Glycyrrhizic acid_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119965
WAC WW domain containing adaptor with coiled-coil 0.0742504
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0726633
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0684097
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0672036
GOLGA4 golgin A4 0.0654502
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0648793
RORA RAR-related orphan receptor A 0.0596241
PABPC1 poly(A) binding protein, cytoplasmic 1 0.057856
NUP58 nucleoporin 58 0.0575818
BIRC6 baculoviral IAP repeat containing 6 0.0502957
CHD1 chromodomain helicase DNA binding protein 1 0.0486019
ZNF292 zinc finger protein 292 0.0484712
DIAPH3 diaphanous-related formin 3 0.0477935
EEF2 eukaryotic translation elongation factor 2 0.0472854
SEC24A SEC24 family member A 0.0471111
SMC4 structural maintenance of chromosomes 4 0.0450071
ECT2 epithelial cell transforming 2 0.0449905
PKM pyruvate kinase, muscle 0.0442754
FLNA filamin A, alpha 0.0428086
CENPF centromere protein F, 350/400kDa 0.0419428
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0410908
NUP153 nucleoporin 153kDa 0.0410596
TPX2 TPX2, microtubule-associated 0.0403229
ZBTB10 zinc finger and BTB domain containing 10 0.0402144
CLTC clathrin, heavy chain (Hc) 0.0397796
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.039053
BIRC3 baculoviral IAP repeat containing 3 0.0386119
NCKAP1 NCK-associated protein 1 0.0383818
IARS1 isoleucyl-tRNA synthetase 1 0.0380839
DEK DEK proto-oncogene 0.0377139
EEF1G eukaryotic translation elongation factor 1 gamma 0.0370856
SRPK2 SRSF protein kinase 2 0.0361377
MKI67 marker of proliferation Ki-67 0.0360503
COG5 component of oligomeric golgi complex 5 0.0357276
SETD5 SET domain containing 5 0.0344647
RBM39 RNA binding motif protein 39 0.0337998
SMYD3 SET and MYND domain containing 3 0.0337082
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0332811
TTK TTK protein kinase 0.0332555
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0331954
TOP2B topoisomerase (DNA) II beta 180kDa 0.0329687
KIAA1958 KIAA1958 0.0329684
DTNA dystrobrevin, alpha 0.0329542
RARS1 arginyl-tRNA synthetase 1 0.0329405
ANKRD17 ankyrin repeat domain 17 0.0324857
RPL4 ribosomal protein L4 0.0322523
NPTN neuroplastin 0.0321837
CCNL1 cyclin L1 0.0318039
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0316664
AHCTF1 AT hook containing transcription factor 1 0.0315791
SNX14 sorting nexin 14 0.0312487
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311339
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0308113
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0307743
PICALM phosphatidylinositol binding clathrin assembly protein 0.030757
TAS2R14 taste receptor, type 2, member 14 0.0305631
NCOR1 nuclear receptor corepressor 1 0.0304664
KIF5B kinesin family member 5B 0.0303293
PBX3 pre-B-cell leukemia homeobox 3 0.0301771
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0301729
GSK3B glycogen synthase kinase 3 beta 0.0300761
RPL23 ribosomal protein L23 0.0300016
MATR3 matrin 3 0.0297996
MIS18BP1 MIS18 binding protein 1 0.0296481
TNPO1 transportin 1 0.0296068
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0293916
TUBB tubulin, beta class I 0.0290558
DSCAM Down syndrome cell adhesion molecule 0.0288814
NKTR natural killer cell triggering receptor 0.0286721
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0286379
CAMTA1 calmodulin binding transcription activator 1 0.0285994
WDR26 WD repeat domain 26 0.0285228
KIAA1328 KIAA1328 0.0281343
WDR45B WD repeat domain 45B 0.0281227
ATP13A3 ATPase type 13A3 0.0280575
NAP1L1 nucleosome assembly protein 1-like 1 0.0279438
HP1BP3 heterochromatin protein 1, binding protein 3 0.0279101
PIBF1 progesterone immunomodulatory binding factor 1 0.0278505
PNISR PNN-interacting serine/arginine-rich protein 0.0277071
U2SURP U2 snRNP-associated SURP domain containing 0.0274345
KIF13A kinesin family member 13A 0.0270215
TCERG1 transcription elongation regulator 1 0.0269894
GGNBP2 gametogenetin binding protein 2 0.0268321
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0268137
TNPO3 transportin 3 0.0267832
TENT2 terminal nucleotidyltransferase 2 0.026766
RBMX RNA binding motif protein, X-linked 0.0265385
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0264595
PRPF4B pre-mRNA processing factor 4B 0.0261795
CKAP2 cytoskeleton associated protein 2 0.0260728
LDHB lactate dehydrogenase B 0.0259264
FXR1 fragile X mental retardation, autosomal homolog 1 0.0259226
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0258215
SPAG9 sperm associated antigen 9 0.025706
SPTBN1 spectrin, beta, non-erythrocytic 1 0.025576
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0255648
ZFR zinc finger RNA binding protein 0.0255277
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0254361
PUM2 pumilio RNA-binding family member 2 0.025294

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0971254
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0918104
HMGA2 high mobility group AT-hook 2 -0.0768432
TPT1 tumor protein, translationally-controlled 1 -0.0718972
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0712285
PRKCA protein kinase C, alpha -0.0692751
MACF1 microtubule-actin crosslinking factor 1 -0.0649935
RIGI RNA sensor RIG-I -0.0606248
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0575731
AHNAK AHNAK nucleoprotein -0.0562567
ZBTB20 zinc finger and BTB domain containing 20 -0.0556125
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0554498
IGFBP3 insulin-like growth factor binding protein 3 -0.0532575
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0477028
AKAP12 A kinase (PRKA) anchor protein 12 -0.0475926
ANGPTL4 angiopoietin-like 4 -0.0469992
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0467814
SQSTM1 sequestosome 1 -0.0458532
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0443012
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0438222
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0423953
SVIL supervillin -0.0423471
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0418565
SH3KBP1 SH3-domain kinase binding protein 1 -0.0414309
PCED1B PC-esterase domain containing 1B -0.041131
RAI14 retinoic acid induced 14 -0.041034
CAVIN1 caveolae associated protein 1 -0.0399229
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0391865
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0390659
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0376624
FER fer (fps/fes related) tyrosine kinase -0.037307
PRR16 proline rich 16 -0.0362178
PODXL podocalyxin-like -0.0359856
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0357882
TPM4 tropomyosin 4 -0.0352668
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0350244
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0349036
SAMD4A sterile alpha motif domain containing 4A -0.0346164
IER3 immediate early response 3 -0.0344129
VIM vimentin -0.0341184
IL1RAP interleukin 1 receptor accessory protein -0.0332768
RAD51B RAD51 paralog B -0.0332286
GPC5 glypican 5 -0.0329089
OSMR oncostatin M receptor -0.0326955
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0326414
PTK2 protein tyrosine kinase 2 -0.0323658
SLC38A2 solute carrier family 38, member 2 -0.0322557
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0319476
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0318934
EFNA5 ephrin-A5 -0.0311922
DPYD dihydropyrimidine dehydrogenase -0.0308981
ARHGAP5 Rho GTPase activating protein 5 -0.0303003
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0297535
FNDC3B fibronectin type III domain containing 3B -0.0295771
CD44 CD44 molecule (Indian blood group) -0.0292946
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0290651
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0287948
BPTF bromodomain PHD finger transcription factor -0.0287801
RNF213 ring finger protein 213 -0.0286707
PRSS23 protease, serine, 23 -0.0286232
ATG7 autophagy related 7 -0.0277579
FMN1 formin 1 -0.0276423
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0275435
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0272331
ZMYND8 zinc finger, MYND-type containing 8 -0.027226
CEMIP2 cell migration inducing hyaluronidase 2 -0.027215
NALCN sodium leak channel, non selective -0.0272108
COL5A1 collagen, type V, alpha 1 -0.0271574
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0270429
INTS6 integrator complex subunit 6 -0.0267937
RIN2 Ras and Rab interactor 2 -0.0267807
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.026739
RPL31 ribosomal protein L31 -0.0266007
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0265617
S100A10 S100 calcium binding protein A10 -0.0260192
BICD1 bicaudal D homolog 1 (Drosophila) -0.0259451
NPEPPS aminopeptidase puromycin sensitive -0.0259294
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0257738
FRMD6 FERM domain containing 6 -0.0256819
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0256274
FLNB filamin B, beta -0.0256059
AEBP2 AE binding protein 2 -0.0253608
XRN1 5'-3' exoribonuclease 1 -0.0253024
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0252306
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0250984
NPAS2 neuronal PAS domain protein 2 -0.0249611
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0248014
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0246173
KLF3 Kruppel-like factor 3 (basic) -0.0243932
VCL vinculin -0.0243023
DOCK4 dedicator of cytokinesis 4 -0.0242161
NDRG1 N-myc downstream regulated 1 -0.0241996
SCAPER S-phase cyclin A-associated protein in the ER -0.0241488
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0239655
ZFHX3 zinc finger homeobox 3 -0.0236593
ABR active BCR-related -0.0233618
AHNAK2 AHNAK nucleoprotein 2 -0.0232947
CYTH1 cytohesin 1 -0.0231059
TAOK3 TAO kinase 3 -0.0227689
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0227336