| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3475 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Gliclazide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MARCHF7 | membrane associated ring-CH-type finger 7 | 1.28 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.77 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.7 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.68 |
| SMIM19 | small integral membrane protein 19 | 0.62 |
| KMT5B | lysine methyltransferase 5B | 0.54 |
| CEP57 | centrosomal protein 57kDa | 0.53 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.5 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | 0.5 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.48 |
| SPEG | SPEG complex locus | 0.47 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 0.46 |
| NCAM1 | neural cell adhesion molecule 1 | 0.46 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.45 |
| NAV3 | neuron navigator 3 | 0.44 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.43 |
| RARA | retinoic acid receptor, alpha | 0.43 |
| ATG2A | autophagy related 2A | 0.42 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | 0.41 |
| RUNDC1 | RUN domain containing 1 | 0.39 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.39 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.39 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | 0.38 |
| ZNF496 | zinc finger protein 496 | 0.37 |
| TNNC2 | troponin C type 2 (fast) | 0.37 |
| KIAA0556 | KIAA0556 | 0.36 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.36 |
| HYLS1 | hydrolethalus syndrome 1 | 0.35 |
| TP73 | tumor protein p73 | 0.35 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.35 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.34 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | 0.34 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 0.34 |
| NADK | NAD kinase | 0.34 |
| ZNF124 | zinc finger protein 124 | 0.33 |
| ZNF449 | zinc finger protein 449 | 0.32 |
| RAD51 | RAD51 recombinase | 0.31 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.31 |
| CBX7 | chromobox homolog 7 | 0.31 |
| HDAC5 | histone deacetylase 5 | 0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.3 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.3 |
| FOXM1 | forkhead box M1 | 0.29 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.28 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | 0.28 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.28 |
| BAG4 | BCL2-associated athanogene 4 | 0.28 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | 0.27 |
| SLC38A7 | solute carrier family 38, member 7 | 0.27 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 0.27 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.27 |
| LMO4 | LIM domain only 4 | 0.27 |
| PTTG1 | pituitary tumor-transforming 1 | 0.27 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.27 |
| HEXD | hexosaminidase D | 0.27 |
| RNF145 | ring finger protein 145 | 0.26 |
| KLHL29 | kelch-like family member 29 | 0.26 |
| C8ORF37 | chromosome 8 open reading frame 37 | 0.25 |
| TMCO4 | transmembrane and coiled-coil domains 4 | 0.25 |
| ACP1 | acid phosphatase 1, soluble | 0.25 |
| DIXDC1 | DIX domain containing 1 | 0.25 |
| TSPAN4 | tetraspanin 4 | 0.25 |
| YBX3 | Y box binding protein 3 | 0.25 |
| MAGEA12 | melanoma antigen family A12 | 0.25 |
| PLK1 | polo-like kinase 1 | 0.25 |
| RPL37 | ribosomal protein L37 | 0.24 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.24 |
| ARHGAP11A | Rho GTPase activating protein 11A | 0.24 |
| EWSR1 | EWS RNA-binding protein 1 | 0.24 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | 0.24 |
| TUBAL3 | tubulin, alpha-like 3 | 0.24 |
| CENPH | centromere protein H | 0.24 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.24 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.23 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.23 |
| UBE3D | ubiquitin protein ligase E3D | 0.23 |
| ATAD5 | ATPase family, AAA domain containing 5 | 0.23 |
| FZD7 | frizzled class receptor 7 | 0.23 |
| TRMT44 | tRNA methyltransferase 44 homolog (S. cerevisiae) | 0.23 |
| PRMT6 | protein arginine methyltransferase 6 | 0.23 |
| SATB2 | SATB homeobox 2 | 0.22 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.22 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.22 |
| KAT5 | K(lysine) acetyltransferase 5 | 0.22 |
| LMF1 | lipase maturation factor 1 | 0.22 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.22 |
| IFT54 | intraflagellar transport 54 | 0.22 |
| FRMPD1 | FERM and PDZ domain containing 1 | 0.22 |
| EHF | ets homologous factor | 0.21 |
| CDCA5 | cell division cycle associated 5 | 0.21 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.21 |
| PRR5 | proline rich 5 (renal) | 0.21 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.21 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | 0.21 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.21 |
| LDB1 | LIM domain binding 1 | 0.21 |
| LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) | 0.21 |
| RBL1 | retinoblastoma-like 1 | 0.21 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.21 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KIAA0513 | KIAA0513 | -0.73 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.56 |
| CRLF1 | cytokine receptor-like factor 1 | -0.56 |
| METTL26 | methyltransferase like 26 | -0.55 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.55 |
| CRCP | CGRP receptor component | -0.47 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.46 |
| CCNYL1 | cyclin Y-like 1 | -0.45 |
| MRC2 | mannose receptor, C type 2 | -0.45 |
| FTL | ferritin, light polypeptide | -0.44 |
| DUSP22 | dual specificity phosphatase 22 | -0.43 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.42 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.42 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.41 |
| ZNF37A | zinc finger protein 37A | -0.41 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.4 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.39 |
| ELAC1 | elaC ribonuclease Z 1 | -0.38 |
| NENF | neudesin neurotrophic factor | -0.37 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.37 |
| TMEM159 | transmembrane protein 159 | -0.37 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.37 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -0.36 |
| CLCN6 | chloride channel, voltage-sensitive 6 | -0.36 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.35 |
| PRR36 | proline rich 36 | -0.34 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.33 |
| SPPL2A | signal peptide peptidase like 2A | -0.33 |
| GRN | granulin | -0.33 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.33 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.32 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.32 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.32 |
| IGSF8 | immunoglobulin superfamily, member 8 | -0.31 |
| SCAND1 | SCAN domain containing 1 | -0.31 |
| ZNF503 | zinc finger protein 503 | -0.3 |
| ZNF302 | zinc finger protein 302 | -0.3 |
| DHRS4L1 | dehydrogenase/reductase (SDR family) member 4 like 1 | -0.3 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.3 |
| ATF3 | activating transcription factor 3 | -0.3 |
| RAB37 | RAB37, member RAS oncogene family | -0.29 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.29 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -0.29 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.29 |
| LRP6 | low density lipoprotein receptor-related protein 6 | -0.29 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.29 |
| C4BPA | complement component 4 binding protein, alpha | -0.28 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.28 |
| MRNIP | MRN complex interacting protein | -0.28 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.28 |
| GLS | glutaminase | -0.27 |
| DTX2 | deltex 2, E3 ubiquitin ligase | -0.27 |
| INHBA | inhibin, beta A | -0.27 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.27 |
| FAM210B | family with sequence similarity 210, member B | -0.27 |
| FBXL14 | F-box and leucine-rich repeat protein 14 | -0.27 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.27 |
| TMEM185B | transmembrane protein 185B | -0.27 |
| RAB8B | RAB8B, member RAS oncogene family | -0.27 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.26 |
| TYK2 | tyrosine kinase 2 | -0.26 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.26 |
| GORASP1 | golgi reassembly stacking protein 1, 65kDa | -0.26 |
| FAM53C | family with sequence similarity 53, member C | -0.26 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.26 |
| RUNX2 | runt-related transcription factor 2 | -0.26 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.26 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | -0.26 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.26 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.26 |
| PLIN2 | perilipin 2 | -0.26 |
| SNX19 | sorting nexin 19 | -0.26 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.26 |
| LAMA3 | laminin, alpha 3 | -0.26 |
| BRD3 | bromodomain containing 3 | -0.26 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.25 |
| APOBEC3F | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | -0.25 |
| CCDC112 | coiled-coil domain containing 112 | -0.25 |
| ALPK3 | alpha-kinase 3 | -0.25 |
| CBR3 | carbonyl reductase 3 | -0.25 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -0.25 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.24 |
| CEP89 | centrosomal protein 89kDa | -0.24 |
| CLTB | clathrin, light chain B | -0.24 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | -0.24 |
| ERG28 | ergosterol biosynthesis 28 homolog | -0.24 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.24 |
| PPP1R2B | PPP1R2 family member B | -0.24 |
| CA8 | carbonic anhydrase VIII | -0.24 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.23 |
| OPTN | optineurin | -0.23 |
| PHF13 | PHD finger protein 13 | -0.23 |
| SNX15 | sorting nexin 15 | -0.23 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.23 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | -0.23 |
| TDRKH | tudor and KH domain containing | -0.23 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | -0.23 |
| RNASET2 | ribonuclease T2 | -0.23 |
| TMEM59 | transmembrane protein 59 | -0.23 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.23 |
