Goserelin (acetate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.132937
AKAP12 A kinase (PRKA) anchor protein 12 0.127202
APLP2 amyloid beta (A4) precursor-like protein 2 0.0669636
HSPA8 heat shock 70kDa protein 8 0.0556849
RPS3 ribosomal protein S3 0.0549785
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.051744
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.049295
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0475743
PRRC2C proline-rich coiled-coil 2C 0.0470201
BCAR3 breast cancer anti-estrogen resistance 3 0.0425467
BCL2L1 BCL2-like 1 0.0415633
KTN1 kinectin 1 (kinesin receptor) 0.0398523
SAMD4A sterile alpha motif domain containing 4A 0.0391278
RPS2 ribosomal protein S2 0.0381343
ITGA6 integrin, alpha 6 0.0369759
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0368223
NDRG1 N-myc downstream regulated 1 0.0365969
RPL37A ribosomal protein L37a 0.0359561
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0358336
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0348581
RPS6 ribosomal protein S6 0.0344854
MYH9 myosin, heavy chain 9, non-muscle 0.034363
MT2A metallothionein 2A 0.0343401
RBM25 RNA binding motif protein 25 0.0342413
FMNL2 formin-like 2 0.0342112
PTPRF protein tyrosine phosphatase, receptor type, F 0.0335979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332847
GOLGA4 golgin A4 0.0328816
MSN moesin 0.0320515
CORO1C coronin, actin binding protein, 1C 0.0319391
RPS21 ribosomal protein S21 0.0318341
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0318142
CD44 CD44 molecule (Indian blood group) 0.0312305
AREG amphiregulin 0.0311023
NAP1L1 nucleosome assembly protein 1-like 1 0.0300991
TMF1 TATA element modulatory factor 1 0.0299976
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0294979
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0289653
TPM3 tropomyosin 3 0.02836
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0282721
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0281389
POTEF POTE ankyrin domain family, member F 0.0279793
RPS12 ribosomal protein S12 0.0279098
SEPTIN9 septin 9 0.0274022
TRIO trio Rho guanine nucleotide exchange factor 0.0272365
KLF6 Kruppel-like factor 6 0.0271173
DSCAM Down syndrome cell adhesion molecule 0.0268909
ZFP36L1 ZFP36 ring finger protein-like 1 0.0268078
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0266846
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0259901
RPS8 ribosomal protein S8 0.0259658
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0259394
ERBIN erbb2 interacting protein 0.0258677
GLS2 glutaminase 2 (liver, mitochondrial) 0.0258559
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0250311
RPS19 ribosomal protein S19 0.0249421
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0247469
VMP1 vacuole membrane protein 1 0.0245711
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0245492
RTN4 reticulon 4 0.0245338
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0244747
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0241691
RPL26 ribosomal protein L26 0.0238542
WWC1 WW and C2 domain containing 1 0.0236142
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.023494
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0233855
AKAP9 A kinase (PRKA) anchor protein 9 0.0233295
FTL ferritin, light polypeptide 0.0231111
IPO7 importin 7 0.0229867
CCNL1 cyclin L1 0.0227451
AKAP13 A kinase (PRKA) anchor protein 13 0.0226694
IRS2 insulin receptor substrate 2 0.0225952
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0224226
LAMC2 laminin, gamma 2 0.0223231
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0221483
PNN pinin, desmosome associated protein 0.0219662
BRD2 bromodomain containing 2 0.0219252
CAB39 calcium binding protein 39 0.0217538
BTBD10 BTB (POZ) domain containing 10 0.0214419
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0212346
RBM39 RNA binding motif protein 39 0.0211095
SET SET nuclear proto-oncogene 0.0208958
ARHGAP29 Rho GTPase activating protein 29 0.0208568
EIF5B eukaryotic translation initiation factor 5B 0.0205817
RPL11 ribosomal protein L11 0.0200716
S100A11 S100 calcium binding protein A11 0.0197411
FOSL1 FOS-like antigen 1 0.0195823
LAMA4 laminin, alpha 4 0.0190678
TMED9 transmembrane emp24 protein transport domain containing 9 0.0190407
EIF4A2 eukaryotic translation initiation factor 4A2 0.0190008
PCBP2 poly(rC) binding protein 2 0.0189012
TJP1 tight junction protein 1 0.0187995
BRD4 bromodomain containing 4 0.0187689
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0185919
RSRC2 arginine/serine-rich coiled-coil 2 0.0185446
KMT2E lysine (K)-specific methyltransferase 2E 0.0184914
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0184568
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0184513
CBX3 chromobox homolog 3 0.0184228
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0183921

decreased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.180838
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.161582
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.15027
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.136644
MUC17 mucin 17, cell surface associated -0.128697
FTH1 ferritin, heavy polypeptide 1 -0.124205
F3 coagulation factor III (thromboplastin, tissue factor) -0.119971
IGFBP3 insulin-like growth factor binding protein 3 -0.111111
LMO7 LIM domain 7 -0.106359
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0854668
SLC35F3 solute carrier family 35, member F3 -0.080322
TPT1 tumor protein, translationally-controlled 1 -0.0779115
TXNRD1 thioredoxin reductase 1 -0.0731728
EGFR epidermal growth factor receptor -0.0699657
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0688624
UBE2H ubiquitin-conjugating enzyme E2H -0.0647557
MAML2 mastermind-like 2 (Drosophila) -0.0612238
MXD1 MAX dimerization protein 1 -0.0606482
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0588046
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0582789
SP100 SP100 nuclear antigen -0.0551717
DIAPH2 diaphanous-related formin 2 -0.0528303
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0512969
SKAP2 src kinase associated phosphoprotein 2 -0.0506466
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.050062
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0493494
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0482058
ANTXR2 anthrax toxin receptor 2 -0.0477464
USP34 ubiquitin specific peptidase 34 -0.0473777
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0472878
SEC31A SEC31 homolog A (S. cerevisiae) -0.0456665
KLK10 kallikrein-related peptidase 10 -0.0449614
VCAN versican -0.044431
PTPRR protein tyrosine phosphatase, receptor type, R -0.0436335
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0433886
HMGA1 high mobility group AT-hook 1 -0.0431606
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0429501
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0424715
GREB1L growth regulation by estrogen in breast cancer-like -0.0423307
RABGAP1L RAB GTPase activating protein 1-like -0.0419166
AHNAK AHNAK nucleoprotein -0.0415386
SVIL supervillin -0.0412894
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0410945
NPSR1 neuropeptide S receptor 1 -0.0406023
TRRAP transformation/transcription domain-associated protein -0.0405749
STK39 serine threonine kinase 39 -0.0401796
GNAS GNAS complex locus -0.0396523
PRSS3 protease, serine, 3 -0.039164
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0388841
NCOA3 nuclear receptor coactivator 3 -0.0387183
ANXA2 annexin A2 -0.0384231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0379992
PGK1 phosphoglycerate kinase 1 -0.0371669
PDE4D phosphodiesterase 4D, cAMP-specific -0.0370449
NPC1 Niemann-Pick disease, type C1 -0.0368879
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0365234
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0362514
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0359912
CLMP CXADR-like membrane protein -0.0356483
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0352532
UBC ubiquitin C -0.0348531
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0347513
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0343018
GRB10 growth factor receptor-bound protein 10 -0.0342012
CD2AP CD2-associated protein -0.0339291
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0337504
FERMT1 fermitin family member 1 -0.0327016
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.032615
FA2H fatty acid 2-hydroxylase -0.0325186
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.032072
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0319632
CD59 CD59 molecule, complement regulatory protein -0.0319304
LOC112694756 uncharaterized LOC112694756 -0.031886
BIRC6 baculoviral IAP repeat containing 6 -0.0317134
ABHD3 abhydrolase domain containing 3 -0.0310097
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0309334
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -0.0307028
SULF2 sulfatase 2 -0.0300642
NBEAL1 neurobeachin-like 1 -0.0298909
SMNDC1 survival motor neuron domain containing 1 -0.0298262
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0297127
MON2 MON2 homolog (S. cerevisiae) -0.0296725
COG5 component of oligomeric golgi complex 5 -0.0289159
HDLBP high density lipoprotein binding protein -0.0287263
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.028629
RNF213 ring finger protein 213 -0.0284373
XYLT1 xylosyltransferase I -0.028409
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0282486
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.0280342
AK1 adenylate kinase 1 -0.0278391
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0274957
PLSCR1 phospholipid scramblase 1 -0.0272589
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0268224
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0267522
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0266843
STAU1 staufen double-stranded RNA binding protein 1 -0.0263328
CALU calumenin -0.0263275
TPM4 tropomyosin 4 -0.0262243
CD164 CD164 molecule, sialomucin -0.0261752
ITPRID2 ITPR interacting domain containing 2 -0.0259318