| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.14428 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.136763 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.112901 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.102738 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0756684 |
| TXNRD1 | thioredoxin reductase 1 | 0.0743833 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0697041 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0680738 |
| FGB | fibrinogen beta chain | 0.067002 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0669715 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0601251 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0549765 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0540083 |
| TPM3 | tropomyosin 3 | 0.0509439 |
| WWOX | WW domain containing oxidoreductase | 0.0480947 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0477863 |
| VIM | vimentin | 0.0473018 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0446446 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0410718 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.04103 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0407559 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0402979 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0395607 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.038517 |
| BICC1 | BicC family RNA binding protein 1 | 0.0378283 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0376231 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0370007 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0361132 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0360154 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0339849 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0339576 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.033847 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0326189 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0321063 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0313758 |
| RTN4 | reticulon 4 | 0.0307218 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0299433 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0298402 |
| FAM168A | family with sequence similarity 168, member A | 0.0294161 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0286302 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0283768 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.028312 |
| KLF6 | Kruppel-like factor 6 | 0.0283 |
| AHNAK | AHNAK nucleoprotein | 0.0282911 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.027328 |
| RRM2 | ribonucleotide reductase M2 | 0.0271046 |
| SET | SET nuclear proto-oncogene | 0.0269832 |
| NRG1 | neuregulin 1 | 0.0269103 |
| SRGN | serglycin | 0.0267998 |
| FAM107B | family with sequence similarity 107, member B | 0.0267223 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0266377 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0263048 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0261548 |
| NRDC | nardilysin convertase | 0.0259668 |
| HDAC9 | histone deacetylase 9 | 0.0252513 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.024772 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0241858 |
| STMN1 | stathmin 1 | 0.0239327 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0237953 |
| ENAH | enabled homolog (Drosophila) | 0.0237455 |
| IMMT | inner membrane protein, mitochondrial | 0.0234756 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0234345 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.023306 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0232103 |
| SMAD3 | SMAD family member 3 | 0.023207 |
| RPL4 | ribosomal protein L4 | 0.0231834 |
| RPL26 | ribosomal protein L26 | 0.0229539 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.022699 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0226419 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.022615 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0225914 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0224538 |
| CENPF | centromere protein F, 350/400kDa | 0.0224455 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0223728 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0222568 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0219334 |
| ACACA | acetyl-CoA carboxylase alpha | 0.021752 |
| CBX5 | chromobox homolog 5 | 0.0217024 |
| THBS1 | thrombospondin 1 | 0.0214714 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0213154 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0211809 |
| BMP6 | bone morphogenetic protein 6 | 0.0208941 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0207648 |
| TPX2 | TPX2, microtubule-associated | 0.0202735 |
| CDC42 | cell division cycle 42 | 0.0202704 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.020247 |
| FBL | fibrillarin | 0.0199298 |
| GLIS3 | GLIS family zinc finger 3 | 0.0196827 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0195769 |
| RBM8A | RNA binding motif protein 8A | 0.0195641 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0192385 |
| ANO6 | anoctamin 6 | 0.0191416 |
| RAD51B | RAD51 paralog B | 0.0189619 |
| PRDX1 | peroxiredoxin 1 | 0.0187406 |
| FDPS | farnesyl diphosphate synthase | 0.0185999 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0185489 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0184947 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0184484 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0184415 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0182074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.193137 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.189057 |
| FTL | ferritin, light polypeptide | -0.183926 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.144282 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.125999 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.104098 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0994707 |
| RBM39 | RNA binding motif protein 39 | -0.0828396 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0786842 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0784665 |
| TMSB10 | thymosin beta 10 | -0.0779791 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0773325 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0754349 |
| RBM25 | RNA binding motif protein 25 | -0.0742144 |
| RPLP1 | ribosomal protein, large, P1 | -0.0707077 |
| IGF2 | insulin-like growth factor 2 | -0.0679289 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0665184 |
| ACTG1 | actin gamma 1 | -0.0663511 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0642802 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0618248 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0612373 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.060104 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0599638 |
| NOP58 | NOP58 ribonucleoprotein | -0.0596103 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0595521 |
| HLA-B | major histocompatibility complex, class I, B | -0.0585374 |
| NDRG1 | N-myc downstream regulated 1 | -0.0580459 |
| ZNF207 | zinc finger protein 207 | -0.0547429 |
| HLA-A | major histocompatibility complex, class I, A | -0.0535668 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0526428 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0526224 |
| RPL35A | ribosomal protein L35a | -0.0521129 |
| GLG1 | golgi glycoprotein 1 | -0.0519349 |
| COPA | coatomer protein complex, subunit alpha | -0.0515662 |
| RPS8 | ribosomal protein S8 | -0.0508424 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0497772 |
| FMNL2 | formin-like 2 | -0.0494835 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0486169 |
| ERBIN | erbb2 interacting protein | -0.0480799 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.047661 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0470145 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0461383 |
| RPL31 | ribosomal protein L31 | -0.0448149 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0448049 |
| TLK1 | tousled-like kinase 1 | -0.0445187 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0434826 |
| RPL36 | ribosomal protein L36 | -0.0431257 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0430197 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0428392 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0418203 |
| FBXO11 | F-box protein 11 | -0.0416948 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0412122 |
| DOCK4 | dedicator of cytokinesis 4 | -0.040748 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0405265 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0391406 |
| PARD3 | par-3 family cell polarity regulator | -0.0390335 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0386773 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0386055 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0385171 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0383787 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0380975 |
| HM13 | histocompatibility (minor) 13 | -0.0377388 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0374931 |
| RPL8 | ribosomal protein L8 | -0.0373482 |
| ARF4 | ADP-ribosylation factor 4 | -0.0373451 |
| SRP54 | signal recognition particle 54kDa | -0.0372942 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0360392 |
| JMJD1C | jumonji domain containing 1C | -0.0360225 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0359202 |
| USP36 | ubiquitin specific peptidase 36 | -0.035628 |
| FLNB | filamin B, beta | -0.0354574 |
| BRD2 | bromodomain containing 2 | -0.0350314 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0349288 |
| MED13 | mediator complex subunit 13 | -0.0345832 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0341658 |
| PYGL | phosphorylase, glycogen, liver | -0.0338147 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0336214 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0333535 |
| RPS19 | ribosomal protein S19 | -0.0332633 |
| CUL3 | cullin 3 | -0.032867 |
| MORF4L2 | mortality factor 4 like 2 | -0.0327574 |
| GDNF | glial cell derived neurotrophic factor | -0.0318543 |
| RPS29 | ribosomal protein S29 | -0.0317121 |
| PTK2 | protein tyrosine kinase 2 | -0.0315844 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0315299 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0313451 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0311981 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0310502 |
| HELZ | helicase with zinc finger | -0.0307469 |
| FOXO3 | forkhead box O3 | -0.0301366 |
| RPS27 | ribosomal protein S27 | -0.0298468 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0298246 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0297635 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0297562 |
| RPL19 | ribosomal protein L19 | -0.0296896 |
| MYO1E | myosin IE | -0.0294785 |
| RPS6 | ribosomal protein S6 | -0.0293645 |
| ADM | adrenomedullin | -0.0292685 |
| IER3 | immediate early response 3 | -0.0292337 |
| JUN | jun proto-oncogene | -0.0292069 |
