Glycyrrhizic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.14097
ZNF292 zinc finger protein 292 0.0873552
ZFAND3 zinc finger, AN1-type domain 3 0.0812928
ENAH enabled homolog (Drosophila) 0.0741801
CDC73 cell division cycle 73 0.0730373
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0724837
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0686879
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0678536
PGAP1 post-GPI attachment to proteins 1 0.0674054
USP3 ubiquitin specific peptidase 3 0.0665654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0618331
PUM1 pumilio RNA-binding family member 1 0.0615603
ACTG1 actin gamma 1 0.0598658
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0593323
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0591877
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0589458
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.058428
PEG10 paternally expressed 10 0.0582418
HDAC9 histone deacetylase 9 0.0558116
ADAM9 ADAM metallopeptidase domain 9 0.0544203
MRPS30 mitochondrial ribosomal protein S30 0.0542936
ANKRD33B ankyrin repeat domain 33B 0.0535085
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0526242
WDR43 WD repeat domain 43 0.0520432
CSDE1 cold shock domain containing E1, RNA-binding 0.0515054
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0495123
FBXO11 F-box protein 11 0.047576
NCKAP1 NCK-associated protein 1 0.0475542
RASAL2 RAS protein activator like 2 0.0470671
THBS1 thrombospondin 1 0.0466015
EEF1G eukaryotic translation elongation factor 1 gamma 0.0454873
NACA nascent polypeptide-associated complex alpha subunit 0.0452156
KIF5B kinesin family member 5B 0.0449638
EEF2 eukaryotic translation elongation factor 2 0.0431525
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0425018
STRN3 striatin, calmodulin binding protein 3 0.0424699
RHEB Ras homolog enriched in brain 0.0424387
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0421062
PDGFC platelet derived growth factor C 0.0410316
MARCHF6 membrane associated ring-CH-type finger 6 0.0409526
RAI1 retinoic acid induced 1 0.0406829
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0406177
MB21D2 Mab-21 domain containing 2 0.0400814
SFPQ splicing factor proline/glutamine-rich 0.0399906
POTEF POTE ankyrin domain family, member F 0.0393607
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0393348
RAD21 RAD21 homolog (S. pombe) 0.0393091
EMP1 epithelial membrane protein 1 0.0390168
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.038629
FNDC3B fibronectin type III domain containing 3B 0.0379151
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0378549
FAM171B family with sequence similarity 171, member B 0.03783
CALR calreticulin 0.0372955
RYBP RING1 and YY1 binding protein 0.0362082
NAMPT nicotinamide phosphoribosyltransferase 0.0360092
PUM2 pumilio RNA-binding family member 2 0.0357957
GPC3 glypican 3 0.0348706
USP25 ubiquitin specific peptidase 25 0.034818
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0347968
TRA2A transformer 2 alpha homolog (Drosophila) 0.0345943
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0344891
FUBP1 far upstream element (FUSE) binding protein 1 0.033321
YAP1 Yes-associated protein 1 0.0332381
ANXA5 annexin A5 0.0329003
ZFR zinc finger RNA binding protein 0.0327608
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0321629
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0313687
ZC3H15 zinc finger CCCH-type containing 15 0.0313293
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0311785
FUS FUS RNA binding protein 0.0309822
IGF1R insulin-like growth factor 1 receptor 0.0308874
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0306579
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0303084
ANXA2 annexin A2 0.0301546
MEMO1 mediator of cell motility 1 0.0301373
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0300075
APP amyloid beta (A4) precursor protein 0.0298985
MATR3 matrin 3 0.029815
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0295406
ARHGAP12 Rho GTPase activating protein 12 0.0295246
OLA1 Obg-like ATPase 1 0.0294911
CCNL1 cyclin L1 0.0294643
KDM1A lysine (K)-specific demethylase 1A 0.0292691
BCLAF1 BCL2-associated transcription factor 1 0.0290651
PICALM phosphatidylinositol binding clathrin assembly protein 0.0287084
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.028449
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282271
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0281535
TRIO trio Rho guanine nucleotide exchange factor 0.0281325
SLMAP sarcolemma associated protein 0.0281146
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0279777
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0278864
PHF3 PHD finger protein 3 0.0278474
TRIP12 thyroid hormone receptor interactor 12 0.0278074
ADGRL2 adhesion G protein-coupled receptor L2 0.0277693
PDIA3 protein disulfide isomerase family A, member 3 0.0275461
CORO1C coronin, actin binding protein, 1C 0.0274836
LHFPL6 LHFPL tetraspan subfamily member 6 0.0273004
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0271753
NEK7 NIMA-related kinase 7 0.0268407

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.155878
TMSB10 thymosin beta 10 -0.0853307
CADM2 cell adhesion molecule 2 -0.0753723
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0703944
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0658998
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0589661
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0561026
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0492973
MBD5 methyl-CpG binding domain protein 5 -0.0417968
MDK midkine (neurite growth-promoting factor 2) -0.041418
RPS12 ribosomal protein S12 -0.0409439
SNX6 sorting nexin 6 -0.0386065
PCLO piccolo presynaptic cytomatrix protein -0.0385205
CUX1 cut-like homeobox 1 -0.0382772
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0354725
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0349982
RPS6 ribosomal protein S6 -0.0347523
CSMD3 CUB and Sushi multiple domains 3 -0.0339694
RPL19 ribosomal protein L19 -0.033767
FTL ferritin, light polypeptide -0.0335999
RPL31 ribosomal protein L31 -0.0334211
PCDH9 protocadherin 9 -0.0331554
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0323721
RPS3 ribosomal protein S3 -0.0316569
RPL12 ribosomal protein L12 -0.0316548
NTM neurotrimin -0.0312956
TUBA1B tubulin, alpha 1b -0.031114
RPLP1 ribosomal protein, large, P1 -0.0308696
KTN1 kinectin 1 (kinesin receptor) -0.0307506
NPAS3 neuronal PAS domain protein 3 -0.0294865
PTMA prothymosin, alpha -0.028957
ZBTB20 zinc finger and BTB domain containing 20 -0.0287682
RAD51B RAD51 paralog B -0.0283353
RPS24 ribosomal protein S24 -0.0283327
YBX1 Y box binding protein 1 -0.0277702
RAB31 RAB31, member RAS oncogene family -0.0277684
FOXP2 forkhead box P2 -0.0270239
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0261635
STMN1 stathmin 1 -0.0259618
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.025769
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0252826
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0250828
GSE1 Gse1 coiled-coil protein -0.0250468
DOCK5 dedicator of cytokinesis 5 -0.0245906
RPLP2 ribosomal protein, large, P2 -0.0244612
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0242772
ZC3H12B zinc finger CCCH-type containing 12B -0.0242057
SCFD1 sec1 family domain containing 1 -0.0238729
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0236985
SMC4 structural maintenance of chromosomes 4 -0.0232835
APOE apolipoprotein E -0.023173
PHIP pleckstrin homology domain interacting protein -0.0231721
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0230354
SSH2 slingshot protein phosphatase 2 -0.0227954
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.022714
UBE2B ubiquitin-conjugating enzyme E2B -0.0223586
RPL35A ribosomal protein L35a -0.0222913
NCOA1 nuclear receptor coactivator 1 -0.0222535
RPL10A ribosomal protein L10a -0.0219999
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0219399
TUT4 terminal uridylyl transferase 4 -0.0218463
NEBL nebulette -0.0217759
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0215662
AHNAK AHNAK nucleoprotein -0.0215087
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0214942
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0213446
NAP1L1 nucleosome assembly protein 1-like 1 -0.0211161
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0210441
RPL32 ribosomal protein L32 -0.0210357
NPEPPS aminopeptidase puromycin sensitive -0.0209419
AKAP12 A kinase (PRKA) anchor protein 12 -0.0207504
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0207457
WSB1 WD repeat and SOCS box containing 1 -0.020321
PHF21A PHD finger protein 21A -0.020059
SQSTM1 sequestosome 1 -0.0197889
NXN nucleoredoxin -0.0195722
RPL27A ribosomal protein L27a -0.0195714
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0195618
ARHGAP5 Rho GTPase activating protein 5 -0.0194617
TPM4 tropomyosin 4 -0.0194594
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.019446
TPT1 tumor protein, translationally-controlled 1 -0.0194357
RPS8 ribosomal protein S8 -0.0194164
GOLGB1 golgin B1 -0.0193847
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0193192
DSTN destrin (actin depolymerizing factor) -0.0193089
PRELID2 PRELI domain containing 2 -0.0192541
DMXL2 Dmx-like 2 -0.0192501
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0190718
BABAM2 BRISC and BRCA1 A complex member 2 -0.0190196
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0189926
MEIS2 Meis homeobox 2 -0.0187433
EPHA5 EPH receptor A5 -0.0187401
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0185632
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0185496
GOLGA4 golgin A4 -0.018513
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0183713
PHF20 PHD finger protein 20 -0.0181736
RPL23 ribosomal protein L23 -0.0181496
XPO1 exportin 1 -0.0180999