| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Glasdegib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.148174 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.116478 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.11331 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.105655 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0945206 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0872427 |
| THOC2 | THO complex 2 | 0.0872017 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0865005 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0858401 |
| NDRG1 | N-myc downstream regulated 1 | 0.0830445 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0777323 |
| ENO1 | enolase 1, (alpha) | 0.0774538 |
| YME1L1 | YME1-like 1 ATPase | 0.0769562 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0761164 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.072434 |
| SBF2 | SET binding factor 2 | 0.0711806 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0708234 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0704042 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0697184 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0692621 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0687493 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0681229 |
| MTSS1 | metastasis suppressor 1 | 0.0678524 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0671016 |
| HELZ | helicase with zinc finger | 0.0640533 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0639627 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0634553 |
| APP | amyloid beta (A4) precursor protein | 0.0633206 |
| AFDN | afadin, adherens junction formation factor | 0.0628918 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0626417 |
| GOLGA4 | golgin A4 | 0.0620394 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0613192 |
| ZNF292 | zinc finger protein 292 | 0.0598327 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0593752 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.059342 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.058412 |
| FLNB | filamin B, beta | 0.0581332 |
| USP3 | ubiquitin specific peptidase 3 | 0.0580941 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0573829 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0566678 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0562103 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.055632 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0540675 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0529991 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0528074 |
| NCOR1 | nuclear receptor corepressor 1 | 0.052758 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0526713 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0523661 |
| VCL | vinculin | 0.0519443 |
| KIF13B | kinesin family member 13B | 0.0517801 |
| POTEF | POTE ankyrin domain family, member F | 0.0515147 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.050699 |
| CD2AP | CD2-associated protein | 0.0497476 |
| DST | dystonin | 0.0496549 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0495911 |
| YEATS2 | YEATS domain containing 2 | 0.0494702 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0492428 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0491507 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0487066 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0486838 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.048355 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0479895 |
| RNF145 | ring finger protein 145 | 0.047871 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0477228 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0476069 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0475838 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0474421 |
| PDE10A | phosphodiesterase 10A | 0.0472471 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0472129 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0453174 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0440691 |
| PTK2 | protein tyrosine kinase 2 | 0.0435044 |
| GLG1 | golgi glycoprotein 1 | 0.0434556 |
| RREB1 | ras responsive element binding protein 1 | 0.0431603 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418238 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0417954 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0417604 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0415649 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0413965 |
| NGLY1 | N-glycanase 1 | 0.0411039 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0406449 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0404128 |
| TCF12 | transcription factor 12 | 0.0403221 |
| ZNF638 | zinc finger protein 638 | 0.04007 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0400457 |
| CCNI | cyclin I | 0.0400094 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0398215 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0396328 |
| GNAS | GNAS complex locus | 0.0393298 |
| MT2A | metallothionein 2A | 0.0392671 |
| USP34 | ubiquitin specific peptidase 34 | 0.0390378 |
| MEF2A | myocyte enhancer factor 2A | 0.03893 |
| YAP1 | Yes-associated protein 1 | 0.0388531 |
| ARFGEF3 | ARFGEF family member 3 | 0.0388489 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0387633 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.03869 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0386595 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.038388 |
| RCOR1 | REST corepressor 1 | 0.0383786 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0379234 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | -0.154712 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.128174 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.121561 |
| LMO7 | LIM domain 7 | -0.119891 |
| MUC16 | mucin 16, cell surface associated | -0.103405 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.102373 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0976336 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0971542 |
| ANXA2 | annexin A2 | -0.0931573 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0876386 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0837464 |
| EGFR | epidermal growth factor receptor | -0.0831452 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0798027 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0790798 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0786442 |
| MMP1 | matrix metallopeptidase 1 | -0.0744195 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0738247 |
| OSMR | oncostatin M receptor | -0.071741 |
| B2M | beta-2-microglobulin | -0.0692508 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.068942 |
| IGF1R | insulin-like growth factor 1 receptor | -0.068938 |
| VIM | vimentin | -0.0685388 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0647172 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0632043 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0630304 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0629859 |
| MED13L | mediator complex subunit 13-like | -0.0626938 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.062611 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0617378 |
| HLA-B | major histocompatibility complex, class I, B | -0.0611341 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0604632 |
| KRT17 | keratin 17, type I | -0.058771 |
| TUFT1 | tuftelin 1 | -0.0582645 |
| TMSB10 | thymosin beta 10 | -0.0575143 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0556124 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0552163 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0547324 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0540625 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0535299 |
| NABP1 | nucleic acid binding protein 1 | -0.0529132 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.052824 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0528225 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0524284 |
| FBXO11 | F-box protein 11 | -0.0523527 |
| SVIL | supervillin | -0.0518887 |
| ASPH | aspartate beta-hydroxylase | -0.051763 |
| FN1 | fibronectin 1 | -0.0514769 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0514134 |
| RIGI | RNA sensor RIG-I | -0.0509361 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0508207 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0508174 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0505502 |
| ATOSA | atos homolog A | -0.0500085 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0497103 |
| LAMB3 | laminin, beta 3 | -0.0490797 |
| MYO5B | myosin VB | -0.0487677 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0484197 |
| AK1 | adenylate kinase 1 | -0.0475809 |
| MXD1 | MAX dimerization protein 1 | -0.0475162 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0460399 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0460324 |
| CUX1 | cut-like homeobox 1 | -0.0456959 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0453845 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0453265 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0451009 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0448899 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0447037 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0440935 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0437885 |
| ERBIN | erbb2 interacting protein | -0.0435247 |
| RBM47 | RNA binding motif protein 47 | -0.0434864 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0434291 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0430558 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0430532 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0427176 |
| INTS6 | integrator complex subunit 6 | -0.0423567 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0420057 |
| NEK7 | NIMA-related kinase 7 | -0.0419264 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0415968 |
| JUP | junction plakoglobin | -0.0409373 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0397291 |
| SEPTIN10 | septin 10 | -0.0391491 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0387048 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0385888 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0379994 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0367437 |
| MUC13 | mucin 13, cell surface associated | -0.0365256 |
| ACTG1 | actin gamma 1 | -0.0363706 |
| IGF2 | insulin-like growth factor 2 | -0.0358984 |
| HPCAL1 | hippocalcin-like 1 | -0.0357609 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0353186 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0347116 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0346068 |
| FAT1 | FAT atypical cadherin 1 | -0.0342008 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0341674 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0339933 |
| BPTF | bromodomain PHD finger transcription factor | -0.0339746 |
| PKP4 | plakophilin 4 | -0.0335188 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0335016 |
| SLC25A51 | solute carrier family 25, member 51 | -0.033347 |
