Glycyrrhizic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1G eukaryotic translation elongation factor 1 gamma 0.092167
EEF2 eukaryotic translation elongation factor 2 0.0728307
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0479438
LINGO2 leucine rich repeat and Ig domain containing 2 0.0430356
FLNA filamin A, alpha 0.042773
SRRM2 serine/arginine repetitive matrix 2 0.0376365
NAV2 neuron navigator 2 0.0364579
MT2A metallothionein 2A 0.0354001
FTH1 ferritin, heavy polypeptide 1 0.0330026
FNIP1 folliculin interacting protein 1 0.0318828
ANKRD28 ankyrin repeat domain 28 0.0294382
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0284532
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.02815
SUCO SUN domain containing ossification factor 0.0272825
RNF145 ring finger protein 145 0.0271956
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0264358
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0257415
TRIO trio Rho guanine nucleotide exchange factor 0.0246396
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240544
ACVR1 activin A receptor, type I 0.023945
ZNF207 zinc finger protein 207 0.0235973
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0233006
CHSY1 chondroitin sulfate synthase 1 0.0230259
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0229956
RAD21 RAD21 homolog (S. pombe) 0.0227702
FAR1 fatty acyl CoA reductase 1 0.0227008
GANAB glucosidase, alpha; neutral AB 0.0221687
SFTPA2 surfactant protein A2 0.0218547
MEF2A myocyte enhancer factor 2A 0.0216816
PKM pyruvate kinase, muscle 0.0212725
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0210579
JAG1 jagged 1 0.0207541
LAMA4 laminin, alpha 4 0.0205692
SCAF4 SR-related CTD-associated factor 4 0.0204927
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0203258
CDK17 cyclin-dependent kinase 17 0.0201742
GSE1 Gse1 coiled-coil protein 0.0201303
DST dystonin 0.0199499
YTHDC1 YTH domain containing 1 0.0199179
CALR calreticulin 0.0197855
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.019737
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0193953
EXOC5 exocyst complex component 5 0.0190854
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0190751
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.019063
AKAP12 A kinase (PRKA) anchor protein 12 0.0189088
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0187916
TRIM33 tripartite motif containing 33 0.0187011
HOXA3 homeobox A3 0.0186892
CABIN1 calcineurin binding protein 1 0.0182773
DMXL2 Dmx-like 2 0.0177454
DBN1 drebrin 1 0.0176052
MSL1 male-specific lethal 1 homolog (Drosophila) 0.0174955
BRD2 bromodomain containing 2 0.0173146
CCDC150 coiled-coil domain containing 150 0.0172005
RAB1A RAB1A, member RAS oncogene family 0.017192
DDIT4 DNA-damage-inducible transcript 4 0.0171724
ATF7IP activating transcription factor 7 interacting protein 0.0171674
DIAPH3 diaphanous-related formin 3 0.017104
CREBZF CREB/ATF bZIP transcription factor 0.0170883
FAM219A family with sequence similarity 219, member A 0.0170502
DIPK2A divergent protein kinase domain 2A 0.0169853
UBE3A ubiquitin protein ligase E3A 0.0169021
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0168543
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0167345
KDM6B lysine (K)-specific demethylase 6B 0.0166214
GNAS GNAS complex locus 0.0165244
CASC3 cancer susceptibility candidate 3 0.0162419
ZNF438 zinc finger protein 438 0.0162248
VGLL4 vestigial-like family member 4 0.0162193
SNX13 sorting nexin 13 0.016195
ZNF462 zinc finger protein 462 0.0161902
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0160951
YEATS2 YEATS domain containing 2 0.0160817
ZNF736 zinc finger protein 736 0.0160551
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0160475
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0159707
KLF10 Kruppel-like factor 10 0.0159373
CBX1 chromobox homolog 1 0.01591
BCLAF1 BCL2-associated transcription factor 1 0.0158746
WWC1 WW and C2 domain containing 1 0.0158588
ANXA2 annexin A2 0.0157692
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0157438
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0157165
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.015664
NEURL1B neuralized E3 ubiquitin protein ligase 1B 0.015544
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0154588
PHF21A PHD finger protein 21A 0.015411
POTEF POTE ankyrin domain family, member F 0.0154011
FBXL5 F-box and leucine-rich repeat protein 5 0.0153993
ARF1 ADP-ribosylation factor 1 0.0153722
ARHGAP26 Rho GTPase activating protein 26 0.0153627
MYH9 myosin, heavy chain 9, non-muscle 0.015337
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0153247
SMAD3 SMAD family member 3 0.0153064
HMGA1 high mobility group AT-hook 1 0.0152706
SEC23B Sec23 homolog B (S. cerevisiae) 0.0152694
IGFBP3 insulin-like growth factor binding protein 3 0.0152533
LMAN1 lectin, mannose-binding, 1 0.0152479
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0152077

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.183637
PRKG1 protein kinase, cGMP-dependent, type I -0.183342
CADM2 cell adhesion molecule 2 -0.0991391
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0920882
HMGA2 high mobility group AT-hook 2 -0.0789015
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0773314
JMJD1C jumonji domain containing 1C -0.0748167
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0686027
FGFR1 fibroblast growth factor receptor 1 -0.0656844
MEST mesoderm specific transcript -0.0656115
PDE4D phosphodiesterase 4D, cAMP-specific -0.0650805
TPK1 thiamin pyrophosphokinase 1 -0.0641465
AFF4 AF4/FMR2 family, member 4 -0.0636805
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0567735
GMDS GDP-mannose 4,6-dehydratase -0.0554684
RANBP17 RAN binding protein 17 -0.0537482
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0526066
TET1 tet methylcytosine dioxygenase 1 -0.0525976
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.051204
CANX calnexin -0.0507878
MARCHF6 membrane associated ring-CH-type finger 6 -0.0507179
TULP4 tubby like protein 4 -0.0500133
PDE10A phosphodiesterase 10A -0.0493066
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0469222
RPS24 ribosomal protein S24 -0.0451237
MSRB3 methionine sulfoxide reductase B3 -0.0446574
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0444347
NFIA nuclear factor I/A -0.0437847
SIK3 SIK family kinase 3 -0.0433309
AK1 adenylate kinase 1 -0.0409149
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0405808
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0396425
ARB2A ARB2 cotranscriptional regulator A -0.039408
FAF1 Fas (TNFRSF6) associated factor 1 -0.0393199
TMSB4X thymosin beta 4, X-linked -0.0389676
NBEA neurobeachin -0.0387603
SOX4 SRY (sex determining region Y)-box 4 -0.0386712
MGP matrix Gla protein -0.0377801
SEPTIN11 septin 11 -0.0375955
VCL vinculin -0.0374376
ATXN2 ataxin 2 -0.0365139
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0361414
RPS12 ribosomal protein S12 -0.0360922
SHROOM3 shroom family member 3 -0.0356511
GPATCH8 G patch domain containing 8 -0.0347444
CTBP2 C-terminal binding protein 2 -0.0344829
SRPK2 SRSF protein kinase 2 -0.0342837
SMC5 structural maintenance of chromosomes 5 -0.0342245
ZFAND3 zinc finger, AN1-type domain 3 -0.0341039
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0340654
RHEB Ras homolog enriched in brain -0.0339955
PARD3 par-3 family cell polarity regulator -0.0339125
BCOR BCL6 corepressor -0.0337349
ZEB1 zinc finger E-box binding homeobox 1 -0.0335997
MEIS2 Meis homeobox 2 -0.0333939
RNF130 ring finger protein 130 -0.0332682
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0332139
DLG1 discs, large homolog 1 (Drosophila) -0.032855
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0326449
BTBD3 BTB (POZ) domain containing 3 -0.0326275
PTMA prothymosin, alpha -0.0325485
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0325102
TOP1 topoisomerase (DNA) I -0.0324912
TSHZ2 teashirt zinc finger homeobox 2 -0.0324852
FER fer (fps/fes related) tyrosine kinase -0.0324834
SENP6 SUMO1/sentrin specific peptidase 6 -0.0323129
TUT4 terminal uridylyl transferase 4 -0.0318427
SMAD2 SMAD family member 2 -0.0313371
GTF2IRD1 GTF2I repeat domain containing 1 -0.0312525
RPL31 ribosomal protein L31 -0.0311912
ANO6 anoctamin 6 -0.0310411
ANKRD11 ankyrin repeat domain 11 -0.0308803
GOLGA4 golgin A4 -0.0306784
MXI1 MAX interactor 1, dimerization protein -0.0306287
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0304409
RFX7 regulatory factor X, 7 -0.0303274
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0302726
TPST1 tyrosylprotein sulfotransferase 1 -0.0301745
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301169
KLHDC10 kelch domain containing 10 -0.0300971
TMSB10 thymosin beta 10 -0.0300094
MYOF myoferlin -0.0298015
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0297538
UTRN utrophin -0.0297163
IWS1 IWS1 homolog (S. cerevisiae) -0.0296355
TRIM9 tripartite motif containing 9 -0.0295568
TRA2A transformer 2 alpha homolog (Drosophila) -0.0294947
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.029416
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0293852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0292703
TAS2R14 taste receptor, type 2, member 14 -0.0291636
RREB1 ras responsive element binding protein 1 -0.0286466
POU2F1 POU class 2 homeobox 1 -0.0285981
RAB7A RAB7A, member RAS oncogene family -0.0285619
IER3 immediate early response 3 -0.0285587
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0283116
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0280862
RACK1 receptor for activated C kinase 1 -0.0280614
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0279892
FBXL7 F-box and leucine-rich repeat protein 7 -0.0279684