| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Glasdegib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.268978 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0665873 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0645789 |
| DTNA | dystrobrevin, alpha | 0.0536631 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0507416 |
| MAP1B | microtubule-associated protein 1B | 0.0502112 |
| CDCP1 | CUB domain containing protein 1 | 0.0402626 |
| SET | SET nuclear proto-oncogene | 0.038268 |
| MMP1 | matrix metallopeptidase 1 | 0.0379164 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0373576 |
| NUP58 | nucleoporin 58 | 0.0361539 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0346042 |
| NGLY1 | N-glycanase 1 | 0.0334823 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0331918 |
| ASPH | aspartate beta-hydroxylase | 0.0320551 |
| PRELID2 | PRELI domain containing 2 | 0.0319771 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0317481 |
| MCL1 | myeloid cell leukemia 1 | 0.0310371 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0306425 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.028955 |
| TMEM41B | transmembrane protein 41B | 0.0286573 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0271852 |
| CANX | calnexin | 0.026621 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0263804 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0255905 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0253682 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.02536 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.024992 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0248283 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0246443 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0234634 |
| NBAS | neuroblastoma amplified sequence | 0.023346 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0233172 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0228876 |
| MYO10 | myosin X | 0.022674 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0225872 |
| ENO1 | enolase 1, (alpha) | 0.0223318 |
| RPS3 | ribosomal protein S3 | 0.0220272 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0219633 |
| PAPOLA | poly(A) polymerase alpha | 0.0216387 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0213204 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0211701 |
| KIF5B | kinesin family member 5B | 0.0210563 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.020963 |
| RPL37A | ribosomal protein L37a | 0.020937 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0206915 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0204565 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0203814 |
| INSIG2 | insulin induced gene 2 | 0.020356 |
| POM121 | POM121 transmembrane nucleoporin | 0.0202738 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0201481 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0198776 |
| MYEF2 | myelin expression factor 2 | 0.0197653 |
| ARFGEF3 | ARFGEF family member 3 | 0.0196597 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0195797 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0194508 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0194004 |
| CALR | calreticulin | 0.0193779 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.019244 |
| PGM3 | phosphoglucomutase 3 | 0.0190956 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.019035 |
| TMF1 | TATA element modulatory factor 1 | 0.0186685 |
| ZNF638 | zinc finger protein 638 | 0.0186624 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0186155 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0184552 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0183443 |
| FAM13A | family with sequence similarity 13, member A | 0.0182818 |
| DENND1A | DENN/MADD domain containing 1A | 0.0182231 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.018131 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0180963 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0180945 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0179992 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0179799 |
| TPD52 | tumor protein D52 | 0.0179037 |
| FCHO2 | FCH domain only 2 | 0.0179031 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0178434 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0177936 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0175512 |
| MMP10 | matrix metallopeptidase 10 | 0.0175234 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0174502 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0174085 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0173071 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0171397 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0170945 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.016964 |
| DIAPH1 | diaphanous-related formin 1 | 0.0169025 |
| HM13 | histocompatibility (minor) 13 | 0.0167712 |
| NCKAP1 | NCK-associated protein 1 | 0.0167106 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0167082 |
| CEP70 | centrosomal protein 70kDa | 0.0166194 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0166042 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0165379 |
| ARF4 | ADP-ribosylation factor 4 | 0.01645 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0164385 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0164247 |
| RECQL | RecQ helicase-like | 0.0164233 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0163723 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0163233 |
| KIF2A | kinesin heavy chain member 2A | 0.0163175 |
| IER3 | immediate early response 3 | 0.0162628 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.324142 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0951011 |
| OSMR | oncostatin M receptor | -0.0935288 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0907951 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0849642 |
| LDHA | lactate dehydrogenase A | -0.0824639 |
| SMYD3 | SET and MYND domain containing 3 | -0.0756046 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0701862 |
| CD44 | CD44 molecule (Indian blood group) | -0.070012 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0604056 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0597704 |
| VIM | vimentin | -0.0593098 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0577991 |
| ANXA2 | annexin A2 | -0.0574131 |
| VCL | vinculin | -0.057248 |
| TMSB10 | thymosin beta 10 | -0.0535386 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0523502 |
| YBX3 | Y box binding protein 3 | -0.0519107 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.050645 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.049739 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0491086 |
| ACTG1 | actin gamma 1 | -0.0462381 |
| RBM39 | RNA binding motif protein 39 | -0.0462338 |
| SMAD3 | SMAD family member 3 | -0.0460017 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0445121 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0433065 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0423261 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0415494 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.041005 |
| DST | dystonin | -0.0401786 |
| NALCN | sodium leak channel, non selective | -0.0400951 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0396868 |
| DIAPH3 | diaphanous-related formin 3 | -0.0395143 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0390646 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0378241 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.036925 |
| EFNA5 | ephrin-A5 | -0.03614 |
| MKI67 | marker of proliferation Ki-67 | -0.0359967 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0359213 |
| GPC6 | glypican 6 | -0.0357027 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0353595 |
| PHF14 | PHD finger protein 14 | -0.0348275 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0346264 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0345022 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0342884 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0337942 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0334909 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0326506 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.032543 |
| EXOC6B | exocyst complex component 6B | -0.0321084 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0320268 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0316889 |
| TMEM123 | transmembrane protein 123 | -0.031329 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0299993 |
| RIGI | RNA sensor RIG-I | -0.029715 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0295822 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0295164 |
| RAD51B | RAD51 paralog B | -0.0294204 |
| GNAS | GNAS complex locus | -0.0292841 |
| VMP1 | vacuole membrane protein 1 | -0.0283924 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0281551 |
| SPAG9 | sperm associated antigen 9 | -0.0281242 |
| CENPF | centromere protein F, 350/400kDa | -0.0281152 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0278799 |
| JMJD1C | jumonji domain containing 1C | -0.0277213 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0276307 |
| KIAA1328 | KIAA1328 | -0.0274624 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0273062 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0271906 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.027187 |
| PTMA | prothymosin, alpha | -0.0271663 |
| TPM4 | tropomyosin 4 | -0.0269749 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0269624 |
| FMN1 | formin 1 | -0.0268681 |
| RTN4 | reticulon 4 | -0.0266319 |
| FNIP1 | folliculin interacting protein 1 | -0.026426 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0264074 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0262987 |
| PCNX4 | pecanex 4 | -0.0257007 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.0256253 |
| DNER | delta/notch-like EGF repeat containing | -0.0252927 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0252444 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0250536 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0248203 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0247388 |
| IL6ST | interleukin 6 signal transducer | -0.024213 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0241822 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0240109 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0238478 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0233796 |
| AHNAK | AHNAK nucleoprotein | -0.0233506 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0232307 |
| SVIL | supervillin | -0.0230713 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0228961 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0228721 |
| NABP1 | nucleic acid binding protein 1 | -0.0228214 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.022529 |
| TPX2 | TPX2, microtubule-associated | -0.0222838 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.022184 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0221185 |
