| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.176751 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.161136 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.101572 |
| TXNRD1 | thioredoxin reductase 1 | 0.0995641 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0601886 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.059189 |
| OGA | O-GlcNAcase | 0.0581804 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0561574 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0559799 |
| XPO1 | exportin 1 | 0.0550503 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0535836 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0514677 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0480733 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0479745 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0475299 |
| RTN4 | reticulon 4 | 0.0453665 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0451123 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0424832 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0405837 |
| SET | SET nuclear proto-oncogene | 0.0403008 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0395721 |
| TPM3 | tropomyosin 3 | 0.039181 |
| PHIP | pleckstrin homology domain interacting protein | 0.0382633 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0376608 |
| MATR3 | matrin 3 | 0.0371623 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0365569 |
| SRPK1 | SRSF protein kinase 1 | 0.0351425 |
| ZFR | zinc finger RNA binding protein | 0.0345399 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0344736 |
| PLCB4 | phospholipase C, beta 4 | 0.0344629 |
| MKI67 | marker of proliferation Ki-67 | 0.0340113 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0334662 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0331627 |
| RBM25 | RNA binding motif protein 25 | 0.0323176 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0320856 |
| KIF5B | kinesin family member 5B | 0.0302699 |
| PGK1 | phosphoglycerate kinase 1 | 0.0297287 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0294624 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0293886 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0293477 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0292873 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.029269 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0292334 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0286179 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0284741 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0282796 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0276349 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0275718 |
| ZNF292 | zinc finger protein 292 | 0.0275406 |
| NCKAP1 | NCK-associated protein 1 | 0.0273751 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0273723 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0273523 |
| EPN2 | epsin 2 | 0.0273173 |
| IPO7 | importin 7 | 0.0272444 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0271273 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0270573 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0265266 |
| ZNF638 | zinc finger protein 638 | 0.0262761 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0260629 |
| CENPF | centromere protein F, 350/400kDa | 0.025988 |
| CCND2 | cyclin D2 | 0.0254311 |
| SEPTIN7 | septin 7 | 0.0251587 |
| PCNX1 | pecanex 1 | 0.0250432 |
| TPR | translocated promoter region, nuclear basket protein | 0.0249599 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0245563 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0244319 |
| BBX | bobby sox homolog (Drosophila) | 0.0243995 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0243202 |
| ANXA5 | annexin A5 | 0.0242204 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0240917 |
| GOLGA4 | golgin A4 | 0.02383 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0236834 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0236276 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0235925 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0235201 |
| CDYL | chromodomain protein, Y-like | 0.0235162 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0233734 |
| RASA2 | RAS p21 protein activator 2 | 0.0233697 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0232411 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0232187 |
| SPAG9 | sperm associated antigen 9 | 0.0231502 |
| VIM | vimentin | 0.0229723 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0228192 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0228062 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0228038 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0227752 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0226964 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0225134 |
| TNPO1 | transportin 1 | 0.0224952 |
| TPX2 | TPX2, microtubule-associated | 0.0223441 |
| CEP192 | centrosomal protein 192kDa | 0.0223433 |
| ZNF654 | zinc finger protein 654 | 0.0221589 |
| CBX3 | chromobox homolog 3 | 0.0221333 |
| NEK7 | NIMA-related kinase 7 | 0.0221296 |
| TPI1 | triosephosphate isomerase 1 | 0.0219513 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0219511 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0217646 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0217554 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0217469 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0217375 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.268909 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.171696 |
| MCL1 | myeloid cell leukemia 1 | -0.148377 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.109305 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.108833 |
| VCL | vinculin | -0.0845353 |
| PDE10A | phosphodiesterase 10A | -0.0816418 |
| EGR1 | early growth response 1 | -0.0815097 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0814109 |
| AEBP2 | AE binding protein 2 | -0.0701971 |
| OSMR | oncostatin M receptor | -0.0689132 |
| INTS6 | integrator complex subunit 6 | -0.0682022 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0651914 |
| HMGA2 | high mobility group AT-hook 2 | -0.0651255 |
| RAD51B | RAD51 paralog B | -0.0646837 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0641752 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.063732 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0631179 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0611967 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0605598 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0595911 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0578121 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0573709 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0571407 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0570626 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0540726 |
| HLA-B | major histocompatibility complex, class I, B | -0.0538433 |
| ATXN1 | ataxin 1 | -0.0528838 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0524107 |
| WWOX | WW domain containing oxidoreductase | -0.0513671 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0503947 |
| TMSB10 | thymosin beta 10 | -0.0497529 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0493881 |
| RYR3 | ryanodine receptor 3 | -0.0492339 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0490599 |
| EXOC4 | exocyst complex component 4 | -0.0477862 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0466507 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0435338 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0433417 |
| NABP1 | nucleic acid binding protein 1 | -0.0430153 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0425667 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.041865 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0418297 |
| FBXO11 | F-box protein 11 | -0.041743 |
| RPL35A | ribosomal protein L35a | -0.0414636 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0413307 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0406369 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0399948 |
| RNF213 | ring finger protein 213 | -0.0397256 |
| CUX1 | cut-like homeobox 1 | -0.0390229 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0382906 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0376762 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.035892 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0357133 |
| ATG7 | autophagy related 7 | -0.0354353 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0354296 |
| PRKCE | protein kinase C, epsilon | -0.0347505 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0341674 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0339699 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0337286 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0334592 |
| EHBP1 | EH domain binding protein 1 | -0.0334271 |
| DENND5B | DENN/MADD domain containing 5B | -0.0332525 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.032408 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0319134 |
| NEK10 | NIMA-related kinase 10 | -0.0314826 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0314394 |
| TPM4 | tropomyosin 4 | -0.0312552 |
| PYGL | phosphorylase, glycogen, liver | -0.0309701 |
| RBM39 | RNA binding motif protein 39 | -0.0307931 |
| FMNL2 | formin-like 2 | -0.0307473 |
| PCNX4 | pecanex 4 | -0.0306488 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0305042 |
| NF1 | neurofibromin 1 | -0.0304871 |
| USP34 | ubiquitin specific peptidase 34 | -0.0302304 |
| EGFR | epidermal growth factor receptor | -0.0301011 |
| FMN1 | formin 1 | -0.0300536 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0299862 |
| TAPBP | TAP binding protein (tapasin) | -0.0292922 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0292393 |
| GOLGB1 | golgin B1 | -0.028997 |
| GPATCH2L | G patch domain containing 2-like | -0.0288368 |
| ACTG1 | actin gamma 1 | -0.0288289 |
| HDAC8 | histone deacetylase 8 | -0.028722 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0284118 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0280157 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0278783 |
| RPL31 | ribosomal protein L31 | -0.0278101 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0277862 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0277766 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0277086 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0276148 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0274766 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.027024 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0268009 |
| LOXL2 | lysyl oxidase-like 2 | -0.026525 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.026138 |
| RPL37 | ribosomal protein L37 | -0.0258667 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.02585 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0258031 |
