Glycyrrhizic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Glycyrrhizic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.12965
EEF1G eukaryotic translation elongation factor 1 gamma 0.119846
RPL13A ribosomal protein L13a 0.0752791
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0688563
RPS19 ribosomal protein S19 0.0682092
RPL9 ribosomal protein L9 0.0654802
MON2 MON2 homolog (S. cerevisiae) 0.0628068
RPL35A ribosomal protein L35a 0.0579677
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0483007
EEF2 eukaryotic translation elongation factor 2 0.0470453
RPL11 ribosomal protein L11 0.045876
RPS6 ribosomal protein S6 0.0457292
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0449691
SRRM2 serine/arginine repetitive matrix 2 0.043157
CCNL1 cyclin L1 0.0428151
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0412421
RPS23 ribosomal protein S23 0.0409235
ACTG1 actin gamma 1 0.0397481
COG5 component of oligomeric golgi complex 5 0.0396998
GOLGA4 golgin A4 0.0394432
RPS21 ribosomal protein S21 0.0393184
RPS2 ribosomal protein S2 0.037606
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0371681
PTEN phosphatase and tensin homolog 0.0357333
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0351676
AKAP9 A kinase (PRKA) anchor protein 9 0.033913
RPL36 ribosomal protein L36 0.0337098
RPL37 ribosomal protein L37 0.033125
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0329599
RPS29 ribosomal protein S29 0.0325961
RPS27 ribosomal protein S27 0.0325806
TMEM41B transmembrane protein 41B 0.0322775
RPL27 ribosomal protein L27 0.0321643
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0319054
NACA nascent polypeptide-associated complex alpha subunit 0.0316514
PRELID2 PRELI domain containing 2 0.0308596
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.030749
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0305763
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0303618
BIRC6 baculoviral IAP repeat containing 6 0.0300784
YBX3 Y box binding protein 3 0.0292259
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.028211
CDK19 cyclin-dependent kinase 19 0.0282085
SPRED2 sprouty-related, EVH1 domain containing 2 0.0277934
EXOC4 exocyst complex component 4 0.0274362
RAD51B RAD51 paralog B 0.0273558
SCFD1 sec1 family domain containing 1 0.0269159
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.026892
S100A14 S100 calcium binding protein A14 0.0266714
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0261483
CALB1 calbindin 1, 28kDa 0.0260771
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0260087
SREBF2 sterol regulatory element binding transcription factor 2 0.0256414
ESYT2 extended synaptotagmin-like protein 2 0.0254402
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0248395
HMGA1 high mobility group AT-hook 1 0.0246236
TMEM165 transmembrane protein 165 0.0246051
ARHGAP29 Rho GTPase activating protein 29 0.0245798
RPL23 ribosomal protein L23 0.0244865
RPS13 ribosomal protein S13 0.0242479
TRA2B transformer 2 beta homolog (Drosophila) 0.0242088
FOXO1 forkhead box O1 0.0241794
UBE3A ubiquitin protein ligase E3A 0.0241652
TENT4A terminal nucleotidyltransferase 4A 0.0240053
TTC3 tetratricopeptide repeat domain 3 0.0239678
NBAS neuroblastoma amplified sequence 0.0232829
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0230235
YARS1 tyrosyl-tRNA synthetase 1 0.0227177
WNK1 WNK lysine deficient protein kinase 1 0.022655
FLNB filamin B, beta 0.0224433
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0224312
LRRC1 leucine rich repeat containing 1 0.0223538
GDF15 growth differentiation factor 15 0.0222952
KDM4C lysine (K)-specific demethylase 4C 0.0222691
METTL15 methyltransferase like 15 0.0222221
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0221585
S100P S100 calcium binding protein P 0.0221167
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0219077
SPRED1 sprouty-related, EVH1 domain containing 1 0.0218512
ARHGAP26 Rho GTPase activating protein 26 0.021814
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0215872
EXT1 exostosin glycosyltransferase 1 0.0215226
NKTR natural killer cell triggering receptor 0.0213116
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0212486
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.021242
RFX7 regulatory factor X, 7 0.0210115
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0210106
CIB1 calcium and integrin binding 1 (calmyrin) 0.0209485
PLAC8 placenta-specific 8 0.0208493
LONP1 lon peptidase 1, mitochondrial 0.0208291
RPS26 ribosomal protein S26 0.0207026
BTBD9 BTB (POZ) domain containing 9 0.0206394
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0206325
LMAN1 lectin, mannose-binding, 1 0.0204056
DYNC2I1 dynein 2 intermediate chain 1 0.0201032
CEP95 centrosomal protein 95kDa 0.0201015
PCNX1 pecanex 1 0.0199284
ABHD2 abhydrolase domain containing 2 0.0198834
FNBP4 formin binding protein 4 0.0198485
SRP54 signal recognition particle 54kDa 0.0198096

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.140404
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.132909
LMO7 LIM domain 7 -0.131367
EZR ezrin -0.127307
TPT1 tumor protein, translationally-controlled 1 -0.125576
RPS27A ribosomal protein S27a -0.125032
RPS12 ribosomal protein S12 -0.12326
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.114016
UBC ubiquitin C -0.110499
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108739
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105983
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0954163
PTMA prothymosin, alpha -0.0953297
RPS17 ribosomal protein S17 -0.0836767
MYO1E myosin IE -0.0834346
AHNAK AHNAK nucleoprotein -0.073324
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0729464
RPS3 ribosomal protein S3 -0.0678004
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0675507
RPL31 ribosomal protein L31 -0.0653378
CANX calnexin -0.0643505
ITPRID2 ITPR interacting domain containing 2 -0.0636712
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0635587
KRT18 keratin 18, type I -0.0629124
RIMKLB ribosomal modification protein rimK-like family member B -0.0586183
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0584025
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0560362
ENO1 enolase 1, (alpha) -0.0557974
RPS8 ribosomal protein S8 -0.0507554
FRMD5 FERM domain containing 5 -0.0504647
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0502789
SERINC5 serine incorporator 5 -0.0501805
FBXO11 F-box protein 11 -0.0482638
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0481002
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0465783
RPS5 ribosomal protein S5 -0.046466
NAP1L1 nucleosome assembly protein 1-like 1 -0.046273
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0457692
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0457558
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0456559
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0453899
JUN jun proto-oncogene -0.0447376
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0445758
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0437914
DSPP dentin sialophosphoprotein -0.0434042
PERP PERP, TP53 apoptosis effector -0.0423705
RPS24 ribosomal protein S24 -0.041494
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0414798
DSG2 desmoglein 2 -0.039182
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0379116
S100A10 S100 calcium binding protein A10 -0.0376206
SKP1 S-phase kinase-associated protein 1 -0.0373166
KTN1 kinectin 1 (kinesin receptor) -0.0367691
OXSR1 oxidative stress responsive 1 -0.0365731
RPL26 ribosomal protein L26 -0.0364029
RRBP1 ribosome binding protein 1 -0.0357179
PCBP2 poly(rC) binding protein 2 -0.0352541
EPCAM epithelial cell adhesion molecule -0.0351532
RPS25 ribosomal protein S25 -0.0347356
SP100 SP100 nuclear antigen -0.0339496
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0339439
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0333875
TPM4 tropomyosin 4 -0.0330269
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329982
RPL14 ribosomal protein L14 -0.0329721
TSPAN8 tetraspanin 8 -0.0323639
MYH14 myosin, heavy chain 14, non-muscle -0.0315451
ARHGAP5 Rho GTPase activating protein 5 -0.0311085
ASPH aspartate beta-hydroxylase -0.0309427
YBX1 Y box binding protein 1 -0.0303009
IFI6 interferon, alpha-inducible protein 6 -0.0302324
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0300698
KLF5 Kruppel-like factor 5 (intestinal) -0.0300603
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0298158
TPM3 tropomyosin 3 -0.0296781
DSG3 desmoglein 3 -0.0295384
AREG amphiregulin -0.0294769
ACTN4 actinin, alpha 4 -0.029351
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292788
LOC105378220 macrophage receptor MARCO-like -0.0291523
MYO5B myosin VB -0.0290866
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0289498
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0285174
DIAPH1 diaphanous-related formin 1 -0.0282576
RIGI RNA sensor RIG-I -0.028123
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0280295
CSNK1A1 casein kinase 1, alpha 1 -0.0273849
RSL1D1 ribosomal L1 domain containing 1 -0.0273471
CATSPERB catsper channel auxiliary subunit beta -0.0273375
ITGA6 integrin, alpha 6 -0.0269824
STAU1 staufen double-stranded RNA binding protein 1 -0.0268069
NPR2 natriuretic peptide receptor 2 -0.0267673
PDIA4 protein disulfide isomerase family A, member 4 -0.0265207
NPSR1 neuropeptide S receptor 1 -0.026507
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0264367
KRT8 keratin 8, type II -0.0260409
POTEF POTE ankyrin domain family, member F -0.025629
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0254424
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0251345
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0250371