Glycyrrhizic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.160076
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.155557
LMTK2 lemur tyrosine kinase 2 0.108206
EEF1G eukaryotic translation elongation factor 1 gamma 0.0883554
FTH1 ferritin, heavy polypeptide 1 0.0845991
ACTG1 actin gamma 1 0.0809013
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0689967
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0625126
PLEC plectin 0.0599074
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0594379
TM4SF1 transmembrane 4 L six family member 1 0.0506047
SMAD3 SMAD family member 3 0.0470015
HMGA1 high mobility group AT-hook 1 0.0466975
CCNL1 cyclin L1 0.0465649
ZSWIM6 zinc finger, SWIM-type containing 6 0.0450792
TXNRD1 thioredoxin reductase 1 0.0446429
MPRIP myosin phosphatase Rho interacting protein 0.0441507
PTK2 protein tyrosine kinase 2 0.0432949
EEF2 eukaryotic translation elongation factor 2 0.0417061
KLK10 kallikrein-related peptidase 10 0.0413711
TRRAP transformation/transcription domain-associated protein 0.0413453
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0393935
GREB1L growth regulation by estrogen in breast cancer-like 0.0392706
FLNB filamin B, beta 0.0386816
RASAL2 RAS protein activator like 2 0.0378685
THSD4 thrombospondin, type I, domain containing 4 0.0344053
EIF3H eukaryotic translation initiation factor 3, subunit H 0.034193
PDLIM5 PDZ and LIM domain 5 0.0333675
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0330082
NACA nascent polypeptide-associated complex alpha subunit 0.0327475
FLNA filamin A, alpha 0.0321832
PMM2 phosphomannomutase 2 0.0319362
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0304808
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0294632
HSPA8 heat shock 70kDa protein 8 0.029241
EXT1 exostosin glycosyltransferase 1 0.0291264
KRT8 keratin 8, type II 0.029114
RPL13A ribosomal protein L13a 0.0289797
TRIP12 thyroid hormone receptor interactor 12 0.0282702
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0280695
EFNA5 ephrin-A5 0.0273131
AKAP13 A kinase (PRKA) anchor protein 13 0.0272826
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0266421
NAMPT nicotinamide phosphoribosyltransferase 0.0266333
NCKAP1 NCK-associated protein 1 0.0263913
FOXO3 forkhead box O3 0.0253792
ABTB3 ankyrin repeat and BTB domain containing 3 0.0249577
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.024783
MCL1 myeloid cell leukemia 1 0.024696
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0246661
RNASEH2A ribonuclease H2, subunit A 0.0244411
NCOR2 nuclear receptor corepressor 2 0.0243936
SIK3 SIK family kinase 3 0.0243204
EFNB2 ephrin-B2 0.0241987
ANKRD10 ankyrin repeat domain 10 0.0241939
EIF3A eukaryotic translation initiation factor 3, subunit A 0.023367
ACTN4 actinin, alpha 4 0.0232088
FOSL1 FOS-like antigen 1 0.0231871
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0228116
NUP98 nucleoporin 98kDa 0.0227177
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.02259
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0224973
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0224337
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0222383
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0221167
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0220517
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0220412
RPS2 ribosomal protein S2 0.0219697
ARHGAP26 Rho GTPase activating protein 26 0.0217288
UPP1 uridine phosphorylase 1 0.021665
RPL23 ribosomal protein L23 0.0215688
SEC31A SEC31 homolog A (S. cerevisiae) 0.0214805
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0214155
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0210808
VMP1 vacuole membrane protein 1 0.0210499
TRA2A transformer 2 alpha homolog (Drosophila) 0.0208509
WDR43 WD repeat domain 43 0.0208261
SND1 staphylococcal nuclease and tudor domain containing 1 0.0206265
CLMP CXADR-like membrane protein 0.020472
RPS26 ribosomal protein S26 0.0203701
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.020301
SBDS Shwachman-Bodian-Diamond syndrome 0.0200312
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0198776
AGFG1 ArfGAP with FG repeats 1 0.0197231
ANTXR2 anthrax toxin receptor 2 0.0196947
SULF2 sulfatase 2 0.0196819
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.019612
PUM2 pumilio RNA-binding family member 2 0.0195262
GLS2 glutaminase 2 (liver, mitochondrial) 0.0195105
RPL9 ribosomal protein L9 0.0192265
ISG15 ISG15 ubiquitin-like modifier 0.0191414
RPS21 ribosomal protein S21 0.0190446
SCAF4 SR-related CTD-associated factor 4 0.0190061
ARHGAP17 Rho GTPase activating protein 17 0.0190043
ZFAND3 zinc finger, AN1-type domain 3 0.0189877
XYLT1 xylosyltransferase I 0.0189459
KIF5B kinesin family member 5B 0.0188835
CELF1 CUGBP, Elav-like family member 1 0.0188425
NPC1 Niemann-Pick disease, type C1 0.0188039
CRY1 cryptochrome circadian clock 1 0.0187025

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.233387
TMSB10 thymosin beta 10 -0.212944
AKAP12 A kinase (PRKA) anchor protein 12 -0.189893
BAIAP2L1 BAI1-associated protein 2-like 1 -0.142193
S100A10 S100 calcium binding protein A10 -0.132229
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123991
VIM vimentin -0.116726
PTMA prothymosin, alpha -0.113291
ITGA6 integrin, alpha 6 -0.110383
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0975542
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0901461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0893532
VCAN versican -0.0848853
ESYT2 extended synaptotagmin-like protein 2 -0.0841614
EZR ezrin -0.0818046
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0809802
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0807052
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0783001
DSG2 desmoglein 2 -0.0698643
AHNAK AHNAK nucleoprotein -0.0656968
FAM107B family with sequence similarity 107, member B -0.0643638
FTL ferritin, light polypeptide -0.0586563
OGA O-GlcNAcase -0.0549028
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0547984
KTN1 kinectin 1 (kinesin receptor) -0.0544917
POTEF POTE ankyrin domain family, member F -0.0537488
UBC ubiquitin C -0.0524205
LDHA lactate dehydrogenase A -0.0522512
LAMA4 laminin, alpha 4 -0.0517894
PERP PERP, TP53 apoptosis effector -0.051203
LMO7 LIM domain 7 -0.0510487
FAM3C family with sequence similarity 3, member C -0.0487001
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0478396
PTPRR protein tyrosine phosphatase, receptor type, R -0.0472311
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0468215
ARHGAP5 Rho GTPase activating protein 5 -0.0459839
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0455661
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0453561
KLF6 Kruppel-like factor 6 -0.0450463
RIOK3 RIO kinase 3 -0.044624
S100A11 S100 calcium binding protein A11 -0.0444463
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0436213
GRB10 growth factor receptor-bound protein 10 -0.0433461
FAM13A family with sequence similarity 13, member A -0.0431673
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.04315
SLC38A2 solute carrier family 38, member 2 -0.0422867
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0421396
ITPRID2 ITPR interacting domain containing 2 -0.0412456
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.04085
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0404364
JMJD1C jumonji domain containing 1C -0.0371588
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.036995
OPTN optineurin -0.0361116
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.035901
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0355507
TSC22D2 TSC22 domain family, member 2 -0.0352773
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0350641
MYO1E myosin IE -0.0344013
ANXA2 annexin A2 -0.0343733
DSPP dentin sialophosphoprotein -0.0341218
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0337196
SKAP2 src kinase associated phosphoprotein 2 -0.0330687
TXNIP thioredoxin interacting protein -0.0330505
CD9 CD9 molecule -0.0325367
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.031864
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0316914
RPS3 ribosomal protein S3 -0.0316906
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0314819
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0312799
XPO1 exportin 1 -0.0309994
INSIG2 insulin induced gene 2 -0.0309859
SDC4 syndecan 4 -0.0308986
LY6E lymphocyte antigen 6 complex, locus E -0.0306129
ANXA1 annexin A1 -0.030557
DSCAM Down syndrome cell adhesion molecule -0.0305336
RPL31 ribosomal protein L31 -0.0299915
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0299896
DSTN destrin (actin depolymerizing factor) -0.0293757
SEPTIN7 septin 7 -0.0288634
RAP1B RAP1B, member of RAS oncogene family -0.0286893
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0285889
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0280174
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.027922
ENO1 enolase 1, (alpha) -0.0278102
LYZ lysozyme -0.026953
MXI1 MAX interactor 1, dimerization protein -0.0268641
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0265109
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0264837
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0263974
DUSP6 dual specificity phosphatase 6 -0.0259149
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0257905
USP3 ubiquitin specific peptidase 3 -0.0257824
DPY19L1 dpy-19-like 1 (C. elegans) -0.0256317
KIAA0040 KIAA0040 -0.0254537
ACBD3 acyl-CoA binding domain containing 3 -0.0253172
PPARG peroxisome proliferator-activated receptor gamma -0.0247994
CSTB cystatin B (stefin B) -0.0245895
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0242313
NPEPPS aminopeptidase puromycin sensitive -0.024089
ARF4 ADP-ribosylation factor 4 -0.0238021