Glycyrrhizic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.196663
SMAD3 SMAD family member 3 0.0555925
ELL2 elongation factor, RNA polymerase II, 2 0.0511333
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0437673
NIBAN2 niban apoptosis regulator 2 0.0434946
HOOK2 hook microtubule-tethering protein 2 0.0429851
LOC112694756 uncharaterized LOC112694756 0.0380251
TRIO trio Rho guanine nucleotide exchange factor 0.0376332
GLIS3 GLIS family zinc finger 3 0.037089
MKI67 marker of proliferation Ki-67 0.0367722
EEF2 eukaryotic translation elongation factor 2 0.0340452
ABLIM3 actin binding LIM protein family, member 3 0.0337838
COL1A2 collagen, type I, alpha 2 0.0333092
STC1 stanniocalcin 1 0.0325394
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.031491
FGFR2 fibroblast growth factor receptor 2 0.0299082
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0295825
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0293478
CD44 CD44 molecule (Indian blood group) 0.0293438
ARRDC3 arrestin domain containing 3 0.0286391
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0285192
MAML2 mastermind-like 2 (Drosophila) 0.0280501
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0275555
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0274604
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0272285
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0267152
LAMB1 laminin, beta 1 0.026324
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0259997
KIAA0319L KIAA0319-like 0.0259522
TLN1 talin 1 0.0257116
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0256963
MT1X metallothionein 1X 0.0256531
PARD3 par-3 family cell polarity regulator 0.0255569
ZFR zinc finger RNA binding protein 0.0253321
DIAPH3 diaphanous-related formin 3 0.0251805
SUCO SUN domain containing ossification factor 0.0251595
TGFBI transforming growth factor, beta-induced, 68kDa 0.0250772
C1D C1D nuclear receptor corepressor 0.0249999
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0248887
LNPEP leucyl/cystinyl aminopeptidase 0.0244749
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024358
RAI1 retinoic acid induced 1 0.0243578
BACE2 beta-site APP-cleaving enzyme 2 0.0241166
NF1 neurofibromin 1 0.0237784
JAG1 jagged 1 0.0237087
PRKCA protein kinase C, alpha 0.023685
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0236558
PKN2 protein kinase N2 0.0236315
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0231704
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0231378
LDHA lactate dehydrogenase A 0.023083
LRRC8C leucine rich repeat containing 8 family, member C 0.0228513
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022526
RUNX1 runt-related transcription factor 1 0.0223894
AGO2 argonaute RISC catalytic component 2 0.0223887
SCLT1 sodium channel and clathrin linker 1 0.0223447
BTBD9 BTB (POZ) domain containing 9 0.0222847
AHR aryl hydrocarbon receptor 0.0221388
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0217415
ARF1 ADP-ribosylation factor 1 0.0216539
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0214474
HIPK3 homeodomain interacting protein kinase 3 0.0213357
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0210793
FRMD6 FERM domain containing 6 0.0210742
RSRC2 arginine/serine-rich coiled-coil 2 0.0210416
DDIT4 DNA-damage-inducible transcript 4 0.0208611
STK17A serine/threonine kinase 17a 0.0205655
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0205356
EEF1G eukaryotic translation elongation factor 1 gamma 0.0203962
CDK19 cyclin-dependent kinase 19 0.0203658
FAT1 FAT atypical cadherin 1 0.0202405
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0202315
KDM6A lysine (K)-specific demethylase 6A 0.0201979
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.020131
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0200113
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0199995
ALK anaplastic lymphoma receptor tyrosine kinase 0.0199129
UBE2H ubiquitin-conjugating enzyme E2H 0.0198818
DSCAM Down syndrome cell adhesion molecule 0.0194403
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0193198
SKAP2 src kinase associated phosphoprotein 2 0.019294
KLF6 Kruppel-like factor 6 0.0191739
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0191457
LPP LIM domain containing preferred translocation partner in lipoma 0.0190726
SMYD3 SET and MYND domain containing 3 0.0190686
TSC22D1 TSC22 domain family, member 1 0.018929
CLTC clathrin, heavy chain (Hc) 0.0188515
COG5 component of oligomeric golgi complex 5 0.0187903
DCLK2 doublecortin-like kinase 2 0.0187881
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187646
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0186054
ESYT2 extended synaptotagmin-like protein 2 0.0185753
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0185054
TAS2R14 taste receptor, type 2, member 14 0.0184844
DST dystonin 0.0183386
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0183311
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0183015
RAD21 RAD21 homolog (S. pombe) 0.0182901
CDC73 cell division cycle 73 0.0182875
FOSL1 FOS-like antigen 1 0.0182082

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.220062
VIM vimentin -0.205434
IGFBP3 insulin-like growth factor binding protein 3 -0.157425
FTL ferritin, light polypeptide -0.140518
MT2A metallothionein 2A -0.123634
HLA-B major histocompatibility complex, class I, B -0.0971007
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0967889
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0887483
B2M beta-2-microglobulin -0.0703292
PTMA prothymosin, alpha -0.0681746
NDRG1 N-myc downstream regulated 1 -0.0569198
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0539429
PDE4D phosphodiesterase 4D, cAMP-specific -0.0515535
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.05083
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0495627
CANX calnexin -0.0477402
IL6 interleukin 6 -0.0464452
CADM1 cell adhesion molecule 1 -0.0454973
TPT1 tumor protein, translationally-controlled 1 -0.0414507
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0409177
RPS8 ribosomal protein S8 -0.0402241
VEGFA vascular endothelial growth factor A -0.0396704
RPL35A ribosomal protein L35a -0.0395824
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0394776
RAB1A RAB1A, member RAS oncogene family -0.0382841
RPL34 ribosomal protein L34 -0.0382473
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0382406
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0375629
S100A9 S100 calcium binding protein A9 -0.0375229
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0369746
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0364905
KTN1 kinectin 1 (kinesin receptor) -0.0355671
RPS3 ribosomal protein S3 -0.0338737
HIP1 huntingtin interacting protein 1 -0.0336323
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0328882
POTEF POTE ankyrin domain family, member F -0.0323835
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0320476
RPS27A ribosomal protein S27a -0.0316797
WSB1 WD repeat and SOCS box containing 1 -0.0312698
ENO1 enolase 1, (alpha) -0.0310864
PDIA6 protein disulfide isomerase family A, member 6 -0.0309371
FNDC3A fibronectin type III domain containing 3A -0.0309234
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.030818
BASP1 brain abundant, membrane attached signal protein 1 -0.0307773
GPBP1 GC-rich promoter binding protein 1 -0.0300071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297409
RPL11 ribosomal protein L11 -0.0297203
MYO1E myosin IE -0.0296034
LMNA lamin A/C -0.0293054
TPM4 tropomyosin 4 -0.0292392
HILPDA hypoxia inducible lipid droplet-associated -0.0290512
IGFBP7 insulin-like growth factor binding protein 7 -0.0289525
UBC ubiquitin C -0.0281865
TIMP2 TIMP metallopeptidase inhibitor 2 -0.028012
MTDH metadherin -0.0278671
SEC24D SEC24 family member D -0.0277675
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0271991
HM13 histocompatibility (minor) 13 -0.0271686
DTNA dystrobrevin, alpha -0.0271542
YIPF5 Yip1 domain family, member 5 -0.027127
PGM3 phosphoglucomutase 3 -0.0270597
FNDC3B fibronectin type III domain containing 3B -0.0269473
S100A10 S100 calcium binding protein A10 -0.0268448
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0268333
INSIG2 insulin induced gene 2 -0.0264345
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0264236
CA12 carbonic anhydrase XII -0.026421
GNAS GNAS complex locus -0.0263734
INTS6 integrator complex subunit 6 -0.0263718
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0263124
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0261379
SCARB2 scavenger receptor class B, member 2 -0.0260469
RPS14 ribosomal protein S14 -0.0258883
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0258665
ATF4 activating transcription factor 4 -0.0254007
DPYD dihydropyrimidine dehydrogenase -0.0252062
PDIA3 protein disulfide isomerase family A, member 3 -0.0247106
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0246958
CLIC4 chloride intracellular channel 4 -0.0246259
BMERB1 bMERB domain containing 1 -0.0244621
HLA-A major histocompatibility complex, class I, A -0.024381
KDM5B lysine (K)-specific demethylase 5B -0.024204
ACTG1 actin gamma 1 -0.0241479
RPS12 ribosomal protein S12 -0.0241206
CLEC1B C-type lectin domain family 1, member B -0.0241127
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0239224
DSTN destrin (actin depolymerizing factor) -0.0238948
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0236893
RPLP1 ribosomal protein, large, P1 -0.0236845
RRBP1 ribosome binding protein 1 -0.0233808
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.023263
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0231626
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0231366
PTN pleiotrophin -0.0230105
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0229996
ECE1 endothelin converting enzyme 1 -0.0227324
RPL37A ribosomal protein L37a -0.0226675
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0224254
WASF2 WAS protein family, member 2 -0.0224167
HLA-C major histocompatibility complex, class I, C -0.0223154