Glycyrrhizic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADGRG6 adhesion G protein-coupled receptor G6 0.105173
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.101437
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.097379
NUP58 nucleoporin 58 0.0850705
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0831634
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0802637
ZNF292 zinc finger protein 292 0.0759307
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0757216
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0716158
JMJD1C jumonji domain containing 1C 0.0661922
TOX thymocyte selection-associated high mobility group box 0.0629141
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0613823
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0599384
KMT2C lysine (K)-specific methyltransferase 2C 0.0593746
EEF2 eukaryotic translation elongation factor 2 0.0560672
EGR1 early growth response 1 0.0482749
EEF1G eukaryotic translation elongation factor 1 gamma 0.0462559
RTN4 reticulon 4 0.0448332
UBA6 ubiquitin-like modifier activating enzyme 6 0.0432375
NGLY1 N-glycanase 1 0.0429002
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0428057
PIAS2 protein inhibitor of activated STAT, 2 0.0426854
QKI QKI, KH domain containing, RNA binding 0.0398886
COL5A2 collagen, type V, alpha 2 0.0397905
SCAF11 SR-related CTD-associated factor 11 0.0397016
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0392738
SLF1 SMC5-SMC6 complex localization factor 1 0.0383035
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0381694
RLF rearranged L-myc fusion 0.0366989
TMEM41B transmembrane protein 41B 0.0363572
MATR3 matrin 3 0.0362534
KDM1A lysine (K)-specific demethylase 1A 0.035761
RPL4 ribosomal protein L4 0.0355732
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0350592
MIMS1 mitochondrial inner membrane scaffold 1 0.034854
MED13L mediator complex subunit 13-like 0.0343253
LDHA lactate dehydrogenase A 0.0340316
ATRN attractin 0.033821
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0335558
ZMYM2 zinc finger, MYM-type 2 0.0334507
PTCH1 patched 1 0.0331994
KDM6A lysine (K)-specific demethylase 6A 0.0330924
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.032933
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0327649
FNBP1L formin binding protein 1-like 0.0326818
RAP1B RAP1B, member of RAS oncogene family 0.0325401
SREBF2 sterol regulatory element binding transcription factor 2 0.0321669
KIF5B kinesin family member 5B 0.0320683
SEPTIN7 septin 7 0.0320669
PHIP pleckstrin homology domain interacting protein 0.0318851
KDM3A lysine (K)-specific demethylase 3A 0.0318782
XPO1 exportin 1 0.0318332
USP9X ubiquitin specific peptidase 9, X-linked 0.0318149
TPD52 tumor protein D52 0.031269
PGK1 phosphoglycerate kinase 1 0.0312272
MXI1 MAX interactor 1, dimerization protein 0.031218
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0310787
ADNP activity-dependent neuroprotector homeobox 0.0310764
FAM162A family with sequence similarity 162, member A 0.0310523
WSB1 WD repeat and SOCS box containing 1 0.0310259
UBE2K ubiquitin-conjugating enzyme E2K 0.0309268
WDR45B WD repeat domain 45B 0.0307509
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0307303
SSBP2 single-stranded DNA binding protein 2 0.0306968
USP3 ubiquitin specific peptidase 3 0.0305683
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0299512
RNF145 ring finger protein 145 0.0298528
VEZT vezatin, adherens junctions transmembrane protein 0.0296284
DDHD1 DDHD domain containing 1 0.0294288
NCKAP1 NCK-associated protein 1 0.0290956
ARFGEF3 ARFGEF family member 3 0.0290218
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0290135
SHROOM3 shroom family member 3 0.0283903
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0282849
RAB6A RAB6A, member RAS oncogene family 0.0282656
RYBP RING1 and YY1 binding protein 0.0281415
CDC73 cell division cycle 73 0.0280906
MED14 mediator complex subunit 14 0.0279451
MEF2A myocyte enhancer factor 2A 0.0278275
CABIN1 calcineurin binding protein 1 0.0277267
PUM2 pumilio RNA-binding family member 2 0.0276728
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0275435
WAC WW domain containing adaptor with coiled-coil 0.0273142
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0271902
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0271627
CHD7 chromodomain helicase DNA binding protein 7 0.0270103
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0268929
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0268268
NFIA nuclear factor I/A 0.0268096
ZFP36L1 ZFP36 ring finger protein-like 1 0.0264632
ADAM9 ADAM metallopeptidase domain 9 0.026431
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0264252
ZFP64 ZFP64 zinc finger protein 0.0263281
ZFR zinc finger RNA binding protein 0.0261686
LRRC1 leucine rich repeat containing 1 0.026156
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0261191
TET2 tet methylcytosine dioxygenase 2 0.0260126
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0259667
SPRED2 sprouty-related, EVH1 domain containing 2 0.0258444
TBK1 TANK-binding kinase 1 0.0256659

decreased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) -0.217013
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.164033
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.141692
TENM3 teneurin transmembrane protein 3 -0.121671
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.112199
NEBL nebulette -0.0926403
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0828925
NPAS3 neuronal PAS domain protein 3 -0.0769167
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0747449
DENND1A DENN/MADD domain containing 1A -0.0669789
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0641063
RAD51B RAD51 paralog B -0.0639672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0611869
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0587642
DSCAM Down syndrome cell adhesion molecule -0.0566602
ARHGAP32 Rho GTPase activating protein 32 -0.0554141
TRIO trio Rho guanine nucleotide exchange factor -0.0540433
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0539206
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0518802
RCC1 regulator of chromosome condensation 1 -0.0514119
TBC1D22A TBC1 domain family, member 22A -0.049635
OSBPL10 oxysterol binding protein-like 10 -0.0477811
CADM2 cell adhesion molecule 2 -0.0456334
EXOC4 exocyst complex component 4 -0.0439688
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0396479
FMNL2 formin-like 2 -0.0367549
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0365724
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0364954
CDH18 cadherin 18, type 2 -0.0360275
UBE3C ubiquitin protein ligase E3C -0.0339571
TAS2R14 taste receptor, type 2, member 14 -0.0336133
CCDC138 coiled-coil domain containing 138 -0.0336042
ASPH aspartate beta-hydroxylase -0.0333892
AEBP2 AE binding protein 2 -0.0327104
INTS6 integrator complex subunit 6 -0.0322973
MSH4 mutS homolog 4 -0.031904
TMSB10 thymosin beta 10 -0.0314384
LARS1 leucyl-tRNA synthetase 1 -0.0310804
HDAC4 histone deacetylase 4 -0.0309339
DOCK1 dedicator of cytokinesis 1 -0.0309208
ATM ATM serine/threonine kinase -0.0305228
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0304526
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0296117
BABAM2 BRISC and BRCA1 A complex member 2 -0.0293999
CANX calnexin -0.0293488
VCL vinculin -0.0292339
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0292115
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0289275
MLIP muscular LMNA-interacting protein -0.0288762
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0287841
ZNF407 zinc finger protein 407 -0.0287099
TPT1 tumor protein, translationally-controlled 1 -0.028271
TBC1D5 TBC1 domain family, member 5 -0.028232
ZBTB20 zinc finger and BTB domain containing 20 -0.0278674
CELF2 CUGBP, Elav-like family member 2 -0.0277466
RPL38 ribosomal protein L38 -0.0276382
IARS1 isoleucyl-tRNA synthetase 1 -0.027412
FN1 fibronectin 1 -0.0271975
VIM vimentin -0.0271049
WLS wntless Wnt ligand secretion mediator -0.0269089
MT2A metallothionein 2A -0.0267899
HLA-B major histocompatibility complex, class I, B -0.0258517
FNDC3B fibronectin type III domain containing 3B -0.025754
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0257326
TOM1L2 target of myb1-like 2 (chicken) -0.0256186
PRICKLE1 prickle homolog 1 (Drosophila) -0.0251999
RPTOR regulatory associated protein of MTOR, complex 1 -0.025078
RPL23 ribosomal protein L23 -0.0249315
AGO2 argonaute RISC catalytic component 2 -0.0247959
ATP9A ATPase, class II, type 9A -0.0246362
ATP11A ATPase, class VI, type 11A -0.0243858
TMEM178B transmembrane protein 178B -0.0239279
RPS21 ribosomal protein S21 -0.0238733
MCTP1 multiple C2 domains, transmembrane 1 -0.0238134
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0235375
RPS19 ribosomal protein S19 -0.0232811
RPS27A ribosomal protein S27a -0.0229523
HMGA2 high mobility group AT-hook 2 -0.022759
MACF1 microtubule-actin crosslinking factor 1 -0.022643
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0225317
APTX aprataxin -0.0224347
FLNB filamin B, beta -0.0223057
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0222392
SPIDR scaffolding protein involved in DNA repair -0.022166
PTPRG protein tyrosine phosphatase, receptor type, G -0.0219493
RIGI RNA sensor RIG-I -0.0218823
SMYD3 SET and MYND domain containing 3 -0.0217741
SNX14 sorting nexin 14 -0.0217036
LARP4B La ribonucleoprotein domain family, member 4B -0.0215656
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0214623
RABGAP1L RAB GTPase activating protein 1-like -0.0214608
TRAF3 TNF receptor-associated factor 3 -0.0213702
ZMYM4 zinc finger, MYM-type 4 -0.0212228
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0211821
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0211304
CTBP2 C-terminal binding protein 2 -0.0210008
ITSN1 intersectin 1 (SH3 domain protein) -0.0209592
DIAPH2 diaphanous-related formin 2 -0.0209082
ANKRD11 ankyrin repeat domain 11 -0.0208384
FBXL17 F-box and leucine-rich repeat protein 17 -0.0206774