Goiter Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency ( HYPOTHYROIDISM), or hormone overproduction ( HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic ( GOITER, ENDEMIC). (Experimental Factor Ontology, EFO_0004283)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006042
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Genes

56 genes/proteins associated with the disease Goiter from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TG thyroglobulin 2.88009
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.88009
CLCN5 chloride channel, voltage-sensitive 5 2.88009
TPO thyroid peroxidase 2.88009
THRA thyroid hormone receptor, alpha 1.72158
THRB thyroid hormone receptor, beta 1.70285
DIO1 deiodinase, iodothyronine, type I 1.65023
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.63586
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.62423
TSHB thyroid stimulating hormone, beta 1.60617
CAT catalase 1.41775
JUN jun proto-oncogene 1.40732
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.39563
BIRC5 baculoviral IAP repeat containing 5 1.34664
APP amyloid beta (A4) precursor protein 1.30941
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 1.29072
DIO2 deiodinase, iodothyronine, type II 1.28765
DUSP1 dual specificity phosphatase 1 1.27845
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.27657
IL4 interleukin 4 1.26483
CSNK1A1 casein kinase 1, alpha 1 1.23775
TRIP4 thyroid hormone receptor interactor 4 1.21823
ING2 inhibitor of growth family, member 2 1.19704
DNM1 dynamin 1 1.17893
PPARG peroxisome proliferator-activated receptor gamma 1.17827
MT4 metallothionein 4 1.17399
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.17333
BAX BCL2-associated X protein 1.165
SNAP29 synaptosomal-associated protein, 29kDa 1.16203
ACO1 aconitase 1, soluble 1.15492
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.1485
IGF1 insulin-like growth factor 1 (somatomedin C) 1.14064
SOD2 superoxide dismutase 2, mitochondrial 1.1403
SELK selenoprotein K 1.13862
GJA5 gap junction protein, alpha 5, 40kDa 1.13655
STAG2 stromal antigen 2 1.11877
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.11466
POU3F4 POU class 3 homeobox 4 1.10459
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.10388
CCL2 chemokine (C-C motif) ligand 2 1.0919
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.08301
PRKCE protein kinase C, epsilon 1.07696
FUNDC2 FUN14 domain containing 2 1.07589
CA2 carbonic anhydrase II 1.07553
POU2F1 POU class 2 homeobox 1 1.07057
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.06987
ANGPTL4 angiopoietin-like 4 1.05793
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.05089
ARL10 ADP-ribosylation factor-like 10 1.04276
TTR transthyretin 1.03715
NPR3 natriuretic peptide receptor 3 1.03641
XBP1 X-box binding protein 1 1.03641
CSK c-src tyrosine kinase 1.02821
FABP2 fatty acid binding protein 2, intestinal 1.02708
CA3 carbonic anhydrase III 1.01852
CD86 CD86 molecule 1.01025