Glycyrrhizic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.118876
EEF1G eukaryotic translation elongation factor 1 gamma 0.10678
ACTG1 actin gamma 1 0.0998956
MUC16 mucin 16, cell surface associated 0.0854959
SMAD3 SMAD family member 3 0.0800187
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0736539
INTS6 integrator complex subunit 6 0.0684949
AFDN afadin, adherens junction formation factor 0.062248
FNDC3B fibronectin type III domain containing 3B 0.0581694
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0569544
LPP LIM domain containing preferred translocation partner in lipoma 0.0548929
ARHGAP26 Rho GTPase activating protein 26 0.0533602
RPL23 ribosomal protein L23 0.0525802
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0514209
NRIP1 nuclear receptor interacting protein 1 0.0503114
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0486639
PARP14 poly (ADP-ribose) polymerase family, member 14 0.04765
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0473815
MUC4 mucin 4, cell surface associated 0.0472077
RIGI RNA sensor RIG-I 0.0462902
VCL vinculin 0.0457769
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0454329
TPT1 tumor protein, translationally-controlled 1 0.0450925
MYH9 myosin, heavy chain 9, non-muscle 0.0443391
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0440867
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0435824
FLNA filamin A, alpha 0.0434656
ETV6 ets variant 6 0.0425233
PLEC plectin 0.0424921
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.041746
LAMC2 laminin, gamma 2 0.0416324
TSC22D2 TSC22 domain family, member 2 0.0409698
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0409136
MYO5B myosin VB 0.0400942
TRIO trio Rho guanine nucleotide exchange factor 0.038399
EEF2 eukaryotic translation elongation factor 2 0.0378854
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0375033
RPL35A ribosomal protein L35a 0.037238
LAMB3 laminin, beta 3 0.0369214
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0364687
IFI44L interferon-induced protein 44-like 0.0358455
CD59 CD59 molecule, complement regulatory protein 0.0354984
PLSCR1 phospholipid scramblase 1 0.0352571
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0352131
RNF213 ring finger protein 213 0.0348866
BACE2 beta-site APP-cleaving enzyme 2 0.0348624
SP100 SP100 nuclear antigen 0.034191
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0339191
NAV2 neuron navigator 2 0.0337251
RPS6 ribosomal protein S6 0.0337092
SYT14 synaptotagmin XIV 0.0333322
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0332729
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0326975
PTK2 protein tyrosine kinase 2 0.0326631
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0325052
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0322558
RPL27 ribosomal protein L27 0.032199
WAC WW domain containing adaptor with coiled-coil 0.0320852
MX1 MX dynamin-like GTPase 1 0.0314601
MACF1 microtubule-actin crosslinking factor 1 0.03054
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.030523
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0303523
AEBP2 AE binding protein 2 0.0298227
MELTF melanotransferrin 0.0296431
WNK1 WNK lysine deficient protein kinase 1 0.0296207
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0294998
RPL9 ribosomal protein L9 0.0292058
DIAPH1 diaphanous-related formin 1 0.0289962
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.028874
NACA nascent polypeptide-associated complex alpha subunit 0.0288217
MPRIP myosin phosphatase Rho interacting protein 0.0287117
HSPA8 heat shock 70kDa protein 8 0.0285407
FHIT fragile histidine triad 0.0283918
TRAF3 TNF receptor-associated factor 3 0.028226
RAD51B RAD51 paralog B 0.0280923
RPL30 ribosomal protein L30 0.0280351
RPLP1 ribosomal protein, large, P1 0.0279523
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0279112
ZSWIM6 zinc finger, SWIM-type containing 6 0.0277179
BCAR3 breast cancer anti-estrogen resistance 3 0.0276877
TGM2 transglutaminase 2 0.0274506
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0271
GRB10 growth factor receptor-bound protein 10 0.0267685
MX2 MX dynamin-like GTPase 2 0.0262253
EXT1 exostosin glycosyltransferase 1 0.0259669
JUP junction plakoglobin 0.0258997
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257775
FMNL2 formin-like 2 0.0257533
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0255714
MAST4 microtubule associated serine/threonine kinase family member 4 0.0254658
ANKRD33B ankyrin repeat domain 33B 0.0254553
FLNB filamin B, beta 0.0251812
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0245848
RPL37A ribosomal protein L37a 0.0245213
RSAD2 radical S-adenosyl methionine domain containing 2 0.0244933
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0244354
RPL34 ribosomal protein L34 0.0243957
IFI44 interferon-induced protein 44 0.0243136
FAM3C family with sequence similarity 3, member C 0.0242919
ACER3 alkaline ceramidase 3 0.0241998

decreased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.145016
PTMA prothymosin, alpha -0.143478
EZR ezrin -0.133415
TMSB10 thymosin beta 10 -0.115882
LOC102724023 ES1 protein homolog, mitochondrial -0.113804
EMP1 epithelial membrane protein 1 -0.102242
DLG1 discs, large homolog 1 (Drosophila) -0.0969076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0888773
TMSB4X thymosin beta 4, X-linked -0.0857783
NDRG1 N-myc downstream regulated 1 -0.0844573
F3 coagulation factor III (thromboplastin, tissue factor) -0.0826396
NPEPPS aminopeptidase puromycin sensitive -0.0787148
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.072594
LMO7 LIM domain 7 -0.0716905
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0638415
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0631678
CANX calnexin -0.0622681
CD2AP CD2-associated protein -0.0595093
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0552117
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0547897
ANXA1 annexin A1 -0.0546138
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0542223
TXNIP thioredoxin interacting protein -0.0535614
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0535266
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0517588
GOLGA4 golgin A4 -0.0513634
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0510553
EIF1 eukaryotic translation initiation factor 1 -0.0491827
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0491463
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0474047
FTL ferritin, light polypeptide -0.0469021
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0468717
WFDC2 WAP four-disulfide core domain 2 -0.046694
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0466129
IGFBP3 insulin-like growth factor binding protein 3 -0.0449728
TPI1 triosephosphate isomerase 1 -0.0435857
ARF4 ADP-ribosylation factor 4 -0.043515
SKAP2 src kinase associated phosphoprotein 2 -0.0432657
RIOK3 RIO kinase 3 -0.0431425
ANLN anillin, actin binding protein -0.0427868
LY6E lymphocyte antigen 6 complex, locus E -0.042564
UGCG UDP-glucose ceramide glucosyltransferase -0.0423634
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.042158
JMJD1C jumonji domain containing 1C -0.0418225
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0416153
GOLGB1 golgin B1 -0.0414414
KRT19 keratin 19, type I -0.0411576
KTN1 kinectin 1 (kinesin receptor) -0.0411086
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0401414
LIPH lipase, member H -0.0400019
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0397975
TXNRD1 thioredoxin reductase 1 -0.0386941
KDM2A lysine (K)-specific demethylase 2A -0.0386255
TMEM123 transmembrane protein 123 -0.0384627
TPM4 tropomyosin 4 -0.0381651
MBNL2 muscleblind-like splicing regulator 2 -0.0380524
ITPRID2 ITPR interacting domain containing 2 -0.0375289
S100A10 S100 calcium binding protein A10 -0.0367552
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0359976
ADGRF1 adhesion G protein-coupled receptor F1 -0.0358658
MYOF myoferlin -0.0349702
PLK2 polo-like kinase 2 -0.0347786
TTC3 tetratricopeptide repeat domain 3 -0.0340342
AKAP9 A kinase (PRKA) anchor protein 9 -0.0338335
ANXA2 annexin A2 -0.0337439
RAB6A RAB6A, member RAS oncogene family -0.0333771
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0331076
ECT2 epithelial cell transforming 2 -0.0330163
UBC ubiquitin C -0.0329753
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0328067
HLA-A major histocompatibility complex, class I, A -0.0323945
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0322678
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0317469
DDIT4 DNA-damage-inducible transcript 4 -0.0315408
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0311817
MKI67 marker of proliferation Ki-67 -0.0309464
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.030894
C6ORF132 chromosome 6 open reading frame 132 -0.0308662
VMP1 vacuole membrane protein 1 -0.0307175
TMF1 TATA element modulatory factor 1 -0.0304326
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.03002
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0298801
ERBIN erbb2 interacting protein -0.0294081
VIM vimentin -0.0293763
MAML2 mastermind-like 2 (Drosophila) -0.0293718
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0291293
KPNB1 karyopherin (importin) beta 1 -0.0290259
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0289789
DSG2 desmoglein 2 -0.0289363
CD47 CD47 molecule -0.0287919
AHNAK AHNAK nucleoprotein -0.0287722
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0287499
S100A6 S100 calcium binding protein A6 -0.0283173
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0281472
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276058
LDHA lactate dehydrogenase A -0.0275781
ESYT2 extended synaptotagmin-like protein 2 -0.0275053
AREG amphiregulin -0.0274042
SMC4 structural maintenance of chromosomes 4 -0.0273165
C15ORF48 chromosome 15 open reading frame 48 -0.0270361