Glycyrrhizic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1G eukaryotic translation elongation factor 1 gamma 0.0573674
FLNA filamin A, alpha 0.0513529
CCNL1 cyclin L1 0.0467545
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0446106
FTH1 ferritin, heavy polypeptide 1 0.032922
EEF2 eukaryotic translation elongation factor 2 0.0296379
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0285183
KMT2E lysine (K)-specific methyltransferase 2E 0.0267721
LENG8 leukocyte receptor cluster (LRC) member 8 0.0248071
JUP junction plakoglobin 0.0205335
PDIA3 protein disulfide isomerase family A, member 3 0.0199791
FXR1 fragile X mental retardation, autosomal homolog 1 0.0195799
RAD23B RAD23 homolog B (S. cerevisiae) 0.0195226
MXD1 MAX dimerization protein 1 0.0192444
HSPA8 heat shock 70kDa protein 8 0.0190021
KDM6A lysine (K)-specific demethylase 6A 0.0185144
MYH9 myosin, heavy chain 9, non-muscle 0.0185025
PKM pyruvate kinase, muscle 0.0182586
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0181483
MAT2A methionine adenosyltransferase II, alpha 0.0175407
PELI1 pellino E3 ubiquitin protein ligase 1 0.0174752
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0172217
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.017198
KRT8 keratin 8, type II 0.0169839
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0168428
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.016828
LMTK2 lemur tyrosine kinase 2 0.0166987
FAT1 FAT atypical cadherin 1 0.0166105
CTSA cathepsin A 0.0164765
PLEC plectin 0.0163719
PUM2 pumilio RNA-binding family member 2 0.0160025
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0157076
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0155596
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0154593
CNOT3 CCR4-NOT transcription complex, subunit 3 0.0153971
HMGA1 high mobility group AT-hook 1 0.0151011
RPL4 ribosomal protein L4 0.0150207
SF1 splicing factor 1 0.0150173
TGFBI transforming growth factor, beta-induced, 68kDa 0.0150114
NCKAP1 NCK-associated protein 1 0.0149524
L1CAM L1 cell adhesion molecule 0.0146678
MUC13 mucin 13, cell surface associated 0.0145009
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0143067
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0142139
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0140971
RBM33 RNA binding motif protein 33 0.0139565
CAPRIN1 cell cycle associated protein 1 0.0139536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0134766
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0134168
FNDC3B fibronectin type III domain containing 3B 0.0133897
AGFG1 ArfGAP with FG repeats 1 0.0133895
SP3 Sp3 transcription factor 0.0133045
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0131759
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0128804
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0128196
PRPF8 pre-mRNA processing factor 8 0.0123548
ZMIZ1 zinc finger, MIZ-type containing 1 0.0122853
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0118963
HOXA3 homeobox A3 0.0118497
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.011822
BIRC6 baculoviral IAP repeat containing 6 0.011814
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0117682
UBE3A ubiquitin protein ligase E3A 0.0117457
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0115465
ACTN4 actinin, alpha 4 0.0115419
SFPQ splicing factor proline/glutamine-rich 0.0114329
PCBP1 poly(rC) binding protein 1 0.0114221
MTMR3 myotubularin related protein 3 0.0113816
MYO18A myosin XVIIIA 0.0113597
ZMIZ2 zinc finger, MIZ-type containing 2 0.0113547
GLS2 glutaminase 2 (liver, mitochondrial) 0.0113242
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.011278
GANAB glucosidase, alpha; neutral AB 0.0112575
STIP1 stress-induced phosphoprotein 1 0.0111859
USP3 ubiquitin specific peptidase 3 0.0111644
TENT4A terminal nucleotidyltransferase 4A 0.0109731
NFE2L1 nuclear factor, erythroid 2-like 1 0.0108395
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0107154
ARID1A AT rich interactive domain 1A (SWI-like) 0.0106806
ATL2 atlastin GTPase 2 0.0106396
CAPN5 calpain 5 0.0106301
KRT20 keratin 20, type I 0.0105302
RYK receptor-like tyrosine kinase 0.0104876
NONO non-POU domain containing, octamer-binding 0.0104211
KCMF1 potassium channel modulatory factor 1 0.0102896
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.0102886
H2AC6 H2A clustered histone 6 0.0102603
RBM4 RNA binding motif protein 4 0.0102291
PTBP1 polypyrimidine tract binding protein 1 0.0102007
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0101961
ELMO2 engulfment and cell motility 2 0.0101556
KRT80 keratin 80, type II 0.0101089
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0101049
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0100964
SND1 staphylococcal nuclease and tudor domain containing 1 0.0100728
NUAK2 NUAK family, SNF1-like kinase, 2 0.00999782
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00987111
GSE1 Gse1 coiled-coil protein 0.00986762
NGFR nerve growth factor receptor 0.00982569
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.00982367

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.233499
PTMA prothymosin, alpha -0.208949
TMSB10 thymosin beta 10 -0.132323
TPT1 tumor protein, translationally-controlled 1 -0.0739678
RPS6 ribosomal protein S6 -0.0534739
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0522689
EZR ezrin -0.0518723
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0515914
LOC102724023 ES1 protein homolog, mitochondrial -0.0515427
RPL12 ribosomal protein L12 -0.0510916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0500515
RPL35A ribosomal protein L35a -0.0496282
RPLP1 ribosomal protein, large, P1 -0.0470648
EPCAM epithelial cell adhesion molecule -0.0469296
GOLGA4 golgin A4 -0.0450563
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0446853
RPL31 ribosomal protein L31 -0.0446788
RPS24 ribosomal protein S24 -0.0433363
RPL23 ribosomal protein L23 -0.0410536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0409084
RPS3 ribosomal protein S3 -0.0408491
RPL19 ribosomal protein L19 -0.0404276
EIF1 eukaryotic translation initiation factor 1 -0.0402029
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0389561
RPLP2 ribosomal protein, large, P2 -0.0384828
RPL32 ribosomal protein L32 -0.0384745
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0380524
RPS5 ribosomal protein S5 -0.0379556
IER3 immediate early response 3 -0.0374652
AHNAK AHNAK nucleoprotein -0.037386
EHBP1 EH domain binding protein 1 -0.0368025
GNAS GNAS complex locus -0.0365295
RPS8 ribosomal protein S8 -0.0363105
S100A10 S100 calcium binding protein A10 -0.0356068
CANX calnexin -0.0346775
RPS21 ribosomal protein S21 -0.0344541
TPM4 tropomyosin 4 -0.0340469
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0337648
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0336082
RPS27A ribosomal protein S27a -0.033545
STAU1 staufen double-stranded RNA binding protein 1 -0.0333407
RPS13 ribosomal protein S13 -0.0313211
RPS12 ribosomal protein S12 -0.0310085
RPL37A ribosomal protein L37a -0.0307292
RPL28 ribosomal protein L28 -0.0301116
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0297815
MAML2 mastermind-like 2 (Drosophila) -0.0296772
RPL34 ribosomal protein L34 -0.0294826
RPS19 ribosomal protein S19 -0.0290724
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0290295
RPS25 ribosomal protein S25 -0.0286979
CST3 cystatin C -0.0284256
TMSB4X thymosin beta 4, X-linked -0.0283939
RPL26 ribosomal protein L26 -0.0281514
PRRC2C proline-rich coiled-coil 2C -0.0275557
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0270755
BBX bobby sox homolog (Drosophila) -0.0268751
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0267361
VCL vinculin -0.0267028
ZBTB20 zinc finger and BTB domain containing 20 -0.0263479
NCEH1 neutral cholesterol ester hydrolase 1 -0.0262255
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0256978
B2M beta-2-microglobulin -0.0255791
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0253871
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0246926
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0245635
PERP PERP, TP53 apoptosis effector -0.0244835
FRMD5 FERM domain containing 5 -0.0243008
RPL36A ribosomal protein L36a -0.024081
DLG1 discs, large homolog 1 (Drosophila) -0.0237937
RPL8 ribosomal protein L8 -0.0237499
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.023625
PRELID2 PRELI domain containing 2 -0.0234167
RPLP0 ribosomal protein, large, P0 -0.0233788
IFRD1 interferon-related developmental regulator 1 -0.0231221
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0230219
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0228382
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.022685
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.022597
ZMYND8 zinc finger, MYND-type containing 8 -0.0224117
RPS14 ribosomal protein S14 -0.022211
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0221557
YBX1 Y box binding protein 1 -0.0219436
RPS17 ribosomal protein S17 -0.0218807
AKAP12 A kinase (PRKA) anchor protein 12 -0.0218698
RSL1D1 ribosomal L1 domain containing 1 -0.0211867
SLC38A1 solute carrier family 38, member 1 -0.0210413
GARS1 glycyl-tRNA synthetase 1 -0.0208095
S100A9 S100 calcium binding protein A9 -0.0207699
LARS1 leucyl-tRNA synthetase 1 -0.0207526
CDK13 cyclin-dependent kinase 13 -0.0207371
PATJ PATJ crumbs cell polarity complex component -0.0206346
CBX3 chromobox homolog 3 -0.0205882
RPL18 ribosomal protein L18 -0.0205762
KTN1 kinectin 1 (kinesin receptor) -0.0205001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0204848
GOLGB1 golgin B1 -0.0203299
GSTP1 glutathione S-transferase pi 1 -0.0203163
RPL7A ribosomal protein L7a -0.020167
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0201635