Glycyrrhizic acid_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TGFBI transforming growth factor, beta-induced, 68kDa 0.151038
TRIO trio Rho guanine nucleotide exchange factor 0.0963374
ATP13A3 ATPase type 13A3 0.0850355
EEF1G eukaryotic translation elongation factor 1 gamma 0.0776264
MT2A metallothionein 2A 0.0705698
TM4SF1 transmembrane 4 L six family member 1 0.0663175
FTH1 ferritin, heavy polypeptide 1 0.0626962
FNDC3B fibronectin type III domain containing 3B 0.0603558
ACTG1 actin gamma 1 0.0595819
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0573666
CADM1 cell adhesion molecule 1 0.0501562
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0495884
EEF2 eukaryotic translation elongation factor 2 0.0474871
FN1 fibronectin 1 0.0458398
LOXL2 lysyl oxidase-like 2 0.0447989
RPS6 ribosomal protein S6 0.0433539
CCNL1 cyclin L1 0.0412432
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0383385
RASA2 RAS p21 protein activator 2 0.0352081
NAMPT nicotinamide phosphoribosyltransferase 0.0349298
FLNA filamin A, alpha 0.0347331
RPL35A ribosomal protein L35a 0.0327529
LOX lysyl oxidase 0.0317936
COL6A3 collagen, type VI, alpha 3 0.0306353
RPL11 ribosomal protein L11 0.0306213
NAV2 neuron navigator 2 0.0305429
RPS19 ribosomal protein S19 0.0298547
KMT2E lysine (K)-specific methyltransferase 2E 0.0293957
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.029111
BHLHE40 basic helix-loop-helix family, member e40 0.0282198
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0270224
FXR1 fragile X mental retardation, autosomal homolog 1 0.026395
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0256351
UGCG UDP-glucose ceramide glucosyltransferase 0.0247478
GANAB glucosidase, alpha; neutral AB 0.0247177
RPL9 ribosomal protein L9 0.0245948
PGK1 phosphoglycerate kinase 1 0.0245767
SMAD3 SMAD family member 3 0.0245593
MTSS1 metastasis suppressor 1 0.0243804
RPS21 ribosomal protein S21 0.024244
TSC22D2 TSC22 domain family, member 2 0.024135
TMEM165 transmembrane protein 165 0.0239099
COL6A2 collagen, type VI, alpha 2 0.0233697
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0230245
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0228731
PTK2 protein tyrosine kinase 2 0.0228102
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0223619
CAVIN1 caveolae associated protein 1 0.0221196
EGFR epidermal growth factor receptor 0.0220799
HMGA1 high mobility group AT-hook 1 0.0219252
ZNF292 zinc finger protein 292 0.0217153
RPS13 ribosomal protein S13 0.0216138
ALCAM activated leukocyte cell adhesion molecule 0.0209304
ADM adrenomedullin 0.0207831
RPL36 ribosomal protein L36 0.0207647
RPL37 ribosomal protein L37 0.0206804
RPL27 ribosomal protein L27 0.020349
RPS2 ribosomal protein S2 0.0200787
ANTXR2 anthrax toxin receptor 2 0.0198729
TRAM1 translocation associated membrane protein 1 0.019718
GNAS GNAS complex locus 0.0194979
WASF2 WAS protein family, member 2 0.0192401
WSB1 WD repeat and SOCS box containing 1 0.0191566
FOXJ3 forkhead box J3 0.0189931
TENT4A terminal nucleotidyltransferase 4A 0.0189724
PKM pyruvate kinase, muscle 0.0188858
HIPK2 homeodomain interacting protein kinase 2 0.0188373
NACA nascent polypeptide-associated complex alpha subunit 0.0187262
ICAM1 intercellular adhesion molecule 1 0.0184269
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0180398
FKBP10 FK506 binding protein 10, 65 kDa 0.0179941
ANKRD11 ankyrin repeat domain 11 0.0179463
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0176424
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0176027
PRELID2 PRELI domain containing 2 0.0175005
FGFR1 fibroblast growth factor receptor 1 0.0173758
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.017315
PDIA3 protein disulfide isomerase family A, member 3 0.0170938
RPL13A ribosomal protein L13a 0.0170102
HMGA2 high mobility group AT-hook 2 0.0169513
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0168675
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.016826
ANXA5 annexin A5 0.016634
CYB5R3 cytochrome b5 reductase 3 0.0166292
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0165389
LMAN1 lectin, mannose-binding, 1 0.0164701
RYK receptor-like tyrosine kinase 0.0163492
CCDC88A coiled-coil domain containing 88A 0.0161976
LENG8 leukocyte receptor cluster (LRC) member 8 0.0161836
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0161358
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.0160248
CAMTA1 calmodulin binding transcription activator 1 0.0160083
ARHGAP29 Rho GTPase activating protein 29 0.0159797
LPP LIM domain containing preferred translocation partner in lipoma 0.0159049
ZFAND3 zinc finger, AN1-type domain 3 0.0158942
TRA2B transformer 2 beta homolog (Drosophila) 0.0158773
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0157458
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0156587
SFTPA2 surfactant protein A2 0.0156468
FOSL1 FOS-like antigen 1 0.0156456

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.175085
TMSB10 thymosin beta 10 -0.105322
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104875
IGFBP3 insulin-like growth factor binding protein 3 -0.0990774
UBC ubiquitin C -0.0848281
COL1A1 collagen, type I, alpha 1 -0.0775235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0724462
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0655089
PTMA prothymosin, alpha -0.0578586
NDRG1 N-myc downstream regulated 1 -0.0557223
ENO1 enolase 1, (alpha) -0.0547335
FTL ferritin, light polypeptide -0.0504785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0498426
AHNAK AHNAK nucleoprotein -0.0490764
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0478807
CD44 CD44 molecule (Indian blood group) -0.0441002
CANX calnexin -0.0440417
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0382685
PSD3 pleckstrin and Sec7 domain containing 3 -0.037954
FBN1 fibrillin 1 -0.0364054
TPM4 tropomyosin 4 -0.0360465
COL1A2 collagen, type I, alpha 2 -0.0349992
ASPH aspartate beta-hydroxylase -0.0323891
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0315149
IER3 immediate early response 3 -0.0302683
CALU calumenin -0.0296049
YBX1 Y box binding protein 1 -0.0289492
COL3A1 collagen, type III, alpha 1 -0.0282775
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0279235
VCAN versican -0.0271566
JUN jun proto-oncogene -0.0267912
CALR calreticulin -0.0263518
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0262423
IGFBP7 insulin-like growth factor binding protein 7 -0.0260654
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0258373
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0251134
PDIA6 protein disulfide isomerase family A, member 6 -0.0249604
INHBA inhibin, beta A -0.0248273
CLIC4 chloride intracellular channel 4 -0.0247724
COL4A1 collagen, type IV, alpha 1 -0.0246228
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0244431
TIMP1 TIMP metallopeptidase inhibitor 1 -0.02422
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0239876
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0229503
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0229355
MAP1B microtubule-associated protein 1B -0.0226969
SERINC3 serine incorporator 3 -0.0218454
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0215371
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0212697
RIGI RNA sensor RIG-I -0.0211116
WWTR1 WW domain containing transcription regulator 1 -0.0208405
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0207561
RRBP1 ribosome binding protein 1 -0.0203982
SPDYA speedy/RINGO cell cycle regulator family member A -0.0202263
RPS27A ribosomal protein S27a -0.019239
SAMD9 sterile alpha motif domain containing 9 -0.019173
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.019117
ZBTB20 zinc finger and BTB domain containing 20 -0.0188802
DPYSL2 dihydropyrimidinase-like 2 -0.0186227
SP100 SP100 nuclear antigen -0.0181711
RPS3 ribosomal protein S3 -0.0181075
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0172813
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0172148
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0171889
PDIA4 protein disulfide isomerase family A, member 4 -0.017075
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0167765
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0165697
S100A10 S100 calcium binding protein A10 -0.0164718
VMP1 vacuole membrane protein 1 -0.0161895
GOLGB1 golgin B1 -0.016135
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0158231
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0157906
MBNL1 muscleblind-like splicing regulator 1 -0.0156658
MAP4 microtubule-associated protein 4 -0.0155865
SEC31A SEC31 homolog A (S. cerevisiae) -0.015503
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0154111
RSRC1 arginine/serine-rich coiled-coil 1 -0.0151033
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0149273
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0148026
KDM3A lysine (K)-specific demethylase 3A -0.0146806
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -0.0143636
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0139217
RPS5 ribosomal protein S5 -0.0138924
TPM3 tropomyosin 3 -0.013887
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0137282
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0137194
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0136444
TOP1 topoisomerase (DNA) I -0.013574
SH3KBP1 SH3-domain kinase binding protein 1 -0.0132204
VCL vinculin -0.0130829
TBC1D22A TBC1 domain family, member 22A -0.0129301
NIPBL Nipped-B homolog (Drosophila) -0.0129155
ARF4 ADP-ribosylation factor 4 -0.0127787
KPNB1 karyopherin (importin) beta 1 -0.012741
ATXN1 ataxin 1 -0.0127369
HDAC9 histone deacetylase 9 -0.0127039
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0126966
IFI6 interferon, alpha-inducible protein 6 -0.0126624
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0125422
RPS12 ribosomal protein S12 -0.0125075