Glycyrrhizic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.159236
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.11267
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.102834
FBN1 fibrillin 1 0.0781121
FNDC3B fibronectin type III domain containing 3B 0.0748947
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.071231
PODXL podocalyxin-like 0.0711723
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0608684
FLNA filamin A, alpha 0.0600718
FTH1 ferritin, heavy polypeptide 1 0.0579738
COL8A1 collagen, type VIII, alpha 1 0.0542306
AUTS2 autism susceptibility candidate 2 0.0512475
C1D C1D nuclear receptor corepressor 0.0470918
EEF1G eukaryotic translation elongation factor 1 gamma 0.0470436
COL1A2 collagen, type I, alpha 2 0.045159
FBXL7 F-box and leucine-rich repeat protein 7 0.0385609
GPC6 glypican 6 0.0364674
CD44 CD44 molecule (Indian blood group) 0.0364421
POTEF POTE ankyrin domain family, member F 0.0363728
MYADM myeloid-associated differentiation marker 0.0358873
LOX lysyl oxidase 0.035743
STC1 stanniocalcin 1 0.0354137
SBF2 SET binding factor 2 0.0347507
LOXL2 lysyl oxidase-like 2 0.0347235
NAV2 neuron navigator 2 0.0341002
PRELID2 PRELI domain containing 2 0.0340838
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0337971
LDHA lactate dehydrogenase A 0.0326702
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.032105
EEF2 eukaryotic translation elongation factor 2 0.0318763
DPYSL3 dihydropyrimidinase-like 3 0.0315923
ATP13A3 ATPase type 13A3 0.0312106
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0297963
SOD2 superoxide dismutase 2, mitochondrial 0.0289435
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0287656
NAV1 neuron navigator 1 0.0286331
LENG8 leukocyte receptor cluster (LRC) member 8 0.0286267
L1CAM L1 cell adhesion molecule 0.0283457
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0266939
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0266265
ACTG1 actin gamma 1 0.0264268
ZBTB20 zinc finger and BTB domain containing 20 0.0259716
ANKRD10 ankyrin repeat domain 10 0.0258368
CTSB cathepsin B 0.0257678
PKM pyruvate kinase, muscle 0.0242537
SP3 Sp3 transcription factor 0.0238666
SDK1 sidekick cell adhesion molecule 1 0.0236821
LPP LIM domain containing preferred translocation partner in lipoma 0.0234577
GLS2 glutaminase 2 (liver, mitochondrial) 0.0230323
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0229724
FRMD5 FERM domain containing 5 0.0226629
PSD3 pleckstrin and Sec7 domain containing 3 0.0226242
SFTPA2 surfactant protein A2 0.0223063
DCAF6 DDB1 and CUL4 associated factor 6 0.0222433
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0221699
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0215572
MTSS1 metastasis suppressor 1 0.0207545
NFE2L1 nuclear factor, erythroid 2-like 1 0.0206404
RPL9 ribosomal protein L9 0.0196293
PGK1 phosphoglycerate kinase 1 0.0195908
MNT MAX network transcriptional repressor 0.0192633
KIFAP3 kinesin-associated protein 3 0.0191671
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0190718
RASA2 RAS p21 protein activator 2 0.0190403
ARRDC3 arrestin domain containing 3 0.0189505
SLC22A23 solute carrier family 22, member 23 0.0185445
RPL23 ribosomal protein L23 0.0183423
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0181446
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0179628
SSBP2 single-stranded DNA binding protein 2 0.017952
KIF16B kinesin family member 16B 0.017886
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0177063
CCNL1 cyclin L1 0.0176458
PCGF5 polycomb group ring finger 5 0.0176194
ARB2A ARB2 cotranscriptional regulator A 0.0174363
CLTC clathrin, heavy chain (Hc) 0.0174088
SVIL supervillin 0.017229
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0171881
TENT4A terminal nucleotidyltransferase 4A 0.0170367
ANXA4 annexin A4 0.0166413
SLC35F5 solute carrier family 35, member F5 0.0166226
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0162474
SRRM2 serine/arginine repetitive matrix 2 0.0162156
NBAS neuroblastoma amplified sequence 0.0161552
GANAB glucosidase, alpha; neutral AB 0.0161506
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0159399
ARHGAP21 Rho GTPase activating protein 21 0.0159311
PML promyelocytic leukemia 0.0159213
ANK2 ankyrin 2, neuronal 0.0158975
PRPF8 pre-mRNA processing factor 8 0.0158741
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.015847
NCOR2 nuclear receptor corepressor 2 0.0158416
KIAA1217 KIAA1217 0.0156805
FBXL5 F-box and leucine-rich repeat protein 5 0.015654
FLNB filamin B, beta 0.0156322
APP amyloid beta (A4) precursor protein 0.015627
DMTF1 cyclin D binding myb-like transcription factor 1 0.0155538
CAPRIN1 cell cycle associated protein 1 0.0155138
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0155129
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0154309

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.336785
AKAP12 A kinase (PRKA) anchor protein 12 -0.271069
IGFBP3 insulin-like growth factor binding protein 3 -0.207152
TMSB10 thymosin beta 10 -0.1999
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12648
S100A10 S100 calcium binding protein A10 -0.0916221
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0889124
LMNA lamin A/C -0.0879429
TPM4 tropomyosin 4 -0.0857679
FN1 fibronectin 1 -0.0812738
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0734423
ABI3BP ABI family, member 3 (NESH) binding protein -0.0726281
CANX calnexin -0.0725629
MAP1B microtubule-associated protein 1B -0.0692501
NDRG1 N-myc downstream regulated 1 -0.0689263
AHNAK AHNAK nucleoprotein -0.0656268
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0652255
TRIO trio Rho guanine nucleotide exchange factor -0.0637339
CSTB cystatin B (stefin B) -0.0635218
SLC38A1 solute carrier family 38, member 1 -0.0634151
PTMA prothymosin, alpha -0.0630442
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0577506
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0576075
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0570969
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0551777
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0536784
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.053205
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0526648
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0486655
FTL ferritin, light polypeptide -0.0478973
S100A6 S100 calcium binding protein A6 -0.0466487
CDH13 cadherin 13 -0.0464183
DLG1 discs, large homolog 1 (Drosophila) -0.0457913
DCLK2 doublecortin-like kinase 2 -0.04539
SAMD9 sterile alpha motif domain containing 9 -0.0431857
COL5A1 collagen, type V, alpha 1 -0.0422406
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0410382
PRSS23 protease, serine, 23 -0.0393
RRBP1 ribosome binding protein 1 -0.0391611
MEIS2 Meis homeobox 2 -0.0372484
SH3KBP1 SH3-domain kinase binding protein 1 -0.0356796
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0353106
CALR calreticulin -0.0337844
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0337352
CAVIN1 caveolae associated protein 1 -0.0335859
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0335714
ZMYND8 zinc finger, MYND-type containing 8 -0.0334213
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0326837
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0325709
ANXA2 annexin A2 -0.0321181
SPDL1 spindle apparatus coiled-coil protein 1 -0.0318622
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0313526
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0313268
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.031193
SLC39A11 solute carrier family 39, member 11 -0.0308706
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0308613
SORBS2 sorbin and SH3 domain containing 2 -0.0306635
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0304385
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0302327
IL7R interleukin 7 receptor -0.0300237
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0298513
GARS1 glycyl-tRNA synthetase 1 -0.0295255
LRRC17 leucine rich repeat containing 17 -0.0291265
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0290986
DDIT4 DNA-damage-inducible transcript 4 -0.0289774
JUN jun proto-oncogene -0.0282225
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0282147
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0280546
ANKRD11 ankyrin repeat domain 11 -0.0279581
ASPH aspartate beta-hydroxylase -0.0278325
IFI16 interferon, gamma-inducible protein 16 -0.0277191
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0273021
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0272849
HLA-B major histocompatibility complex, class I, B -0.0271667
MACF1 microtubule-actin crosslinking factor 1 -0.0267215
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0257987
KPNB1 karyopherin (importin) beta 1 -0.0257077
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0256952
RIGI RNA sensor RIG-I -0.0255167
EZR ezrin -0.02546
RTN4 reticulon 4 -0.0252656
GOLGB1 golgin B1 -0.0252474
ULK1 unc-51 like autophagy activating kinase 1 -0.0251585
S100A11 S100 calcium binding protein A11 -0.0248519
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0246404
TMSB4X thymosin beta 4, X-linked -0.0245271
AFF4 AF4/FMR2 family, member 4 -0.0242486
OASL 2'-5'-oligoadenylate synthetase-like -0.0241756
AHNAK2 AHNAK nucleoprotein 2 -0.0240001
FLT1 fms-related tyrosine kinase 1 -0.0237697
SUCNR1 succinate receptor 1 -0.0236703
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0233811
CUX1 cut-like homeobox 1 -0.023342
KRT81 keratin 81, type II -0.0231945
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0230023
CCND1 cyclin D1 -0.0228123
MX2 MX dynamin-like GTPase 2 -0.0224383
SYTL3 synaptotagmin-like 3 -0.022096
ACBD3 acyl-CoA binding domain containing 3 -0.0219702
RAI1 retinoic acid induced 1 -0.0217921