Glycyrrhizic acid_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.155952
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.14406
FTH1 ferritin, heavy polypeptide 1 0.111216
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.104512
EREG epiregulin 0.0966564
PTMA prothymosin, alpha 0.0863109
TXNIP thioredoxin interacting protein 0.0855582
NDRG1 N-myc downstream regulated 1 0.0847462
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0835046
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0773621
FAM13A family with sequence similarity 13, member A 0.0701523
LDHA lactate dehydrogenase A 0.0693247
GOLGA4 golgin A4 0.0689691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0673331
EEF2 eukaryotic translation elongation factor 2 0.0670444
WAC WW domain containing adaptor with coiled-coil 0.0665084
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0595366
PKM pyruvate kinase, muscle 0.0594376
RNF145 ring finger protein 145 0.0590328
ANKRD11 ankyrin repeat domain 11 0.0569019
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0544318
RNF43 ring finger protein 43 0.054109
MED13L mediator complex subunit 13-like 0.0532425
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.052438
ZFAND3 zinc finger, AN1-type domain 3 0.0522005
USP3 ubiquitin specific peptidase 3 0.0507823
ANXA2 annexin A2 0.049389
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0487326
PTBP3 polypyrimidine tract binding protein 3 0.0483554
ZNF292 zinc finger protein 292 0.0469117
KMT2E lysine (K)-specific methyltransferase 2E 0.0467218
TNS4 tensin 4 0.0455232
PGK1 phosphoglycerate kinase 1 0.0450122
RREB1 ras responsive element binding protein 1 0.0447732
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0442547
RBM39 RNA binding motif protein 39 0.0437925
SREBF2 sterol regulatory element binding transcription factor 2 0.043615
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0435401
NUP58 nucleoporin 58 0.0430173
FAT1 FAT atypical cadherin 1 0.0423061
UBE2H ubiquitin-conjugating enzyme E2H 0.0417212
ESYT2 extended synaptotagmin-like protein 2 0.0416298
PDIA3 protein disulfide isomerase family A, member 3 0.0415726
MXD1 MAX dimerization protein 1 0.0410174
WDR45B WD repeat domain 45B 0.0405616
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0405123
UBA6 ubiquitin-like modifier activating enzyme 6 0.0396506
KRT8 keratin 8, type II 0.0392222
KIF5B kinesin family member 5B 0.0386629
EEF1G eukaryotic translation elongation factor 1 gamma 0.0385681
H1-0 H1.0 linker histone 0.0374603
CD46 CD46 molecule, complement regulatory protein 0.0367846
PRSS3 protease, serine, 3 0.0365932
KDM3A lysine (K)-specific demethylase 3A 0.0364936
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0363363
SHROOM3 shroom family member 3 0.0362544
PELI1 pellino E3 ubiquitin protein ligase 1 0.0358047
KRT18 keratin 18, type I 0.0352642
CCNL1 cyclin L1 0.0347944
COG5 component of oligomeric golgi complex 5 0.0344174
NCKAP1 NCK-associated protein 1 0.0337674
ESRP1 epithelial splicing regulatory protein 1 0.0333342
SEC31A SEC31 homolog A (S. cerevisiae) 0.0330968
GARS1 glycyl-tRNA synthetase 1 0.0330728
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0328582
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0327684
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0326871
USP6NL USP6 N-terminal like 0.0323828
RTN4 reticulon 4 0.0323455
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0323225
TFG TRK-fused gene 0.0322684
COPA coatomer protein complex, subunit alpha 0.0322256
STRN3 striatin, calmodulin binding protein 3 0.0322012
SETD5 SET domain containing 5 0.0320523
KDM6A lysine (K)-specific demethylase 6A 0.0319022
KDM7A lysine (K)-specific demethylase 7A 0.0316795
SRRM2 serine/arginine repetitive matrix 2 0.0315247
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.031202
FOXJ3 forkhead box J3 0.0311556
NEK7 NIMA-related kinase 7 0.0305918
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0305369
KCMF1 potassium channel modulatory factor 1 0.0305044
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0301393
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0300604
TPD52 tumor protein D52 0.0299812
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.029927
YME1L1 YME1-like 1 ATPase 0.0297826
SPRED2 sprouty-related, EVH1 domain containing 2 0.0296905
CALR calreticulin 0.0295873
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.029567
KLF3 Kruppel-like factor 3 (basic) 0.0295382
RAB6A RAB6A, member RAS oncogene family 0.0295166
FNBP1L formin binding protein 1-like 0.0291768
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.028458
ADAM17 ADAM metallopeptidase domain 17 0.0283546
ZMYM2 zinc finger, MYM-type 2 0.0282523
CLTC clathrin, heavy chain (Hc) 0.02824
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0281061
RAB1A RAB1A, member RAS oncogene family 0.027933
TM9SF3 transmembrane 9 superfamily member 3 0.0278613

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.162819
VCL vinculin -0.112261
NALF1 NALCN channel auxiliary factor 1 -0.108909
PTPRK protein tyrosine phosphatase, receptor type, K -0.0836903
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0789317
TPT1 tumor protein, translationally-controlled 1 -0.0667311
PDE4D phosphodiesterase 4D, cAMP-specific -0.065274
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0644793
LAMA4 laminin, alpha 4 -0.064078
TMSB10 thymosin beta 10 -0.0600371
MYO1E myosin IE -0.0578173
FHIT fragile histidine triad -0.0576715
SLC35F3 solute carrier family 35, member F3 -0.0574012
GMDS GDP-mannose 4,6-dehydratase -0.0573905
EXT1 exostosin glycosyltransferase 1 -0.0572023
ANTXR2 anthrax toxin receptor 2 -0.0557728
PTPRB protein tyrosine phosphatase, receptor type, B -0.054604
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0539593
ASPH aspartate beta-hydroxylase -0.0538858
GREB1L growth regulation by estrogen in breast cancer-like -0.0520434
RPL9 ribosomal protein L9 -0.0506791
AHNAK AHNAK nucleoprotein -0.0498113
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.04812
RPS19 ribosomal protein S19 -0.0462592
RAD51B RAD51 paralog B -0.0461167
ACTG1 actin gamma 1 -0.0460947
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0459007
EGFR epidermal growth factor receptor -0.0458963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0452404
POF1B premature ovarian failure, 1B -0.0445564
PSD3 pleckstrin and Sec7 domain containing 3 -0.0439819
DENND1A DENN/MADD domain containing 1A -0.0427181
SMYD3 SET and MYND domain containing 3 -0.042481
PDLIM5 PDZ and LIM domain 5 -0.0422326
RNF217 ring finger protein 217 -0.0418885
ALCAM activated leukocyte cell adhesion molecule -0.041744
EXOC4 exocyst complex component 4 -0.0397417
CCSER1 coiled-coil serine-rich protein 1 -0.0386105
S100P S100 calcium binding protein P -0.0384896
MAML2 mastermind-like 2 (Drosophila) -0.0383826
RPL36 ribosomal protein L36 -0.0379615
RPL23 ribosomal protein L23 -0.0373318
RPS29 ribosomal protein S29 -0.0371615
RPLP2 ribosomal protein, large, P2 -0.037125
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0367877
MAML3 mastermind-like 3 (Drosophila) -0.0366966
CADPS Ca++-dependent secretion activator -0.0366503
ZBTB20 zinc finger and BTB domain containing 20 -0.0362715
PATJ PATJ crumbs cell polarity complex component -0.0359952
ONECUT3 one cut homeobox 3 -0.035961
RPL34 ribosomal protein L34 -0.0359034
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0358724
RPS8 ribosomal protein S8 -0.03532
TBC1D22A TBC1 domain family, member 22A -0.0349533
SAMD5 sterile alpha motif domain containing 5 -0.0342175
PRELID2 PRELI domain containing 2 -0.0338716
RPL35A ribosomal protein L35a -0.0337559
MT2A metallothionein 2A -0.032944
EHBP1 EH domain binding protein 1 -0.0320408
RPS21 ribosomal protein S21 -0.0305594
PARD3B par-3 family cell polarity regulator beta -0.030325
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0301423
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.02831
TRAPPC9 trafficking protein particle complex 9 -0.0277455
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0275566
DIAPH2 diaphanous-related formin 2 -0.0272005
MYH14 myosin, heavy chain 14, non-muscle -0.0271488
RPS27A ribosomal protein S27a -0.0271198
RPS27 ribosomal protein S27 -0.0268525
SETX senataxin -0.0265647
LPP LIM domain containing preferred translocation partner in lipoma -0.0265646
CEMIP cell migration inducing protein, hyaluronan binding -0.0264283
FRMD5 FERM domain containing 5 -0.0264138
NRXN3 neurexin 3 -0.026207
BACE2 beta-site APP-cleaving enzyme 2 -0.0262035
TAS2R14 taste receptor, type 2, member 14 -0.0259221
AEBP2 AE binding protein 2 -0.0258669
INTS6 integrator complex subunit 6 -0.0258167
SAMD4A sterile alpha motif domain containing 4A -0.0256968
RPS23 ribosomal protein S23 -0.0253653
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0251662
MBNL1 muscleblind-like splicing regulator 1 -0.024863
TPM1 tropomyosin 1 (alpha) -0.0247574
RPL38 ribosomal protein L38 -0.0247089
SVIL supervillin -0.0246434
RPS6 ribosomal protein S6 -0.0245026
RPLP1 ribosomal protein, large, P1 -0.0244477
FBXO11 F-box protein 11 -0.0244236
EFNB2 ephrin-B2 -0.0242962
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0242123
RABGAP1L RAB GTPase activating protein 1-like -0.0236808
RPL27 ribosomal protein L27 -0.0235978
THSD4 thrombospondin, type I, domain containing 4 -0.0235151
GPR39 G protein-coupled receptor 39 -0.0234627
MYO1D myosin ID -0.0233655
MARCHF3 membrane associated ring-CH-type finger 3 -0.0229361
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0228268
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0226406
ITGA6 integrin, alpha 6 -0.0224875
CATSPERB catsper channel auxiliary subunit beta -0.022161