Glycyrrhizic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104185
NUP58 nucleoporin 58 0.080923
ADAM9 ADAM metallopeptidase domain 9 0.046588
MCTP1 multiple C2 domains, transmembrane 1 0.0460154
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0441017
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0433838
ZNF292 zinc finger protein 292 0.0418012
FLNA filamin A, alpha 0.0411926
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0391089
PKM pyruvate kinase, muscle 0.0385566
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0380753
SPAG9 sperm associated antigen 9 0.0370853
TSC22D2 TSC22 domain family, member 2 0.0361007
EEF2 eukaryotic translation elongation factor 2 0.0346961
RTN4 reticulon 4 0.0319175
UGCG UDP-glucose ceramide glucosyltransferase 0.0317595
HELZ helicase with zinc finger 0.0315545
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0309644
ELL2 elongation factor, RNA polymerase II, 2 0.030633
GLS2 glutaminase 2 (liver, mitochondrial) 0.0303841
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0300163
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0294712
WAC WW domain containing adaptor with coiled-coil 0.0292956
MYH9 myosin, heavy chain 9, non-muscle 0.0279621
RYBP RING1 and YY1 binding protein 0.0270484
NAMPT nicotinamide phosphoribosyltransferase 0.0268566
RBM39 RNA binding motif protein 39 0.0267737
ATP13A3 ATPase type 13A3 0.0265386
EEF1G eukaryotic translation elongation factor 1 gamma 0.0263082
CCNL1 cyclin L1 0.0261407
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.026112
PGK1 phosphoglycerate kinase 1 0.0257184
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0253491
NDRG1 N-myc downstream regulated 1 0.0249036
RLF rearranged L-myc fusion 0.0244953
NCKAP1 NCK-associated protein 1 0.0241835
ZNF207 zinc finger protein 207 0.0240538
HSPA8 heat shock 70kDa protein 8 0.0240518
LDHA lactate dehydrogenase A 0.0240182
HOOK2 hook microtubule-tethering protein 2 0.0238281
ARID1A AT rich interactive domain 1A (SWI-like) 0.0238039
UBA6 ubiquitin-like modifier activating enzyme 6 0.0237838
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0236048
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0235917
LOC112694756 uncharaterized LOC112694756 0.0235422
DTNA dystrobrevin, alpha 0.0229121
MALT1 MALT1 paracaspase 0.0223907
TFRC transferrin receptor 0.0218734
BRD2 bromodomain containing 2 0.0216074
PHIP pleckstrin homology domain interacting protein 0.021332
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0211015
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0205165
KMT2E lysine (K)-specific methyltransferase 2E 0.020495
RNF145 ring finger protein 145 0.0203898
CYRIB CYFIP related Rac1 interactor B 0.0203111
CDC73 cell division cycle 73 0.0193504
VEZT vezatin, adherens junctions transmembrane protein 0.01919
TRA2A transformer 2 alpha homolog (Drosophila) 0.019067
WDR43 WD repeat domain 43 0.0189884
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0187047
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.018677
QKI QKI, KH domain containing, RNA binding 0.018593
RAB8B RAB8B, member RAS oncogene family 0.0184987
STRN3 striatin, calmodulin binding protein 3 0.0184986
PNISR PNN-interacting serine/arginine-rich protein 0.0184862
USP3 ubiquitin specific peptidase 3 0.018464
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0183473
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0182873
RBM33 RNA binding motif protein 33 0.0182323
NUP153 nucleoporin 153kDa 0.0181543
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0174594
CORO1C coronin, actin binding protein, 1C 0.0173779
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0171211
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0169486
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0169045
OSBPL9 oxysterol binding protein-like 9 0.0168022
CNOT1 CCR4-NOT transcription complex, subunit 1 0.016684
PICALM phosphatidylinositol binding clathrin assembly protein 0.0165954
OLA1 Obg-like ATPase 1 0.0162999
CHD1 chromodomain helicase DNA binding protein 1 0.0161771
CUL3 cullin 3 0.0161659
APLP2 amyloid beta (A4) precursor-like protein 2 0.0161574
MARCHF6 membrane associated ring-CH-type finger 6 0.0158995
FUBP1 far upstream element (FUSE) binding protein 1 0.0158851
ZMYM2 zinc finger, MYM-type 2 0.0155644
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0154654
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0150448
FXR1 fragile X mental retardation, autosomal homolog 1 0.0150142
KDM3A lysine (K)-specific demethylase 3A 0.0149234
PRPF8 pre-mRNA processing factor 8 0.0148724
TRA2B transformer 2 beta homolog (Drosophila) 0.0148356
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0148026
PUM2 pumilio RNA-binding family member 2 0.0147574
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0145974
MSN moesin 0.0145786
NEK7 NIMA-related kinase 7 0.0145435
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0144994
CCN2 cellular communication network factor 2 0.0144621
TFG TRK-fused gene 0.014462
RPL4 ribosomal protein L4 0.0144608

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.233073
AKAP12 A kinase (PRKA) anchor protein 12 -0.132319
TMSB10 thymosin beta 10 -0.113023
PRKG1 protein kinase, cGMP-dependent, type I -0.11096
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0907008
SAMD3 sterile alpha motif domain containing 3 -0.0720203
EFNA5 ephrin-A5 -0.0696886
PHACTR1 phosphatase and actin regulator 1 -0.0692819
MMP12 matrix metallopeptidase 12 -0.0684425
PTMA prothymosin, alpha -0.067472
RPS6 ribosomal protein S6 -0.0662405
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0659693
AHNAK AHNAK nucleoprotein -0.0657532
TPT1 tumor protein, translationally-controlled 1 -0.0616939
NTM neurotrimin -0.0599123
PTCHD4 patched domain containing 4 -0.0592461
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0588169
LSAMP limbic system-associated membrane protein -0.0583512
PTPRG protein tyrosine phosphatase, receptor type, G -0.0563223
EXT1 exostosin glycosyltransferase 1 -0.0534434
MT2A metallothionein 2A -0.0514711
KIAA1217 KIAA1217 -0.051202
SDCCAG8 serologically defined colon cancer antigen 8 -0.045982
RPL35A ribosomal protein L35a -0.0451053
RPS19 ribosomal protein S19 -0.0443209
CDH13 cadherin 13 -0.0437889
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0432338
FOXP1 forkhead box P1 -0.0424338
KIAA1549L KIAA1549-like -0.0415754
HMGA2 high mobility group AT-hook 2 -0.0409339
HDAC9 histone deacetylase 9 -0.0408366
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.040547
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0402135
RPS3 ribosomal protein S3 -0.0385823
ENKUR enkurin, TRPC channel interacting protein -0.0376354
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0374108
RPLP2 ribosomal protein, large, P2 -0.0367372
RPL23 ribosomal protein L23 -0.0363967
RPL31 ribosomal protein L31 -0.0360265
CDK6 cyclin-dependent kinase 6 -0.0356404
GPC6 glypican 6 -0.035615
RPS8 ribosomal protein S8 -0.0353579
RPS27A ribosomal protein S27a -0.0353528
ZNF804A zinc finger protein 804A -0.0346202
MACF1 microtubule-actin crosslinking factor 1 -0.0345432
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0338301
RPS13 ribosomal protein S13 -0.0328807
SBF2 SET binding factor 2 -0.0324883
RPL37A ribosomal protein L37a -0.0320223
PTPRK protein tyrosine phosphatase, receptor type, K -0.0318552
RPLP1 ribosomal protein, large, P1 -0.0318021
DST dystonin -0.0311837
RPL19 ribosomal protein L19 -0.0307943
ASPH aspartate beta-hydroxylase -0.0307876
RPL12 ribosomal protein L12 -0.0304433
CUX1 cut-like homeobox 1 -0.0295451
RPS29 ribosomal protein S29 -0.0291607
CAVIN1 caveolae associated protein 1 -0.0288811
PDE4D phosphodiesterase 4D, cAMP-specific -0.0288722
RPL34 ribosomal protein L34 -0.0288482
ALCAM activated leukocyte cell adhesion molecule -0.0287679
C2CD2 C2 calcium-dependent domain containing 2 -0.028133
BPTF bromodomain PHD finger transcription factor -0.0279573
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0278372
AEBP2 AE binding protein 2 -0.0278328
ZBTB20 zinc finger and BTB domain containing 20 -0.0277161
DOCK4 dedicator of cytokinesis 4 -0.0276925
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0273922
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0273447
EIF1 eukaryotic translation initiation factor 1 -0.0270307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0270091
RPS24 ribosomal protein S24 -0.0269409
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0267754
RPL36 ribosomal protein L36 -0.0265155
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0264192
RPL38 ribosomal protein L38 -0.0261587
NALF1 NALCN channel auxiliary factor 1 -0.0260574
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0256984
RPS25 ribosomal protein S25 -0.0255458
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0253466
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0246121
RPL26 ribosomal protein L26 -0.0244112
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0243138
FMN1 formin 1 -0.0240801
RPS23 ribosomal protein S23 -0.0238773
RAI14 retinoic acid induced 14 -0.0234364
IFI16 interferon, gamma-inducible protein 16 -0.0234104
VCL vinculin -0.0233
RPL7A ribosomal protein L7a -0.0231399
RPL37 ribosomal protein L37 -0.0231207
RPL11 ribosomal protein L11 -0.0230674
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0229984
RPS14 ribosomal protein S14 -0.0228977
NAV1 neuron navigator 1 -0.0226928
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0226185
RPL9 ribosomal protein L9 -0.0224777
NAV3 neuron navigator 3 -0.0220502
MSR1 macrophage scavenger receptor 1 -0.0220148
TAS2R14 taste receptor, type 2, member 14 -0.0219633
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.021936