Glycyrrhizic acid_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.117424
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109564
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0954687
RPS16 ribosomal protein S16 0.0877143
PDE10A phosphodiesterase 10A 0.0777621
PRRC2C proline-rich coiled-coil 2C 0.0761006
SMAD3 SMAD family member 3 0.0748834
FN1 fibronectin 1 0.0728225
MT2A metallothionein 2A 0.0716985
LMNA lamin A/C 0.0707233
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.070191
IGF2 insulin-like growth factor 2 0.0657014
SMYD3 SET and MYND domain containing 3 0.0637117
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0626691
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0601523
FBL fibrillarin 0.0601172
MYOF myoferlin 0.0600832
MYO9B myosin IXB 0.0553685
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0544739
FAT1 FAT atypical cadherin 1 0.0538492
RPL23 ribosomal protein L23 0.053833
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.053436
EEF1G eukaryotic translation elongation factor 1 gamma 0.050644
VIM vimentin 0.0498715
RORA RAR-related orphan receptor A 0.0497718
AREG amphiregulin 0.0493932
SAMD4A sterile alpha motif domain containing 4A 0.0491144
GARS1 glycyl-tRNA synthetase 1 0.0483089
CENPF centromere protein F, 350/400kDa 0.0481016
RPS21 ribosomal protein S21 0.0480506
SRRM2 serine/arginine repetitive matrix 2 0.0473318
ATXN1 ataxin 1 0.0473295
ANKRD17 ankyrin repeat domain 17 0.047076
RPL34 ribosomal protein L34 0.0468593
TMEM165 transmembrane protein 165 0.0467512
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0459633
GPC6 glypican 6 0.0458915
MKI67 marker of proliferation Ki-67 0.0455102
FBF1 Fas (TNFRSF6) binding factor 1 0.0454141
NAV2 neuron navigator 2 0.0453448
RPS3 ribosomal protein S3 0.0449771
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0446761
SAMD4B sterile alpha motif domain containing 4B 0.0445455
POTEF POTE ankyrin domain family, member F 0.0445407
SND1 staphylococcal nuclease and tudor domain containing 1 0.0421932
DST dystonin 0.0416564
TENM3 teneurin transmembrane protein 3 0.0415202
VMP1 vacuole membrane protein 1 0.0413671
CTNND1 catenin (cadherin-associated protein), delta 1 0.0409871
CCDC88A coiled-coil domain containing 88A 0.0407833
ANKHD1 ankyrin repeat and KH domain containing 1 0.040765
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0404443
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0400215
FUS FUS RNA binding protein 0.0399589
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0391773
SEPTIN7 septin 7 0.0390458
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0390362
HMGA1 high mobility group AT-hook 1 0.0375523
PIBF1 progesterone immunomodulatory binding factor 1 0.0372747
MSI2 musashi RNA-binding protein 2 0.037199
ERRFI1 ERBB receptor feedback inhibitor 1 0.0368527
PRKCA protein kinase C, alpha 0.0362463
PCBP2 poly(rC) binding protein 2 0.0362414
RNF213 ring finger protein 213 0.0361972
EEF2 eukaryotic translation elongation factor 2 0.0360917
MORF4L2 mortality factor 4 like 2 0.0359385
HLA-B major histocompatibility complex, class I, B 0.035882
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0358572
STAG2 stromal antigen 2 0.0357909
MYH10 myosin, heavy chain 10, non-muscle 0.0351195
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0350299
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0349109
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0348952
GLS2 glutaminase 2 (liver, mitochondrial) 0.0348136
DUSP5 dual specificity phosphatase 5 0.034741
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0346359
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.034635
SBF2 SET binding factor 2 0.0336743
FOXK2 forkhead box K2 0.0336523
TRIO trio Rho guanine nucleotide exchange factor 0.0335993
ARHGAP5 Rho GTPase activating protein 5 0.0332178
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0329244
RPS11 ribosomal protein S11 0.0328705
TBC1D22A TBC1 domain family, member 22A 0.0327905
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0325498
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0322187
RPL13A ribosomal protein L13a 0.0321637
NDFIP1 Nedd4 family interacting protein 1 0.0317939
ZC3H13 zinc finger CCCH-type containing 13 0.031738
ENO1 enolase 1, (alpha) 0.0315612
TCERG1 transcription elongation regulator 1 0.0313111
SFXN1 sideroflexin 1 0.0311384
TOP1 topoisomerase (DNA) I 0.0310377
TTC17 tetratricopeptide repeat domain 17 0.0306043
GLG1 golgi glycoprotein 1 0.0305898
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0300501
ARB2A ARB2 cotranscriptional regulator A 0.0298989
ACTN4 actinin, alpha 4 0.0298066
NIPBL Nipped-B homolog (Drosophila) 0.0293804
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0293702

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.158658
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.157031
LAMB3 laminin, beta 3 -0.131381
TMSB10 thymosin beta 10 -0.127155
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.121374
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.119996
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.11065
NAMPT nicotinamide phosphoribosyltransferase -0.101445
KRT17 keratin 17, type I -0.0992971
ASPH aspartate beta-hydroxylase -0.0987121
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0942942
DSCAM Down syndrome cell adhesion molecule -0.0912998
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0904422
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0854738
PDE4D phosphodiesterase 4D, cAMP-specific -0.078602
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.077692
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0750837
OGA O-GlcNAcase -0.0748025
NPTN neuroplastin -0.0725606
DICER1 dicer 1, ribonuclease type III -0.0723888
KMT2C lysine (K)-specific methyltransferase 2C -0.072201
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0714342
PICALM phosphatidylinositol binding clathrin assembly protein -0.0706937
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0674476
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0672517
KTN1 kinectin 1 (kinesin receptor) -0.0669897
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0667833
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0657437
EXT1 exostosin glycosyltransferase 1 -0.06467
GRB10 growth factor receptor-bound protein 10 -0.063687
UBC ubiquitin C -0.0636539
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0622044
TPT1 tumor protein, translationally-controlled 1 -0.0610484
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0598785
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0591064
SRPK2 SRSF protein kinase 2 -0.0588636
ACVR1 activin A receptor, type I -0.0583806
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0583296
KDM6A lysine (K)-specific demethylase 6A -0.0574232
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0568959
IFIH1 interferon induced with helicase C domain 1 -0.0562358
GOLGA4 golgin A4 -0.056176
KYNU kynureninase -0.055373
NEK7 NIMA-related kinase 7 -0.0545214
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0536382
GCLC glutamate-cysteine ligase, catalytic subunit -0.0524264
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0513967
RBM39 RNA binding motif protein 39 -0.0502535
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0494673
RAB8B RAB8B, member RAS oncogene family -0.0485896
FNDC3B fibronectin type III domain containing 3B -0.0483311
MXD1 MAX dimerization protein 1 -0.0479737
KDM3A lysine (K)-specific demethylase 3A -0.0473023
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0466681
RNF149 ring finger protein 149 -0.0465678
MEF2A myocyte enhancer factor 2A -0.0465001
SSH2 slingshot protein phosphatase 2 -0.0461132
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0451368
PLAUR plasminogen activator, urokinase receptor -0.0447842
MARCHF6 membrane associated ring-CH-type finger 6 -0.044601
ARID4B AT rich interactive domain 4B (RBP1-like) -0.044587
STC1 stanniocalcin 1 -0.0443279
BBX bobby sox homolog (Drosophila) -0.0437303
PTMA prothymosin, alpha -0.043519
ZNF638 zinc finger protein 638 -0.0432111
EFNA5 ephrin-A5 -0.0430102
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0423809
KDM5B lysine (K)-specific demethylase 5B -0.0422714
ZNFX1 zinc finger, NFX1-type containing 1 -0.0415794
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0415548
TXNRD1 thioredoxin reductase 1 -0.0415261
TRA2A transformer 2 alpha homolog (Drosophila) -0.0407091
ZEB1 zinc finger E-box binding homeobox 1 -0.04067
H3-3B H3.3 histone B -0.0404345
NPEPPS aminopeptidase puromycin sensitive -0.0401089
RAB10 RAB10, member RAS oncogene family -0.0397064
S100A6 S100 calcium binding protein A6 -0.0384378
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0384277
TNIP1 TNFAIP3 interacting protein 1 -0.038192
GNAS GNAS complex locus -0.0379332
PKM pyruvate kinase, muscle -0.0374125
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0372375
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0370464
CANX calnexin -0.0367083
RAB1A RAB1A, member RAS oncogene family -0.0367002
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0366855
ZMYND8 zinc finger, MYND-type containing 8 -0.035748
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.03558
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0353756
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0353126
CDK6 cyclin-dependent kinase 6 -0.0349845
RPS24 ribosomal protein S24 -0.0344116
SNX9 sorting nexin 9 -0.0343859
JMJD1C jumonji domain containing 1C -0.0337286
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0331944
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0331566
RB1CC1 RB1-inducible coiled-coil 1 -0.0325442
FTH1 ferritin, heavy polypeptide 1 -0.0322491
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0319079
AKAP9 A kinase (PRKA) anchor protein 9 -0.031502