Glycyrrhizic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.078237
TRIO trio Rho guanine nucleotide exchange factor 0.0730762
NAMPT nicotinamide phosphoribosyltransferase 0.060149
EEF1G eukaryotic translation elongation factor 1 gamma 0.0492485
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0486293
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.047313
DSCAM Down syndrome cell adhesion molecule 0.0459393
NAV2 neuron navigator 2 0.0456463
SMAD3 SMAD family member 3 0.0434554
GOLGA4 golgin A4 0.0415654
PRELID2 PRELI domain containing 2 0.0412501
NBAS neuroblastoma amplified sequence 0.0397652
RICTOR RPTOR independent companion of MTOR, complex 2 0.0388685
GRB10 growth factor receptor-bound protein 10 0.0369493
RBM39 RNA binding motif protein 39 0.0357023
PDE4D phosphodiesterase 4D, cAMP-specific 0.0356638
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0354862
PDIA3 protein disulfide isomerase family A, member 3 0.0346278
YEATS2 YEATS domain containing 2 0.0346199
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0343369
TAS2R14 taste receptor, type 2, member 14 0.0329362
EEF2 eukaryotic translation elongation factor 2 0.032109
FAM13A family with sequence similarity 13, member A 0.0319278
TENT5A terminal nucleotidyltransferase 5A 0.0318085
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.031792
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312054
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0311563
USP34 ubiquitin specific peptidase 34 0.0308087
WAC WW domain containing adaptor with coiled-coil 0.0295439
SRP54 signal recognition particle 54kDa 0.0295359
FAM20C family with sequence similarity 20, member C 0.0289664
SIK3 SIK family kinase 3 0.0289646
COG5 component of oligomeric golgi complex 5 0.0280563
ANKRD17 ankyrin repeat domain 17 0.027975
ITCH itchy E3 ubiquitin protein ligase 0.0279426
FNIP1 folliculin interacting protein 1 0.0278668
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0277536
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0277521
DLG1 discs, large homolog 1 (Drosophila) 0.0276807
IGFBP3 insulin-like growth factor binding protein 3 0.0276737
RUNX2 runt-related transcription factor 2 0.0275237
BIRC6 baculoviral IAP repeat containing 6 0.0275013
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0272167
MRPS6 mitochondrial ribosomal protein S6 0.0269063
MON2 MON2 homolog (S. cerevisiae) 0.0256809
STRN3 striatin, calmodulin binding protein 3 0.0250186
SBF2 SET binding factor 2 0.0248949
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0248861
ZFAND3 zinc finger, AN1-type domain 3 0.0245517
EFNA5 ephrin-A5 0.0244174
UBA6 ubiquitin-like modifier activating enzyme 6 0.02386
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0236474
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234908
OSMR oncostatin M receptor 0.0231731
NGLY1 N-glycanase 1 0.0229523
SAMD4A sterile alpha motif domain containing 4A 0.0226212
GPC6 glypican 6 0.0225692
RAB1A RAB1A, member RAS oncogene family 0.0223664
ATP13A3 ATPase type 13A3 0.0221594
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0220567
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0220495
LMAN1 lectin, mannose-binding, 1 0.0220024
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0218398
ACTG1 actin gamma 1 0.0216158
SEPTIN2 septin 2 0.0214523
RPL4 ribosomal protein L4 0.0213058
HDAC9 histone deacetylase 9 0.0212978
CTNND1 catenin (cadherin-associated protein), delta 1 0.0209654
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0209642
SUN1 Sad1 and UNC84 domain containing 1 0.0204588
FAM3C family with sequence similarity 3, member C 0.0201876
RPL13A ribosomal protein L13a 0.0200894
AKAP9 A kinase (PRKA) anchor protein 9 0.0199183
PICALM phosphatidylinositol binding clathrin assembly protein 0.0198527
ZCCHC7 zinc finger, CCHC domain containing 7 0.0197136
LIMCH1 LIM and calponin homology domains 1 0.0196371
LRRC49 leucine rich repeat containing 49 0.0194797
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0194397
RPS21 ribosomal protein S21 0.0192772
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.019017
SCFD1 sec1 family domain containing 1 0.0189962
MYOF myoferlin 0.018717
ZBTB20 zinc finger and BTB domain containing 20 0.0186723
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0185626
KMT2C lysine (K)-specific methyltransferase 2C 0.0184831
CLTC clathrin, heavy chain (Hc) 0.0184535
EXT1 exostosin glycosyltransferase 1 0.0183838
JAK1 Janus kinase 1 0.0182822
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0179857
RBM33 RNA binding motif protein 33 0.0179855
GCC2 GRIP and coiled-coil domain containing 2 0.0179546
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0178632
PUM2 pumilio RNA-binding family member 2 0.0177213
OGA O-GlcNAcase 0.0175925
CTNNBL1 catenin, beta like 1 0.0175551
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0173661
RPL23 ribosomal protein L23 0.0171659
ARHGAP32 Rho GTPase activating protein 32 0.0171276
MARCHF6 membrane associated ring-CH-type finger 6 0.0171106
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0171098

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.136286
TMSB10 thymosin beta 10 -0.130661
VIM vimentin -0.124917
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0982656
CD44 CD44 molecule (Indian blood group) -0.0571489
AKAP12 A kinase (PRKA) anchor protein 12 -0.0521894
MT2A metallothionein 2A -0.0480317
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0476597
NDRG1 N-myc downstream regulated 1 -0.0446995
PTMA prothymosin, alpha -0.0442419
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0439185
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0413727
RPL31 ribosomal protein L31 -0.037853
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0375252
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0346439
EGR1 early growth response 1 -0.0345763
RPS12 ribosomal protein S12 -0.0321142
GLCCI1 glucocorticoid induced 1 -0.0299119
STC1 stanniocalcin 1 -0.0294514
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0292817
LOC102724023 ES1 protein homolog, mitochondrial -0.0279238
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0271619
ECE1 endothelin converting enzyme 1 -0.0266706
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.026611
FN1 fibronectin 1 -0.0256419
TFPI2 tissue factor pathway inhibitor 2 -0.0254262
IER3 immediate early response 3 -0.0248477
C15ORF48 chromosome 15 open reading frame 48 -0.0237478
EZR ezrin -0.023075
MYO10 myosin X -0.022697
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0226282
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0224091
CDCP1 CUB domain containing protein 1 -0.0223562
PNRC1 proline-rich nuclear receptor coactivator 1 -0.022033
SDK1 sidekick cell adhesion molecule 1 -0.0216043
ELL2 elongation factor, RNA polymerase II, 2 -0.021332
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0206626
PLIN2 perilipin 2 -0.0203057
ANGPTL4 angiopoietin-like 4 -0.0202639
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0202481
RPS17 ribosomal protein S17 -0.0201098
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0199354
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0192576
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0190504
SAMD9 sterile alpha motif domain containing 9 -0.0189036
NTN4 netrin 4 -0.0187504
SYAP1 synapse associated protein 1 -0.0183449
TGFB1 transforming growth factor, beta 1 -0.017911
ZMYND8 zinc finger, MYND-type containing 8 -0.0174885
IFI6 interferon, alpha-inducible protein 6 -0.0169244
KLF6 Kruppel-like factor 6 -0.0166095
NCOA7 nuclear receptor coactivator 7 -0.0165613
RPS8 ribosomal protein S8 -0.016519
RPL19 ribosomal protein L19 -0.0164516
RPS5 ribosomal protein S5 -0.0164396
TPT1 tumor protein, translationally-controlled 1 -0.0164023
KTN1 kinectin 1 (kinesin receptor) -0.0163652
HAS2 hyaluronan synthase 2 -0.0162898
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0162308
JUN jun proto-oncogene -0.0155256
S100A10 S100 calcium binding protein A10 -0.0152861
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0152179
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0151743
RPL32 ribosomal protein L32 -0.0151596
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0149661
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0147519
RAB27B RAB27B, member RAS oncogene family -0.0142017
NRG1 neuregulin 1 -0.0141676
SOX4 SRY (sex determining region Y)-box 4 -0.0139715
TGM2 transglutaminase 2 -0.0139179
IFI16 interferon, gamma-inducible protein 16 -0.013803
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0137657
RPLP1 ribosomal protein, large, P1 -0.0136318
MT1X metallothionein 1X -0.0135865
CST3 cystatin C -0.0135098
RPS24 ribosomal protein S24 -0.0134579
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0131877
IFITM3 interferon induced transmembrane protein 3 -0.0131071
ARHGAP5 Rho GTPase activating protein 5 -0.0129932
KDM2A lysine (K)-specific demethylase 2A -0.0129353
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.0127172
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0125854
ASPH aspartate beta-hydroxylase -0.0125584
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0125043
PLAUR plasminogen activator, urokinase receptor -0.0124918
LIMA1 LIM domain and actin binding 1 -0.0124145
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0123933
CA12 carbonic anhydrase XII -0.0123458
EIF1 eukaryotic translation initiation factor 1 -0.0122832
LTBP1 latent transforming growth factor beta binding protein 1 -0.012103
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0119513
CANX calnexin -0.0118813
RPL36AL ribosomal protein L36a-like -0.0117828
MARCHF3 membrane associated ring-CH-type finger 3 -0.0117338
PRR16 proline rich 16 -0.0116411
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0114972
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0114597
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.011389
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0113726
TMCC3 transmembrane and coiled-coil domain family 3 -0.0112908