Glycyrrhizic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 0.0954759
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0719991
EEF1G eukaryotic translation elongation factor 1 gamma 0.0653392
RPL4 ribosomal protein L4 0.0358383
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0337137
YBX3 Y box binding protein 3 0.0333947
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303329
USP3 ubiquitin specific peptidase 3 0.0294241
RRM2 ribonucleotide reductase M2 0.0293274
RTN4 reticulon 4 0.0281501
EEF2 eukaryotic translation elongation factor 2 0.0281422
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276877
CCNL1 cyclin L1 0.0270299
NUP58 nucleoporin 58 0.026024
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0260155
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0247605
WDR43 WD repeat domain 43 0.0244919
NAMPT nicotinamide phosphoribosyltransferase 0.0242892
APP amyloid beta (A4) precursor protein 0.023252
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.022856
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.022654
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0226217
ZNF292 zinc finger protein 292 0.0225221
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0223414
HSPA8 heat shock 70kDa protein 8 0.0219698
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0218936
KMT2E lysine (K)-specific methyltransferase 2E 0.0205115
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.020437
FAM168A family with sequence similarity 168, member A 0.0198006
JAK1 Janus kinase 1 0.0197609
ADGRG6 adhesion G protein-coupled receptor G6 0.019649
MIS18BP1 MIS18 binding protein 1 0.0194507
RAD21 RAD21 homolog (S. pombe) 0.0189301
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0180194
ZFAND3 zinc finger, AN1-type domain 3 0.0176233
NCKAP1 NCK-associated protein 1 0.017396
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.017329
PKM pyruvate kinase, muscle 0.0172191
RBM33 RNA binding motif protein 33 0.0170725
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0168887
RBM39 RNA binding motif protein 39 0.0163994
ANXA5 annexin A5 0.0162317
FLNA filamin A, alpha 0.0161672
TRA2B transformer 2 beta homolog (Drosophila) 0.01602
THBS1 thrombospondin 1 0.0157906
MKI67 marker of proliferation Ki-67 0.0155723
PDIA3 protein disulfide isomerase family A, member 3 0.0154275
ANKRD28 ankyrin repeat domain 28 0.0154044
SMAD3 SMAD family member 3 0.0152125
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0151984
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0150245
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0150215
PDS5A PDS5 cohesin associated factor A 0.0149557
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0149267
ECT2 epithelial cell transforming 2 0.0148174
SPAG9 sperm associated antigen 9 0.0147972
IST1 increased sodium tolerance 1 homolog (yeast) 0.0146728
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0144249
CHN1 chimerin 1 0.014404
OLA1 Obg-like ATPase 1 0.0143729
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0142635
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0142105
EIF4A2 eukaryotic translation initiation factor 4A2 0.0141723
KDM3A lysine (K)-specific demethylase 3A 0.0141424
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0140286
TMEM123 transmembrane protein 123 0.0140008
PUM2 pumilio RNA-binding family member 2 0.0139526
NCOR1 nuclear receptor corepressor 1 0.0139113
SP3 Sp3 transcription factor 0.0138428
FXR1 fragile X mental retardation, autosomal homolog 1 0.0136347
MATR3 matrin 3 0.0135916
MTMR3 myotubularin related protein 3 0.0132119
CPNE8 copine VIII 0.0132013
ADAM17 ADAM metallopeptidase domain 17 0.0131999
PTK2 protein tyrosine kinase 2 0.0131846
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0131211
NUP153 nucleoporin 153kDa 0.013076
PABPN1 poly(A) binding protein, nuclear 1 0.0129885
RPL13A ribosomal protein L13a 0.0128761
ANKRD11 ankyrin repeat domain 11 0.0128315
AGFG1 ArfGAP with FG repeats 1 0.0127828
BUB3 BUB3 mitotic checkpoint protein 0.0127608
FKBP10 FK506 binding protein 10, 65 kDa 0.0126479
BIRC3 baculoviral IAP repeat containing 3 0.0125318
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0125256
TENT4A terminal nucleotidyltransferase 4A 0.0125011
UBAP2L ubiquitin associated protein 2-like 0.0124855
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.012444
WBP11 WW domain binding protein 11 0.0124368
UCK2 uridine-cytidine kinase 2 0.0124162
PTBP1 polypyrimidine tract binding protein 1 0.0123987
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0123628
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0123154
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.012271
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.0122642
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0121969
CBFB core-binding factor, beta subunit 0.0121785
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0121353
RPS21 ribosomal protein S21 0.0120775
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.012062

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.137202
FTL ferritin, light polypeptide -0.113191
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0846415
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0835391
VIM vimentin -0.0722431
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0469027
MT2A metallothionein 2A -0.0435953
PM20D1 peptidase M20 domain containing 1 -0.0383742
DOCK4 dedicator of cytokinesis 4 -0.035701
THSD4 thrombospondin, type I, domain containing 4 -0.0342044
EGR1 early growth response 1 -0.0315783
AKAP12 A kinase (PRKA) anchor protein 12 -0.0314845
IGF2 insulin-like growth factor 2 -0.0307865
IGFBP3 insulin-like growth factor binding protein 3 -0.0259748
SVIL supervillin -0.0241153
GRAMD1B GRAM domain containing 1B -0.0240608
IER3 immediate early response 3 -0.0231277
LOC102724023 ES1 protein homolog, mitochondrial -0.0223124
PDE4D phosphodiesterase 4D, cAMP-specific -0.0220333
RPL31 ribosomal protein L31 -0.0218172
C15ORF48 chromosome 15 open reading frame 48 -0.0213237
S100A6 S100 calcium binding protein A6 -0.0211427
TPM4 tropomyosin 4 -0.0211296
POTEF POTE ankyrin domain family, member F -0.0209656
TXNRD1 thioredoxin reductase 1 -0.0206235
RPS17 ribosomal protein S17 -0.0199589
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0193894
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0193812
BASP1 brain abundant, membrane attached signal protein 1 -0.0188827
CMIP c-Maf inducing protein -0.0187155
OSMR oncostatin M receptor -0.0184046
ZBTB20 zinc finger and BTB domain containing 20 -0.0175364
KTN1 kinectin 1 (kinesin receptor) -0.0172121
MAML3 mastermind-like 3 (Drosophila) -0.0169565
BICC1 BicC family RNA binding protein 1 -0.0167106
PYGL phosphorylase, glycogen, liver -0.0164361
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0163042
ARHGAP26 Rho GTPase activating protein 26 -0.0163002
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0159785
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0156539
HLA-B major histocompatibility complex, class I, B -0.0154347
RPL19 ribosomal protein L19 -0.0152616
HDAC9 histone deacetylase 9 -0.0150105
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.014828
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0148061
NEBL nebulette -0.0147996
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0147838
DOCK5 dedicator of cytokinesis 5 -0.0144599
S100A10 S100 calcium binding protein A10 -0.0140048
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0138834
PDLIM5 PDZ and LIM domain 5 -0.0137436
RICTOR RPTOR independent companion of MTOR, complex 2 -0.013723
VMP1 vacuole membrane protein 1 -0.0135156
EHBP1 EH domain binding protein 1 -0.0134795
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0131585
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0131484
EIF1 eukaryotic translation initiation factor 1 -0.0130241
KYNU kynureninase -0.0128392
EGFR epidermal growth factor receptor -0.0126456
NTN4 netrin 4 -0.0125612
COPA coatomer protein complex, subunit alpha -0.0124567
PLS3 plastin 3 -0.0124107
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0123254
CUX1 cut-like homeobox 1 -0.0122588
EXT1 exostosin glycosyltransferase 1 -0.0121647
RPL36AL ribosomal protein L36a-like -0.0120847
PCNX4 pecanex 4 -0.0119693
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0118885
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0118227
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0113202
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0111733
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0111709
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0111206
FGB fibrinogen beta chain -0.0109225
ASTN2 astrotactin 2 -0.0107793
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0107681
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0107611
GLIS3 GLIS family zinc finger 3 -0.010695
TMEM87A transmembrane protein 87A -0.0106829
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.010633
RPL28 ribosomal protein L28 -0.0103967
CALD1 caldesmon 1 -0.0102941
MCL1 myeloid cell leukemia 1 -0.0102239
RPS8 ribosomal protein S8 -0.0101009
RPS3 ribosomal protein S3 -0.0100805
CDK12 cyclin-dependent kinase 12 -0.010047
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0100327
ARF4 ADP-ribosylation factor 4 -0.00996944
RPS27A ribosomal protein S27a -0.00993454
FOS FBJ murine osteosarcoma viral oncogene homolog -0.00990613
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.00989724
RAB31 RAB31, member RAS oncogene family -0.00984809
LAMC2 laminin, gamma 2 -0.0098004
BRD2 bromodomain containing 2 -0.00975413
BICD1 bicaudal D homolog 1 (Drosophila) -0.00973106
JMJD1C jumonji domain containing 1C -0.00971851
GLG1 golgi glycoprotein 1 -0.00965974
RPS12 ribosomal protein S12 -0.00959162
BPTF bromodomain PHD finger transcription factor -0.00951405
NEGR1 neuronal growth regulator 1 -0.00944955