Glycyrrhizic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.184236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.116939
GOLGA4 golgin A4 0.106611
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104597
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0895548
EEF1G eukaryotic translation elongation factor 1 gamma 0.0840558
PDIA3 protein disulfide isomerase family A, member 3 0.0802129
EEF2 eukaryotic translation elongation factor 2 0.0778695
PGK1 phosphoglycerate kinase 1 0.072704
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0670738
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0638102
RAD51B RAD51 paralog B 0.0632993
KDM4C lysine (K)-specific demethylase 4C 0.0613971
SEC31A SEC31 homolog A (S. cerevisiae) 0.06049
NUP58 nucleoporin 58 0.0591029
YEATS2 YEATS domain containing 2 0.0550013
BIRC6 baculoviral IAP repeat containing 6 0.0534162
HELZ helicase with zinc finger 0.0509264
SRP54 signal recognition particle 54kDa 0.0508805
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0502216
DSCAM Down syndrome cell adhesion molecule 0.0498406
ZNF292 zinc finger protein 292 0.0483654
SEC24A SEC24 family member A 0.047566
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0474257
FNDC3B fibronectin type III domain containing 3B 0.0471798
MYH9 myosin, heavy chain 9, non-muscle 0.0463046
IARS1 isoleucyl-tRNA synthetase 1 0.0433636
NBAS neuroblastoma amplified sequence 0.0431357
SEC24D SEC24 family member D 0.0426905
MON2 MON2 homolog (S. cerevisiae) 0.0425511
MINDY2 MINDY lysine 48 deubiquitinase 2 0.04221
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.041421
FTH1 ferritin, heavy polypeptide 1 0.0413744
PRELID2 PRELI domain containing 2 0.0413194
INSIG2 insulin induced gene 2 0.0410102
UBA6 ubiquitin-like modifier activating enzyme 6 0.0395809
SRRM2 serine/arginine repetitive matrix 2 0.0389117
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.038195
ZNF638 zinc finger protein 638 0.0379833
FNIP1 folliculin interacting protein 1 0.0372574
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0371859
TTC3 tetratricopeptide repeat domain 3 0.0371704
COG6 component of oligomeric golgi complex 6 0.0370556
COPA coatomer protein complex, subunit alpha 0.0369684
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0368897
ANKRD12 ankyrin repeat domain 12 0.0368689
CLTC clathrin, heavy chain (Hc) 0.0366242
GSK3B glycogen synthase kinase 3 beta 0.0359784
COG5 component of oligomeric golgi complex 5 0.0357875
PAPOLA poly(A) polymerase alpha 0.0355778
MORF4L2 mortality factor 4 like 2 0.0353975
CCNL1 cyclin L1 0.034984
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0346845
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0346474
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0345539
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0345489
ATXN1 ataxin 1 0.0344319
CNOT2 CCR4-NOT transcription complex, subunit 2 0.034138
SUCO SUN domain containing ossification factor 0.0340863
KMT2C lysine (K)-specific methyltransferase 2C 0.0338317
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0338275
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0331936
WSB1 WD repeat and SOCS box containing 1 0.0330798
CCNG2 cyclin G2 0.0329928
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0329836
HM13 histocompatibility (minor) 13 0.032677
SPAG9 sperm associated antigen 9 0.0324552
FOXO3 forkhead box O3 0.0321883
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.032108
ATXN2L ataxin 2-like 0.0316655
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0314344
CDK19 cyclin-dependent kinase 19 0.0313237
WAC WW domain containing adaptor with coiled-coil 0.0311958
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0311734
TMEM41B transmembrane protein 41B 0.0306789
ERRFI1 ERBB receptor feedback inhibitor 1 0.0306261
WDR26 WD repeat domain 26 0.0302388
CALU calumenin 0.0301055
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0300807
PDIA4 protein disulfide isomerase family A, member 4 0.0300801
MBNL2 muscleblind-like splicing regulator 2 0.0298422
ESRP1 epithelial splicing regulatory protein 1 0.0298306
SEC16A SEC16 homolog A (S. cerevisiae) 0.029761
TMEM39A transmembrane protein 39A 0.0295984
RARS1 arginyl-tRNA synthetase 1 0.0295791
XPOT exportin, tRNA 0.0295228
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0293954
N4BP2L2 NEDD4 binding protein 2-like 2 0.029291
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0290857
RUNX1 runt-related transcription factor 1 0.0289277
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0285203
BRD2 bromodomain containing 2 0.0283332
PCBP2 poly(rC) binding protein 2 0.0283263
AKAP9 A kinase (PRKA) anchor protein 9 0.0281495
TRA2B transformer 2 beta homolog (Drosophila) 0.0279977
PKM pyruvate kinase, muscle 0.0277399
COPB1 coatomer protein complex, subunit beta 1 0.0276178
PGM3 phosphoglucomutase 3 0.0274331
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0271485
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0271384

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.19637
PTMA prothymosin, alpha -0.178347
TPT1 tumor protein, translationally-controlled 1 -0.153276
AHNAK AHNAK nucleoprotein -0.134345
FTL ferritin, light polypeptide -0.120083
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.104533
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.085789
TPM4 tropomyosin 4 -0.0725499
RPS8 ribosomal protein S8 -0.0667479
RPS12 ribosomal protein S12 -0.0552081
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0532587
S100A10 S100 calcium binding protein A10 -0.0530863
RPL31 ribosomal protein L31 -0.0516078
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0506484
RPL35A ribosomal protein L35a -0.0469679
RPS27A ribosomal protein S27a -0.0465918
RPS3 ribosomal protein S3 -0.0457653
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0451918
RPL26 ribosomal protein L26 -0.044933
EZR ezrin -0.0429316
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.042707
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0407747
RPL19 ribosomal protein L19 -0.0403553
RPS17 ribosomal protein S17 -0.0399459
VCL vinculin -0.0397526
RPLP1 ribosomal protein, large, P1 -0.0378018
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0362934
SET SET nuclear proto-oncogene -0.0353565
RPLP2 ribosomal protein, large, P2 -0.0351803
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0343254
RPS24 ribosomal protein S24 -0.0339456
EPCAM epithelial cell adhesion molecule -0.0338463
RPS15 ribosomal protein S15 -0.033304
RPL37A ribosomal protein L37a -0.03189
RPL5 ribosomal protein L5 -0.0318282
KRT18 keratin 18, type I -0.0315567
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0300019
KPNB1 karyopherin (importin) beta 1 -0.0294353
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0291237
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0279653
RPL36AL ribosomal protein L36a-like -0.0276959
RPLP0 ribosomal protein, large, P0 -0.0275153
SKP1 S-phase kinase-associated protein 1 -0.026521
HMGB1 high mobility group box 1 -0.0265137
RPS5 ribosomal protein S5 -0.0263473
IFITM3 interferon induced transmembrane protein 3 -0.0261272
YBX1 Y box binding protein 1 -0.0255602
NAP1L1 nucleosome assembly protein 1-like 1 -0.0253469
KTN1 kinectin 1 (kinesin receptor) -0.0252225
SERINC5 serine incorporator 5 -0.0247853
DSPP dentin sialophosphoprotein -0.0243111
RPL32 ribosomal protein L32 -0.0243026
CCND1 cyclin D1 -0.0242982
WWC1 WW and C2 domain containing 1 -0.0242133
RPL7A ribosomal protein L7a -0.0237815
PERP PERP, TP53 apoptosis effector -0.0234042
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0233826
HLA-B major histocompatibility complex, class I, B -0.0233451
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0233066
RHOBTB3 Rho-related BTB domain containing 3 -0.0232175
RSL1D1 ribosomal L1 domain containing 1 -0.023153
PLIN3 perilipin 3 -0.0227679
PLAUR plasminogen activator, urokinase receptor -0.0222783
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0222207
RPL18 ribosomal protein L18 -0.0221782
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.021938
CDK12 cyclin-dependent kinase 12 -0.021902
RPS6 ribosomal protein S6 -0.0218849
WWOX WW domain containing oxidoreductase -0.0218578
IER3 immediate early response 3 -0.0218074
RPL8 ribosomal protein L8 -0.0214485
CLOCK clock circadian regulator -0.0212777
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0212183
RPS16 ribosomal protein S16 -0.0211492
RPL15 ribosomal protein L15 -0.0206774
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0204915
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0203594
RPS25 ribosomal protein S25 -0.0201431
RPL30 ribosomal protein L30 -0.0195821
FAF1 Fas (TNFRSF6) associated factor 1 -0.0193449
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0193018
KRT8 keratin 8, type II -0.0192912
RACK1 receptor for activated C kinase 1 -0.0192158
FRMD5 FERM domain containing 5 -0.0190299
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0190276
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0189785
RRBP1 ribosome binding protein 1 -0.0189049
RABGAP1L RAB GTPase activating protein 1-like -0.0187782
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0185882
LOC102724023 ES1 protein homolog, mitochondrial -0.0184368
SPIDR scaffolding protein involved in DNA repair -0.0184336
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0182071
RPL14 ribosomal protein L14 -0.0180976
ZBTB7A zinc finger and BTB domain containing 7A -0.0180266
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0179662
RPL7L1 ribosomal protein L7-like 1 -0.017907
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0178775
GPATCH8 G patch domain containing 8 -0.0176365
FAT1 FAT atypical cadherin 1 -0.0176347
RPL12 ribosomal protein L12 -0.017577