Glasdegib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glasdegib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glasdegib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.0622752
CENPF centromere protein F, 350/400kDa 0.0523204
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0520702
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0488031
SOD2 superoxide dismutase 2, mitochondrial 0.0424982
MYH9 myosin, heavy chain 9, non-muscle 0.0403669
OGA O-GlcNAcase 0.0398896
ATP13A3 ATPase type 13A3 0.0372403
ZNF292 zinc finger protein 292 0.0352623
ANLN anillin, actin binding protein 0.0334489
GOLGA4 golgin A4 0.0330778
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0314615
PDE10A phosphodiesterase 10A 0.0291408
HELZ helicase with zinc finger 0.0287243
LCORL ligand dependent nuclear receptor corepressor-like 0.0285605
USP9X ubiquitin specific peptidase 9, X-linked 0.0284832
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281209
MXI1 MAX interactor 1, dimerization protein 0.0277704
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0272646
SPAG9 sperm associated antigen 9 0.0267964
CCNL1 cyclin L1 0.0262715
MSN moesin 0.024627
UBA6 ubiquitin-like modifier activating enzyme 6 0.0235991
CADM1 cell adhesion molecule 1 0.0235903
CKAP5 cytoskeleton associated protein 5 0.023471
MATR3 matrin 3 0.0234068
RNF145 ring finger protein 145 0.0233577
NGLY1 N-glycanase 1 0.0233229
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0216815
SUCO SUN domain containing ossification factor 0.0208606
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0208119
AFDN afadin, adherens junction formation factor 0.0203786
EPS8 epidermal growth factor receptor pathway substrate 8 0.0203171
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0199658
MYOF myoferlin 0.0199144
MKI67 marker of proliferation Ki-67 0.0198156
BCLAF1 BCL2-associated transcription factor 1 0.0194916
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0194781
RB1CC1 RB1-inducible coiled-coil 1 0.0192858
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0192032
ZFC3H1 zinc finger, C3H1-type containing 0.0191953
ELL2 elongation factor, RNA polymerase II, 2 0.0191023
TPX2 TPX2, microtubule-associated 0.0190872
ESYT2 extended synaptotagmin-like protein 2 0.0187016
KIF4A kinesin family member 4A 0.0186512
NAMPT nicotinamide phosphoribosyltransferase 0.0182639
KDM6A lysine (K)-specific demethylase 6A 0.0180944
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0178482
TFG TRK-fused gene 0.0175895
PICALM phosphatidylinositol binding clathrin assembly protein 0.0174006
DIAPH3 diaphanous-related formin 3 0.0173483
GLS2 glutaminase 2 (liver, mitochondrial) 0.0173186
FAM13A family with sequence similarity 13, member A 0.0169453
USP37 ubiquitin specific peptidase 37 0.0167903
WDR43 WD repeat domain 43 0.0167281
NUP58 nucleoporin 58 0.0167111
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0166347
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0165279
CYLD cylindromatosis (turban tumor syndrome) 0.016326
ECT2 epithelial cell transforming 2 0.0162948
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0162656
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0158516
PCBP2 poly(rC) binding protein 2 0.0158331
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0157714
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0156316
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0155381
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0152145
PUM2 pumilio RNA-binding family member 2 0.0146304
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0145971
PRELID2 PRELI domain containing 2 0.0145342
RAB8B RAB8B, member RAS oncogene family 0.0145285
ABI1 abl-interactor 1 0.014431
RLF rearranged L-myc fusion 0.0142932
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0142747
CAMTA1 calmodulin binding transcription activator 1 0.014162
NCKAP1 NCK-associated protein 1 0.0141367
DENND5A DENN/MADD domain containing 5A 0.0141362
ZNF451 zinc finger protein 451 0.0141254
PEX3 peroxisomal biogenesis factor 3 0.0138427
GAS2L3 growth arrest-specific 2 like 3 0.0138339
SMC4 structural maintenance of chromosomes 4 0.013745
TTK TTK protein kinase 0.013743
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0137209
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0137083
KIF11 kinesin family member 11 0.0136499
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.01348
NUP153 nucleoporin 153kDa 0.013467
TOP2B topoisomerase (DNA) II beta 180kDa 0.0134063
AMPD3 adenosine monophosphate deaminase 3 0.0131813
EIF4B eukaryotic translation initiation factor 4B 0.0131137
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0130233
ETNK1 ethanolamine kinase 1 0.0130229
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.012955
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0129306
TSC22D2 TSC22 domain family, member 2 0.0128036
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0127425
RBM33 RNA binding motif protein 33 0.0127322
RPL3 ribosomal protein L3 0.0126967
GARS1 glycyl-tRNA synthetase 1 0.0126212
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.012538

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.328392
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.271925
HLA-B major histocompatibility complex, class I, B -0.172432
TMSB10 thymosin beta 10 -0.160105
MARCKS myristoylated alanine-rich protein kinase C substrate -0.15295
FTL ferritin, light polypeptide -0.145599
CD44 CD44 molecule (Indian blood group) -0.138703
GLIS3 GLIS family zinc finger 3 -0.130076
TPT1 tumor protein, translationally-controlled 1 -0.110576
IER3 immediate early response 3 -0.0944316
MT2A metallothionein 2A -0.0939822
VCL vinculin -0.088371
AKAP12 A kinase (PRKA) anchor protein 12 -0.0876371
IGFBP3 insulin-like growth factor binding protein 3 -0.0833661
EXT1 exostosin glycosyltransferase 1 -0.0764113
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0658719
NDRG1 N-myc downstream regulated 1 -0.0656535
RPL35A ribosomal protein L35a -0.0653576
EGR1 early growth response 1 -0.0645603
HMGA2 high mobility group AT-hook 2 -0.064443
LDHA lactate dehydrogenase A -0.0643849
HLA-A major histocompatibility complex, class I, A -0.0617494
RPS24 ribosomal protein S24 -0.061675
ZMYND8 zinc finger, MYND-type containing 8 -0.0591385
CTSD cathepsin D -0.0569494
BICC1 BicC family RNA binding protein 1 -0.0565299
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0554062
LOC112694756 uncharaterized LOC112694756 -0.0542676
RPLP1 ribosomal protein, large, P1 -0.0538356
COL6A3 collagen, type VI, alpha 3 -0.0527938
RPS23 ribosomal protein S23 -0.0526088
ACTG1 actin gamma 1 -0.0525762
FTH1 ferritin, heavy polypeptide 1 -0.0515183
RPLP2 ribosomal protein, large, P2 -0.0501506
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0501061
SFTPA2 surfactant protein A2 -0.0498225
PGK1 phosphoglycerate kinase 1 -0.0491168
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0489548
B2M beta-2-microglobulin -0.0484901
IFITM3 interferon induced transmembrane protein 3 -0.0484049
RPL19 ribosomal protein L19 -0.0460049
RPS8 ribosomal protein S8 -0.0457757
EIF1 eukaryotic translation initiation factor 1 -0.0457305
RPL36A ribosomal protein L36a -0.0455669
COL1A1 collagen, type I, alpha 1 -0.044969
ENO1 enolase 1, (alpha) -0.0447785
NAV1 neuron navigator 1 -0.0443335
RPS19 ribosomal protein S19 -0.0441886
TGFBI transforming growth factor, beta-induced, 68kDa -0.043738
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0427374
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0425926
SLC38A2 solute carrier family 38, member 2 -0.0425416
RPL23 ribosomal protein L23 -0.0424173
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0418789
CDH13 cadherin 13 -0.0417252
HLA-E major histocompatibility complex, class I, E -0.040996
RPS4X ribosomal protein S4, X-linked -0.0404634
GPC6 glypican 6 -0.0401695
RPS12 ribosomal protein S12 -0.0399322
SLC38A1 solute carrier family 38, member 1 -0.0398178
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0396836
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0395768
RPL37A ribosomal protein L37a -0.0395046
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0394627
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0391596
RPS21 ribosomal protein S21 -0.0386534
RPS13 ribosomal protein S13 -0.0386049
RPS6 ribosomal protein S6 -0.0382278
RPS3 ribosomal protein S3 -0.0381298
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0377809
RAI14 retinoic acid induced 14 -0.0374605
RPL12 ribosomal protein L12 -0.0373893
GNAS GNAS complex locus -0.0372551
RPL36 ribosomal protein L36 -0.0370855
ADM adrenomedullin -0.0364404
EGFR epidermal growth factor receptor -0.0363904
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0362012
VCAN versican -0.0359173
S100A9 S100 calcium binding protein A9 -0.0357721
DIAPH2 diaphanous-related formin 2 -0.0357314
RPL32 ribosomal protein L32 -0.0356898
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0351108
HDAC9 histone deacetylase 9 -0.0350616
ZBTB38 zinc finger and BTB domain containing 38 -0.0348454
BASP1 brain abundant, membrane attached signal protein 1 -0.03469
VDAC1 voltage-dependent anion channel 1 -0.0344161
C3 complement component 3 -0.0339934
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0339476
IFI6 interferon, alpha-inducible protein 6 -0.03382
RPLP0 ribosomal protein, large, P0 -0.0331785
RPL31 ribosomal protein L31 -0.0330755
AHNAK AHNAK nucleoprotein -0.032953
ANXA2 annexin A2 -0.0326716
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0326516
CTSB cathepsin B -0.0326331
TPM4 tropomyosin 4 -0.0326238
IFI16 interferon, gamma-inducible protein 16 -0.0322992
ENO2 enolase 2 (gamma, neuronal) -0.0322462
ZBTB20 zinc finger and BTB domain containing 20 -0.0321242
EPAS1 endothelial PAS domain protein 1 -0.0320471