Glycyrrhizic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glycyrrhizic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glycyrrhizic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PGK1 phosphoglycerate kinase 1 0.0193339
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0182911
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0174823
RPL4 ribosomal protein L4 0.0135087
HSPA8 heat shock 70kDa protein 8 0.0133455
MYH9 myosin, heavy chain 9, non-muscle 0.0126382
ANLN anillin, actin binding protein 0.0102493
FLNA filamin A, alpha 0.0102433
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0102396
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0099879
BHLHE40 basic helix-loop-helix family, member e40 0.00995568
ESYT2 extended synaptotagmin-like protein 2 0.00991514
WWOX WW domain containing oxidoreductase 0.00976815
SPRED2 sprouty-related, EVH1 domain containing 2 0.00961618
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00942743
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.00933892
NCKAP1 NCK-associated protein 1 0.00918166
PRPF8 pre-mRNA processing factor 8 0.00885657
RICTOR RPTOR independent companion of MTOR, complex 2 0.00884536
EEF1G eukaryotic translation elongation factor 1 gamma 0.00867334
NONO non-POU domain containing, octamer-binding 0.00844943
RNF43 ring finger protein 43 0.0079182
KDM6A lysine (K)-specific demethylase 6A 0.0077103
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00763231
NPTN neuroplastin 0.00758981
PLEC plectin 0.00755448
DAND5 DAN domain family member 5, BMP antagonist 0.00744235
STIP1 stress-induced phosphoprotein 1 0.00731267
BMP5 bone morphogenetic protein 5 0.00723095
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.00717315
CAPRIN1 cell cycle associated protein 1 0.00682237
HELZ helicase with zinc finger 0.00681296
DSPP dentin sialophosphoprotein 0.00675933
SP3 Sp3 transcription factor 0.00659249
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.00651617
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00650676
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.00644153
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00634484
WDR26 WD repeat domain 26 0.00617603
ARRDC3 arrestin domain containing 3 0.00610285
STK38L serine/threonine kinase 38 like 0.00602262
ADAM17 ADAM metallopeptidase domain 17 0.0059379
RAB30 RAB30, member RAS oncogene family 0.00590689
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0056692
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.00559996
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00558062
OSBPL3 oxysterol binding protein-like 3 0.00547065
UBQLN1 ubiquilin 1 0.00541848
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00541472
KDM4B lysine (K)-specific demethylase 4B 0.00541343
RBM33 RNA binding motif protein 33 0.00539296
PUM2 pumilio RNA-binding family member 2 0.00539286
PTBP1 polypyrimidine tract binding protein 1 0.00533061
FAT1 FAT atypical cadherin 1 0.00531218
NUP58 nucleoporin 58 0.00530511
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.00526689
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00519648
H1-4 H1.4 linker histone, cluster member 0.00513673
WAC WW domain containing adaptor with coiled-coil 0.00512732
MIS18BP1 MIS18 binding protein 1 0.00511864
MED13L mediator complex subunit 13-like 0.00510394
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00509924
MXD1 MAX dimerization protein 1 0.00505141
PLPP3 phospholipid phosphatase 3 0.00502201
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00499364
PRKCA protein kinase C, alpha 0.00494412
MARCHF6 membrane associated ring-CH-type finger 6 0.00493646
CLTC clathrin, heavy chain (Hc) 0.00492135
SLC35F5 solute carrier family 35, member F5 0.0048886
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0048827
RFWD3 ring finger and WD repeat domain 3 0.00485302
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00483792
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00480672
YEATS2 YEATS domain containing 2 0.00478203
MAT2A methionine adenosyltransferase II, alpha 0.00475276
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00471188
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.00469912
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00468623
WNK1 WNK lysine deficient protein kinase 1 0.00468188
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.00467193
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.00464354
UBA6 ubiquitin-like modifier activating enzyme 6 0.0045141
CUL3 cullin 3 0.00447519
SNX9 sorting nexin 9 0.00438559
KDM7A lysine (K)-specific demethylase 7A 0.00438168
EIF4B eukaryotic translation initiation factor 4B 0.00434928
TENT4A terminal nucleotidyltransferase 4A 0.00432813
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.00432055
BRWD3 bromodomain and WD repeat domain containing 3 0.00430216
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00429966
MAN1A1 mannosidase, alpha, class 1A, member 1 0.00429895
TNRC6A trinucleotide repeat containing 6A 0.00429838
ZNRF3 zinc and ring finger 3 0.00429523
USP9X ubiquitin specific peptidase 9, X-linked 0.00429238
HPCAL1 hippocalcin-like 1 0.00422892
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00421077
TNNC1 troponin C type 1 (slow) 0.00420744
VGLL4 vestigial-like family member 4 0.00419833
ATXN2L ataxin 2-like 0.00416946
KIF18A kinesin family member 18A 0.00416733

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0533641
NKD1 naked cuticle homolog 1 (Drosophila) -0.0508044
PTMA prothymosin, alpha -0.0407339
RPS6 ribosomal protein S6 -0.0400873
AKAP12 A kinase (PRKA) anchor protein 12 -0.0374137
EZR ezrin -0.0327079
RPS19 ribosomal protein S19 -0.0325522
VIM vimentin -0.0300535
RPL35A ribosomal protein L35a -0.0294281
MAML2 mastermind-like 2 (Drosophila) -0.0293136
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0288376
RPS3 ribosomal protein S3 -0.0283321
TPT1 tumor protein, translationally-controlled 1 -0.0280515
CDH13 cadherin 13 -0.0274131
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0267547
CDK6 cyclin-dependent kinase 6 -0.02651
EIF1 eukaryotic translation initiation factor 1 -0.0262085
ACTG1 actin gamma 1 -0.025369
RPL23 ribosomal protein L23 -0.0238579
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0229291
RPS13 ribosomal protein S13 -0.0227914
RPS8 ribosomal protein S8 -0.0221711
MT2A metallothionein 2A -0.0217519
DST dystonin -0.0214375
TPM4 tropomyosin 4 -0.0209528
RPL26 ribosomal protein L26 -0.0207606
PDE4D phosphodiesterase 4D, cAMP-specific -0.0206633
ITGA6 integrin, alpha 6 -0.020213
RPL12 ribosomal protein L12 -0.0199112
ENO1 enolase 1, (alpha) -0.0194332
RPS24 ribosomal protein S24 -0.019035
ZBTB20 zinc finger and BTB domain containing 20 -0.0187848
LOC102724023 ES1 protein homolog, mitochondrial -0.0186704
RPS21 ribosomal protein S21 -0.0184358
RPL7A ribosomal protein L7a -0.0183281
VCL vinculin -0.0180917
RPLP2 ribosomal protein, large, P2 -0.0176331
TMSB4X thymosin beta 4, X-linked -0.0175213
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0174674
RPS27A ribosomal protein S27a -0.0173732
PERP PERP, TP53 apoptosis effector -0.016965
RPL31 ribosomal protein L31 -0.0169014
RPL19 ribosomal protein L19 -0.0165505
ANXA2 annexin A2 -0.0165192
SLC38A1 solute carrier family 38, member 1 -0.0165099
EGR1 early growth response 1 -0.016432
KRT18 keratin 18, type I -0.016074
RPS14 ribosomal protein S14 -0.0157898
PCBP2 poly(rC) binding protein 2 -0.0155156
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0152552
RPL32 ribosomal protein L32 -0.0152215
AKAP9 A kinase (PRKA) anchor protein 9 -0.0151813
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0150617
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0148496
RPLP1 ribosomal protein, large, P1 -0.0148279
RPL36 ribosomal protein L36 -0.0148267
CANX calnexin -0.0147868
S100A6 S100 calcium binding protein A6 -0.0147814
FTL ferritin, light polypeptide -0.0147466
PIBF1 progesterone immunomodulatory binding factor 1 -0.0147369
MRPS6 mitochondrial ribosomal protein S6 -0.0147099
TPI1 triosephosphate isomerase 1 -0.0145651
PROX1 prospero homeobox 1 -0.0144759
S100A10 S100 calcium binding protein A10 -0.0144202
RPL36A ribosomal protein L36a -0.0144044
CCND1 cyclin D1 -0.0143706
RPL11 ribosomal protein L11 -0.014336
RPL5 ribosomal protein L5 -0.0143149
RPS23 ribosomal protein S23 -0.014244
PFN1 profilin 1 -0.014242
ANO1 anoctamin 1, calcium activated chloride channel -0.0141009
IARS1 isoleucyl-tRNA synthetase 1 -0.0140453
RPL34 ribosomal protein L34 -0.0140293
ITGB4 integrin, beta 4 -0.0138459
RPS29 ribosomal protein S29 -0.013656
RPL9 ribosomal protein L9 -0.0135981
FLNB filamin B, beta -0.0135452
SKAP1 src kinase associated phosphoprotein 1 -0.0134641
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0134589
RPL37A ribosomal protein L37a -0.0133717
RPS25 ribosomal protein S25 -0.0133437
NAP1L1 nucleosome assembly protein 1-like 1 -0.0133159
OXR1 oxidation resistance 1 -0.0132985
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0130998
RPS11 ribosomal protein S11 -0.0129558
IGFBP3 insulin-like growth factor binding protein 3 -0.0125534
RPL35 ribosomal protein L35 -0.0125524
VMP1 vacuole membrane protein 1 -0.0123105
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0122529
RPL37 ribosomal protein L37 -0.0122527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0121866
INTS6 integrator complex subunit 6 -0.0121824
ARF4 ADP-ribosylation factor 4 -0.0121502
RPL7 ribosomal protein L7 -0.0121013
RACK1 receptor for activated C kinase 1 -0.0120816
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0120755
PATJ PATJ crumbs cell polarity complex component -0.0120646
RPS16 ribosomal protein S16 -0.0120505
NPAS2 neuronal PAS domain protein 2 -0.0119328
GMDS GDP-mannose 4,6-dehydratase -0.0118392