Glycyrrhizic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.179356
EEF1G eukaryotic translation elongation factor 1 gamma 0.164124
PGK1 phosphoglycerate kinase 1 0.101908
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0956171
PDIA3 protein disulfide isomerase family A, member 3 0.0817692
LDHA lactate dehydrogenase A 0.0759531
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0754641
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.063799
NDRG1 N-myc downstream regulated 1 0.0599051
HMGA1 high mobility group AT-hook 1 0.0575858
CCNL1 cyclin L1 0.0547464
EEF2 eukaryotic translation elongation factor 2 0.0522865
LOC112694756 uncharaterized LOC112694756 0.0452877
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0441327
GANAB glucosidase, alpha; neutral AB 0.0423037
KRT8 keratin 8, type II 0.0421961
P4HB prolyl 4-hydroxylase, beta polypeptide 0.039008
RPL35A ribosomal protein L35a 0.03849
RPL13A ribosomal protein L13a 0.0374996
ACTG1 actin gamma 1 0.0371131
NUP58 nucleoporin 58 0.0364179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0343696
PKM pyruvate kinase, muscle 0.0338942
JUP junction plakoglobin 0.0335422
BIRC6 baculoviral IAP repeat containing 6 0.0331134
RAB7A RAB7A, member RAS oncogene family 0.0330074
FNDC3B fibronectin type III domain containing 3B 0.031833
TMEM41B transmembrane protein 41B 0.0312923
ANXA2 annexin A2 0.0310791
LENG8 leukocyte receptor cluster (LRC) member 8 0.0302613
RPL23 ribosomal protein L23 0.0301755
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0300527
FLNA filamin A, alpha 0.029786
PTPRH protein tyrosine phosphatase, receptor type, H 0.0293789
CALU calumenin 0.0289905
SLC45A4 solute carrier family 45, member 4 0.028812
SRRM2 serine/arginine repetitive matrix 2 0.028342
RNASEH2A ribonuclease H2, subunit A 0.0279684
VASP vasodilator-stimulated phosphoprotein 0.0273921
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0265494
RPL9 ribosomal protein L9 0.0263847
SREBF2 sterol regulatory element binding transcription factor 2 0.0255687
ANKRD10 ankyrin repeat domain 10 0.0255451
ZNF207 zinc finger protein 207 0.0255247
H1-0 H1.0 linker histone 0.0249371
LRATD2 LRAT domain containing 2 0.024782
RPN1 ribophorin I 0.0247809
ARF1 ADP-ribosylation factor 1 0.0247263
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.0245929
RPL4 ribosomal protein L4 0.0236797
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0235039
C1D C1D nuclear receptor corepressor 0.0234487
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0233462
SPRED2 sprouty-related, EVH1 domain containing 2 0.0230675
NACA nascent polypeptide-associated complex alpha subunit 0.0227046
ARID1A AT rich interactive domain 1A (SWI-like) 0.0226639
PYGB phosphorylase, glycogen; brain 0.022508
MARCHF6 membrane associated ring-CH-type finger 6 0.0224637
MYO18A myosin XVIIIA 0.0223846
LPIN2 lipin 2 0.0223176
DNM2 dynamin 2 0.0221817
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0221635
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.022013
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.021954
HM13 histocompatibility (minor) 13 0.0219499
WASF2 WAS protein family, member 2 0.0217263
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0216733
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0214982
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0213554
COPG1 coatomer protein complex, subunit gamma 1 0.0213374
RAD23B RAD23 homolog B (S. cerevisiae) 0.0213176
WAC WW domain containing adaptor with coiled-coil 0.021312
STIP1 stress-induced phosphoprotein 1 0.0212692
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0211968
ADAM17 ADAM metallopeptidase domain 17 0.0211687
CALR calreticulin 0.0209074
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0208767
RICTOR RPTOR independent companion of MTOR, complex 2 0.0208259
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0206051
SEPTIN2 septin 2 0.020536
KCMF1 potassium channel modulatory factor 1 0.0204778
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.020092
CNOT3 CCR4-NOT transcription complex, subunit 3 0.0200327
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0197661
EWSR1 EWS RNA-binding protein 1 0.0196646
ITGB4 integrin, beta 4 0.0196327
LMAN1 lectin, mannose-binding, 1 0.0196282
ESRP1 epithelial splicing regulatory protein 1 0.0192481
GRB10 growth factor receptor-bound protein 10 0.0192301
LASP1 LIM and SH3 protein 1 0.0192238
PLXNB2 plexin B2 0.0192231
LAMA5 laminin, alpha 5 0.0192024
GPX2 glutathione peroxidase 2 0.0189205
SND1 staphylococcal nuclease and tudor domain containing 1 0.0188215
AGRN agrin 0.0187916
WDR26 WD repeat domain 26 0.018682
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0186508
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0184085
ATXN2L ataxin 2-like 0.0182834
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.0181291

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.139901
LMO7 LIM domain 7 -0.138269
PTMA prothymosin, alpha -0.108104
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0961904
TPT1 tumor protein, translationally-controlled 1 -0.0855929
EZR ezrin -0.085376
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0791035
TJP1 tight junction protein 1 -0.0779696
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0759531
AHNAK AHNAK nucleoprotein -0.0742253
MYH14 myosin, heavy chain 14, non-muscle -0.0735712
RPS3 ribosomal protein S3 -0.0724907
RPS12 ribosomal protein S12 -0.0714388
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0672394
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0671785
LYZ lysozyme -0.0652445
RPS17 ribosomal protein S17 -0.0616974
GOLGB1 golgin B1 -0.061435
RPL21 ribosomal protein L21 -0.0613553
EXT1 exostosin glycosyltransferase 1 -0.0605158
RPS6 ribosomal protein S6 -0.0598178
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0592211
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0581766
DST dystonin -0.0576167
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0572494
TMSB10 thymosin beta 10 -0.057032
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0557164
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0544108
SAMD12 sterile alpha motif domain containing 12 -0.0539771
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0538086
KRT20 keratin 20, type I -0.0510793
JMJD1C jumonji domain containing 1C -0.0509629
LOC102724023 ES1 protein homolog, mitochondrial -0.0463081
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0462114
RPL31 ribosomal protein L31 -0.0461389
S100A10 S100 calcium binding protein A10 -0.0460896
MYO1E myosin IE -0.045402
RPS8 ribosomal protein S8 -0.0451793
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0446033
RPS2 ribosomal protein S2 -0.0426214
RPS5 ribosomal protein S5 -0.0422782
PDZD8 PDZ domain containing 8 -0.0421293
VCL vinculin -0.0415478
DSPP dentin sialophosphoprotein -0.0413456
NCEH1 neutral cholesterol ester hydrolase 1 -0.0405174
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0398252
PTPRK protein tyrosine phosphatase, receptor type, K -0.0393853
TMC5 transmembrane channel-like 5 -0.0376814
RPS24 ribosomal protein S24 -0.0364833
MACF1 microtubule-actin crosslinking factor 1 -0.0364451
CD2AP CD2-associated protein -0.0362835
PLK2 polo-like kinase 2 -0.0360843
ATAD2 ATPase family, AAA domain containing 2 -0.0357842
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0357831
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0347713
PRKN parkin RBR E3 ubiquitin protein ligase -0.034547
BPTF bromodomain PHD finger transcription factor -0.0341839
WWC1 WW and C2 domain containing 1 -0.0334292
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0333005
BCL2L1 BCL2-like 1 -0.0327739
TES testin LIM domain protein -0.0325186
RPL7 ribosomal protein L7 -0.0322363
ARHGAP32 Rho GTPase activating protein 32 -0.0321613
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0320627
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0318224
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0312996
PDE4D phosphodiesterase 4D, cAMP-specific -0.0310709
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0309742
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0309486
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0309392
POF1B premature ovarian failure, 1B -0.0308017
NTN4 netrin 4 -0.0307751
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0306468
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0305064
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0301345
ETV6 ets variant 6 -0.0300922
TRAPPC9 trafficking protein particle complex 9 -0.0299347
TXNRD1 thioredoxin reductase 1 -0.029737
TPM3 tropomyosin 3 -0.0296936
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0294551
MBNL1 muscleblind-like splicing regulator 1 -0.0294525
RPL18 ribosomal protein L18 -0.0293208
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0286656
PLAUR plasminogen activator, urokinase receptor -0.0285625
PDLIM5 PDZ and LIM domain 5 -0.0285051
RPS27A ribosomal protein S27a -0.0284981
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0280518
RPL5 ribosomal protein L5 -0.0279846
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0279561
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0278338
PATJ PATJ crumbs cell polarity complex component -0.0277027
KDM2A lysine (K)-specific demethylase 2A -0.0275536
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0274864
UTRN utrophin -0.027467
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0272888
DSCAM Down syndrome cell adhesion molecule -0.0272239
SET SET nuclear proto-oncogene -0.0272211
AKAP9 A kinase (PRKA) anchor protein 9 -0.0269635
MYO6 myosin VI -0.0268875
EIF1 eukaryotic translation initiation factor 1 -0.0267414