Glasdegib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glasdegib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glasdegib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.116963
NAMPT nicotinamide phosphoribosyltransferase 0.112166
ESYT2 extended synaptotagmin-like protein 2 0.0717069
EFNA5 ephrin-A5 0.0672188
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0632343
MYOF myoferlin 0.0620754
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0606053
FAM13A family with sequence similarity 13, member A 0.0589982
PCBP3 poly(rC) binding protein 3 0.0582406
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0537092
PSD3 pleckstrin and Sec7 domain containing 3 0.0530713
DNER delta/notch-like EGF repeat containing 0.050252
PDE10A phosphodiesterase 10A 0.0499297
PYGL phosphorylase, glycogen, liver 0.0491359
SET SET nuclear proto-oncogene 0.0489149
OGA O-GlcNAcase 0.0486657
LIMCH1 LIM and calponin homology domains 1 0.0479139
PRELID2 PRELI domain containing 2 0.0473356
DGKD diacylglycerol kinase, delta 130kDa 0.0469609
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0453556
KMT2E lysine (K)-specific methyltransferase 2E 0.044464
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0443079
FLNB filamin B, beta 0.0439082
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0425428
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0391602
PDE4D phosphodiesterase 4D, cAMP-specific 0.038973
RAD51B RAD51 paralog B 0.0369443
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0363178
AGFG1 ArfGAP with FG repeats 1 0.0358167
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0356159
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0348279
MSN moesin 0.0339862
SUCO SUN domain containing ossification factor 0.0338389
ZFC3H1 zinc finger, C3H1-type containing 0.0332157
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0331586
GIGYF2 GRB10 interacting GYF protein 2 0.0320622
PDGFA platelet-derived growth factor alpha polypeptide 0.0320002
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0317904
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317868
USP34 ubiquitin specific peptidase 34 0.0314808
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0313617
TPM3 tropomyosin 3 0.0312957
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0311657
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0299709
ADARB1 adenosine deaminase, RNA-specific, B1 0.0296191
MATR3 matrin 3 0.0294196
ANO6 anoctamin 6 0.029376
KTN1 kinectin 1 (kinesin receptor) 0.029202
KMT2C lysine (K)-specific methyltransferase 2C 0.0290546
NBEAL1 neurobeachin-like 1 0.0290264
YEATS2 YEATS domain containing 2 0.0281208
NALF1 NALCN channel auxiliary factor 1 0.0279544
DDIT4 DNA-damage-inducible transcript 4 0.0276278
BZW1 basic leucine zipper and W2 domains 1 0.0270315
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0267715
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0264976
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0263389
GRB10 growth factor receptor-bound protein 10 0.0259564
AKAP12 A kinase (PRKA) anchor protein 12 0.0259493
EIF4B eukaryotic translation initiation factor 4B 0.0258482
USP9X ubiquitin specific peptidase 9, X-linked 0.0249775
CHD1L chromodomain helicase DNA binding protein 1-like 0.0248399
INSIG2 insulin induced gene 2 0.0247657
AUTS2 autism susceptibility candidate 2 0.0247286
GRAMD1B GRAM domain containing 1B 0.0243677
PRRC2C proline-rich coiled-coil 2C 0.0241315
ZNF638 zinc finger protein 638 0.0240766
PGK1 phosphoglycerate kinase 1 0.0239906
CAMTA1 calmodulin binding transcription activator 1 0.0237616
NFE2L1 nuclear factor, erythroid 2-like 1 0.0236849
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0235608
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0234826
MLKL mixed lineage kinase domain-like 0.0234798
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0233886
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0232877
PRKD3 protein kinase D3 0.0232421
ANKRD36 ankyrin repeat domain 36 0.0231893
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0230274
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0229104
TNIP1 TNFAIP3 interacting protein 1 0.0228549
CTBP2 C-terminal binding protein 2 0.0228497
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0227888
MCL1 myeloid cell leukemia 1 0.0225415
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0225296
WARS1 tryptophanyl-tRNA synthetase 1 0.022522
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0225179
SEPTIN10 septin 10 0.0222685
ZC3H11A zinc finger CCCH-type containing 11A 0.0218007
NCOR2 nuclear receptor corepressor 2 0.0217411
ZNF292 zinc finger protein 292 0.0216351
CEP350 centrosomal protein 350kDa 0.0215644
RPS12 ribosomal protein S12 0.0213674
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0213472
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0212914
NGLY1 N-glycanase 1 0.0212849
FAM219A family with sequence similarity 219, member A 0.021281
DIAPH1 diaphanous-related formin 1 0.021266
DYNC2I1 dynein 2 intermediate chain 1 0.0211357
CDH13 cadherin 13 0.0204487
NRCAM neuronal cell adhesion molecule 0.020329

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.282716
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.230402
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.13137
GDA guanine deaminase -0.108385
FTL ferritin, light polypeptide -0.106865
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101009
TXNRD1 thioredoxin reductase 1 -0.0938258
TMSB10 thymosin beta 10 -0.0912669
FN1 fibronectin 1 -0.0871889
PDLIM5 PDZ and LIM domain 5 -0.078093
TPT1 tumor protein, translationally-controlled 1 -0.076718
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0758841
COL5A2 collagen, type V, alpha 2 -0.0731011
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0712933
CANX calnexin -0.0705858
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0675284
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0670808
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0668661
ZEB2 zinc finger E-box binding homeobox 2 -0.0629801
RPS24 ribosomal protein S24 -0.0624594
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0610033
RPL35A ribosomal protein L35a -0.0590611
PM20D1 peptidase M20 domain containing 1 -0.0581668
NEK7 NIMA-related kinase 7 -0.0548121
COL8A1 collagen, type VIII, alpha 1 -0.0540651
VCL vinculin -0.0510229
RPLP1 ribosomal protein, large, P1 -0.0484841
NT5C2 5'-nucleotidase, cytosolic II -0.0482343
RPL12 ribosomal protein L12 -0.0462961
TFPI2 tissue factor pathway inhibitor 2 -0.0454038
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0453768
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0439379
TM4SF1 transmembrane 4 L six family member 1 -0.0438376
RPLP0 ribosomal protein, large, P0 -0.0431255
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0418249
JMJD1C jumonji domain containing 1C -0.0406614
FTH1 ferritin, heavy polypeptide 1 -0.0397936
KYNU kynureninase -0.039568
PTMA prothymosin, alpha -0.0380745
S100A10 S100 calcium binding protein A10 -0.0366022
VDAC1 voltage-dependent anion channel 1 -0.0357551
RTN1 reticulon 1 -0.0356205
DOCK4 dedicator of cytokinesis 4 -0.0355089
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0354289
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0353587
RTN4 reticulon 4 -0.034618
SMYD3 SET and MYND domain containing 3 -0.0340522
ACTG1 actin gamma 1 -0.0330446
B2M beta-2-microglobulin -0.0326329
ELL2 elongation factor, RNA polymerase II, 2 -0.0325332
UBC ubiquitin C -0.0324007
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0321648
CTSC cathepsin C -0.0319894
NTN4 netrin 4 -0.0315907
RPS23 ribosomal protein S23 -0.0309088
RPL19 ribosomal protein L19 -0.0305935
LOC112694756 uncharaterized LOC112694756 -0.0303928
RPL34 ribosomal protein L34 -0.0303527
RPS19 ribosomal protein S19 -0.0300537
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0283963
SLC38A2 solute carrier family 38, member 2 -0.0282895
CALR calreticulin -0.0280446
BASP1 brain abundant, membrane attached signal protein 1 -0.0278834
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0276854
GNAS GNAS complex locus -0.0273541
EIF1 eukaryotic translation initiation factor 1 -0.0272841
ENAH enabled homolog (Drosophila) -0.0266914
PDIA4 protein disulfide isomerase family A, member 4 -0.0262807
PALLD palladin, cytoskeletal associated protein -0.0262374
EPHA4 EPH receptor A4 -0.0261526
DOCK5 dedicator of cytokinesis 5 -0.0260106
VIM vimentin -0.0258386
MAP1B microtubule-associated protein 1B -0.0257313
RAB7A RAB7A, member RAS oncogene family -0.0255662
TSC22D2 TSC22 domain family, member 2 -0.0252644
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0251921
HLA-B major histocompatibility complex, class I, B -0.0251112
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0249303
RPS4X ribosomal protein S4, X-linked -0.0245503
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0245277
RPL13A ribosomal protein L13a -0.0243146
PRRC2B proline-rich coiled-coil 2B -0.024238
DST dystonin -0.023981
CCL5 chemokine (C-C motif) ligand 5 -0.0239258
ATAD1 ATPase family, AAA domain containing 1 -0.0238874
YBX3 Y box binding protein 3 -0.0238297
ANTXR1 anthrax toxin receptor 1 -0.023692
ARF1 ADP-ribosylation factor 1 -0.02335
TKT transketolase -0.0232892
RPS16 ribosomal protein S16 -0.023205
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0231187
SRGN serglycin -0.022686
RPL32 ribosomal protein L32 -0.0225487
BSG basigin (Ok blood group) -0.0224807
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0224045
NABP1 nucleic acid binding protein 1 -0.022192
NF1 neurofibromin 1 -0.0221531
TNPO1 transportin 1 -0.0220357
MT2A metallothionein 2A -0.0216756
RHEB Ras homolog enriched in brain -0.0216706