Glycyrrhizic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152061
EEF1G eukaryotic translation elongation factor 1 gamma 0.108843
MT2A metallothionein 2A 0.081901
EEF2 eukaryotic translation elongation factor 2 0.0801081
POTEF POTE ankyrin domain family, member F 0.0731137
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0652592
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0629074
PGK1 phosphoglycerate kinase 1 0.060776
HMGA1 high mobility group AT-hook 1 0.0516372
FTH1 ferritin, heavy polypeptide 1 0.0492182
CCNL1 cyclin L1 0.0484735
RAI1 retinoic acid induced 1 0.0450141
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0447672
YEATS2 YEATS domain containing 2 0.0426934
PKM pyruvate kinase, muscle 0.0374894
MT1E metallothionein 1E 0.0372038
NUP58 nucleoporin 58 0.0370434
FOSL1 FOS-like antigen 1 0.0367916
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0352261
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0341076
MYADM myeloid-associated differentiation marker 0.0340252
ACTG1 actin gamma 1 0.0333874
PDIA3 protein disulfide isomerase family A, member 3 0.032869
SLC38A2 solute carrier family 38, member 2 0.032828
RPL23 ribosomal protein L23 0.0327646
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0325181
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0325128
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0306707
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0303673
MCL1 myeloid cell leukemia 1 0.0298342
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0291827
RTN4 reticulon 4 0.0285872
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0281578
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0276739
EGR1 early growth response 1 0.0273861
XPO6 exportin 6 0.027354
FNIP1 folliculin interacting protein 1 0.0272154
KCMF1 potassium channel modulatory factor 1 0.0271823
HOOK2 hook microtubule-tethering protein 2 0.0265483
TRA2B transformer 2 beta homolog (Drosophila) 0.0264043
TENT4A terminal nucleotidyltransferase 4A 0.0257516
ADAM17 ADAM metallopeptidase domain 17 0.0254121
SFPQ splicing factor proline/glutamine-rich 0.0253467
WNK1 WNK lysine deficient protein kinase 1 0.0252758
LDHA lactate dehydrogenase A 0.0246804
APLP2 amyloid beta (A4) precursor-like protein 2 0.0244947
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0241209
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0240743
NONO non-POU domain containing, octamer-binding 0.023955
MYH9 myosin, heavy chain 9, non-muscle 0.0237679
CAPRIN2 caprin family member 2 0.0235724
POM121 POM121 transmembrane nucleoporin 0.023498
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0231591
MSN moesin 0.0224393
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0220078
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0218818
SRRM2 serine/arginine repetitive matrix 2 0.0214225
RPL27 ribosomal protein L27 0.0212282
PCBP2 poly(rC) binding protein 2 0.0210038
LENG8 leukocyte receptor cluster (LRC) member 8 0.0209402
NBAS neuroblastoma amplified sequence 0.0207255
MAT2A methionine adenosyltransferase II, alpha 0.0207174
PABPN1 poly(A) binding protein, nuclear 1 0.0200205
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0198535
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195574
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0195422
CAMTA1 calmodulin binding transcription activator 1 0.0194348
SP3 Sp3 transcription factor 0.0193163
SND1 staphylococcal nuclease and tudor domain containing 1 0.0185328
LOXL2 lysyl oxidase-like 2 0.0184785
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0184307
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0181008
NAV2 neuron navigator 2 0.0180916
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0180405
RPS2 ribosomal protein S2 0.0178638
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0175306
USP22 ubiquitin specific peptidase 22 0.0175267
PRPF8 pre-mRNA processing factor 8 0.017459
GANAB glucosidase, alpha; neutral AB 0.0173594
FXR1 fragile X mental retardation, autosomal homolog 1 0.0172944
SMC4 structural maintenance of chromosomes 4 0.0171698
ANKRD12 ankyrin repeat domain 12 0.01716
ARRDC3 arrestin domain containing 3 0.017112
ESYT2 extended synaptotagmin-like protein 2 0.0169953
CDK19 cyclin-dependent kinase 19 0.0169746
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0169431
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0169313
PFN1 profilin 1 0.0168276
MIDEAS mitotic deacetylase associated SANT domain protein 0.016761
FLNA filamin A, alpha 0.0167594
SFTPA2 surfactant protein A2 0.0167167
CAPRIN1 cell cycle associated protein 1 0.0165194
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0164977
FAM120A family with sequence similarity 120A 0.0164874
HDGF hepatoma-derived growth factor 0.0164141
SRP54 signal recognition particle 54kDa 0.0163598
RPL13A ribosomal protein L13a 0.0163065
PRDX1 peroxiredoxin 1 0.0162348
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.016202
RRM2 ribonucleotide reductase M2 0.0161953

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.321484
TMSB10 thymosin beta 10 -0.183456
TP63 tumor protein p63 -0.156913
PTMA prothymosin, alpha -0.152546
CD44 CD44 molecule (Indian blood group) -0.129095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.125031
PSD3 pleckstrin and Sec7 domain containing 3 -0.101098
TMSB4X thymosin beta 4, X-linked -0.0964784
AHNAK AHNAK nucleoprotein -0.0904332
FTL ferritin, light polypeptide -0.0864657
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.083927
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0780898
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0724217
TPT1 tumor protein, translationally-controlled 1 -0.0721121
DST dystonin -0.0657521
ARHGAP5 Rho GTPase activating protein 5 -0.0644991
CANX calnexin -0.0610665
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.060327
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0597858
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0587681
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0559165
EHBP1 EH domain binding protein 1 -0.0553164
RUNX1 runt-related transcription factor 1 -0.053611
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0524386
RIGI RNA sensor RIG-I -0.0523608
GCLM glutamate-cysteine ligase, modifier subunit -0.0474922
SP100 SP100 nuclear antigen -0.0472915
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0461627
DPYD dihydropyrimidine dehydrogenase -0.0435703
VCL vinculin -0.0432529
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0418558
IFIH1 interferon induced with helicase C domain 1 -0.0400983
KLF6 Kruppel-like factor 6 -0.0387381
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0386342
KTN1 kinectin 1 (kinesin receptor) -0.038532
DLG1 discs, large homolog 1 (Drosophila) -0.0375792
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0372492
RPL31 ribosomal protein L31 -0.0368081
RPS24 ribosomal protein S24 -0.0365544
ZBTB38 zinc finger and BTB domain containing 38 -0.0363526
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0360521
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0359966
WARS1 tryptophanyl-tRNA synthetase 1 -0.0352143
PLSCR1 phospholipid scramblase 1 -0.0348534
ZNF217 zinc finger protein 217 -0.0344938
HLA-B major histocompatibility complex, class I, B -0.0343326
RSL1D1 ribosomal L1 domain containing 1 -0.0343277
EREG epiregulin -0.0342
BIRC2 baculoviral IAP repeat containing 2 -0.0339347
RPS8 ribosomal protein S8 -0.0337037
KDM3A lysine (K)-specific demethylase 3A -0.0331924
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0327337
WWTR1 WW domain containing transcription regulator 1 -0.0322737
FMNL2 formin-like 2 -0.0314806
CDK6 cyclin-dependent kinase 6 -0.0312718
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0311926
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0309067
MACF1 microtubule-actin crosslinking factor 1 -0.0303117
TOP1 topoisomerase (DNA) I -0.0299835
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.029674
PLK2 polo-like kinase 2 -0.0295496
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0294596
RGS4 regulator of G-protein signaling 4 -0.0293702
APP amyloid beta (A4) precursor protein -0.0293253
JUN jun proto-oncogene -0.0291281
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0290059
YBX1 Y box binding protein 1 -0.0288378
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0285618
CADM2 cell adhesion molecule 2 -0.0284715
RPS3 ribosomal protein S3 -0.0278291
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0277465
EPHA4 EPH receptor A4 -0.0277351
CFAP299 cilia and flagella associated protein 299 -0.0274969
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0270452
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0269459
JMJD1C jumonji domain containing 1C -0.026842
EMP1 epithelial membrane protein 1 -0.0267219
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0266931
NAP1L1 nucleosome assembly protein 1-like 1 -0.0266286
FBXO11 F-box protein 11 -0.026357
RPL26 ribosomal protein L26 -0.0261549
BIRC3 baculoviral IAP repeat containing 3 -0.0261162
EZR ezrin -0.026035
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0258761
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0258426
RPL19 ribosomal protein L19 -0.0257655
AHNAK2 AHNAK nucleoprotein 2 -0.0255558
RPL12 ribosomal protein L12 -0.0252122
KPNB1 karyopherin (importin) beta 1 -0.0249742
BCAR3 breast cancer anti-estrogen resistance 3 -0.0248167
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0246654
ADGRG6 adhesion G protein-coupled receptor G6 -0.024651
OGA O-GlcNAcase -0.0244069
H1-0 H1.0 linker histone -0.0243309
CMIP c-Maf inducing protein -0.024219
NF1 neurofibromin 1 -0.024215
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0240914
RAB27B RAB27B, member RAS oncogene family -0.0239939
OSBPL8 oxysterol binding protein-like 8 -0.023688
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0236095