Glycyrrhizic acid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.0838524
FLNB filamin B, beta 0.0814756
TRIO trio Rho guanine nucleotide exchange factor 0.0709688
MEF2A myocyte enhancer factor 2A 0.0527417
CEMIP cell migration inducing protein, hyaluronan binding 0.0405075
MYOF myoferlin 0.0388878
ITCH itchy E3 ubiquitin protein ligase 0.038559
RAI14 retinoic acid induced 14 0.0351629
FLNA filamin A, alpha 0.0320972
RICTOR RPTOR independent companion of MTOR, complex 2 0.0314546
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0313179
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0291774
NAV2 neuron navigator 2 0.02839
PTK2 protein tyrosine kinase 2 0.0264163
NAMPT nicotinamide phosphoribosyltransferase 0.0252835
NRIP1 nuclear receptor interacting protein 1 0.025055
HSPG2 heparan sulfate proteoglycan 2 0.0240362
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0232458
FNDC3B fibronectin type III domain containing 3B 0.021977
PSD3 pleckstrin and Sec7 domain containing 3 0.0216973
MYH9 myosin, heavy chain 9, non-muscle 0.0208356
MYO10 myosin X 0.0207603
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0198996
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0197987
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0195144
FN1 fibronectin 1 0.0190288
ZEB1 zinc finger E-box binding homeobox 1 0.0188705
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0187627
ESYT2 extended synaptotagmin-like protein 2 0.0187078
AOPEP aminopeptidase O (putative) 0.0186487
PRELID2 PRELI domain containing 2 0.018467
HP1BP3 heterochromatin protein 1, binding protein 3 0.018434
NUP58 nucleoporin 58 0.0183106
LOXL2 lysyl oxidase-like 2 0.017933
FNIP1 folliculin interacting protein 1 0.0174863
ARRDC3 arrestin domain containing 3 0.0174346
ARHGAP21 Rho GTPase activating protein 21 0.017416
MBNL2 muscleblind-like splicing regulator 2 0.0174134
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0171993
KDM6A lysine (K)-specific demethylase 6A 0.0170833
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0170541
TGM2 transglutaminase 2 0.0167945
ABI3BP ABI family, member 3 (NESH) binding protein 0.0166792
PLEC plectin 0.0166064
SULF1 sulfatase 1 0.01655
COG5 component of oligomeric golgi complex 5 0.0164988
ZMYM2 zinc finger, MYM-type 2 0.0164864
NRG1 neuregulin 1 0.0163665
AKAP13 A kinase (PRKA) anchor protein 13 0.01631
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0162316
EEF1G eukaryotic translation elongation factor 1 gamma 0.015957
APLP2 amyloid beta (A4) precursor-like protein 2 0.0158451
DLG1 discs, large homolog 1 (Drosophila) 0.0158001
PODXL podocalyxin-like 0.0156445
KIAA1217 KIAA1217 0.015463
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0154096
HELZ helicase with zinc finger 0.0154094
PGK1 phosphoglycerate kinase 1 0.015297
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0151896
DOCK5 dedicator of cytokinesis 5 0.0148876
NBAS neuroblastoma amplified sequence 0.0147572
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0146487
KIF16B kinesin family member 16B 0.0146318
LAMA5 laminin, alpha 5 0.0145657
NFIA nuclear factor I/A 0.0144456
SRP54 signal recognition particle 54kDa 0.0143066
SMAD3 SMAD family member 3 0.0142614
SBF2 SET binding factor 2 0.0142484
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0141498
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0139987
KMT2E lysine (K)-specific methyltransferase 2E 0.0138946
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0136024
METTL15 methyltransferase like 15 0.0134583
RUNX1 runt-related transcription factor 1 0.0133161
ZFR zinc finger RNA binding protein 0.0132977
USP12 ubiquitin specific peptidase 12 0.0132034
EXOC4 exocyst complex component 4 0.0131624
DOK5 docking protein 5 0.0131051
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.013069
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0129952
NCOR2 nuclear receptor corepressor 2 0.0128145
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0128128
ANKRD10 ankyrin repeat domain 10 0.0127966
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0127484
BIRC6 baculoviral IAP repeat containing 6 0.0126784
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0126035
PHKB phosphorylase kinase, beta 0.0125776
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0125709
ZNF292 zinc finger protein 292 0.0125274
PDLIM1 PDZ and LIM domain 1 0.0125264
C4BPB complement component 4 binding protein, beta 0.0125132
BHLHE40 basic helix-loop-helix family, member e40 0.0123367
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0123051
ICE1 interactor of little elongation complex ELL subunit 1 0.0122067
SUCO SUN domain containing ossification factor 0.0121451
FTH1 ferritin, heavy polypeptide 1 0.0121304
LRRC8C leucine rich repeat containing 8 family, member C 0.0120843
JAG1 jagged 1 0.0120789
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0120762
PARD3 par-3 family cell polarity regulator 0.0120686

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.142907
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0932898
TMSB10 thymosin beta 10 -0.0906738
TPT1 tumor protein, translationally-controlled 1 -0.0769447
MT2A metallothionein 2A -0.0615742
B2M beta-2-microglobulin -0.0598346
POTEF POTE ankyrin domain family, member F -0.0565945
S100A10 S100 calcium binding protein A10 -0.0559234
HLA-B major histocompatibility complex, class I, B -0.0514146
PTMA prothymosin, alpha -0.0512021
RPS21 ribosomal protein S21 -0.0456926
RPS8 ribosomal protein S8 -0.0454679
RPLP2 ribosomal protein, large, P2 -0.0426801
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0424407
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.042386
IFITM3 interferon induced transmembrane protein 3 -0.0422229
EGR1 early growth response 1 -0.0398617
RPS24 ribosomal protein S24 -0.0397747
RPLP1 ribosomal protein, large, P1 -0.0372818
RPS6 ribosomal protein S6 -0.0371974
FTL ferritin, light polypeptide -0.0371917
RPL11 ribosomal protein L11 -0.0363021
IFI6 interferon, alpha-inducible protein 6 -0.0355115
RPS13 ribosomal protein S13 -0.0346332
RPL37A ribosomal protein L37a -0.0318516
RPS12 ribosomal protein S12 -0.0313128
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0308628
LMNA lamin A/C -0.030844
IFITM1 interferon induced transmembrane protein 1 -0.0307212
RIGI RNA sensor RIG-I -0.0304769
S100A9 S100 calcium binding protein A9 -0.0299008
RPL37 ribosomal protein L37 -0.0296394
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0294581
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0293972
VCL vinculin -0.028714
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0280174
RPS3 ribosomal protein S3 -0.0277932
SAMD9 sterile alpha motif domain containing 9 -0.0268327
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0268229
RPL31 ribosomal protein L31 -0.0266048
TXNIP thioredoxin interacting protein -0.0265843
RPL34 ribosomal protein L34 -0.0262952
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0261629
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0259143
RPL5 ribosomal protein L5 -0.0257983
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0257263
RPS25 ribosomal protein S25 -0.025665
NDRG1 N-myc downstream regulated 1 -0.0248408
RPL12 ribosomal protein L12 -0.0248389
GNAS GNAS complex locus -0.0248325
TMSB4X thymosin beta 4, X-linked -0.0247044
ZNFX1 zinc finger, NFX1-type containing 1 -0.0242516
S100A11 S100 calcium binding protein A11 -0.023804
LDHA lactate dehydrogenase A -0.0233415
RPL32 ribosomal protein L32 -0.0230896
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0227325
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0226174
S100A6 S100 calcium binding protein A6 -0.0224447
ENO1 enolase 1, (alpha) -0.0221809
EIF1 eukaryotic translation initiation factor 1 -0.0220975
RPS19 ribosomal protein S19 -0.0220865
RPL35A ribosomal protein L35a -0.0220778
ACTN4 actinin, alpha 4 -0.0215898
RPS27A ribosomal protein S27a -0.0214953
ISG15 ISG15 ubiquitin-like modifier -0.021162
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0210743
RPL19 ribosomal protein L19 -0.0202944
RPL23 ribosomal protein L23 -0.0202011
RPS4X ribosomal protein S4, X-linked -0.0196587
LAMC2 laminin, gamma 2 -0.0196347
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0195712
RPLP0 ribosomal protein, large, P0 -0.0194399
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0193602
RPL26 ribosomal protein L26 -0.019287
WARS1 tryptophanyl-tRNA synthetase 1 -0.0192032
CLU clusterin -0.0190908
RACK1 receptor for activated C kinase 1 -0.0189374
RPL7A ribosomal protein L7a -0.018791
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0186389
MYL12B myosin, light chain 12B, regulatory -0.0181049
IER3 immediate early response 3 -0.0181045
RPS14 ribosomal protein S14 -0.0179951
RPS5 ribosomal protein S5 -0.0178791
RPL36A ribosomal protein L36a -0.0178184
RPS15 ribosomal protein S15 -0.0176582
LOC102724023 ES1 protein homolog, mitochondrial -0.0175198
SP100 SP100 nuclear antigen -0.0173679
RAB7A RAB7A, member RAS oncogene family -0.017292
IFI27 interferon, alpha-inducible protein 27 -0.0172153
RPL36 ribosomal protein L36 -0.0171881
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0171153
CAV1 caveolin 1, caveolae protein, 22kDa -0.0170771
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0170064
RPS23 ribosomal protein S23 -0.0169616
RPL9 ribosomal protein L9 -0.0169306
FOSL1 FOS-like antigen 1 -0.0167246
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0165915
INTS6 integrator complex subunit 6 -0.0165631
CLIC4 chloride intracellular channel 4 -0.0165343
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0165088