544 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0196175 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0194899 |
| TXNRD1 | thioredoxin reductase 1 | 0.0194068 |
| CAB39 | calcium binding protein 39 | 0.0193778 |
| RBM26 | RNA binding motif protein 26 | 0.0192364 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0191349 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0190041 |
| ASPH | aspartate beta-hydroxylase | 0.0188829 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0187993 |
| THOC2 | THO complex 2 | 0.0187861 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0187779 |
| ANO6 | anoctamin 6 | 0.0187659 |
| SEPTIN2 | septin 2 | 0.0187296 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0187242 |
| ADAR | adenosine deaminase, RNA-specific | 0.01861 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0185756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.590512 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.127545 |
| TMSB10 | thymosin beta 10 | -0.122139 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0992636 |
| EGR1 | early growth response 1 | -0.0961498 |
| FTL | ferritin, light polypeptide | -0.0863783 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0782177 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0706768 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0700244 |
| PKM | pyruvate kinase, muscle | -0.0562923 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0556995 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.053658 |
| NDRG1 | N-myc downstream regulated 1 | -0.0523313 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0463455 |
| RPLP1 | ribosomal protein, large, P1 | -0.0457844 |
| INTS6 | integrator complex subunit 6 | -0.0457157 |
| SEC61G | Sec61 gamma subunit | -0.0453724 |
| ANXA2 | annexin A2 | -0.0452494 |
| S100A10 | S100 calcium binding protein A10 | -0.0444389 |
| PTMA | prothymosin, alpha | -0.0440503 |
| ACTG1 | actin gamma 1 | -0.0431801 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0428957 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0424071 |
| CST3 | cystatin C | -0.0402384 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0366526 |
| LDHA | lactate dehydrogenase A | -0.036482 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0352704 |
| BRD2 | bromodomain containing 2 | -0.0349984 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0348212 |
| RPL35A | ribosomal protein L35a | -0.0331452 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0330898 |
| MORF4L2 | mortality factor 4 like 2 | -0.0325738 |
| UBC | ubiquitin C | -0.0310491 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0309673 |
| VMP1 | vacuole membrane protein 1 | -0.0303688 |
| NABP1 | nucleic acid binding protein 1 | -0.0301604 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0301591 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0293153 |
| MT2A | metallothionein 2A | -0.0288186 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0286642 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0280055 |
| HMGA1 | high mobility group AT-hook 1 | -0.0275713 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0271044 |
| TJP1 | tight junction protein 1 | -0.0263841 |
| B2M | beta-2-microglobulin | -0.0258559 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0256482 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0256261 |
| EMP1 | epithelial membrane protein 1 | -0.0255946 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0251587 |
| SPAG9 | sperm associated antigen 9 | -0.0250972 |
| AREG | amphiregulin | -0.0242148 |
| PFN1 | profilin 1 | -0.0239235 |
| RPL8 | ribosomal protein L8 | -0.0235694 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0234852 |
| WASF2 | WAS protein family, member 2 | -0.023443 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0233545 |
| MYO1E | myosin IE | -0.0231779 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0218639 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0212636 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0211282 |
| MCL1 | myeloid cell leukemia 1 | -0.0209869 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.020867 |
| S100A11 | S100 calcium binding protein A11 | -0.0204559 |
| VCL | vinculin | -0.0203644 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0201469 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0197415 |
| S100P | S100 calcium binding protein P | -0.0196701 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0195709 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0195602 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0194711 |
| ANXA1 | annexin A1 | -0.0193681 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0192466 |
| PDE8A | phosphodiesterase 8A | -0.0192357 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0191014 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0185528 |
| SLC38A1 | solute carrier family 38, member 1 | -0.018158 |
| RPLP0 | ribosomal protein, large, P0 | -0.018098 |
| CPE | carboxypeptidase E | -0.0180564 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0180065 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0179748 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0177176 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0174804 |
| POTEF | POTE ankyrin domain family, member F | -0.0169941 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.016965 |
| CALR | calreticulin | -0.016923 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0167967 |
| RPL19 | ribosomal protein L19 | -0.016728 |
| RPL28 | ribosomal protein L28 | -0.0167158 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0166853 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.016631 |
| RPL12 | ribosomal protein L12 | -0.0166116 |
| H1-0 | H1.0 linker histone | -0.0164937 |
| FBXO11 | F-box protein 11 | -0.0164239 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0162635 |
| PER2 | period circadian clock 2 | -0.0162086 |
| MAGT1 | magnesium transporter 1 | -0.0161937 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0161744 |
| SCEL | sciellin | -0.0161098 |
| EZR | ezrin | -0.0160828 |
| MT1X | metallothionein 1X | -0.016061 |
