Glycyrrhizic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0991247
PKM pyruvate kinase, muscle 0.0911264
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0664874
FLNB filamin B, beta 0.0656496
USP3 ubiquitin specific peptidase 3 0.0611585
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0541766
PGK1 phosphoglycerate kinase 1 0.0519651
NUP58 nucleoporin 58 0.0498046
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0473789
POTEF POTE ankyrin domain family, member F 0.0460915
MCL1 myeloid cell leukemia 1 0.0447599
RPL4 ribosomal protein L4 0.0427522
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0419756
SPAG9 sperm associated antigen 9 0.0413214
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0384647
HELZ helicase with zinc finger 0.0379984
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0379084
FLNA filamin A, alpha 0.037225
BIRC6 baculoviral IAP repeat containing 6 0.0358292
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0351929
LDHA lactate dehydrogenase A 0.0351018
EEF2 eukaryotic translation elongation factor 2 0.0349545
TNS1 tensin 1 0.0327759
AUTS2 autism susceptibility candidate 2 0.032516
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0316438
ZNF292 zinc finger protein 292 0.0313056
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0307023
BIRC3 baculoviral IAP repeat containing 3 0.0297853
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0296219
FA2H fatty acid 2-hydroxylase 0.0291526
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291223
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0289502
KMT2E lysine (K)-specific methyltransferase 2E 0.0288353
ANO6 anoctamin 6 0.0284297
SHB Src homology 2 domain containing adaptor protein B 0.0276361
NRIP1 nuclear receptor interacting protein 1 0.0265887
ANKRD11 ankyrin repeat domain 11 0.0265659
C1D C1D nuclear receptor corepressor 0.0265523
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0264715
ANXA4 annexin A4 0.0264282
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0259356
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0258878
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0257552
GOLGA4 golgin A4 0.0255759
CCNL1 cyclin L1 0.0253495
SETD5 SET domain containing 5 0.0245416
SEPTIN7 septin 7 0.0243376
PTK2 protein tyrosine kinase 2 0.0242945
TNIP1 TNFAIP3 interacting protein 1 0.0242293
NBAS neuroblastoma amplified sequence 0.0240827
EEF1G eukaryotic translation elongation factor 1 gamma 0.023732
HDGF hepatoma-derived growth factor 0.0236421
VIM vimentin 0.0232449
WDR43 WD repeat domain 43 0.0228128
MSN moesin 0.022423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0224153
LAMA5 laminin, alpha 5 0.0222409
MAP1B microtubule-associated protein 1B 0.0218503
MSI2 musashi RNA-binding protein 2 0.0216482
ADAM17 ADAM metallopeptidase domain 17 0.0215572
ENO1 enolase 1, (alpha) 0.0215278
SRP54 signal recognition particle 54kDa 0.0214804
WAC WW domain containing adaptor with coiled-coil 0.021441
RAP1B RAP1B, member of RAS oncogene family 0.0213295
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0212665
PYGL phosphorylase, glycogen, liver 0.021204
UBA6 ubiquitin-like modifier activating enzyme 6 0.02116
SOD2 superoxide dismutase 2, mitochondrial 0.0211503
LTBP4 latent transforming growth factor beta binding protein 4 0.0210672
PRPF8 pre-mRNA processing factor 8 0.0209861
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0209378
MACF1 microtubule-actin crosslinking factor 1 0.0208151
NAV2 neuron navigator 2 0.0206268
ZFHX3 zinc finger homeobox 3 0.0205316
FAM13A family with sequence similarity 13, member A 0.0201215
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0201114
SUCO SUN domain containing ossification factor 0.0200286
CNOT2 CCR4-NOT transcription complex, subunit 2 0.019916
MAP2K1 mitogen-activated protein kinase kinase 1 0.019781
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0196251
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0195271
MATR3 matrin 3 0.0195216
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0194752
PFN1 profilin 1 0.0194296
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0193751
SFTPA2 surfactant protein A2 0.0193539
NONO non-POU domain containing, octamer-binding 0.0192497
GRB10 growth factor receptor-bound protein 10 0.0190448
NGLY1 N-glycanase 1 0.0189914
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0189859
RPS17 ribosomal protein S17 0.0189221
RAD51B RAD51 paralog B 0.0188455
RLF rearranged L-myc fusion 0.0188025
KTN1 kinectin 1 (kinesin receptor) 0.0185074
FN1 fibronectin 1 0.0184472
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0184354
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0182986
CA12 carbonic anhydrase XII 0.0182712
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.0181664
SPDYA speedy/RINGO cell cycle regulator family member A 0.0181417

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.194714
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.172658
MT2A metallothionein 2A -0.16934
PDE4D phosphodiesterase 4D, cAMP-specific -0.154455
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.113365
KYNU kynureninase -0.103601
RPS19 ribosomal protein S19 -0.0967361
MT1X metallothionein 1X -0.0849973
OSMR oncostatin M receptor -0.0816795
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0816152
VCL vinculin -0.0798548
BASP1 brain abundant, membrane attached signal protein 1 -0.079229
EXT1 exostosin glycosyltransferase 1 -0.0633037
PDE10A phosphodiesterase 10A -0.0632075
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0625021
NCOA7 nuclear receptor coactivator 7 -0.0620393
RNF213 ring finger protein 213 -0.0528443
EHBP1 EH domain binding protein 1 -0.0506075
EIF1 eukaryotic translation initiation factor 1 -0.0503917
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.047825
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0473796
RHCG Rh family, C glycoprotein -0.0455279
BMAL2 basic helix-loop-helix ARNT like 2 -0.0452119
DOCK4 dedicator of cytokinesis 4 -0.0434443
RPL12 ribosomal protein L12 -0.0425089
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0418083
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0417368
ZBTB20 zinc finger and BTB domain containing 20 -0.0411583
RRBP1 ribosome binding protein 1 -0.0403637
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0388225
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0388035
RPL23 ribosomal protein L23 -0.038522
RIGI RNA sensor RIG-I -0.0376766
C15ORF48 chromosome 15 open reading frame 48 -0.037365
RPL26 ribosomal protein L26 -0.0372674
RPL32 ribosomal protein L32 -0.0372582
STC1 stanniocalcin 1 -0.0369499
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0362655
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0355558
RPS16 ribosomal protein S16 -0.0355267
NTN4 netrin 4 -0.0352807
SP100 SP100 nuclear antigen -0.0329822
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0328167
RPLP0 ribosomal protein, large, P0 -0.0326661
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0325351
WWC1 WW and C2 domain containing 1 -0.0322805
IGF1R insulin-like growth factor 1 receptor -0.0322512
THSD4 thrombospondin, type I, domain containing 4 -0.0321286
ARHGAP5 Rho GTPase activating protein 5 -0.0316205
TM4SF1 transmembrane 4 L six family member 1 -0.0314848
ZC3H12C zinc finger CCCH-type containing 12C -0.0311828
SH3KBP1 SH3-domain kinase binding protein 1 -0.0308956
SLC35F3 solute carrier family 35, member F3 -0.0308677
RSPO3 R-spondin 3 -0.030768
RPLP1 ribosomal protein, large, P1 -0.0303863
EPAS1 endothelial PAS domain protein 1 -0.0302483
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0296122
ELL2 elongation factor, RNA polymerase II, 2 -0.0295576
BICC1 BicC family RNA binding protein 1 -0.0294707
PMP22 peripheral myelin protein 22 -0.0290883
VMP1 vacuole membrane protein 1 -0.0286634
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0283704
ARHGAP26 Rho GTPase activating protein 26 -0.0280956
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0280758
PDLIM5 PDZ and LIM domain 5 -0.0279015
RAI14 retinoic acid induced 14 -0.0278922
BMERB1 bMERB domain containing 1 -0.0278384
ALCAM activated leukocyte cell adhesion molecule -0.0277287
BPTF bromodomain PHD finger transcription factor -0.0277141
GLIS3 GLIS family zinc finger 3 -0.0274825
PLSCR1 phospholipid scramblase 1 -0.0270852
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0269113
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0268908
YBX3 Y box binding protein 3 -0.0265694
NF1 neurofibromin 1 -0.0261292
RPLP2 ribosomal protein, large, P2 -0.0256962
LMO7 LIM domain 7 -0.0256024
EZR ezrin -0.0253768
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0252869
FOXP1 forkhead box P1 -0.0246747
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0237459
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0237423
FNDC3A fibronectin type III domain containing 3A -0.0237027
NCOA1 nuclear receptor coactivator 1 -0.0232222
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.022945
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0228443
DUSP16 dual specificity phosphatase 16 -0.0227894
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0225875
KLF6 Kruppel-like factor 6 -0.0220993
RBBP6 retinoblastoma binding protein 6 -0.0220032
RPL7 ribosomal protein L7 -0.021925
GRAMD1B GRAM domain containing 1B -0.0218777
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0218626
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0218542
ABLIM1 actin binding LIM protein 1 -0.0217149
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0216266
ADAM10 ADAM metallopeptidase domain 10 -0.0215562
CEP112 centrosomal protein 112kDa -0.0214219
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0213373
RPS24 ribosomal protein S24 -0.0212708