Glycyrrhizic acid_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.140303
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.104987
MYH9 myosin, heavy chain 9, non-muscle 0.10152
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0920718
EEF1G eukaryotic translation elongation factor 1 gamma 0.0746054
UGCG UDP-glucose ceramide glucosyltransferase 0.0672519
NAV2 neuron navigator 2 0.0657628
FLNA filamin A, alpha 0.0654509
NAMPT nicotinamide phosphoribosyltransferase 0.0645566
EEF2 eukaryotic translation elongation factor 2 0.0623332
TGFBI transforming growth factor, beta-induced, 68kDa 0.0574102
FTH1 ferritin, heavy polypeptide 1 0.0526373
CCNL1 cyclin L1 0.0509359
MSN moesin 0.0484224
UBA6 ubiquitin-like modifier activating enzyme 6 0.0464216
ZNF292 zinc finger protein 292 0.041002
PGK1 phosphoglycerate kinase 1 0.0407084
ICAM1 intercellular adhesion molecule 1 0.0396296
TSC22D2 TSC22 domain family, member 2 0.0373096
RBM39 RNA binding motif protein 39 0.0364399
RTN4 reticulon 4 0.0363797
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0360661
NONO non-POU domain containing, octamer-binding 0.0356379
PCBP2 poly(rC) binding protein 2 0.035
POTEF POTE ankyrin domain family, member F 0.0347734
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.034555
TENT5A terminal nucleotidyltransferase 5A 0.0343668
MKI67 marker of proliferation Ki-67 0.0330458
VEGFA vascular endothelial growth factor A 0.0327259
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326356
HELZ helicase with zinc finger 0.032583
ARRDC3 arrestin domain containing 3 0.0317154
SPAG9 sperm associated antigen 9 0.0314905
APLP2 amyloid beta (A4) precursor-like protein 2 0.0310811
FLNB filamin B, beta 0.0296192
CENPF centromere protein F, 350/400kDa 0.0291477
FNDC3B fibronectin type III domain containing 3B 0.0289299
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0286415
ZMIZ1 zinc finger, MIZ-type containing 1 0.0285942
RB1CC1 RB1-inducible coiled-coil 1 0.0285391
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0282114
SFTPA2 surfactant protein A2 0.028132
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0277894
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0270345
HMGA1 high mobility group AT-hook 1 0.0269878
ANLN anillin, actin binding protein 0.0260531
GOLGA4 golgin A4 0.0258889
UVRAG UV radiation resistance associated 0.0256946
NUP58 nucleoporin 58 0.0256518
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0249854
WTAP Wilms tumor 1 associated protein 0.0246264
CADM1 cell adhesion molecule 1 0.0245625
PKM pyruvate kinase, muscle 0.0242249
SNX9 sorting nexin 9 0.0238844
NUP153 nucleoporin 153kDa 0.0238361
ATP13A3 ATPase type 13A3 0.0232943
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0231404
THBS1 thrombospondin 1 0.0226078
PTBP3 polypyrimidine tract binding protein 3 0.0221158
CKAP5 cytoskeleton associated protein 5 0.0218338
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0217336
MMP2 matrix metallopeptidase 2 0.0216564
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0213702
KMT2E lysine (K)-specific methyltransferase 2E 0.0213595
KDM6A lysine (K)-specific demethylase 6A 0.0213566
TXNRD1 thioredoxin reductase 1 0.0212016
ADAM17 ADAM metallopeptidase domain 17 0.0211172
TXNIP thioredoxin interacting protein 0.020955
FOSL1 FOS-like antigen 1 0.020798
CYLD cylindromatosis (turban tumor syndrome) 0.0207919
BRD2 bromodomain containing 2 0.0206723
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0205902
PRRC2C proline-rich coiled-coil 2C 0.0201579
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0200845
SRRM2 serine/arginine repetitive matrix 2 0.0199719
ELL2 elongation factor, RNA polymerase II, 2 0.0199649
BCLAF1 BCL2-associated transcription factor 1 0.0199297
RNF145 ring finger protein 145 0.0198945
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0196997
TNIP1 TNFAIP3 interacting protein 1 0.0196891
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0196224
KIF4A kinesin family member 4A 0.019553
TBK1 TANK-binding kinase 1 0.0194692
DSTN destrin (actin depolymerizing factor) 0.0190704
TENT4A terminal nucleotidyltransferase 4A 0.0190035
FOXO3 forkhead box O3 0.0188811
ZNF207 zinc finger protein 207 0.0188207
NCKAP1 NCK-associated protein 1 0.0188152
ZFAND3 zinc finger, AN1-type domain 3 0.0188
SRP54 signal recognition particle 54kDa 0.018676
TMEM123 transmembrane protein 123 0.0184847
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0182754
ANXA5 annexin A5 0.0181442
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0181135
FXR1 fragile X mental retardation, autosomal homolog 1 0.0180579
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0178301
ECPAS Ecm29 proteasome adaptor and scaffold 0.0178184
RAD23B RAD23 homolog B (S. cerevisiae) 0.0174313
USP36 ubiquitin specific peptidase 36 0.0173748
RPS2 ribosomal protein S2 0.0173231

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.153186
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.145566
GLIS3 GLIS family zinc finger 3 -0.131629
AKAP12 A kinase (PRKA) anchor protein 12 -0.130113
TPT1 tumor protein, translationally-controlled 1 -0.112403
HMGA2 high mobility group AT-hook 2 -0.107657
IER3 immediate early response 3 -0.105228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0958952
CDH13 cadherin 13 -0.0856489
IGFBP3 insulin-like growth factor binding protein 3 -0.083774
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0825008
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0782648
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0756332
AHNAK AHNAK nucleoprotein -0.0750165
DST dystonin -0.0696985
BICC1 BicC family RNA binding protein 1 -0.0694528
HLA-B major histocompatibility complex, class I, B -0.0663421
RAI14 retinoic acid induced 14 -0.0659268
TMSB10 thymosin beta 10 -0.063756
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0634079
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0613943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0589159
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0575326
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0572535
VCL vinculin -0.0560964
FRMD4A FERM domain containing 4A -0.0558499
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0554725
SQSTM1 sequestosome 1 -0.0543796
TMSB4X thymosin beta 4, X-linked -0.0537739
SOD2 superoxide dismutase 2, mitochondrial -0.0532694
INTS6 integrator complex subunit 6 -0.0525312
CANX calnexin -0.0518949
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0516074
KYNU kynureninase -0.0510311
ZMYND8 zinc finger, MYND-type containing 8 -0.0509032
ZBTB38 zinc finger and BTB domain containing 38 -0.0505973
HLA-A major histocompatibility complex, class I, A -0.0484526
VCAN versican -0.0475177
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0464899
HDAC9 histone deacetylase 9 -0.0461504
TMEM132D transmembrane protein 132D -0.0457777
RPS24 ribosomal protein S24 -0.0443821
COL6A3 collagen, type VI, alpha 3 -0.0435465
HLA-E major histocompatibility complex, class I, E -0.0434387
MACF1 microtubule-actin crosslinking factor 1 -0.0429427
AFF3 AF4/FMR2 family, member 3 -0.0425732
EFNA5 ephrin-A5 -0.039871
PTPRK protein tyrosine phosphatase, receptor type, K -0.0395035
MT2A metallothionein 2A -0.0390878
GOLGB1 golgin B1 -0.0390775
BTG1 B-cell translocation gene 1, anti-proliferative -0.0390502
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0389813
ASPH aspartate beta-hydroxylase -0.0388712
EGFR epidermal growth factor receptor -0.0388574
DIAPH2 diaphanous-related formin 2 -0.0385708
PDE10A phosphodiesterase 10A -0.0375294
SOX5 SRY (sex determining region Y)-box 5 -0.0373346
EIF1 eukaryotic translation initiation factor 1 -0.037263
ZBTB20 zinc finger and BTB domain containing 20 -0.036929
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0365445
SP100 SP100 nuclear antigen -0.0361896
FAM20C family with sequence similarity 20, member C -0.036128
EXT1 exostosin glycosyltransferase 1 -0.0342471
SLC38A1 solute carrier family 38, member 1 -0.0340218
FTL ferritin, light polypeptide -0.0340084
INHBA inhibin, beta A -0.033366
RND3 Rho family GTPase 3 -0.0331619
NABP1 nucleic acid binding protein 1 -0.0331466
IFI16 interferon, gamma-inducible protein 16 -0.032847
SDK1 sidekick cell adhesion molecule 1 -0.0325729
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0321335
TBC1D22A TBC1 domain family, member 22A -0.0318377
COL5A1 collagen, type V, alpha 1 -0.0317416
PLIN2 perilipin 2 -0.0315817
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0312052
TNS3 tensin 3 -0.0310973
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0309813
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0307728
PHF3 PHD finger protein 3 -0.0306009
SMYD3 SET and MYND domain containing 3 -0.0295954
BASP1 brain abundant, membrane attached signal protein 1 -0.0294622
BACE2 beta-site APP-cleaving enzyme 2 -0.0294548
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0293586
CXCL8 chemokine (C-X-C motif) ligand 8 -0.028859
SAMD3 sterile alpha motif domain containing 3 -0.0286683
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0282085
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0280438
FBXL7 F-box and leucine-rich repeat protein 7 -0.0278851
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0278565
ARHGAP22 Rho GTPase activating protein 22 -0.0277354
MBD5 methyl-CpG binding domain protein 5 -0.0277169
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0276456
GPC6 glypican 6 -0.0273047
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0269951
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0269418
ADAM12 ADAM metallopeptidase domain 12 -0.0266009
BPTF bromodomain PHD finger transcription factor -0.0263797
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0260885
EHBP1 EH domain binding protein 1 -0.0260797
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0259227