GnRH secretion Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are key regulators of reproduction. They release GnRH into the portal circulation. In turn, GnRH stimulates the pituitary gland to secrete follicle-stimulating hormone and luteinizing hormone (LH) to regulate gonadal functions. Gonadal steroids provide feedback to regulate GnRH release. GnRH neurons express the kisspeptin receptor, GPR 54, and kisspeptins potently stimulate the release of GnRH by depolarising and inducing sustained action potential firing in GnRH neurons. It is also demonstrated that Kisspeptin-GPR54 system positively regulates the GnRH expression with a time course consistent with activation of Akt and MAP kinase signaling pathways. (Kyoto Encyclopedia of Genes and Genomes, hsa04929)
External Link https://www.kegg.jp/entry/hsa04929
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64 proteins participating in the GnRH secretion pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CHGA chromogranin A
CLSTN1 calsyntenin 1
CXXC1 CXXC finger protein 1
ENTHD1 ENTH domain containing 1
ESR2 estrogen receptor 2 (ER beta)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GPER1 G protein-coupled estrogen receptor 1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3
HRAS Harvey rat sarcoma viral oncogene homolog
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LHB luteinizing hormone beta polypeptide
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
RNASE3 ribonuclease, RNase A family, 3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC5 transient receptor potential cation channel, subfamily C, member 5