Glycyrrhizic acid_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.238391
EEF2 eukaryotic translation elongation factor 2 0.101
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0788246
CSDE1 cold shock domain containing E1, RNA-binding 0.0773514
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0719234
PGK1 phosphoglycerate kinase 1 0.0711462
THSD4 thrombospondin, type I, domain containing 4 0.0670199
CCNL1 cyclin L1 0.0655463
OSMR oncostatin M receptor 0.0616661
EEF1G eukaryotic translation elongation factor 1 gamma 0.0606693
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0589491
EGR1 early growth response 1 0.0579524
EML4 echinoderm microtubule associated protein like 4 0.0553438
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0547377
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0524953
SPRED2 sprouty-related, EVH1 domain containing 2 0.0495792
NF1 neurofibromin 1 0.0484593
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0481263
KCMF1 potassium channel modulatory factor 1 0.0454867
ZFR zinc finger RNA binding protein 0.0450774
NUP58 nucleoporin 58 0.0443213
BIRC6 baculoviral IAP repeat containing 6 0.0439247
FLNA filamin A, alpha 0.0438322
LDHA lactate dehydrogenase A 0.0426414
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0423415
PKM pyruvate kinase, muscle 0.0400997
UBAP2L ubiquitin associated protein 2-like 0.0398654
ADAR adenosine deaminase, RNA-specific 0.0393369
EIF4B eukaryotic translation initiation factor 4B 0.0392303
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0388905
PFN1 profilin 1 0.0387741
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0386088
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0386044
PRPF8 pre-mRNA processing factor 8 0.038262
SMAD3 SMAD family member 3 0.0373685
SLC38A2 solute carrier family 38, member 2 0.0367412
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0367348
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0365141
VMP1 vacuole membrane protein 1 0.0360018
WASF2 WAS protein family, member 2 0.0348936
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0347785
RPL4 ribosomal protein L4 0.0344113
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0343421
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0341088
SEPTIN2 septin 2 0.0336188
SNX9 sorting nexin 9 0.0334384
RAB7A RAB7A, member RAS oncogene family 0.0332795
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0325927
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0325834
USP22 ubiquitin specific peptidase 22 0.0324095
ATXN2L ataxin 2-like 0.0319071
ZNF292 zinc finger protein 292 0.0318302
RICTOR RPTOR independent companion of MTOR, complex 2 0.031735
PTBP1 polypyrimidine tract binding protein 1 0.0313246
ARID1A AT rich interactive domain 1A (SWI-like) 0.0308675
MARCHF4 membrane associated ring-CH-type finger 4 0.0307497
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0304683
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.030328
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0301277
KPNB1 karyopherin (importin) beta 1 0.0300878
COPA coatomer protein complex, subunit alpha 0.0297137
MOB1A MOB kinase activator 1A 0.029418
RPN1 ribophorin I 0.0293752
TCERG1 transcription elongation regulator 1 0.029333
NUP155 nucleoporin 155kDa 0.0292934
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0286462
TBK1 TANK-binding kinase 1 0.0285767
SREBF2 sterol regulatory element binding transcription factor 2 0.0285378
PCBP1 poly(rC) binding protein 1 0.0285284
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0285193
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0284104
CAMTA1 calmodulin binding transcription activator 1 0.028264
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0282631
MORF4L2 mortality factor 4 like 2 0.0281991
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0278606
ZFP64 ZFP64 zinc finger protein 0.0277491
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0275966
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0273791
ZNF207 zinc finger protein 207 0.027126
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0268609
INTS1 integrator complex subunit 1 0.0264203
TNPO3 transportin 3 0.025969
RBBP4 retinoblastoma binding protein 4 0.0259464
EHBP1 EH domain binding protein 1 0.0258935
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0258754
DAND5 DAN domain family member 5, BMP antagonist 0.0257185
GANAB glucosidase, alpha; neutral AB 0.0256794
SFTPA2 surfactant protein A2 0.025445
RNF213 ring finger protein 213 0.0253168
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0250401
MAT2A methionine adenosyltransferase II, alpha 0.024991
NONO non-POU domain containing, octamer-binding 0.0249835
LDHB lactate dehydrogenase B 0.0249413
ANKRD28 ankyrin repeat domain 28 0.0248856
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0247148
ICAM1 intercellular adhesion molecule 1 0.0246768
KLF6 Kruppel-like factor 6 0.0245402
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0244473
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0243102
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0242206

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.185758
YBX3 Y box binding protein 3 -0.126246
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.11764
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.101744
PTMA prothymosin, alpha -0.0893898
KTN1 kinectin 1 (kinesin receptor) -0.0880698
RPS29 ribosomal protein S29 -0.0662168
RPS8 ribosomal protein S8 -0.0658875
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0653989
AKAP12 A kinase (PRKA) anchor protein 12 -0.0589643
GOLGB1 golgin B1 -0.0589277
RPS2 ribosomal protein S2 -0.0571829
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0567603
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0566613
RPL12 ribosomal protein L12 -0.0561456
RPL37 ribosomal protein L37 -0.0517867
RPS3 ribosomal protein S3 -0.0502877
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0501392
RPS19 ribosomal protein S19 -0.0497298
NIPBL Nipped-B homolog (Drosophila) -0.0495364
MT2A metallothionein 2A -0.0488313
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0480669
RPS27A ribosomal protein S27a -0.0477005
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0464232
RPL26 ribosomal protein L26 -0.0450471
RPS6 ribosomal protein S6 -0.0446618
RPL9 ribosomal protein L9 -0.0426595
RPLP1 ribosomal protein, large, P1 -0.0422515
MYL12B myosin, light chain 12B, regulatory -0.0415637
EIF5B eukaryotic translation initiation factor 5B -0.0414599
RPL36 ribosomal protein L36 -0.0411112
STK4 serine/threonine kinase 4 -0.0407919
RPL38 ribosomal protein L38 -0.0404041
RPL23 ribosomal protein L23 -0.0397513
RPS10 ribosomal protein S10 -0.039682
RPS21 ribosomal protein S21 -0.0391412
RPL5 ribosomal protein L5 -0.0391115
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0376862
TPT1 tumor protein, translationally-controlled 1 -0.0373211
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0371919
EIF1 eukaryotic translation initiation factor 1 -0.0369213
DST dystonin -0.0365026
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0361865
TPI1 triosephosphate isomerase 1 -0.0352089
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0340615
RPS15 ribosomal protein S15 -0.0337916
INTS6 integrator complex subunit 6 -0.0336243
RPL7 ribosomal protein L7 -0.0334246
ANO6 anoctamin 6 -0.0333363
CALD1 caldesmon 1 -0.0330946
RPS12 ribosomal protein S12 -0.0330647
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0327888
RPLP2 ribosomal protein, large, P2 -0.032542
RPL7A ribosomal protein L7a -0.0315636
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0313572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0313224
WNT2B wingless-type MMTV integration site family, member 2B -0.0306636
GPX4 glutathione peroxidase 4 -0.0295556
RPL19 ribosomal protein L19 -0.0291944
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0290314
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0287227
AEBP2 AE binding protein 2 -0.0278315
KDM2A lysine (K)-specific demethylase 2A -0.0276577
RPL32 ribosomal protein L32 -0.0275601
RPL34 ribosomal protein L34 -0.0272594
TPX2 TPX2, microtubule-associated -0.0266822
RSL24D1 ribosomal L24 domain containing 1 -0.0262804
RPS27 ribosomal protein S27 -0.0262495
CSNK1A1 casein kinase 1, alpha 1 -0.0261402
NUSAP1 nucleolar and spindle associated protein 1 -0.026029
RPL37A ribosomal protein L37a -0.0258499
LRRC23 leucine rich repeat containing 23 -0.0257765
B2M beta-2-microglobulin -0.025685
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0255543
ZFAND3 zinc finger, AN1-type domain 3 -0.0251981
RPL27 ribosomal protein L27 -0.0249625
SET SET nuclear proto-oncogene -0.0248472
PHF20L1 PHD finger protein 20-like 1 -0.0248404
JMJD1C jumonji domain containing 1C -0.0247105
RPS25 ribosomal protein S25 -0.0245908
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0245422
RPL3 ribosomal protein L3 -0.0242622
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0241568
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0240398
RPS13 ribosomal protein S13 -0.0237486
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0237076
RPL31 ribosomal protein L31 -0.0236488
TPM3 tropomyosin 3 -0.0236473
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0235762
PFDN2 prefoldin subunit 2 -0.0230563
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229219
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0227913
TBCA tubulin folding cofactor A -0.0227295
RSRP1 arginine/serine-rich protein 1 -0.0227143
DENR density-regulated protein -0.0224982
PRPF4B pre-mRNA processing factor 4B -0.0224274
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0224114
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0223149
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0222931
HSPE1 heat shock 10kDa protein 1 -0.0221816