Glycolysis / Gluconeogenesis Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. (Kyoto Encyclopedia of Genes and Genomes, hsa00010)
External Link https://www.kegg.jp/entry/hsa00010
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Genes

65 proteins participating in the Glycolysis / Gluconeogenesis pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACSS1 acyl-CoA synthetase short-chain family member 1
ACSS2 acyl-CoA synthetase short-chain family member 2
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADPGK ADP-dependent glucokinase
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
BPGM 2,3-bisphosphoglycerate mutase
DLAT dihydrolipoamide S-acetyltransferase
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENO3 enolase 3 (beta, muscle)
ENO4 enolase family member 4
FBP1 fructose-1,6-bisphosphatase 1
G6PC1 glucose-6-phosphatase catalytic subunit 1
G6PC2 glucose-6-phosphatase, catalytic, 2
G6PC3 glucose 6 phosphatase, catalytic, 3
GALM galactose mutarotase (aldose 1-epimerase)
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GNPDA1 glucosamine-6-phosphate deaminase 1
HKDC1 hexokinase domain containing 1
HOOK2 hook microtubule-tethering protein 2
HOOK3 hook microtubule-tethering protein 3
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHAL6B lactate dehydrogenase A-like 6B
LDHB lactate dehydrogenase B
LDHC lactate dehydrogenase C
LDHD lactate dehydrogenase D
LOC112694756 uncharaterized LOC112694756
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MINPP1 multiple inositol-polyphosphate phosphatase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNX4 pecanex 4
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PFKL phosphofructokinase, liver
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PGAM2 phosphoglycerate mutase 2 (muscle)
PGAM4 phosphoglycerate mutase family member 4
PGK1 phosphoglycerate kinase 1
PGK2 phosphoglycerate kinase 2
PGM1 phosphoglucomutase 1
PGM2 phosphoglucomutase 2
PKLR pyruvate kinase, liver and RBC
PKM pyruvate kinase, muscle
TAC4 tachykinin 4 (hemokinin)
TPI1 triosephosphate isomerase 1