Glycyrrhizic acid_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.286194
PDIA3 protein disulfide isomerase family A, member 3 0.0758318
EEF1G eukaryotic translation elongation factor 1 gamma 0.0636905
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0566083
PGK1 phosphoglycerate kinase 1 0.0499193
FTH1 ferritin, heavy polypeptide 1 0.0398603
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0390993
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0346678
GOLGA4 golgin A4 0.0335826
CLTC clathrin, heavy chain (Hc) 0.0310355
ATXN1 ataxin 1 0.0307549
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0306542
HMGA1 high mobility group AT-hook 1 0.0298985
ARHGAP32 Rho GTPase activating protein 32 0.0293812
ZFAND3 zinc finger, AN1-type domain 3 0.0292291
FNDC3B fibronectin type III domain containing 3B 0.028204
RAB1A RAB1A, member RAS oncogene family 0.027534
BIRC6 baculoviral IAP repeat containing 6 0.0271464
ANLN anillin, actin binding protein 0.0265834
IARS1 isoleucyl-tRNA synthetase 1 0.0255422
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0252451
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0250289
ESRP1 epithelial splicing regulatory protein 1 0.0248365
PMM2 phosphomannomutase 2 0.0248262
HYOU1 hypoxia up-regulated 1 0.0243264
ZCCHC7 zinc finger, CCHC domain containing 7 0.0239018
COG5 component of oligomeric golgi complex 5 0.023675
H1-0 H1.0 linker histone 0.023479
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0233563
EEF2 eukaryotic translation elongation factor 2 0.0227188
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0225694
MBNL2 muscleblind-like splicing regulator 2 0.0219556
HM13 histocompatibility (minor) 13 0.0218257
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0218196
NBAS neuroblastoma amplified sequence 0.0209009
COPG1 coatomer protein complex, subunit gamma 1 0.02049
PDIA4 protein disulfide isomerase family A, member 4 0.0202885
ANKHD1 ankyrin repeat and KH domain containing 1 0.0202231
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.020176
RPN1 ribophorin I 0.0200864
KLHL29 kelch-like family member 29 0.0199703
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0198363
SEC31A SEC31 homolog A (S. cerevisiae) 0.0196484
GARS1 glycyl-tRNA synthetase 1 0.0194742
NFE2L1 nuclear factor, erythroid 2-like 1 0.0194175
SRP54 signal recognition particle 54kDa 0.0194013
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0193238
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0193001
CCNL1 cyclin L1 0.0190626
MYH9 myosin, heavy chain 9, non-muscle 0.0189917
RBM39 RNA binding motif protein 39 0.0188191
S100A6 S100 calcium binding protein A6 0.0186929
ZNF292 zinc finger protein 292 0.0186794
FLNB filamin B, beta 0.0184317
SEC23B Sec23 homolog B (S. cerevisiae) 0.0184173
KRT17 keratin 17, type I 0.0182073
SPAG9 sperm associated antigen 9 0.0181546
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0181384
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0181235
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0181141
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0179906
ANKRD10 ankyrin repeat domain 10 0.0179725
LAMB3 laminin, beta 3 0.0178361
ANKRD17 ankyrin repeat domain 17 0.01783
ITCH itchy E3 ubiquitin protein ligase 0.0176723
PUM2 pumilio RNA-binding family member 2 0.0176087
ACTG1 actin gamma 1 0.017509
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0174368
FNIP1 folliculin interacting protein 1 0.0173137
MORF4L2 mortality factor 4 like 2 0.0172602
HELZ helicase with zinc finger 0.0172579
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0171241
HKDC1 hexokinase domain containing 1 0.0166979
NUP58 nucleoporin 58 0.0165257
WSB1 WD repeat and SOCS box containing 1 0.0164451
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0164111
AVL9 AVL9 homolog (S. cerevisiase) 0.0162856
SREBF2 sterol regulatory element binding transcription factor 2 0.0162824
MON2 MON2 homolog (S. cerevisiae) 0.0162395
CEMIP cell migration inducing protein, hyaluronan binding 0.015954
AFDN afadin, adherens junction formation factor 0.0158434
YARS1 tyrosyl-tRNA synthetase 1 0.0158057
PICALM phosphatidylinositol binding clathrin assembly protein 0.0156218
PREPL prolyl endopeptidase-like 0.0154062
TM9SF3 transmembrane 9 superfamily member 3 0.015406
RPS6 ribosomal protein S6 0.0153497
NPSR1 neuropeptide S receptor 1 0.0151255
SRRM2 serine/arginine repetitive matrix 2 0.0150595
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0149934
GANAB glucosidase, alpha; neutral AB 0.0148314
PAPOLA poly(A) polymerase alpha 0.0147052
KIF5B kinesin family member 5B 0.0146899
PKM pyruvate kinase, muscle 0.0146088
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.014607
SUN1 Sad1 and UNC84 domain containing 1 0.0145577
RB1CC1 RB1-inducible coiled-coil 1 0.0144739
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0143308
CADPS2 Ca++-dependent secretion activator 2 0.0142921
CTNND1 catenin (cadherin-associated protein), delta 1 0.0142656
C6ORF62 chromosome 6 open reading frame 62 0.0142614

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.119175
FTL ferritin, light polypeptide -0.0733432
EZR ezrin -0.0474693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0447932
LMO7 LIM domain 7 -0.0314302
LOC102724023 ES1 protein homolog, mitochondrial -0.0269284
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0239969
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0221269
NDRG1 N-myc downstream regulated 1 -0.0217345
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0210834
RPS12 ribosomal protein S12 -0.0207269
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0204312
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0203932
RPS3 ribosomal protein S3 -0.0200661
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0189185
RPL31 ribosomal protein L31 -0.0185863
RPS17 ribosomal protein S17 -0.0183168
S100A10 S100 calcium binding protein A10 -0.01818
CST3 cystatin C -0.0180265
LIMA1 LIM domain and actin binding 1 -0.0176829
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0174743
LAMA4 laminin, alpha 4 -0.016812
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0167725
IFI6 interferon, alpha-inducible protein 6 -0.0166924
RPL19 ribosomal protein L19 -0.0165655
IFI27 interferon, alpha-inducible protein 27 -0.0159839
TPM4 tropomyosin 4 -0.015899
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0158861
EPCAM epithelial cell adhesion molecule -0.0156888
PTMA prothymosin, alpha -0.0155579
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0152888
VCL vinculin -0.0151159
RPS8 ribosomal protein S8 -0.0145605
LYZ lysozyme -0.0142759
RPL5 ribosomal protein L5 -0.0139407
ANXA1 annexin A1 -0.0138458
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.013797
MACC1 metastasis associated in colon cancer 1 -0.0137784
YBX1 Y box binding protein 1 -0.0136878
AREG amphiregulin -0.0136388
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0133858
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0132938
RPS5 ribosomal protein S5 -0.0127997
NCEH1 neutral cholesterol ester hydrolase 1 -0.0121858
ASPH aspartate beta-hydroxylase -0.01217
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0121543
RPL32 ribosomal protein L32 -0.0121505
CLDN4 claudin 4 -0.0120665
EMP1 epithelial membrane protein 1 -0.0119742
WWC1 WW and C2 domain containing 1 -0.0117277
ITGA6 integrin, alpha 6 -0.0115314
MYOF myoferlin -0.0113363
MUC1 mucin 1, cell surface associated -0.0113228
EDN1 endothelin 1 -0.0113118
TUBA1B tubulin, alpha 1b -0.0112379
EGR1 early growth response 1 -0.0110514
IFITM3 interferon induced transmembrane protein 3 -0.0110058
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0108353
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0107688
RPLP1 ribosomal protein, large, P1 -0.0106675
INSIG1 insulin induced gene 1 -0.010522
SKAP2 src kinase associated phosphoprotein 2 -0.0104851
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0103132
INTS6 integrator complex subunit 6 -0.0102567
GPHN gephyrin -0.0102447
RPL21 ribosomal protein L21 -0.00999484
RPL28 ribosomal protein L28 -0.00992604
LIPH lipase, member H -0.00980465
TMC5 transmembrane channel-like 5 -0.00977489
TOP2A topoisomerase (DNA) II alpha 170kDa -0.00974916
ACTN4 actinin, alpha 4 -0.00971569
RPL26 ribosomal protein L26 -0.00970385
BAIAP2L1 BAI1-associated protein 2-like 1 -0.00963609
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.00962941
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.00959106
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00940636
KLF6 Kruppel-like factor 6 -0.00912518
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0088961
FOSL1 FOS-like antigen 1 -0.00886309
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00877112
CBX3 chromobox homolog 3 -0.00873752
STK17A serine/threonine kinase 17a -0.00869355
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.00868601
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0085963
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.00851463
C6ORF132 chromosome 6 open reading frame 132 -0.00840281
RPL36AL ribosomal protein L36a-like -0.00838124
LMNA lamin A/C -0.00825627
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.00817855
MYO1E myosin IE -0.00807927
KPNB1 karyopherin (importin) beta 1 -0.00803297
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0079896
KTN1 kinectin 1 (kinesin receptor) -0.00798671
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.00796669
FHL2 four and a half LIM domains 2 -0.00794785
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00786409
ATP5F1B ATP synthase F1 subunit beta -0.0078601
PCDH7 protocadherin 7 -0.00779981
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.00772485
UGCG UDP-glucose ceramide glucosyltransferase -0.00771451