Glycyrrhizic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.148079
EEF1G eukaryotic translation elongation factor 1 gamma 0.137829
HMGA2 high mobility group AT-hook 2 0.0970021
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0783227
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0774601
RRM2 ribonucleotide reductase M2 0.0768598
NHSL1 NHS-like 1 0.0716548
ANKRD12 ankyrin repeat domain 12 0.0642481
YAP1 Yes-associated protein 1 0.0622857
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0616823
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0594276
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0580452
PCDH7 protocadherin 7 0.046324
ACTG1 actin gamma 1 0.0459842
TRIO trio Rho guanine nucleotide exchange factor 0.0459017
PCDH9 protocadherin 9 0.044203
RPS26 ribosomal protein S26 0.0435616
WWOX WW domain containing oxidoreductase 0.0423912
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0422528
KCMF1 potassium channel modulatory factor 1 0.0412549
TBC1D5 TBC1 domain family, member 5 0.0395861
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0392026
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0391561
CNRIP1 cannabinoid receptor interacting protein 1 0.0382692
PGK1 phosphoglycerate kinase 1 0.0370231
CCN2 cellular communication network factor 2 0.0363644
HMGA1 high mobility group AT-hook 1 0.03614
PDGFC platelet derived growth factor C 0.0358915
TENM3 teneurin transmembrane protein 3 0.0358833
FLNA filamin A, alpha 0.0357184
ASPH aspartate beta-hydroxylase 0.035391
CCNL1 cyclin L1 0.03523
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0340999
PFN1 profilin 1 0.0340474
TRA2B transformer 2 beta homolog (Drosophila) 0.0339587
EXOC4 exocyst complex component 4 0.0337946
CCSER1 coiled-coil serine-rich protein 1 0.0334909
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0333772
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0327777
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0310227
WNK1 WNK lysine deficient protein kinase 1 0.0308605
P3H2 prolyl 3-hydroxylase 2 0.030532
RPL9 ribosomal protein L9 0.0295885
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0290649
STIP1 stress-induced phosphoprotein 1 0.0290507
EPHA6 EPH receptor A6 0.0290118
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0285393
LDHB lactate dehydrogenase B 0.028093
NECTIN3 nectin cell adhesion molecule 3 0.0277639
NEBL nebulette 0.0276299
EEF2 eukaryotic translation elongation factor 2 0.0275545
EPHA5 EPH receptor A5 0.0274267
RPS21 ribosomal protein S21 0.0264478
RASAL2 RAS protein activator like 2 0.0261164
GANAB glucosidase, alpha; neutral AB 0.0256108
BMPR1B bone morphogenetic protein receptor, type IB 0.0253852
INTS6 integrator complex subunit 6 0.0253724
TUBA1C tubulin, alpha 1c 0.0251893
RPL36 ribosomal protein L36 0.0249558
WDPCP WD repeat containing planar cell polarity effector 0.0244947
ADGRG6 adhesion G protein-coupled receptor G6 0.0244371
RPL23 ribosomal protein L23 0.0243936
LPP LIM domain containing preferred translocation partner in lipoma 0.0243147
DENND5A DENN/MADD domain containing 5A 0.023927
TENT4A terminal nucleotidyltransferase 4A 0.0239063
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0236391
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0236079
FGFR1 fibroblast growth factor receptor 1 0.0233877
TGM2 transglutaminase 2 0.0233537
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0233103
RPL27 ribosomal protein L27 0.0229047
BABAM2 BRISC and BRCA1 A complex member 2 0.0226878
ERRFI1 ERBB receptor feedback inhibitor 1 0.0224221
R3HDM2 R3H domain containing 2 0.0224091
DOCK1 dedicator of cytokinesis 1 0.0221975
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0217765
FAT1 FAT atypical cadherin 1 0.0217495
MED13L mediator complex subunit 13-like 0.0215481
LRMDA leucine rich melanocyte differentiation associated 0.0215474
RYK receptor-like tyrosine kinase 0.0214168
EHBP1 EH domain binding protein 1 0.0212173
PKM pyruvate kinase, muscle 0.0211554
RPS19 ribosomal protein S19 0.021108
COMMD10 COMM domain containing 10 0.0208838
NDUFA4 NDUFA4, mitochondrial complex associated 0.0208096
PTK2 protein tyrosine kinase 2 0.0207771
FSTL5 follistatin-like 5 0.020592
NACA nascent polypeptide-associated complex alpha subunit 0.0205612
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.020535
LDHA lactate dehydrogenase A 0.0203368
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0202963
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.020288
POTEF POTE ankyrin domain family, member F 0.0202261
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0202236
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0199563
TAS2R14 taste receptor, type 2, member 14 0.0199058
GSE1 Gse1 coiled-coil protein 0.0197764
DIAPH2 diaphanous-related formin 2 0.0195532
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0195405
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0194899

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.3498
TMSB10 thymosin beta 10 -0.233965
FTL ferritin, light polypeptide -0.123898
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.085291
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0838515
PTMA prothymosin, alpha -0.0768403
YBX1 Y box binding protein 1 -0.0649655
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0627674
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0562991
ANXA1 annexin A1 -0.0552331
IFIH1 interferon induced with helicase C domain 1 -0.0528545
RPS12 ribosomal protein S12 -0.0487713
MAP1B microtubule-associated protein 1B -0.0477683
AHNAK AHNAK nucleoprotein -0.0457575
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0448064
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0447093
AREG amphiregulin -0.0444506
CANX calnexin -0.044302
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0437254
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0431148
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0414233
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0410415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0386524
RPS27A ribosomal protein S27a -0.0381632
KPNB1 karyopherin (importin) beta 1 -0.0374437
CSNK1A1 casein kinase 1, alpha 1 -0.0368599
CELF2 CUGBP, Elav-like family member 2 -0.036833
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0368129
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0366667
PCM1 pericentriolar material 1 -0.0358751
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0357161
RPS5 ribosomal protein S5 -0.0346523
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.033951
MATR3 matrin 3 -0.0337534
AKAP9 A kinase (PRKA) anchor protein 9 -0.0336052
TXNRD1 thioredoxin reductase 1 -0.0335335
NAP1L1 nucleosome assembly protein 1-like 1 -0.0328712
NF1 neurofibromin 1 -0.0328215
RPS3 ribosomal protein S3 -0.032307
GOLGB1 golgin B1 -0.0321213
AFF4 AF4/FMR2 family, member 4 -0.0320199
CHD1 chromodomain helicase DNA binding protein 1 -0.0314068
OGA O-GlcNAcase -0.0311875
AKAP12 A kinase (PRKA) anchor protein 12 -0.0309885
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0305705
EIF1 eukaryotic translation initiation factor 1 -0.0301551
COPA coatomer protein complex, subunit alpha -0.0297215
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0296736
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0293644
RB1CC1 RB1-inducible coiled-coil 1 -0.0291373
GOLGA4 golgin A4 -0.0289744
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0288579
FBXO11 F-box protein 11 -0.0287446
KDM2A lysine (K)-specific demethylase 2A -0.0282799
GARS1 glycyl-tRNA synthetase 1 -0.0277426
SQSTM1 sequestosome 1 -0.0275079
NPR2 natriuretic peptide receptor 2 -0.0273803
CDK6 cyclin-dependent kinase 6 -0.0266471
RPS6 ribosomal protein S6 -0.0266219
LARS1 leucyl-tRNA synthetase 1 -0.0266179
GOLIM4 golgi integral membrane protein 4 -0.026352
MMP12 matrix metallopeptidase 12 -0.0263489
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0261154
PARK7 parkinson protein 7 -0.0260755
PTMS parathymosin -0.0260362
DSCAM Down syndrome cell adhesion molecule -0.0260303
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0259173
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0258108
LOC102724023 ES1 protein homolog, mitochondrial -0.0257952
GJA1 gap junction protein, alpha 1, 43kDa -0.0257766
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0255976
HDLBP high density lipoprotein binding protein -0.0251971
JMJD1C jumonji domain containing 1C -0.0251362
NARS1 asparaginyl-tRNA synthetase 1 -0.025056
KTN1 kinectin 1 (kinesin receptor) -0.0250104
TPT1 tumor protein, translationally-controlled 1 -0.0249752
RPL31 ribosomal protein L31 -0.0249348
BPTF bromodomain PHD finger transcription factor -0.0246339
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.024541
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0243696
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0243497
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0242692
BIRC3 baculoviral IAP repeat containing 3 -0.0240538
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.024029
EZR ezrin -0.0239105
SEC31A SEC31 homolog A (S. cerevisiae) -0.0238934
KDM5A lysine (K)-specific demethylase 5A -0.0238882
RTN4 reticulon 4 -0.0238217
KDM3A lysine (K)-specific demethylase 3A -0.0235723
TOP1 topoisomerase (DNA) I -0.0235344
TTC3 tetratricopeptide repeat domain 3 -0.0235268
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0234938
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0234768
ZBTB35 zinc finger and BTB domain containing 35 -0.0234724
CXADR coxsackie virus and adenovirus receptor -0.0234102
GLG1 golgi glycoprotein 1 -0.0233634
PRRC2C proline-rich coiled-coil 2C -0.0233279
RPL37A ribosomal protein L37a -0.0230206
CLDN1 claudin 1 -0.0228422
CCDC47 coiled-coil domain containing 47 -0.0227825