Glycyrrhizic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0979311
COL6A3 collagen, type VI, alpha 3 0.0793439
EGFR epidermal growth factor receptor 0.0711853
NDRG1 N-myc downstream regulated 1 0.0651377
SMAD3 SMAD family member 3 0.0575232
GLIS3 GLIS family zinc finger 3 0.0561775
EEF1G eukaryotic translation elongation factor 1 gamma 0.0472645
FLNA filamin A, alpha 0.0387778
DGKD diacylglycerol kinase, delta 130kDa 0.0369248
CADM1 cell adhesion molecule 1 0.0360807
MYH9 myosin, heavy chain 9, non-muscle 0.0360734
LOX lysyl oxidase 0.0358912
ATP13A3 ATPase type 13A3 0.0353649
PKM pyruvate kinase, muscle 0.0353645
PGK1 phosphoglycerate kinase 1 0.034915
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0347718
EEF2 eukaryotic translation elongation factor 2 0.0340186
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0337114
LOXL2 lysyl oxidase-like 2 0.0328645
TGFBI transforming growth factor, beta-induced, 68kDa 0.0328431
CLTC clathrin, heavy chain (Hc) 0.0289179
STC1 stanniocalcin 1 0.0287582
YEATS2 YEATS domain containing 2 0.0277884
PDIA3 protein disulfide isomerase family A, member 3 0.0274462
ANKRD17 ankyrin repeat domain 17 0.0273566
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0269818
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0261164
CCNL1 cyclin L1 0.0261054
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0259988
CEMIP cell migration inducing protein, hyaluronan binding 0.0254642
UBA6 ubiquitin-like modifier activating enzyme 6 0.0253276
MSN moesin 0.0251745
COG5 component of oligomeric golgi complex 5 0.0247323
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0246612
TNS3 tensin 3 0.0243434
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0242033
WWTR1 WW domain containing transcription regulator 1 0.0240527
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0239443
SEC24D SEC24 family member D 0.0229073
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.022775
SETD5 SET domain containing 5 0.0226207
SPRED1 sprouty-related, EVH1 domain containing 1 0.0222315
PRELID2 PRELI domain containing 2 0.0222262
LPP LIM domain containing preferred translocation partner in lipoma 0.0220914
DOCK5 dedicator of cytokinesis 5 0.0220395
HELZ helicase with zinc finger 0.0213316
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0209949
ZNF292 zinc finger protein 292 0.0209627
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0206075
SPRED2 sprouty-related, EVH1 domain containing 2 0.020607
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0204975
NFE2L1 nuclear factor, erythroid 2-like 1 0.0200532
HOOK2 hook microtubule-tethering protein 2 0.0200529
AVL9 AVL9 homolog (S. cerevisiase) 0.0200369
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0197978
ZNF841 zinc finger protein 841 0.0197948
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.019584
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0194246
NBAS neuroblastoma amplified sequence 0.0194227
BTBD10 BTB (POZ) domain containing 10 0.019362
SMYD3 SET and MYND domain containing 3 0.0193047
OSMR oncostatin M receptor 0.01923
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0192269
GANAB glucosidase, alpha; neutral AB 0.0190965
SHB Src homology 2 domain containing adaptor protein B 0.0189832
ANTXR2 anthrax toxin receptor 2 0.0188267
SBF2 SET binding factor 2 0.0187744
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.018736
LENG8 leukocyte receptor cluster (LRC) member 8 0.0186181
MEF2D myocyte enhancer factor 2D 0.0186071
BACE2 beta-site APP-cleaving enzyme 2 0.0184916
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0182403
RUNX1 runt-related transcription factor 1 0.0182094
ANXA5 annexin A5 0.0179842
DSCAM Down syndrome cell adhesion molecule 0.0179361
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0178119
TRIO trio Rho guanine nucleotide exchange factor 0.0177583
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0174161
WDR26 WD repeat domain 26 0.0173241
COL5A1 collagen, type V, alpha 1 0.0170583
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0168511
SAMD4A sterile alpha motif domain containing 4A 0.016752
FTH1 ferritin, heavy polypeptide 1 0.0167075
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0166265
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.016249
SP3 Sp3 transcription factor 0.0162454
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0162253
KLF7 Kruppel-like factor 7 (ubiquitous) 0.016103
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0160815
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0159318
C1D C1D nuclear receptor corepressor 0.015916
BBS9 Bardet-Biedl syndrome 9 0.0158553
FOXK1 forkhead box K1 0.0157403
COPG1 coatomer protein complex, subunit gamma 1 0.0157141
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0157131
RNF216 ring finger protein 216 0.0155365
STK17B serine/threonine kinase 17b 0.0154083
MYOF myoferlin 0.01524
PHF21A PHD finger protein 21A 0.0151718
PICALM phosphatidylinositol binding clathrin assembly protein 0.0149513

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.241884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.237484
FTL ferritin, light polypeptide -0.23131
VIM vimentin -0.175349
IGFBP3 insulin-like growth factor binding protein 3 -0.146785
PTMA prothymosin, alpha -0.113439
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109576
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.101459
TPM4 tropomyosin 4 -0.0800874
HLA-B major histocompatibility complex, class I, B -0.0757745
B2M beta-2-microglobulin -0.0742278
IGFBP5 insulin-like growth factor binding protein 5 -0.0703977
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0630114
FN1 fibronectin 1 -0.0627604
GRB10 growth factor receptor-bound protein 10 -0.055627
CANX calnexin -0.0487255
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0473679
TPT1 tumor protein, translationally-controlled 1 -0.0462894
HILPDA hypoxia inducible lipid droplet-associated -0.0459356
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0448851
EIF1 eukaryotic translation initiation factor 1 -0.0429304
RPS8 ribosomal protein S8 -0.0428152
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0395812
PDE4D phosphodiesterase 4D, cAMP-specific -0.0395342
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0388799
NALF1 NALCN channel auxiliary factor 1 -0.0377185
CENPF centromere protein F, 350/400kDa -0.0372231
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0369622
NAP1L1 nucleosome assembly protein 1-like 1 -0.0357524
YBX1 Y box binding protein 1 -0.0352301
SQSTM1 sequestosome 1 -0.0349558
RPS24 ribosomal protein S24 -0.0339296
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0331002
NLGN1 neuroligin 1 -0.0328539
GARS1 glycyl-tRNA synthetase 1 -0.0328252
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0328245
GNAS GNAS complex locus -0.0327755
POTEF POTE ankyrin domain family, member F -0.0318022
TPI1 triosephosphate isomerase 1 -0.0317497
CALR calreticulin -0.0316088
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0312403
S100A10 S100 calcium binding protein A10 -0.0309132
RAB7A RAB7A, member RAS oncogene family -0.0304336
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.030199
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.029391
RPL31 ribosomal protein L31 -0.0292104
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0290926
KYNU kynureninase -0.0289348
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0287011
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0275839
TXNRD1 thioredoxin reductase 1 -0.0275253
KPNB1 karyopherin (importin) beta 1 -0.026642
ENO1 enolase 1, (alpha) -0.0266027
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0265963
WDR45B WD repeat domain 45B -0.0265029
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0262535
BZW2 basic leucine zipper and W2 domains 2 -0.025919
HLA-A major histocompatibility complex, class I, A -0.0259033
TUBA1B tubulin, alpha 1b -0.0253875
RPS3 ribosomal protein S3 -0.0252559
MAP4 microtubule-associated protein 4 -0.0251907
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0247354
TRA2A transformer 2 alpha homolog (Drosophila) -0.0245987
CD44 CD44 molecule (Indian blood group) -0.0242985
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.024234
DIAPH3 diaphanous-related formin 3 -0.0240375
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0239785
SEPTIN7 septin 7 -0.0239668
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0239353
PDIA6 protein disulfide isomerase family A, member 6 -0.0235608
CBX3 chromobox homolog 3 -0.0233637
RPLP2 ribosomal protein, large, P2 -0.022876
INHBA inhibin, beta A -0.0228476
RPLP1 ribosomal protein, large, P1 -0.0227628
RPL32 ribosomal protein L32 -0.0227372
RPS17 ribosomal protein S17 -0.02273
RPL37A ribosomal protein L37a -0.022331
ANKRD11 ankyrin repeat domain 11 -0.0223002
RPS27A ribosomal protein S27a -0.0220132
RPL34 ribosomal protein L34 -0.0219608
CCND1 cyclin D1 -0.0218487
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0218084
CKAP4 cytoskeleton-associated protein 4 -0.0217057
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0216879
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0213572
MAP1B microtubule-associated protein 1B -0.0213521
RPS12 ribosomal protein S12 -0.0213292
ENO2 enolase 2 (gamma, neuronal) -0.0211945
H3-3B H3.3 histone B -0.0211286
SP100 SP100 nuclear antigen -0.0207837
SMC4 structural maintenance of chromosomes 4 -0.0207408
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0207044
ANLN anillin, actin binding protein -0.0203538
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0200991
DST dystonin -0.0195291
RPL12 ribosomal protein L12 -0.0194212
CDK6 cyclin-dependent kinase 6 -0.0193839
UBC ubiquitin C -0.0192029
PTPRG protein tyrosine phosphatase, receptor type, G -0.0191869
JUN jun proto-oncogene -0.0191623