Goserelin (acetate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.18098
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.180954
RPS3 ribosomal protein S3 0.135614
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.119724
VMP1 vacuole membrane protein 1 0.105165
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0840564
ANKRD36C ankyrin repeat domain 36C 0.0791157
PTMA prothymosin, alpha 0.0782708
PRRC2C proline-rich coiled-coil 2C 0.0779053
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0768694
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0740764
SET SET nuclear proto-oncogene 0.0739351
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0728424
IFI6 interferon, alpha-inducible protein 6 0.0717535
RPL19 ribosomal protein L19 0.0702864
HSPA8 heat shock 70kDa protein 8 0.0664573
DSPP dentin sialophosphoprotein 0.0644168
RPS6 ribosomal protein S6 0.0623935
PDLIM5 PDZ and LIM domain 5 0.0606172
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0587936
RPS2 ribosomal protein S2 0.0578842
CLTC clathrin, heavy chain (Hc) 0.0571982
PNN pinin, desmosome associated protein 0.0571585
BZW1 basic leucine zipper and W2 domains 1 0.05601
MT2A metallothionein 2A 0.0558219
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0549645
B2M beta-2-microglobulin 0.0528858
KTN1 kinectin 1 (kinesin receptor) 0.0524504
LOC102724023 ES1 protein homolog, mitochondrial 0.0513768
RBM39 RNA binding motif protein 39 0.0507857
RSRC2 arginine/serine-rich coiled-coil 2 0.0506857
APLP2 amyloid beta (A4) precursor-like protein 2 0.0497764
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0494416
RPL26 ribosomal protein L26 0.048725
EZR ezrin 0.0476992
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0473062
VEGFA vascular endothelial growth factor A 0.0465391
TPM3 tropomyosin 3 0.0463576
MYH9 myosin, heavy chain 9, non-muscle 0.0463209
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0456462
HMGB2 high mobility group box 2 0.0455948
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0453879
RPS12 ribosomal protein S12 0.045244
NRIP1 nuclear receptor interacting protein 1 0.0451244
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0448315
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0445554
IGFBP5 insulin-like growth factor binding protein 5 0.0440225
ADARB1 adenosine deaminase, RNA-specific, B1 0.0438381
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0431761
EIF4A2 eukaryotic translation initiation factor 4A2 0.0430562
KIF5B kinesin family member 5B 0.0425721
PFDN4 prefoldin subunit 4 0.0419526
RPL37A ribosomal protein L37a 0.0411153
RPS8 ribosomal protein S8 0.040241
RPL12 ribosomal protein L12 0.0397673
FBXL20 F-box and leucine-rich repeat protein 20 0.0397364
RPL35A ribosomal protein L35a 0.0393376
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0391637
NCOA3 nuclear receptor coactivator 3 0.0384028
YBX3 Y box binding protein 3 0.0374476
EXT1 exostosin glycosyltransferase 1 0.0372744
CENPF centromere protein F, 350/400kDa 0.0372382
GOLGA4 golgin A4 0.037235
MYOF myoferlin 0.0366206
GOLGB1 golgin B1 0.0363862
TAPBP TAP binding protein (tapasin) 0.0362084
NDRG1 N-myc downstream regulated 1 0.0360976
BRD4 bromodomain containing 4 0.0358752
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0358182
AKAP9 A kinase (PRKA) anchor protein 9 0.0357084
ANKRD12 ankyrin repeat domain 12 0.0356718
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0353088
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0350241
VCL vinculin 0.0348068
BRD2 bromodomain containing 2 0.0346218
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0345734
RAD51B RAD51 paralog B 0.0333891
AREG amphiregulin 0.0332892
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0332795
LIMCH1 LIM and calponin homology domains 1 0.0324861
RPL13A ribosomal protein L13a 0.0324731
RBM25 RNA binding motif protein 25 0.0323261
CCNL1 cyclin L1 0.0322792
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0320858
RB1CC1 RB1-inducible coiled-coil 1 0.032019
DSTN destrin (actin depolymerizing factor) 0.0318385
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0317283
AKAP12 A kinase (PRKA) anchor protein 12 0.0312398
TRA2A transformer 2 alpha homolog (Drosophila) 0.0311444
SERINC1 serine incorporator 1 0.0311235
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0309332
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0309255
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0306842
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0304937
DOCK5 dedicator of cytokinesis 5 0.0303357
ZNF292 zinc finger protein 292 0.030324
OGA O-GlcNAcase 0.0303119
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0301247
ANLN anillin, actin binding protein 0.0296838
KMT2E lysine (K)-specific methyltransferase 2E 0.0293422

decreased expression

Symbol Name Standardized Value
CATSPERB catsper channel auxiliary subunit beta -0.115991
ACACA acetyl-CoA carboxylase alpha -0.107355
TMEM123 transmembrane protein 123 -0.0842034
CCND1 cyclin D1 -0.0632077
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0631001
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0629268
ZMYND8 zinc finger, MYND-type containing 8 -0.0574987
TRPS1 trichorhinophalangeal syndrome I -0.0569294
CDK12 cyclin-dependent kinase 12 -0.0567394
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0519414
SHROOM3 shroom family member 3 -0.0451753
FTH1 ferritin, heavy polypeptide 1 -0.0445445
GMDS GDP-mannose 4,6-dehydratase -0.0412502
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0387866
PBX1 pre-B-cell leukemia homeobox 1 -0.0384932
TSC22D2 TSC22 domain family, member 2 -0.0379532
LASP1 LIM and SH3 protein 1 -0.0367114
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0361268
DNAH14 dynein, axonemal, heavy chain 14 -0.0358055
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.035445
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0352735
FADS2 fatty acid desaturase 2 -0.034129
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0328857
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0328744
KRT7 keratin 7, type II -0.0324093
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0318936
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0311693
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0305054
TC2N tandem C2 domains, nuclear -0.0280384
TENM2 teneurin transmembrane protein 2 -0.0273024
YPEL2 yippee-like 2 (Drosophila) -0.0262066
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -0.0260964
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.02541
TRIO trio Rho guanine nucleotide exchange factor -0.0243273
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.024254
NCOA6 nuclear receptor coactivator 6 -0.024148
DLG1 discs, large homolog 1 (Drosophila) -0.0238982
RUNX1 runt-related transcription factor 1 -0.0236208
CSNK1A1 casein kinase 1, alpha 1 -0.0235043
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0234919
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0231814
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0230688
ZNF652 zinc finger protein 652 -0.0224876
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0224759
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0224356
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0223831
FASN fatty acid synthase -0.0222107
TRAPPC9 trafficking protein particle complex 9 -0.0221961
SOX4 SRY (sex determining region Y)-box 4 -0.0220294
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0219808
STAU1 staufen double-stranded RNA binding protein 1 -0.0219028
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0218421
LMAN1 lectin, mannose-binding, 1 -0.0217811
UGCG UDP-glucose ceramide glucosyltransferase -0.0216921
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0214973
TMSB10 thymosin beta 10 -0.0212719
TUBB tubulin, beta class I -0.021173
SPTSSA serine palmitoyltransferase, small subunit A -0.0209868
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0208076
KAZN kazrin, periplakin interacting protein -0.0204727
VDAC1 voltage-dependent anion channel 1 -0.0201663
LRP1B low density lipoprotein receptor-related protein 1B -0.0201388
CCNI cyclin I -0.0200407
PKM pyruvate kinase, muscle -0.0199141
DPYD dihydropyrimidine dehydrogenase -0.0198083
TTC6 tetratricopeptide repeat domain 6 -0.0195454
DENND1A DENN/MADD domain containing 1A -0.0194567
CD24 CD24 molecule -0.0192054
LY6E lymphocyte antigen 6 complex, locus E -0.0190222
SMIM14 small integral membrane protein 14 -0.0186473
ARF1 ADP-ribosylation factor 1 -0.0184705
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0184544
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0183703
SEPTIN11 septin 11 -0.0183697
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0182674
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0182429
NFIA nuclear factor I/A -0.0180917
EEF2 eukaryotic translation elongation factor 2 -0.0180196
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0179867
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0177717
RPS24 ribosomal protein S24 -0.0175292
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.017488
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0174427
MACROD1 MACRO domain containing 1 -0.0174344
TOB1 transducer of ERBB2, 1 -0.0172119
STOM stomatin -0.0171945
ZNF609 zinc finger protein 609 -0.0171779
RPS16 ribosomal protein S16 -0.0171138
NCAM2 neural cell adhesion molecule 2 -0.0169915
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.016969
BLTP2 bridge-like lipid transfer protein family member 2 -0.0169214
AGO2 argonaute RISC catalytic component 2 -0.0168254
FSTL4 follistatin-like 4 -0.0163748
BCAS1 breast carcinoma amplified sequence 1 -0.0163546
ATF6 activating transcription factor 6 -0.0163501
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0162978
TFRC transferrin receptor -0.0161518
TUBA1B tubulin, alpha 1b -0.0161106
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0160568
C6ORF132 chromosome 6 open reading frame 132 -0.0159875