Glycyrrhizic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0899973
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0894219
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0882595
EEF2 eukaryotic translation elongation factor 2 0.087953
EEF1G eukaryotic translation elongation factor 1 gamma 0.0841106
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0820687
NDRG1 N-myc downstream regulated 1 0.0794943
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0768669
KDM6A lysine (K)-specific demethylase 6A 0.076634
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0710077
LDHA lactate dehydrogenase A 0.0685466
KMT2C lysine (K)-specific methyltransferase 2C 0.0624819
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0623196
WAC WW domain containing adaptor with coiled-coil 0.0614519
PKM pyruvate kinase, muscle 0.0568789
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0555913
ESYT2 extended synaptotagmin-like protein 2 0.0555412
TSC22D2 TSC22 domain family, member 2 0.0546225
COG5 component of oligomeric golgi complex 5 0.0524619
EREG epiregulin 0.051457
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0509978
PARD3 par-3 family cell polarity regulator 0.0497028
CD36 CD36 molecule (thrombospondin receptor) 0.0480678
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0462263
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0457208
TOP1 topoisomerase (DNA) I 0.0449703
NAMPT nicotinamide phosphoribosyltransferase 0.0437161
USP3 ubiquitin specific peptidase 3 0.0432631
WDR43 WD repeat domain 43 0.0421904
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0416827
PUM2 pumilio RNA-binding family member 2 0.0413134
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0405139
NUP58 nucleoporin 58 0.0401836
HILPDA hypoxia inducible lipid droplet-associated 0.0400995
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.039131
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0391254
RUNX2 runt-related transcription factor 2 0.0390326
RNF145 ring finger protein 145 0.0388353
SLMAP sarcolemma associated protein 0.0388262
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0385803
FAT1 FAT atypical cadherin 1 0.0384949
PDE4B phosphodiesterase 4B, cAMP-specific 0.03806
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0367578
NCKAP1 NCK-associated protein 1 0.0364402
CHD1 chromodomain helicase DNA binding protein 1 0.0360315
UBA6 ubiquitin-like modifier activating enzyme 6 0.0360174
RAB6A RAB6A, member RAS oncogene family 0.0359507
SFPQ splicing factor proline/glutamine-rich 0.0358374
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0355289
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0347671
ZFAND3 zinc finger, AN1-type domain 3 0.034663
RNF43 ring finger protein 43 0.0344274
CCNL1 cyclin L1 0.0341858
FLNA filamin A, alpha 0.0338737
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0336351
RREB1 ras responsive element binding protein 1 0.0335768
ANXA1 annexin A1 0.0334981
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0320927
PGK1 phosphoglycerate kinase 1 0.0316332
FAR1 fatty acyl CoA reductase 1 0.0316159
CDC73 cell division cycle 73 0.0312298
GOLGA4 golgin A4 0.0312197
CLTC clathrin, heavy chain (Hc) 0.0310213
TRIO trio Rho guanine nucleotide exchange factor 0.0307233
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0306993
HSPA8 heat shock 70kDa protein 8 0.0306432
PRRC1 proline-rich coiled-coil 1 0.0305856
PDIA3 protein disulfide isomerase family A, member 3 0.0305001
TXNIP thioredoxin interacting protein 0.0303375
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0300582
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0296854
EWSR1 EWS RNA-binding protein 1 0.0296138
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0295704
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0295109
FMNL2 formin-like 2 0.0291186
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0289946
BBX bobby sox homolog (Drosophila) 0.0288652
PRPF8 pre-mRNA processing factor 8 0.0287876
ADAM9 ADAM metallopeptidase domain 9 0.0278916
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.027868
LENG8 leukocyte receptor cluster (LRC) member 8 0.0273137
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0273103
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0269091
SREBF2 sterol regulatory element binding transcription factor 2 0.0266004
SF1 splicing factor 1 0.0265374
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0263636
TFRC transferrin receptor 0.0263377
MAT2A methionine adenosyltransferase II, alpha 0.0263285
STK39 serine threonine kinase 39 0.0261938
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.025579
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0254338
ZNF292 zinc finger protein 292 0.025298
ECPAS Ecm29 proteasome adaptor and scaffold 0.0252269
FXR1 fragile X mental retardation, autosomal homolog 1 0.0251895
FOXO1 forkhead box O1 0.0251815
SRPK1 SRSF protein kinase 1 0.0251576
MARCHF6 membrane associated ring-CH-type finger 6 0.0249714
NPEPPS aminopeptidase puromycin sensitive 0.0249288
CCNY cyclin Y 0.024897
SRRM2 serine/arginine repetitive matrix 2 0.0248492

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.107766
NCEH1 neutral cholesterol ester hydrolase 1 -0.106774
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0957251
EGFR epidermal growth factor receptor -0.0951208
LOC102724023 ES1 protein homolog, mitochondrial -0.0835654
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0821159
LAMA4 laminin, alpha 4 -0.0773143
TMSB10 thymosin beta 10 -0.0748489
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0709278
LMO7 LIM domain 7 -0.0708579
ITPKC inositol-trisphosphate 3-kinase C -0.0685854
RAD51B RAD51 paralog B -0.0635021
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0603988
MTAP methylthioadenosine phosphorylase -0.0600286
ATXN1 ataxin 1 -0.0594899
HMGA2 high mobility group AT-hook 2 -0.058716
RPS24 ribosomal protein S24 -0.0513916
IER3 immediate early response 3 -0.0510779
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0498286
PATJ PATJ crumbs cell polarity complex component -0.0485091
TPT1 tumor protein, translationally-controlled 1 -0.0483907
SEPTIN9 septin 9 -0.0440894
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0422283
PHF14 PHD finger protein 14 -0.0422012
EXOC4 exocyst complex component 4 -0.0415546
EHBP1 EH domain binding protein 1 -0.0407481
CDK13 cyclin-dependent kinase 13 -0.0401298
ACTG1 actin gamma 1 -0.0397927
RPL12 ribosomal protein L12 -0.0394537
DOCK5 dedicator of cytokinesis 5 -0.0393389
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0382493
TNS3 tensin 3 -0.0346459
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0340868
SMYD3 SET and MYND domain containing 3 -0.0338163
RPLP0 ribosomal protein, large, P0 -0.0337176
SMAD3 SMAD family member 3 -0.0327265
S100A10 S100 calcium binding protein A10 -0.0326977
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0326839
FHL2 four and a half LIM domains 2 -0.0325446
BCL2L1 BCL2-like 1 -0.0323357
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0321558
SKAP1 src kinase associated phosphoprotein 1 -0.0320102
LPP LIM domain containing preferred translocation partner in lipoma -0.0315159
SGMS2 sphingomyelin synthase 2 -0.0314589
CLIP2 CAP-GLY domain containing linker protein 2 -0.0306516
RPL35A ribosomal protein L35a -0.0305756
ABR active BCR-related -0.0301516
EMP1 epithelial membrane protein 1 -0.0301315
RPL26 ribosomal protein L26 -0.0286873
NTSR1 neurotensin receptor 1 (high affinity) -0.02863
BICD1 bicaudal D homolog 1 (Drosophila) -0.0284135
PTMA prothymosin, alpha -0.0283587
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0281538
RCOR1 REST corepressor 1 -0.0281376
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0280864
AHNAK AHNAK nucleoprotein -0.0278387
GOLGB1 golgin B1 -0.0273366
RAB10 RAB10, member RAS oncogene family -0.0272197
RABGAP1L RAB GTPase activating protein 1-like -0.0269123
TBC1D5 TBC1 domain family, member 5 -0.0268248
LAMC2 laminin, gamma 2 -0.0267271
RPL31 ribosomal protein L31 -0.0265827
CUX1 cut-like homeobox 1 -0.0263159
RPS8 ribosomal protein S8 -0.0261844
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0257554
FMN1 formin 1 -0.0256694
DST dystonin -0.0250504
RPL23 ribosomal protein L23 -0.0248917
AK1 adenylate kinase 1 -0.024851
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0247029
SLC30A10 solute carrier family 30, member 10 -0.0243983
PTPRK protein tyrosine phosphatase, receptor type, K -0.0240958
NUP50 nucleoporin 50kDa -0.0240358
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0240288
ITGA6 integrin, alpha 6 -0.0236568
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0234709
FNIP1 folliculin interacting protein 1 -0.0233842
OSBPL10 oxysterol binding protein-like 10 -0.0233418
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0229262
UTRN utrophin -0.0228972
FHIT fragile histidine triad -0.0228835
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0228301
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0224846
RPL28 ribosomal protein L28 -0.0224483
RPS5 ribosomal protein S5 -0.0223886
KIAA1217 KIAA1217 -0.0223456
RPS17 ribosomal protein S17 -0.0221106
PCNX4 pecanex 4 -0.0220423
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0219737
RPL14 ribosomal protein L14 -0.021943
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0218345
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0217474
PRKN parkin RBR E3 ubiquitin protein ligase -0.0215461
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0212937
BPTF bromodomain PHD finger transcription factor -0.0210894
RPL34 ribosomal protein L34 -0.0210646
ERI2 ERI1 exoribonuclease family member 2 -0.0209137
TENM3 teneurin transmembrane protein 3 -0.0207687
ATG7 autophagy related 7 -0.0207232
SPATA13 spermatogenesis associated 13 -0.0207004