Glycyrrhizic acid_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.109391
EEF1G eukaryotic translation elongation factor 1 gamma 0.0914034
VCL vinculin 0.0852084
ACTG1 actin gamma 1 0.0720915
THSD4 thrombospondin, type I, domain containing 4 0.0685021
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0680889
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0676444
ZFP36 ZFP36 ring finger protein 0.0601154
TRIO trio Rho guanine nucleotide exchange factor 0.0599003
EGFR epidermal growth factor receptor 0.0575738
HSPG2 heparan sulfate proteoglycan 2 0.0558643
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0557066
ACTN4 actinin, alpha 4 0.0555207
SLC35F3 solute carrier family 35, member F3 0.0554578
EGR1 early growth response 1 0.0499057
L1CAM L1 cell adhesion molecule 0.0489122
FOSL1 FOS-like antigen 1 0.0455557
SFTPA2 surfactant protein A2 0.0452421
MYH9 myosin, heavy chain 9, non-muscle 0.0420629
SEPTIN9 septin 9 0.0414986
PKM pyruvate kinase, muscle 0.0406293
FLNA filamin A, alpha 0.0405567
EEF2 eukaryotic translation elongation factor 2 0.0390932
DST dystonin 0.0373417
PGK1 phosphoglycerate kinase 1 0.0372757
NPAS2 neuronal PAS domain protein 2 0.0368758
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0361407
NUP98 nucleoporin 98kDa 0.0350475
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.035015
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0349195
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0344233
MT2A metallothionein 2A 0.0334104
SRRM2 serine/arginine repetitive matrix 2 0.0331692
HMGA1 high mobility group AT-hook 1 0.0327246
MSN moesin 0.0323338
HMGA2 high mobility group AT-hook 2 0.0321982
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0317484
TGFBI transforming growth factor, beta-induced, 68kDa 0.0314918
MYADM myeloid-associated differentiation marker 0.0310884
NCOR2 nuclear receptor corepressor 2 0.0307075
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303291
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0297321
WNK1 WNK lysine deficient protein kinase 1 0.0295679
GANAB glucosidase, alpha; neutral AB 0.0295533
ARID1A AT rich interactive domain 1A (SWI-like) 0.0289342
MCL1 myeloid cell leukemia 1 0.0288535
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286981
TM9SF4 transmembrane 9 superfamily protein member 4 0.0285612
CCNL1 cyclin L1 0.0279938
TM4SF1 transmembrane 4 L six family member 1 0.0273684
SAMD4B sterile alpha motif domain containing 4B 0.0270554
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0269987
CDK19 cyclin-dependent kinase 19 0.0265489
SAMD4A sterile alpha motif domain containing 4A 0.0256088
PTK2 protein tyrosine kinase 2 0.0255357
SDK1 sidekick cell adhesion molecule 1 0.0255095
UBAP2 ubiquitin associated protein 2 0.0254
CMIP c-Maf inducing protein 0.025279
LDHA lactate dehydrogenase A 0.0252555
PDIA3 protein disulfide isomerase family A, member 3 0.0251912
CD68 CD68 molecule 0.0249631
NHSL1 NHS-like 1 0.0240413
NAV2 neuron navigator 2 0.0236458
BRD2 bromodomain containing 2 0.0233499
TNS3 tensin 3 0.0233433
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0233363
PXDN peroxidasin 0.0232425
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0231384
LENG8 leukocyte receptor cluster (LRC) member 8 0.0230023
ATXN1 ataxin 1 0.022958
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0227459
RNF220 ring finger protein 220 0.0226784
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0226625
RAD51B RAD51 paralog B 0.0222624
SFPQ splicing factor proline/glutamine-rich 0.0222379
POTEF POTE ankyrin domain family, member F 0.0220538
AKAP13 A kinase (PRKA) anchor protein 13 0.0216445
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.021269
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0206649
SLC38A2 solute carrier family 38, member 2 0.0206068
RAB7A RAB7A, member RAS oncogene family 0.0205882
GOLT1A golgi transport 1A 0.0205796
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0204622
WDR27 WD repeat domain 27 0.0203709
FNDC3B fibronectin type III domain containing 3B 0.020354
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0203459
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0203397
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0201078
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0200644
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0198335
RPS2 ribosomal protein S2 0.0197543
MACF1 microtubule-actin crosslinking factor 1 0.0195791
EXT1 exostosin glycosyltransferase 1 0.0194688
YARS1 tyrosyl-tRNA synthetase 1 0.0193486
LPP LIM domain containing preferred translocation partner in lipoma 0.0192789
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0190804
EXOC4 exocyst complex component 4 0.0189706
SPRED2 sprouty-related, EVH1 domain containing 2 0.0189665
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0187634
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183898

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.256461
PTMA prothymosin, alpha -0.174149
TMSB10 thymosin beta 10 -0.129624
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0979999
AHNAK AHNAK nucleoprotein -0.091681
FBL fibrillarin -0.0783577
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0761045
FTL ferritin, light polypeptide -0.0734274
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0694925
CANX calnexin -0.0683797
YBX1 Y box binding protein 1 -0.0657224
AKAP12 A kinase (PRKA) anchor protein 12 -0.0656129
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0648694
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0647908
NAP1L1 nucleosome assembly protein 1-like 1 -0.0636252
TXNRD1 thioredoxin reductase 1 -0.0595248
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0576732
OGA O-GlcNAcase -0.0561149
RPS16 ribosomal protein S16 -0.0529305
RPS24 ribosomal protein S24 -0.0518008
BIRC2 baculoviral IAP repeat containing 2 -0.0421807
RPS5 ribosomal protein S5 -0.0419905
RPS3 ribosomal protein S3 -0.0407838
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0401738
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0398695
TPT1 tumor protein, translationally-controlled 1 -0.0396989
ANXA2 annexin A2 -0.0395464
S100A10 S100 calcium binding protein A10 -0.0385884
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0371721
KDM3A lysine (K)-specific demethylase 3A -0.0370715
TMEM123 transmembrane protein 123 -0.0363909
RSL1D1 ribosomal L1 domain containing 1 -0.0362019
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0358369
SPAG9 sperm associated antigen 9 -0.0344531
MORF4L2 mortality factor 4 like 2 -0.0335065
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.033338
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0330314
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.032805
RPS12 ribosomal protein S12 -0.0324142
SNX14 sorting nexin 14 -0.0318834
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0316249
KMT2A lysine (K)-specific methyltransferase 2A -0.0315359
GOLGA4 golgin A4 -0.0314003
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0312637
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0310929
C15ORF48 chromosome 15 open reading frame 48 -0.0308346
ANLN anillin, actin binding protein -0.0306969
GARS1 glycyl-tRNA synthetase 1 -0.0300222
KTN1 kinectin 1 (kinesin receptor) -0.029865
SEPTIN7 septin 7 -0.0298462
CD44 CD44 molecule (Indian blood group) -0.0297346
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0293217
RPL31 ribosomal protein L31 -0.0292819
IER3 immediate early response 3 -0.0288984
DDIT4 DNA-damage-inducible transcript 4 -0.0288794
MED29 mediator complex subunit 29 -0.0286287
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0283336
MATR3 matrin 3 -0.0279585
KPNB1 karyopherin (importin) beta 1 -0.0278866
RPLP0 ribosomal protein, large, P0 -0.0277338
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0277176
USP3 ubiquitin specific peptidase 3 -0.0276559
RPLP1 ribosomal protein, large, P1 -0.0275551
WDR45B WD repeat domain 45B -0.0271575
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0268594
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0261852
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0260968
RLF rearranged L-myc fusion -0.0257713
NAMPT nicotinamide phosphoribosyltransferase -0.0254643
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0253945
RPL12 ribosomal protein L12 -0.0253347
NPR2 natriuretic peptide receptor 2 -0.0251906
NIPBL Nipped-B homolog (Drosophila) -0.0251791
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0251085
RBM39 RNA binding motif protein 39 -0.0250911
RPS17 ribosomal protein S17 -0.0246934
NPEPPS aminopeptidase puromycin sensitive -0.0246066
TRA2A transformer 2 alpha homolog (Drosophila) -0.0243745
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0242369
UBC ubiquitin C -0.0241513
TMSB4X thymosin beta 4, X-linked -0.0241358
PDIA6 protein disulfide isomerase family A, member 6 -0.024078
RPS25 ribosomal protein S25 -0.0240296
RAD21 RAD21 homolog (S. pombe) -0.0237739
NIPSNAP2 nipsnap homolog 2 -0.0235741
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0234855
DLG1 discs, large homolog 1 (Drosophila) -0.0232915
CENPF centromere protein F, 350/400kDa -0.0232883
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0231952
EIF1 eukaryotic translation initiation factor 1 -0.0230564
NOP58 NOP58 ribonucleoprotein -0.0229519
TPX2 TPX2, microtubule-associated -0.022677
PERP PERP, TP53 apoptosis effector -0.0224142
RPS8 ribosomal protein S8 -0.0221535
RPS27A ribosomal protein S27a -0.0217427
IPO7 importin 7 -0.0214832
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214346
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.021394
ZNF292 zinc finger protein 292 -0.0213344
H1-0 H1.0 linker histone -0.0208609