Glycyrrhizic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0591267
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0578411
TSC22D2 TSC22 domain family, member 2 0.053344
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0529271
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0496763
FAM13A family with sequence similarity 13, member A 0.0450402
SPAG9 sperm associated antigen 9 0.0392254
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0391084
CCNL1 cyclin L1 0.0390756
MYH9 myosin, heavy chain 9, non-muscle 0.0387802
PGK1 phosphoglycerate kinase 1 0.0383754
NUP58 nucleoporin 58 0.0358352
TOP1 topoisomerase (DNA) I 0.0334539
ADAM9 ADAM metallopeptidase domain 9 0.0320397
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0311719
ACTG1 actin gamma 1 0.030814
ELL2 elongation factor, RNA polymerase II, 2 0.0306055
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.030132
ANKRD11 ankyrin repeat domain 11 0.0300078
KMT2E lysine (K)-specific methyltransferase 2E 0.0297288
EEF1G eukaryotic translation elongation factor 1 gamma 0.0281425
PDIA3 protein disulfide isomerase family A, member 3 0.0274671
DTNA dystrobrevin, alpha 0.0274668
HOOK2 hook microtubule-tethering protein 2 0.0271628
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0268812
SMAD3 SMAD family member 3 0.0266179
FLNB filamin B, beta 0.0262066
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0261631
FLNA filamin A, alpha 0.0261057
CCNY cyclin Y 0.0249064
WSB1 WD repeat and SOCS box containing 1 0.0248514
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0244948
PLAU plasminogen activator, urokinase 0.0244747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.024358
NDRG1 N-myc downstream regulated 1 0.0242812
RBM39 RNA binding motif protein 39 0.0242713
MXD1 MAX dimerization protein 1 0.0240508
FNDC3B fibronectin type III domain containing 3B 0.0238515
RPL4 ribosomal protein L4 0.0236629
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0223197
FXR1 fragile X mental retardation, autosomal homolog 1 0.0221357
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0215272
HELZ helicase with zinc finger 0.0213344
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0211095
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0207877
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0204349
USP3 ubiquitin specific peptidase 3 0.0199803
WAC WW domain containing adaptor with coiled-coil 0.0196163
MCTP1 multiple C2 domains, transmembrane 1 0.0192068
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0191975
PABPC1 poly(A) binding protein, cytoplasmic 1 0.019179
MATR3 matrin 3 0.0191519
CDC73 cell division cycle 73 0.0189116
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0188656
ARRDC3 arrestin domain containing 3 0.018825
HPCAL1 hippocalcin-like 1 0.0184549
VEZT vezatin, adherens junctions transmembrane protein 0.018376
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0182011
PNPLA8 patatin-like phospholipase domain containing 8 0.0180968
APLP2 amyloid beta (A4) precursor-like protein 2 0.0180715
EEF2 eukaryotic translation elongation factor 2 0.0178543
MYO1B myosin IB 0.0177286
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.017683
HSPA8 heat shock 70kDa protein 8 0.0168714
MEF2A myocyte enhancer factor 2A 0.0168687
POTEF POTE ankyrin domain family, member F 0.0168587
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0168155
PEG10 paternally expressed 10 0.0167716
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0166795
YTHDC1 YTH domain containing 1 0.0166763
ARL5B ADP-ribosylation factor-like 5B 0.0166708
UBA6 ubiquitin-like modifier activating enzyme 6 0.0161
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0159109
RAB1A RAB1A, member RAS oncogene family 0.0158191
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0155977
TMEM123 transmembrane protein 123 0.015545
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0154877
APP amyloid beta (A4) precursor protein 0.0152742
FOSL1 FOS-like antigen 1 0.015271
KDM3A lysine (K)-specific demethylase 3A 0.0150088
NCKAP1 NCK-associated protein 1 0.0149767
ATP11B ATPase, class VI, type 11B 0.0148725
MCL1 myeloid cell leukemia 1 0.0146158
FAM162A family with sequence similarity 162, member A 0.0146057
RAB8B RAB8B, member RAS oncogene family 0.0145153
ABI1 abl-interactor 1 0.0145045
TGFBI transforming growth factor, beta-induced, 68kDa 0.0144904
GARS1 glycyl-tRNA synthetase 1 0.0144596
RLF rearranged L-myc fusion 0.0142346
OLA1 Obg-like ATPase 1 0.0141352
PPARD peroxisome proliferator-activated receptor delta 0.0140454
ITCH itchy E3 ubiquitin protein ligase 0.0139913
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0139775
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0139396
TRIO trio Rho guanine nucleotide exchange factor 0.0139088
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0138709
ARHGAP29 Rho GTPase activating protein 29 0.013542
UGCG UDP-glucose ceramide glucosyltransferase 0.0134921
NPTN neuroplastin 0.0134797
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0134554

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0914209
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0758577
MT2A metallothionein 2A -0.0710577
MMP7 matrix metallopeptidase 7 -0.0693649
IGFBP3 insulin-like growth factor binding protein 3 -0.0665207
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0638675
CP ceruloplasmin (ferroxidase) -0.0610859
EFNA5 ephrin-A5 -0.0583274
IFI27 interferon, alpha-inducible protein 27 -0.0559138
APOL1 apolipoprotein L, 1 -0.0473173
MAML2 mastermind-like 2 (Drosophila) -0.0453732
FTL ferritin, light polypeptide -0.0408923
KRT19 keratin 19, type I -0.0403234
B2M beta-2-microglobulin -0.0400123
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0388257
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0382251
HLA-B major histocompatibility complex, class I, B -0.036365
LMO7 LIM domain 7 -0.0352286
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0335341
EHBP1 EH domain binding protein 1 -0.0334652
LAMA4 laminin, alpha 4 -0.0334589
S100A6 S100 calcium binding protein A6 -0.0305964
ITGA6 integrin, alpha 6 -0.0291801
PDE4D phosphodiesterase 4D, cAMP-specific -0.0282918
AHNAK AHNAK nucleoprotein -0.0281926
VIM vimentin -0.0281715
RNF213 ring finger protein 213 -0.027933
MX2 MX dynamin-like GTPase 2 -0.0269684
LAMB3 laminin, beta 3 -0.0265125
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0260976
ALCAM activated leukocyte cell adhesion molecule -0.0259566
RAD51B RAD51 paralog B -0.0258089
DST dystonin -0.0256103
PCDH7 protocadherin 7 -0.0253337
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0244551
MT1X metallothionein 1X -0.0243897
IFI6 interferon, alpha-inducible protein 6 -0.0242395
ISG15 ISG15 ubiquitin-like modifier -0.0239766
TMC5 transmembrane channel-like 5 -0.0235115
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0233668
S100A10 S100 calcium binding protein A10 -0.0231889
PARD3 par-3 family cell polarity regulator -0.0228622
C15ORF48 chromosome 15 open reading frame 48 -0.0220218
PTMA prothymosin, alpha -0.0217174
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0214375
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0211514
EZR ezrin -0.0208524
NCKAP5 NCK-associated protein 5 -0.0206673
TPT1 tumor protein, translationally-controlled 1 -0.0205367
MYO1E myosin IE -0.0202014
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.020069
MX1 MX dynamin-like GTPase 1 -0.0200549
NRG3 neuregulin 3 -0.0195248
TPM4 tropomyosin 4 -0.0194734
SP100 SP100 nuclear antigen -0.0194463
EXT1 exostosin glycosyltransferase 1 -0.0194073
LOC102724023 ES1 protein homolog, mitochondrial -0.0189904
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0188639
CNRIP1 cannabinoid receptor interacting protein 1 -0.0187092
CSTB cystatin B (stefin B) -0.0186826
RPS29 ribosomal protein S29 -0.0186114
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0184739
PLAT plasminogen activator, tissue -0.0183904
OSMR oncostatin M receptor -0.0183209
BLZF1 basic leucine zipper nuclear factor 1 -0.017872
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0176652
PMP22 peripheral myelin protein 22 -0.0176226
RASAL2 RAS protein activator like 2 -0.0174982
LAMC2 laminin, gamma 2 -0.0172916
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0172273
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0170509
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0170298
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0170292
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0169932
LCN2 lipocalin 2 -0.0169056
HLA-A major histocompatibility complex, class I, A -0.0167626
BPTF bromodomain PHD finger transcription factor -0.0167126
ZMYND8 zinc finger, MYND-type containing 8 -0.0166389
HMGA2 high mobility group AT-hook 2 -0.0165799
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0164804
RPLP1 ribosomal protein, large, P1 -0.0164544
CDK6 cyclin-dependent kinase 6 -0.0164321
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0164191
NABP1 nucleic acid binding protein 1 -0.0162657
SVIL supervillin -0.0161924
RPL19 ribosomal protein L19 -0.0161666
IFITM1 interferon induced transmembrane protein 1 -0.0161631
IFITM3 interferon induced transmembrane protein 3 -0.0160554
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0159978
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0157387
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0157374
RPS8 ribosomal protein S8 -0.0156933
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0156913
CD2AP CD2-associated protein -0.0156417
ASPH aspartate beta-hydroxylase -0.0156399
SLC38A1 solute carrier family 38, member 1 -0.0156002
ENO1 enolase 1, (alpha) -0.0154492
ARHGAP5 Rho GTPase activating protein 5 -0.0153039
GLIS3 GLIS family zinc finger 3 -0.0151877
SAMD9 sterile alpha motif domain containing 9 -0.0150584