| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | 0.138114 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117015 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0857191 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0811231 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0797653 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0784846 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0750772 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0738744 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0685599 |
| FNDC3B | fibronectin type III domain containing 3B | 0.064137 |
| SETD5 | SET domain containing 5 | 0.0636506 |
| DST | dystonin | 0.0620387 |
| NCKAP1 | NCK-associated protein 1 | 0.0613784 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0582655 |
| CDC73 | cell division cycle 73 | 0.0578393 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.057271 |
| ENAH | enabled homolog (Drosophila) | 0.0562256 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0559062 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0541036 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.054027 |
| SPAG9 | sperm associated antigen 9 | 0.0536521 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0527136 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0524885 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0496036 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0484473 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0484281 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0478639 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0471 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.046885 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0466632 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0465125 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.046425 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0457542 |
| RBM33 | RNA binding motif protein 33 | 0.0453183 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0444612 |
| ITGAV | integrin, alpha V | 0.0444289 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0442626 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0439154 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0434729 |
| CCNL1 | cyclin L1 | 0.0434707 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0421244 |
| THOC2 | THO complex 2 | 0.0408207 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0407403 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0406749 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0405665 |
| ANXA1 | annexin A1 | 0.0402612 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0395826 |
| OGA | O-GlcNAcase | 0.0393687 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0391361 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.038903 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0387253 |
| NEK7 | NIMA-related kinase 7 | 0.0380178 |
| B2M | beta-2-microglobulin | 0.0379121 |
| IPO7 | importin 7 | 0.0378808 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0377975 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0376526 |
| RPS12 | ribosomal protein S12 | 0.0376276 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0374372 |
| CCN2 | cellular communication network factor 2 | 0.0372622 |
| ATXN2 | ataxin 2 | 0.0370117 |
| TLK2 | tousled-like kinase 2 | 0.0368591 |
| ECT2 | epithelial cell transforming 2 | 0.0366539 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0366402 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0366241 |
| MTF2 | metal response element binding transcription factor 2 | 0.0365337 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0363821 |
| MEMO1 | mediator of cell motility 1 | 0.0362636 |
| PHIP | pleckstrin homology domain interacting protein | 0.03619 |
| STAG2 | stromal antigen 2 | 0.0357891 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0355845 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0355235 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.0354723 |
| MED13L | mediator complex subunit 13-like | 0.0348923 |
| TFG | TRK-fused gene | 0.0348284 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0347415 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0345528 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0345152 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0343454 |
| HDAC2 | histone deacetylase 2 | 0.0343047 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.033624 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0334129 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0331805 |
| FNBP1L | formin binding protein 1-like | 0.0327968 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0327516 |
| RLF | rearranged L-myc fusion | 0.0327351 |
| SRP54 | signal recognition particle 54kDa | 0.032709 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0325902 |
| RTN4 | reticulon 4 | 0.0324214 |
| SET | SET nuclear proto-oncogene | 0.032044 |
| PTK2 | protein tyrosine kinase 2 | 0.0318774 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.0316541 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0311737 |
| HDAC9 | histone deacetylase 9 | 0.0310966 |
| SLMAP | sarcolemma associated protein | 0.0310922 |
| MATR3 | matrin 3 | 0.0308519 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0304252 |
| YAP1 | Yes-associated protein 1 | 0.0302574 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0300866 |
| USP12 | ubiquitin specific peptidase 12 | 0.0299709 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0298038 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.173658 |
| CADM2 | cell adhesion molecule 2 | -0.141083 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.121798 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.112531 |
| COL11A1 | collagen, type XI, alpha 1 | -0.108374 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0985144 |
| GPC3 | glypican 3 | -0.0927134 |
| PEG10 | paternally expressed 10 | -0.0838057 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0761381 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0757027 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0667118 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0653984 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0651403 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0640781 |
| TENM3 | teneurin transmembrane protein 3 | -0.0613721 |
| MEIS2 | Meis homeobox 2 | -0.0565424 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0555446 |
| ACTG1 | actin gamma 1 | -0.0553563 |
| RPS16 | ribosomal protein S16 | -0.0544381 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0529552 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.052414 |
| CDH19 | cadherin 19, type 2 | -0.0517687 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0502451 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0477456 |
| SHROOM3 | shroom family member 3 | -0.0471868 |
| TMSB10 | thymosin beta 10 | -0.0466708 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0453094 |
| VIM | vimentin | -0.0451636 |
| SYT1 | synaptotagmin I | -0.0450613 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.043049 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0395316 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0391644 |
| RPL35A | ribosomal protein L35a | -0.0388836 |
| RAD51B | RAD51 paralog B | -0.038389 |
| FOXP2 | forkhead box P2 | -0.0382884 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0365092 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0355141 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.035133 |
| THBS1 | thrombospondin 1 | -0.034757 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0346436 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0330172 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0330044 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0329894 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0325461 |
| RPLP1 | ribosomal protein, large, P1 | -0.0317891 |
| ZNF385D | zinc finger protein 385D | -0.0314515 |
| SMYD3 | SET and MYND domain containing 3 | -0.0312869 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0301891 |
| RPL19 | ribosomal protein L19 | -0.0297582 |
| HMCN1 | hemicentin 1 | -0.0296283 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.029614 |
| YBX1 | Y box binding protein 1 | -0.0294719 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0294363 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.0288501 |
| SIK2 | salt-inducible kinase 2 | -0.0286308 |
| SON | SON DNA binding protein | -0.0284756 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.02843 |
| PCDH9 | protocadherin 9 | -0.0280707 |
| EPHA5 | EPH receptor A5 | -0.027452 |
| CDK6 | cyclin-dependent kinase 6 | -0.0274272 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0273047 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.027167 |
| WDR70 | WD repeat domain 70 | -0.0270614 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0268587 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0265248 |
| METAP2 | methionyl aminopeptidase 2 | -0.0261934 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0260258 |
| PALLD | palladin, cytoskeletal associated protein | -0.025925 |
| FBL | fibrillarin | -0.0257458 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0253534 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0253482 |
| HMGA1 | high mobility group AT-hook 1 | -0.0252737 |
| AHNAK | AHNAK nucleoprotein | -0.0252291 |
| RPL12 | ribosomal protein L12 | -0.0251007 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0250111 |
| SCFD1 | sec1 family domain containing 1 | -0.0249288 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -0.0247496 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0245885 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0245504 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0242536 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.024227 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0239564 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0238871 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.023767 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0236702 |
| AK1 | adenylate kinase 1 | -0.0236614 |
| COL5A2 | collagen, type V, alpha 2 | -0.0236197 |
| PCDH17 | protocadherin 17 | -0.0233887 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | -0.0232278 |
| KLHL5 | kelch-like family member 5 | -0.0229913 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | -0.0229752 |
| GOLGB1 | golgin B1 | -0.0229616 |
| KIAA1328 | KIAA1328 | -0.0229591 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0227826 |
| R3HDM1 | R3H domain containing 1 | -0.0226871 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0226445 |
| PCNX4 | pecanex 4 | -0.0225888 |
| ACTN4 | actinin, alpha 4 | -0.0223895 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0223477 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.0222774 |
