Glomerulonephritis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A nephritis that causes inflammation of the glomeruli located_in kidney. (Human Disease Ontology, DOID_2921)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D005921
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Genes

332 genes/proteins associated with the disease Glomerulonephritis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
CXCR3 chemokine (C-X-C motif) receptor 3 2.88009
IFNG interferon, gamma 2.88009
IL1B interleukin 1, beta 2.88009
ADM adrenomedullin 2.88009
JUND jun D proto-oncogene 2.88009
PPARG peroxisome proliferator-activated receptor gamma 2.88009
IL18 interleukin 18 2.88009
IL10 interleukin 10 2.88009
ALB albumin 2.88009
DES desmin 2.88009
NGF nerve growth factor (beta polypeptide) 2.88009
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.88009
POMC proopiomelanocortin 2.88009
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.88009
TNF tumor necrosis factor 2.88009
IL2 interleukin 2 2.88009
ESR1 estrogen receptor 1 2.88009
CCL5 chemokine (C-C motif) ligand 5 2.88009
CCL2 chemokine (C-C motif) ligand 2 2.88009
IL6 interleukin 6 2.88009
CXCL8 chemokine (C-X-C motif) ligand 8 2.88009
CCL3 chemokine (C-C motif) ligand 3 2.88009
CCL1 chemokine (C-C motif) ligand 1 2.88009
WT1 Wilms tumor 1 2.88009
CCL4 chemokine (C-C motif) ligand 4 2.88009
CFD complement factor D (adipsin) 2.88009
CCL7 chemokine (C-C motif) ligand 7 2.88009
IL2RA interleukin 2 receptor, alpha 2.88009
TGFB1 transforming growth factor, beta 1 2.32663
EDN1 endothelin 1 2.29765
VEGFA vascular endothelial growth factor A 2.28154
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.25395
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.20328
BAX BCL2-associated X protein 2.1973
BCL2 B-cell CLL/lymphoma 2 2.18331
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.15598
NPPB natriuretic peptide B 2.14182
NOS2 nitric oxide synthase 2, inducible 2.1336
FOS FBJ murine osteosarcoma viral oncogene homolog 2.02129
TIMP1 TIMP metallopeptidase inhibitor 1 1.9658
NOS3 nitric oxide synthase 3 (endothelial cell) 1.96101
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.95026
HMOX1 heme oxygenase 1 1.94874
COL1A1 collagen, type I, alpha 1 1.93088
DDIT3 DNA-damage-inducible transcript 3 1.92328
JUN jun proto-oncogene 1.90142
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.89568
REN renin 1.89074
ICAM1 intercellular adhesion molecule 1 1.88491
IGF1 insulin-like growth factor 1 (somatomedin C) 1.87443
VCAM1 vascular cell adhesion molecule 1 1.87008
MAPK1 mitogen-activated protein kinase 1 1.85415
BCL2L1 BCL2-like 1 1.84959
IL4 interleukin 4 1.84729
CAT catalase 1.84693
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.84534
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.84393
EGR1 early growth response 1 1.83877
SOD2 superoxide dismutase 2, mitochondrial 1.83681
MPO myeloperoxidase 1.81593
AGTR2 angiotensin II receptor, type 2 1.78892
MMP2 matrix metallopeptidase 2 1.78568
SPP1 secreted phosphoprotein 1 1.78207
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.77335
MAPK3 mitogen-activated protein kinase 3 1.76597
NPPA natriuretic peptide A 1.76501
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.76309
FASLG Fas ligand (TNF superfamily, member 6) 1.7621
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.76013
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.73898
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.72738
PCNA proliferating cell nuclear antigen 1.71728
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.7107
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.69805
GADD45A growth arrest and DNA-damage-inducible, alpha 1.69275
FN1 fibronectin 1 1.68932
TP53 tumor protein p53 1.68825
VIM vimentin 1.68825
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.67825
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.67547
AQP2 aquaporin 2 (collecting duct) 1.67355
F3 coagulation factor III (thromboplastin, tissue factor) 1.63294
BIRC5 baculoviral IAP repeat containing 5 1.62848
EDNRA endothelin receptor type A 1.62246
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.60711
TIMP2 TIMP metallopeptidase inhibitor 2 1.60711
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.59591
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.5903
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.58561
DUSP1 dual specificity phosphatase 1 1.58444
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.58279
HSPB1 heat shock 27kDa protein 1 1.5709
NOX4 NADPH oxidase 4 1.56994
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.56755
HSPE1 heat shock 10kDa protein 1 1.55896
MAPK8 mitogen-activated protein kinase 8 1.55747
IL1A interleukin 1, alpha 1.55206
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.53579
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.53061
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.53061
TJP1 tight junction protein 1 1.53036
APOE apolipoprotein E 1.52566
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.51759
AGTR1 angiotensin II receptor, type 1 1.51683
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.51582
CYCS cytochrome c, somatic 1.49711
CFLAR CASP8 and FADD-like apoptosis regulator 1.47864
FAS Fas cell surface death receptor 1.47634
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.47634
CXCL2 chemokine (C-X-C motif) ligand 2 1.47634
NFE2L2 nuclear factor, erythroid 2-like 2 1.47478
ACTA2 actin, alpha 2, smooth muscle, aorta 1.46986
ACTA1 actin, alpha 1, skeletal muscle 1.46409
NCF1 neutrophil cytosolic factor 1 1.45063
PARP1 poly (ADP-ribose) polymerase 1 1.443
CCND2 cyclin D2 1.44193
RAD50 RAD50 homolog (S. cerevisiae) 1.43239
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.42967
CLU clusterin 1.42669
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.42074
ACE angiotensin I converting enzyme 1.41802
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.41694
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.41229
ANGPT1 angiopoietin 1 1.39591
SMAD3 SMAD family member 3 1.39535
CCND1 cyclin D1 1.38071
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.38043
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.37846
IRS1 insulin receptor substrate 1 1.37246
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.36161
COL3A1 collagen, type III, alpha 1 1.36161
EDNRB endothelin receptor type B 1.35934
TGFB2 transforming growth factor, beta 2 1.35734
CRP C-reactive protein, pentraxin-related 1.35734
SOD1 superoxide dismutase 1, soluble 1.35357
PPARA peroxisome proliferator-activated receptor alpha 1.35357
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.35299
CDK2 cyclin-dependent kinase 2 1.35242
CTGF connective tissue growth factor 1.34869
IL12B interleukin 12B 1.3484
ATF3 activating transcription factor 3 1.34694
GSTP1 glutathione S-transferase pi 1 1.34372
IL5 interleukin 5 1.34024
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.33761
HMGB1 high mobility group box 1 1.33701
COL18A1 collagen, type XVIII, alpha 1 1.33434
LCN2 lipocalin 2 1.33199
AQP3 aquaporin 3 (Gill blood group) 1.33169
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.32786
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.32667
GSTM1 glutathione S-transferase mu 1 1.32547
GPX1 glutathione peroxidase 1 1.32221
SMAD7 SMAD family member 7 1.31686
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.31416
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.31387
S100A9 S100 calcium binding protein A9 1.31387
ARC activity-regulated cytoskeleton-associated protein 1.31357
CYP3A cytochrome P450, family 3, subfamily A 1.31357
GCLC glutamate-cysteine ligase, catalytic subunit 1.31297
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.3039
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.3036
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.30177
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.29996
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.29996
LEP leptin 1.29843
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.2941
HSPA1A heat shock 70kDa protein 1A 1.29379
COL4A1 collagen, type IV, alpha 1 1.29379
S100A8 S100 calcium binding protein A8 1.28919
CYBB cytochrome b-245, beta polypeptide 1.27751
BID BH3 interacting domain death agonist 1.27564
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.2744
KDR kinase insert domain receptor 1.2744
MAPK9 mitogen-activated protein kinase 9 1.27286
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.27193
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.27193
ACE2 angiotensin I converting enzyme 2 1.26947
CCNA2 cyclin A2 1.26856
PRL prolactin 1.267
BDKRB1 bradykinin receptor B1 1.267
CYR61 cysteine-rich, angiogenic inducer, 61 1.26175
GSTT1 glutathione S-transferase theta 1 1.25838
CCND3 cyclin D3 1.25745
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.25713
KLF4 Kruppel-like factor 4 (gut) 1.24874
NPY neuropeptide Y 1.24874
CREM cAMP responsive element modulator 1.24874
MAPK14 mitogen-activated protein kinase 14 1.24718
HSPA8 heat shock 70kDa protein 8 1.24655
CDKN2A cyclin-dependent kinase inhibitor 2A 1.24655
MMP1 matrix metallopeptidase 1 1.24496
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.24244
RB1 retinoblastoma 1 1.24118
MGP matrix Gla protein 1.24024
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.23775
APOA1 apolipoprotein A-I 1.23648
TLR4 toll-like receptor 4 1.23137
STAT1 signal transducer and activator of transcription 1, 91kDa 1.22821
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.22242
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.22177
CTSB cathepsin B 1.22177
ZWINT ZW10 interacting kinetochore protein 1.21663
CPT1A carnitine palmitoyltransferase 1A (liver) 1.2137
GNAS GNAS complex locus 1.21337
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.21043
MMP9 matrix metallopeptidase 9 1.20946
BMP4 bone morphogenetic protein 4 1.20816
CD44 CD44 molecule (Indian blood group) 1.20751
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.20719
GSK3B glycogen synthase kinase 3 beta 1.2046
ODC1 ornithine decarboxylase 1 1.20427
PTH1R parathyroid hormone 1 receptor 1.2013
COL1A2 collagen, type I, alpha 2 1.19412
CDK4 cyclin-dependent kinase 4 1.19345
NQO1 NAD(P)H dehydrogenase, quinone 1 1.19312
ETFB electron-transfer-flavoprotein, beta polypeptide 1.19113
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.18587
HBEGF heparin-binding EGF-like growth factor 1.18587
LHB luteinizing hormone beta polypeptide 1.18293
BDKRB2 bradykinin receptor B2 1.18226
FAM129A family with sequence similarity 129, member A 1.18126
CALR calreticulin 1.18093
C1S complement component 1, s subcomponent 1.17893
ARG1 arginase 1 1.1786
PLN phospholamban 1.17662
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.17399
NOS1 nitric oxide synthase 1 (neuronal) 1.17366
CDC25A cell division cycle 25A 1.17268
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.17168
HAVCR1 hepatitis A virus cellular receptor 1 1.16933
EPO erythropoietin 1.167
ADRB2 adrenoceptor beta 2, surface 1.16633
CYBA cytochrome b-245, alpha polypeptide 1.16236
BIRC3 baculoviral IAP repeat containing 3 1.16104
RYR2 ryanodine receptor 2 (cardiac) 1.15831
ANXA5 annexin A5 1.15763
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.15661
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.1556
APOB apolipoprotein B 1.1556
CCNB1 cyclin B1 1.15425
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.14816
ACHE acetylcholinesterase (Yt blood group) 1.14438
SRXN1 sulfiredoxin 1 1.14234
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 1.14166
MKI67 marker of proliferation Ki-67 1.1403
CCNG2 cyclin G2 1.13621
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.13621
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.13347
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.13245
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.13143
GPX3 glutathione peroxidase 3 1.13143
GDF15 growth differentiation factor 15 1.12703
TOP2A topoisomerase (DNA) II alpha 170kDa 1.12703
G6PD glucose-6-phosphate dehydrogenase 1.1253
MAOA monoamine oxidase A 1.1253
BAD BCL2-associated agonist of cell death 1.1253
INS insulin 1.12391
BTG1 B-cell translocation gene 1, anti-proliferative 1.12219
FOXO1 forkhead box O1 1.11945
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.11116
GSTM3 glutathione S-transferase mu 3 (brain) 1.10282
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.10069
CBR1 carbonyl reductase 1 1.09786
ATM ATM serine/threonine kinase 1.09681
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.09681
TTK TTK protein kinase 1.09401
FLT1 fms-related tyrosine kinase 1 1.09011
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.08762
FASN fatty acid synthase 1.08301
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.08161
LPL lipoprotein lipase 1.08161
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.08161
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.08126
ILF3 interleukin enhancer binding factor 3, 90kDa 1.08091
TOPBP1 topoisomerase (DNA) II binding protein 1 1.08091
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.08019
AVP arginine vasopressin 1.07768
POR P450 (cytochrome) oxidoreductase 1.07589
DTYMK deoxythymidylate kinase (thymidylate kinase) 1.07553
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.07518
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.07057
CCNE1 cyclin E1 1.06844
PLAU plasminogen activator, urokinase 1.06661
PPARD peroxisome proliferator-activated receptor delta 1.06552
EGFR epidermal growth factor receptor 1.05864
PDGFB platelet-derived growth factor beta polypeptide 1.0561
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.0561
STIP1 stress-induced phosphoprotein 1 1.05573
ANXA4 annexin A4 1.05573
MT1A metallothionein 1A 1.05423
S100A10 S100 calcium binding protein A10 1.05237
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.05126
IGFBP3 insulin-like growth factor binding protein 3 1.05052
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.04978
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.04904
GCLM glutamate-cysteine ligase, modifier subunit 1.04831
TIMP3 TIMP metallopeptidase inhibitor 3 1.04647
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.04611
NTF3 neurotrophin 3 1.04611
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.04538
TPM2 tropomyosin 2 (beta) 1.04465
LDLR low density lipoprotein receptor 1.04163
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.03715
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.0353
SERINC3 serine incorporator 3 1.03493
TGFA transforming growth factor, alpha 1.03271
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.03046
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.03046
CCNG1 cyclin G1 1.02821
FSHB follicle stimulating hormone, beta polypeptide 1.02783
BIRC2 baculoviral IAP repeat containing 2 1.02634
APP amyloid beta (A4) precursor protein 1.02447
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.0241
KLF10 Kruppel-like factor 10 1.0241
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.0241
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.0241
MCM4 minichromosome maintenance complex component 4 1.02114
RRM2 ribonucleotide reductase M2 1.01966
TXNIP thioredoxin interacting protein 1.01739
JUNB jun B proto-oncogene 1.01625
DPP4 dipeptidyl-peptidase 4 1.01512
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.01512
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.01512
DCN decorin 1.01512
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.01286
FST follistatin 1.01212
MCM5 minichromosome maintenance complex component 5 1.01212
RET ret proto-oncogene 1.01212
PLAT plasminogen activator, tissue 1.01137
PON1 paraoxonase 1 1.01137
H2AFX H2A histone family, member X 1.01137
CDK1 cyclin-dependent kinase 1 1.01025