Glycyrrhizic acid_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.194182
FTH1 ferritin, heavy polypeptide 1 0.124373
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0919474
ATP13A3 ATPase type 13A3 0.0895769
FLNB filamin B, beta 0.0763702
TRIO trio Rho guanine nucleotide exchange factor 0.0750339
PODXL podocalyxin-like 0.0653489
PGK1 phosphoglycerate kinase 1 0.064846
CCNL1 cyclin L1 0.0622411
EEF1G eukaryotic translation elongation factor 1 gamma 0.0608289
FN1 fibronectin 1 0.0583627
TUBB tubulin, beta class I 0.0514289
PDIA3 protein disulfide isomerase family A, member 3 0.0481789
PKM pyruvate kinase, muscle 0.0469856
FLNA filamin A, alpha 0.0458415
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0384786
NALF1 NALCN channel auxiliary factor 1 0.0373233
COL5A1 collagen, type V, alpha 1 0.0347555
EXT1 exostosin glycosyltransferase 1 0.0302888
L1CAM L1 cell adhesion molecule 0.029665
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0294287
LDHA lactate dehydrogenase A 0.029223
ANKRD10 ankyrin repeat domain 10 0.0287092
GANAB glucosidase, alpha; neutral AB 0.0286993
FNDC3B fibronectin type III domain containing 3B 0.0283396
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0280845
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0271388
NUP58 nucleoporin 58 0.0251646
SOD2 superoxide dismutase 2, mitochondrial 0.0249094
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0249027
NUP153 nucleoporin 153kDa 0.0244029
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0241654
TGFB2 transforming growth factor, beta 2 0.0240114
SLC12A8 solute carrier family 12, member 8 0.0229732
CCBE1 collagen and calcium binding EGF domains 1 0.0226573
ZEB2 zinc finger E-box binding homeobox 2 0.0222754
OSMR oncostatin M receptor 0.0222459
KRT8 keratin 8, type II 0.0222228
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0220949
LOX lysyl oxidase 0.0212736
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0207267
LOC112694756 uncharaterized LOC112694756 0.0207219
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0205969
ICAM1 intercellular adhesion molecule 1 0.0205832
TMEM178B transmembrane protein 178B 0.0205489
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0205448
TSC22D2 TSC22 domain family, member 2 0.0200808
GLIS3 GLIS family zinc finger 3 0.0198595
CTSD cathepsin D 0.0193599
KRT7 keratin 7, type II 0.0193183
NUP98 nucleoporin 98kDa 0.0191584
ARID1A AT rich interactive domain 1A (SWI-like) 0.0190081
TMEM41B transmembrane protein 41B 0.0187543
ARGLU1 arginine and glutamate rich 1 0.0186563
LENG8 leukocyte receptor cluster (LRC) member 8 0.0183169
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0182642
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0180658
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0180039
BHLHE40 basic helix-loop-helix family, member e40 0.0174435
ATXN2L ataxin 2-like 0.0169459
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0166889
IGFBP3 insulin-like growth factor binding protein 3 0.0166101
POTEF POTE ankyrin domain family, member F 0.0165605
POSTN periostin, osteoblast specific factor 0.0165466
PFN1 profilin 1 0.0158345
ZNF207 zinc finger protein 207 0.0153376
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0151647
NAMPT nicotinamide phosphoribosyltransferase 0.0151068
LAMP1 lysosomal-associated membrane protein 1 0.0148962
VGLL3 vestigial-like family member 3 0.0148922
FAT1 FAT atypical cadherin 1 0.0147827
GATA2 GATA binding protein 2 0.0146212
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0142827
DENND5A DENN/MADD domain containing 5A 0.0142535
KDM6A lysine (K)-specific demethylase 6A 0.0142492
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0141809
EGFR epidermal growth factor receptor 0.0141598
XPO6 exportin 6 0.0140663
USP36 ubiquitin specific peptidase 36 0.0138583
RPL23 ribosomal protein L23 0.0136938
SF1 splicing factor 1 0.0136875
SNX4 sorting nexin 4 0.0136426
TENT4A terminal nucleotidyltransferase 4A 0.0136169
CALR calreticulin 0.013546
COG5 component of oligomeric golgi complex 5 0.0132201
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0132002
MCM7 minichromosome maintenance complex component 7 0.0131022
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0129665
FGFR1 fibroblast growth factor receptor 1 0.0129374
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0128788
BSG basigin (Ok blood group) 0.0128424
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0128383
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0127877
SMAD3 SMAD family member 3 0.0127091
IFITM3 interferon induced transmembrane protein 3 0.0126962
TMEM248 transmembrane protein 248 0.0126735
CLIC1 chloride intracellular channel 1 0.0125956
ZMIZ1 zinc finger, MIZ-type containing 1 0.0125371
PLPP3 phospholipid phosphatase 3 0.0125274
NPPB natriuretic peptide B 0.0123548

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.122599
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0764737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0742828
TXNRD1 thioredoxin reductase 1 -0.0628959
ASPH aspartate beta-hydroxylase -0.0590972
AKAP12 A kinase (PRKA) anchor protein 12 -0.055358
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0550092
CANX calnexin -0.0528973
SET SET nuclear proto-oncogene -0.0482244
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0455999
KTN1 kinectin 1 (kinesin receptor) -0.0447047
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0428846
CENPF centromere protein F, 350/400kDa -0.0421587
GOLGB1 golgin B1 -0.0406917
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0374823
DST dystonin -0.0370265
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0363253
MAP4 microtubule-associated protein 4 -0.0357915
ZNF432 zinc finger protein 432 -0.035319
DLG1 discs, large homolog 1 (Drosophila) -0.03484
PTMA prothymosin, alpha -0.0347323
TPM3 tropomyosin 3 -0.0336818
NDRG1 N-myc downstream regulated 1 -0.0319489
KPNB1 karyopherin (importin) beta 1 -0.031612
MAP1B microtubule-associated protein 1B -0.0315328
NIPBL Nipped-B homolog (Drosophila) -0.0309364
TPX2 TPX2, microtubule-associated -0.0302188
TPT1 tumor protein, translationally-controlled 1 -0.0299487
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0296046
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0295131
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0281309
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0275291
AHNAK AHNAK nucleoprotein -0.0275212
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0270414
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0265211
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0258143
STK4 serine/threonine kinase 4 -0.0250738
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0250169
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0249833
RAI14 retinoic acid induced 14 -0.024941
RPS6 ribosomal protein S6 -0.0248535
TMF1 TATA element modulatory factor 1 -0.0247037
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245676
ATXN1 ataxin 1 -0.0237759
TMSB4X thymosin beta 4, X-linked -0.0235481
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0230863
SMYD3 SET and MYND domain containing 3 -0.0224816
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0223474
PRRC2C proline-rich coiled-coil 2C -0.0222608
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0222517
YBX1 Y box binding protein 1 -0.0222475
B2M beta-2-microglobulin -0.0220299
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0219327
STAU1 staufen double-stranded RNA binding protein 1 -0.0219011
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0217785
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0214434
H1-4 H1.4 linker histone, cluster member -0.0212569
BBX bobby sox homolog (Drosophila) -0.0211688
PPME1 protein phosphatase methylesterase 1 -0.0209375
RIOK3 RIO kinase 3 -0.0207953
RRBP1 ribosome binding protein 1 -0.0206084
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0205076
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.020021
KDM2A lysine (K)-specific demethylase 2A -0.0198654
MKI67 marker of proliferation Ki-67 -0.0196457
RPS2 ribosomal protein S2 -0.0195716
CUL4B cullin 4B -0.0194761
SQSTM1 sequestosome 1 -0.0191741
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0190358
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0189365
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0187597
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0187505
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0186922
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.018639
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0186058
ATAD2 ATPase family, AAA domain containing 2 -0.0182152
EEA1 early endosome antigen 1 -0.0181665
NSD3 nuclear receptor binding SET domain protein 3 -0.0181384
DEK DEK proto-oncogene -0.0180128
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0179063
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0177598
TMSB10 thymosin beta 10 -0.0177224
CD44 CD44 molecule (Indian blood group) -0.0175837
SSR1 signal sequence receptor, alpha -0.0175559
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.017217
COPB1 coatomer protein complex, subunit beta 1 -0.0170915
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0170203
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0163953
OPTN optineurin -0.0162959
CKAP5 cytoskeleton associated protein 5 -0.0162532
LRMDA leucine rich melanocyte differentiation associated -0.0162339
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0162222
GOLGA4 golgin A4 -0.0161491
LMNA lamin A/C -0.0161252
MSN moesin -0.0160369
NSD1 nuclear receptor binding SET domain protein 1 -0.0160291
SEPTIN9 septin 9 -0.0159407
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0158419
AKAP9 A kinase (PRKA) anchor protein 9 -0.0157483
HMGB2 high mobility group box 2 -0.0156945