Glycyrrhizic acid_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PGK1 phosphoglycerate kinase 1 0.114292
CXCL8 chemokine (C-X-C motif) ligand 8 0.107976
FN1 fibronectin 1 0.0907664
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0843279
FNDC3B fibronectin type III domain containing 3B 0.0797054
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0777381
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0738223
ZNF292 zinc finger protein 292 0.0682191
NAMPT nicotinamide phosphoribosyltransferase 0.0659902
PKM pyruvate kinase, muscle 0.0644077
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0631961
SOD2 superoxide dismutase 2, mitochondrial 0.0631584
NAV2 neuron navigator 2 0.0555872
CEMIP cell migration inducing protein, hyaluronan binding 0.0528757
MYH9 myosin, heavy chain 9, non-muscle 0.0524674
BHLHE40 basic helix-loop-helix family, member e40 0.0523771
CD109 CD109 molecule 0.049665
CCNL1 cyclin L1 0.0474471
MMP12 matrix metallopeptidase 12 0.0469986
ANXA5 annexin A5 0.0455906
EEF2 eukaryotic translation elongation factor 2 0.0454816
THBS1 thrombospondin 1 0.0451523
LDHA lactate dehydrogenase A 0.0440968
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0429127
WSB1 WD repeat and SOCS box containing 1 0.0420958
GOLGA4 golgin A4 0.0411045
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0410845
NUP58 nucleoporin 58 0.0399997
ATP13A3 ATPase type 13A3 0.0392619
RAB1A RAB1A, member RAS oncogene family 0.0383981
HOOK2 hook microtubule-tethering protein 2 0.0376394
MCTP2 multiple C2 domains, transmembrane 2 0.0368852
ICAM1 intercellular adhesion molecule 1 0.0354847
FLNA filamin A, alpha 0.0342663
MMP2 matrix metallopeptidase 2 0.0340382
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0339587
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0337316
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.033683
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0324986
ESYT2 extended synaptotagmin-like protein 2 0.0321583
LMAN1 lectin, mannose-binding, 1 0.0312222
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0311188
ADM adrenomedullin 0.0306187
RLF rearranged L-myc fusion 0.030295
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0302536
FLNB filamin B, beta 0.0302276
NAP1L1 nucleosome assembly protein 1-like 1 0.0300451
IARS1 isoleucyl-tRNA synthetase 1 0.0297416
RAD23B RAD23 homolog B (S. cerevisiae) 0.0294105
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0285664
KDM5B lysine (K)-specific demethylase 5B 0.0285229
USP3 ubiquitin specific peptidase 3 0.0281708
FAM13A family with sequence similarity 13, member A 0.0280663
PDIA3 protein disulfide isomerase family A, member 3 0.02799
SRP54 signal recognition particle 54kDa 0.0275609
EEF1G eukaryotic translation elongation factor 1 gamma 0.0269659
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0268087
OGA O-GlcNAcase 0.026664
LCORL ligand dependent nuclear receptor corepressor-like 0.0265838
ANKRD11 ankyrin repeat domain 11 0.0265111
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0265074
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0259842
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0259511
CYLD cylindromatosis (turban tumor syndrome) 0.0254349
XPO1 exportin 1 0.0253331
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0251642
KMT2C lysine (K)-specific methyltransferase 2C 0.0250755
WAC WW domain containing adaptor with coiled-coil 0.0249077
NONO non-POU domain containing, octamer-binding 0.0248931
UBA6 ubiquitin-like modifier activating enzyme 6 0.0247842
SPAG9 sperm associated antigen 9 0.0244945
YEATS2 YEATS domain containing 2 0.0243374
KDM3A lysine (K)-specific demethylase 3A 0.0242537
INSIG2 insulin induced gene 2 0.0242524
FBXO32 F-box protein 32 0.0242391
FTH1 ferritin, heavy polypeptide 1 0.0240428
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0240389
ARL8B ADP-ribosylation factor-like 8B 0.0238758
ADNP activity-dependent neuroprotector homeobox 0.0234679
TRIO trio Rho guanine nucleotide exchange factor 0.0232929
TRA2A transformer 2 alpha homolog (Drosophila) 0.0232869
HELZ helicase with zinc finger 0.0232738
GRB10 growth factor receptor-bound protein 10 0.0230848
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0230755
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0229917
STC1 stanniocalcin 1 0.0229494
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.022856
SDC4 syndecan 4 0.0224107
MYOF myoferlin 0.0222465
FGFR1 fibroblast growth factor receptor 1 0.0221015
RPL11 ribosomal protein L11 0.0220404
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0217435
NCKAP1 NCK-associated protein 1 0.0216613
PPME1 protein phosphatase methylesterase 1 0.0215828
DENND4A DENN/MADD domain containing 4A 0.0213629
CALU calumenin 0.0213128
UBA2 ubiquitin-like modifier activating enzyme 2 0.0211516
CDC73 cell division cycle 73 0.0211446
KIF5B kinesin family member 5B 0.0208158
FNIP1 folliculin interacting protein 1 0.0207466

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.11729
PSD3 pleckstrin and Sec7 domain containing 3 -0.0976587
COL1A2 collagen, type I, alpha 2 -0.0974649
TMSB10 thymosin beta 10 -0.0879672
COL1A1 collagen, type I, alpha 1 -0.0868008
VIM vimentin -0.0841763
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0798135
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0786786
FTL ferritin, light polypeptide -0.072862
NRP1 neuropilin 1 -0.0648316
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0611304
HLA-B major histocompatibility complex, class I, B -0.0598606
VCL vinculin -0.0551621
IFI6 interferon, alpha-inducible protein 6 -0.0541282
GLIS3 GLIS family zinc finger 3 -0.0530735
TPM4 tropomyosin 4 -0.0489581
ZEB1 zinc finger E-box binding homeobox 1 -0.0487017
CD44 CD44 molecule (Indian blood group) -0.0457172
ASPH aspartate beta-hydroxylase -0.0453873
COL5A3 collagen, type V, alpha 3 -0.0448154
HPCAL1 hippocalcin-like 1 -0.0439682
NAV1 neuron navigator 1 -0.0406766
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0404241
ZBTB20 zinc finger and BTB domain containing 20 -0.0403242
WWTR1 WW domain containing transcription regulator 1 -0.0383974
B2M beta-2-microglobulin -0.0382841
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0368621
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.036227
HMGA2 high mobility group AT-hook 2 -0.0355492
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0352939
SVIL supervillin -0.0351317
SP100 SP100 nuclear antigen -0.0324556
TMEM178B transmembrane protein 178B -0.0323079
PMP22 peripheral myelin protein 22 -0.0317141
VEGFA vascular endothelial growth factor A -0.0312745
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0302922
TIMP1 TIMP metallopeptidase inhibitor 1 -0.029659
MAML2 mastermind-like 2 (Drosophila) -0.0296129
PTPRG protein tyrosine phosphatase, receptor type, G -0.0291608
ZBTB38 zinc finger and BTB domain containing 38 -0.0289614
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0287455
CST3 cystatin C -0.0282546
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0275472
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273485
EXT1 exostosin glycosyltransferase 1 -0.0269531
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0266919
MX2 MX dynamin-like GTPase 2 -0.0260666
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0255745
PHF14 PHD finger protein 14 -0.0252208
EGR1 early growth response 1 -0.0249945
RRBP1 ribosome binding protein 1 -0.0249871
PTMA prothymosin, alpha -0.0248016
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.024157
VMP1 vacuole membrane protein 1 -0.0240863
SETBP1 SET binding protein 1 -0.0240019
ATM ATM serine/threonine kinase -0.0238304
PTPRE protein tyrosine phosphatase, receptor type, E -0.0235272
COL6A2 collagen, type VI, alpha 2 -0.0234237
FBN1 fibrillin 1 -0.0224913
TGFB1 transforming growth factor, beta 1 -0.0222263
IGFBP5 insulin-like growth factor binding protein 5 -0.0220189
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0220016
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0219157
SLIT2 slit homolog 2 (Drosophila) -0.0218943
IFITM3 interferon induced transmembrane protein 3 -0.0216297
SAMD9 sterile alpha motif domain containing 9 -0.0216064
BBS9 Bardet-Biedl syndrome 9 -0.0215353
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0213102
FHIT fragile histidine triad -0.0213008
IGFBP3 insulin-like growth factor binding protein 3 -0.0208389
AHNAK AHNAK nucleoprotein -0.0208021
EPSTI1 epithelial stromal interaction 1 (breast) -0.0205415
NPAS2 neuronal PAS domain protein 2 -0.0204461
ETV6 ets variant 6 -0.0202825
EHBP1 EH domain binding protein 1 -0.0202001
ITGA1 integrin, alpha 1 -0.0200964
AKAP13 A kinase (PRKA) anchor protein 13 -0.0200893
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0200879
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0197791
MAML3 mastermind-like 3 (Drosophila) -0.0197401
ANKH ANKH inorganic pyrophosphate transport regulator -0.0196254
CAPZB capping protein (actin filament) muscle Z-line, beta -0.01943
TSPAN9 tetraspanin 9 -0.019386
RCOR1 REST corepressor 1 -0.0192968
C1R complement component 1, r subcomponent -0.0190276
IFI16 interferon, gamma-inducible protein 16 -0.0189859
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0186188
MYADM myeloid-associated differentiation marker -0.0183465
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0181023
CHD9 chromodomain helicase DNA binding protein 9 -0.0179814
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0179583
ITGA11 integrin, alpha 11 -0.0178003
COL4A1 collagen, type IV, alpha 1 -0.0176857
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0176371
MYO9A myosin IXA -0.0175166
ACTN1 actinin, alpha 1 -0.0174811
IFIH1 interferon induced with helicase C domain 1 -0.0170572
FNDC3A fibronectin type III domain containing 3A -0.0170313
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.0169067
MSN moesin -0.0167814